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Volumn 7, Issue , 2012, Pages 3259-3278

Neurological disorders and therapeutics targeted to surmount the blood-brain barrier

Author keywords

Blood brain barrier; Brain delivery; Neurological diseases; Targeted nanoparticles

Indexed keywords

BAPINEUZUMAB; BETA1A INTERFERON; CITICOLINE; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DIMEBON; DONEPEZIL; ENALAPRIL; FINGOLIMOD; GALANTAMINE; INTERFERON; INTERFERON BETA SERINE; LAQUINIMOD; LOSARTAN; MEMANTINE; METHOTREXATE; METHYLPREDNISOLONE; MITOXANTRONE; NANOCONJUGATE; PREDNISOLONE; PREDNISONE; PROCARBAZINE; RAMIPRIL; RILUZOLE; RIVASTIGMINE; SEMAGACESTAT; SOLANEZUMAB; UNINDEXED DRUG; VALSARTAN; VINCRISTINE;

EID: 84870309846     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S30919     Document Type: Review
Times cited : (100)

References (171)
  • 1
    • 67651059851 scopus 로고    scopus 로고
    • Age specific rates of neurological disease
    • In: Hof PR, Mobbs CV, editors, San Diego, CA Press: Academic Press
    • Riggs JE. Age specific rates of neurological disease. In: Hof PR, Mobbs CV, editors. Functional Neurobiology of Aging. San Diego, CA Press: Academic Press; 2001.
    • (2001) Functional Neurobiology of Aging
    • Riggs, J.E.1
  • 2
    • 0036460265 scopus 로고    scopus 로고
    • Quantification and localisation of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during allergic encephalomyelitis in the rat
    • Calvo P, Gouritin B, Villarroya H, etal. Quantification and localisation of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during allergic encephalomyelitis in the rat. Eur J Neurosci. 2002;15(8):1317-1326.
    • (2002) Eur J Neurosci , vol.15 , Issue.8 , pp. 1317-1326
    • Calvo, P.1    Gouritin, B.2    Villarroya, H.3
  • 3
    • 26944462345 scopus 로고    scopus 로고
    • The role of nanobiotechnology in drug discovery
    • Jain KK. The role of nanobiotechnology in drug discovery. Drug Discov Today. 2005;10(21):1435-1442.
    • (2005) Drug Discov Today , vol.10 , Issue.21 , pp. 1435-1442
    • Jain, K.K.1
  • 4
    • 0029066919 scopus 로고
    • Antisense drug delivery through the blood-brain barrier
    • Boado RJ. Antisense drug delivery through the blood-brain barrier. Adv Drug Deliv Rev. 1995;15:73-107.
    • (1995) Adv Drug Deliv Rev , vol.15 , pp. 73-107
    • Boado, R.J.1
  • 6
    • 70349829328 scopus 로고    scopus 로고
    • Optical properties and biomedical applications of plasmonic nanoparticles
    • Khlebtsov NG, Dykman LA. Optical properties and biomedical applications of plasmonic nanoparticles. J Quantit Spectrosc Radiat Trans. 2009;12:1-35.
    • (2009) J Quantit Spectrosc Radiat Trans , vol.12 , pp. 1-35
    • Khlebtsov, N.G.1    Dykman, L.A.2
  • 7
    • 27744599588 scopus 로고    scopus 로고
    • Targeted nanoparticle delivery through blood-brain barrier for Alzheimer's disease
    • Roney C, Kulkarni AR, Arora V, etal. Targeted nanoparticle delivery through blood-brain barrier for Alzheimer's disease. J Control Release. 2005;108(2-3):193-214.
    • (2005) J Control Release , vol.108 , Issue.2-3 , pp. 193-214
    • Roney, C.1    Kulkarni, A.R.2    Arora, V.3
  • 8
    • 63249115678 scopus 로고    scopus 로고
    • The blood-brain barrier in brain homeostasis and neurological diseases
    • Weiss N, Miller F, Cazaubon S, Couraud PO. The blood-brain barrier in brain homeostasis and neurological diseases. Biochim Biophys Acta. 2009;1788(4):842-857.
    • (2009) Biochim Biophys Acta , vol.1788 , Issue.4 , pp. 842-857
    • Weiss, N.1    Miller, F.2    Cazaubon, S.3    Couraud, P.O.4
  • 9
    • 65949088798 scopus 로고    scopus 로고
    • Promises of nanotechnology for drug delivery to brain in neurodegenerative diseases
    • Baratchi S, Kanwar RK, Khoshmanesh K, etal. Promises of nanotechnology for drug delivery to brain in neurodegenerative diseases. Curr Nanosci. 2008;5:1-11.
    • (2008) Curr Nanosci , vol.5 , pp. 1-11
    • Baratchi, S.1    Kanwar, R.K.2    Khoshmanesh, K.3
  • 11
    • 0026608742 scopus 로고
    • Epidemiology of Parkinson's disease
    • Tanner CM. Epidemiology of Parkinson's disease. Neurol Clin. 1992;109(2):317-329.
    • (1992) Neurol Clin , vol.109 , Issue.2 , pp. 317-329
    • Tanner, C.M.1
  • 12
    • 0002726942 scopus 로고
    • Molecular biology of aging in the nervous system: A synopsis of the levels of mechanisms
    • In: Calne DB, editor, Philadelphia, PA: Saunders;
    • Finch CE, Day JR. Molecular biology of aging in the nervous system: a synopsis of the levels of mechanisms. In: Calne DB, editor. Neurodegenerative Diseases. Philadelphia, PA: Saunders; 1994.
    • (1994) Neurodegenerative Diseases
    • Finch, C.E.1    Day, J.R.2
  • 13
    • 0024512326 scopus 로고
    • The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease
    • Gibb WR, Lees AJ. The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease. Neuropathol Appl Neurobiol. 1989;15(1):27-44.
    • (1989) Neuropathol Appl Neurobiol , vol.15 , Issue.1 , pp. 27-44
    • Gibb, W.R.1    Lees, A.J.2
  • 14
    • 0036178612 scopus 로고    scopus 로고
    • Ageing of the brain
    • Anderton BH. Ageing of the brain. Mech Ageing Dev. 2002;123(7): 811-817.
    • (2002) Mech Ageing Dev , vol.123 , Issue.7 , pp. 811-817
    • Anderton, B.H.1
  • 15
    • 0023946960 scopus 로고
    • Amyotrophic lateral sclerosis and Parkinson's disease complex on Guam linked to an environmental neurotoxin
    • Kurtland LT. Amyotrophic lateral sclerosis and Parkinson's disease complex on Guam linked to an environmental neurotoxin. Trends Neurosci. 1988;11(2):51-54.
    • (1988) Trends Neurosci , vol.11 , Issue.2 , pp. 51-54
    • Kurtland, L.T.1
  • 16
    • 0001485756 scopus 로고    scopus 로고
    • MPTP: A review of its mechanisms of neurotoxicity
    • Przedborski S, Vila M. MPTP: a review of its mechanisms of neurotoxicity. Clin Neurosci Res. 2001;1(6):407-418.
    • (2001) Clin Neurosci Res , vol.1 , Issue.6 , pp. 407-418
    • Przedborski, S.1    Vila, M.2
  • 18
    • 0037377189 scopus 로고    scopus 로고
    • Prospects for antiapoptotic drug therapy of neurodegenerative diseases
    • Waldmeier PC. Prospects for antiapoptotic drug therapy of neurodegenerative diseases. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27(2):303-321.
    • (2003) Prog Neuropsychopharmacol Biol Psychiatry , vol.27 , Issue.2 , pp. 303-321
    • Waldmeier, P.C.1
  • 19
    • 70349384629 scopus 로고    scopus 로고
    • Recent advances on the roles of NO in cancer and chronic inflammatory disorders
    • Kanwar JR, Kanwar RK, Burrow H, Baratchi S. Recent advances on the roles of NO in cancer and chronic inflammatory disorders. Curr Med Chem. 2009;16(19):2373-2394.
    • (2009) Curr Med Chem , vol.16 , Issue.19 , pp. 2373-2394
    • Kanwar, J.R.1    Kanwar, R.K.2    Burrow, H.3    Baratchi, S.4
  • 20
    • 0025283961 scopus 로고
    • Developmental cell death: Morphological diversity and multiple mechanisms
    • Clarke PGH. Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol. 1990;181(3):195-213.
    • (1990) Anat Embryol , vol.181 , Issue.3 , pp. 195-213
    • Clarke, P.G.H.1
  • 21
    • 12344251715 scopus 로고    scopus 로고
    • Novel D-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's disease and other CNS diseases
    • Cui Z, Lockman PR, Atwood CS, etal. Novel D-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's disease and other CNS diseases. Eur J Pharm Biopharm. 2005;59(2):263-272.
    • (2005) Eur J Pharm Biopharm , vol.59 , Issue.2 , pp. 263-272
    • Cui, Z.1    Lockman, P.R.2    Atwood, C.S.3
  • 22
    • 68249158658 scopus 로고    scopus 로고
    • Neurodegenerative disorders and nanoformulated drug development
    • Nowacek A, Kosloski LM, Gendelman HE. Neurodegenerative disorders and nanoformulated drug development. Nanomedicine (Lond). 2009;4(5):541-555.
    • (2009) Nanomedicine (Lond) , vol.4 , Issue.5 , pp. 541-555
    • Nowacek, A.1    Kosloski, L.M.2    Gendelman, H.E.3
  • 23
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner D, Eckman C, Jensen M, etal. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med. 1996;2(8):864-870.
    • (1996) Nat Med , vol.2 , Issue.8 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3
  • 24
    • 0032587772 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer's disease: A genetic, molecular and neuroimaging review
    • Swartz RH, Black SE, St George-Hyslop P. Apolipoprotein E and Alzheimer's disease: A genetic, molecular and neuroimaging review. Can J Neurol Sci. 1999;26(2):77-88.
    • (1999) Can J Neurol Sci. , vol.26 , Issue.2 , pp. 77-88
    • Swartz, R.H.1    Black, S.E.2    St George-Hyslop, P.3
  • 25
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh DM, Klyubin I, Fadeeva JV, etal. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 2002;416(6880):535-539.
    • (2002) Nature , vol.416 , Issue.6880 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3
  • 26
    • 11544279355 scopus 로고    scopus 로고
    • Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
    • Lambert MP, Barlow AK, Chromy BA, etal. Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A. 1998;95(11):6448-6453.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.11 , pp. 6448-6453
    • Lambert, M.P.1    Barlow, A.K.2    Chromy, B.A.3
  • 27
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
    • Karran E, Mercken M, Strooper BD. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov. 2011;10(9):698-712.
    • (2011) Nat Rev Drug Discov , vol.10 , Issue.9 , pp. 698-712
    • Karran, E.1    Mercken, M.2    Strooper, B.D.3
  • 29
    • 31144450053 scopus 로고    scopus 로고
    • Current pharmacotherapy for Alzheimer's disease
    • Lleó A, Greenberg SM, Growdon JH. Current pharmacotherapy for Alzheimer's disease. Annu Rev Med. 2006;57:513-533.
    • (2006) Annu Rev Med , vol.57 , pp. 513-533
    • Lleó, A.1    Greenberg, S.M.2    Growdon, J.H.3
  • 30
    • 0035853064 scopus 로고    scopus 로고
    • CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task
    • Rondi-Reig L, Libbey M, Eichenbaum H, Tonegawa S. CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task. Proc Natl Acad Sci U S A. 2001;98(6):3543-3548.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.6 , pp. 3543-3548
    • Rondi-Reig, L.1    Libbey, M.2    Eichenbaum, H.3    Tonegawa, S.4
  • 32
    • 0037126035 scopus 로고    scopus 로고
    • Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761
    • Luo Y, Smith JV, Paramasivam V, Burdick A, Curry KJ, Buford JP. Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc Natl Acad Sci U S A. 2002;99(19): 12197-12202.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.19 , pp. 12197-12202
    • Luo, Y.1    Smith, J.V.2    Paramasivam, V.3    Burdick, A.4    Curry, K.J.5    Buford, J.P.6
  • 33
    • 0038375640 scopus 로고    scopus 로고
    • Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: Systematic review and meta-analysis of observational studies
    • Etminan M, Gill S, Samii A. Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ. 2003;327(7407):128.
    • (2003) BMJ. , vol.327 , Issue.7407 , pp. 128
    • Etminan, M.1    Gill, S.2    Samii, A.3
  • 34
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D, Barbour R, Dunn W, etal. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 1999;400(6740):173-177.
    • (1999) Nature , vol.400 , Issue.6740 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 35
    • 49449101906 scopus 로고    scopus 로고
    • Phase 2safety trial targeting amyloid β production with a γ-secretase inhibitor in Alzheimer disease
    • Fleisher AS, Raman R, Siemers ER, etal. Phase 2safety trial targeting amyloid β production with a γ-secretase inhibitor in Alzheimer disease. Arch Neurol. 2008;65(8):1031-1038.
    • (2008) Arch Neurol , vol.65 , Issue.8 , pp. 1031-1038
    • Fleisher, A.S.1    Raman, R.2    Siemers, E.R.3
  • 36
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F, Cannon C, Barbour R, etal. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med. 2000;6(8): 916-919.
    • (2000) Nat Med , vol.6 , Issue.8 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3
  • 37
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, etal. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2001;98(15):8850-8855.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.15 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3
  • 38
    • 68949169046 scopus 로고    scopus 로고
    • IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders
    • Fillit H, Hess G, Hill J, Bonner P, Toso C. IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders. Neurology. 2009;73(3):180-185.
    • (2009) Neurology , vol.73 , Issue.3 , pp. 180-185
    • Fillit, H.1    Hess, G.2    Hill, J.3    Bonner, P.4    Toso, C.5
  • 39
    • 4043167747 scopus 로고    scopus 로고
    • Immunotherapy leads to early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • Oddo S, Billings L, Kessiak JP, Cribbs DH, LaFerla FM. Immunotherapy leads to early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron. 2004;43:321-332.
    • (2004) Neuron , vol.43 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kessiak, J.P.3    Cribbs, D.H.4    LaFerla, F.M.5
  • 40
    • 0034944798 scopus 로고    scopus 로고
    • Antihistamine agent dimebon as a novel neuroprotector and cognition enhancer
    • Bachurin S, Bukatina E, Lermontova N, etal. Antihistamine agent dimebon as a novel neuroprotector and cognition enhancer. Ann N Y Acad Sci. 2001;939:425-435.
    • (2001) Ann N Y Acad Sci , vol.939 , pp. 425-435
    • Bachurin, S.1    Bukatina, E.2    Lermontova, N.3
  • 41
    • 62049083420 scopus 로고    scopus 로고
    • Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
    • Nagahara AH, Merrill DA, Coppola G, etal. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009;15(3):331-337.
    • (2009) Nat Med , vol.15 , Issue.3 , pp. 331-337
    • Nagahara, A.H.1    Merrill, D.A.2    Coppola, G.3
  • 42
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficitsinAD mouse models
    • Cramer PE, Cirrito JR, Wesson DW, etal. ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficitsinAD mouse models. Science. 2012;335(6075):1503-1506.
    • (2012) Science , vol.335 , Issue.6075 , pp. 1503-1506
    • Cramer, P.E.1    Cirrito, J.R.2    Wesson, D.W.3
  • 43
    • 84870331865 scopus 로고    scopus 로고
    • Pathophysiology of Parkinson's disease. Neuropsychopharmacology
    • In: Coyle JT, Charney D, Davis KL, editors. The Fifth Generation of Progress, Philidelphia, PA: Lippincott Williams and Wilkins;
    • Michael JZ, Robert EB. Pathophysiology of Parkinson's disease. Neuropsychopharmacology. In: Coyle JT, Charney D, Davis KL, editors. The Fifth Generation of Progress. An Official Publication of the American College of Neuropsychopharmacology. Philidelphia, PA: Lippincott Williams and Wilkins; 1996.
    • (1996) An Official Publication of the American College of Neuropsychopharmacology
    • Michael, J.Z.1    Robert, E.B.2
  • 44
    • 0025976482 scopus 로고
    • Neuronal inclusions of Parkinson's disease
    • Gibb WR, Scott T, Lees AJ. Neuronal inclusions of Parkinson's disease. Mov Disord. 1991;6(1):2-11.
    • (1991) Mov Disord. , vol.6 , Issue.1 , pp. 2-11
    • Gibb, W.R.1    Scott, T.2    Lees, A.J.3
  • 45
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the α-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science. 1997;276(5321):2045-2047.
    • (1997) Science , vol.276 , Issue.5321 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3    Ide, S.E.4    Dehejia, A.5
  • 47
    • 2442668926 scopus 로고    scopus 로고
    • Hereditary early-onset Parkinson's disease caused by mutations in PINK1
    • Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science. 2004;304(5674):1158-1160.
    • (2004) Science , vol.304 , Issue.5674 , pp. 1158-1160
    • Valente, E.M.1    Abou-Sleiman, P.M.2    Caputo, V.3    Muqit, M.M.4    Harvey, K.5
  • 48
    • 0029257497 scopus 로고
    • The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: Is NAC a common trigger or target in neurodegenerative disease?
    • Han H, Weinreb PH, Lansbury PTJ. The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease? Chem Biol. 1995;2(3):163-169.
    • (1995) Chem Biol , vol.2 , Issue.3 , pp. 163-169
    • Han, H.1    Weinreb, P.H.2    Lansbury, P.T.J.3
  • 49
    • 0032707654 scopus 로고    scopus 로고
    • Increased expression of rat synuclein1in the substantia nigra pars compacta identified by differential display in a model of developmental target injury
    • Kholodilov NG, Neystat M, Oo TF, etal. Increased expression of rat synuclein1in the substantia nigra pars compacta identified by differential display in a model of developmental target injury. J Neurochem. 1999;73(6):2586-2599.
    • (1999) J Neurochem , vol.73 , Issue.6 , pp. 2586-2599
    • Kholodilov, N.G.1    Neystat, M.2    Oo, T.F.3
  • 51
    • 0026484388 scopus 로고
    • The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
    • Fahn S, Cohen G. The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann Neurol. 1992;32(6):804-812.
    • (1992) Ann Neurol , vol.32 , Issue.6 , pp. 804-812
    • Fahn, S.1    Cohen, G.2
  • 52
    • 84859421209 scopus 로고    scopus 로고
    • A mitochondrial etiology of Alzheimer and Parkinson disease
    • Coskun P, Wyrembak J, Schriner S, etal. A mitochondrial etiology of Alzheimer and Parkinson disease. Biochim Biophys Acta. 2012;1820(5): 553-564.
    • (2012) Biochim Biophys Acta , vol.1820 , Issue.5 , pp. 553-564
    • Coskun, P.1    Wyrembak, J.2    Schriner, S.3
  • 53
    • 77954590427 scopus 로고    scopus 로고
    • Duodopa pump treatment in patients with advanced Parkinson's disease
    • Karlsborg M, Korbo L, Regeur L, Glad A. Duodopa pump treatment in patients with advanced Parkinson's disease. Dan Med Bull. 2010;57(6): A4155.
    • (2010) Dan Med Bull , vol.57 , Issue.6
    • Karlsborg, M.1    Korbo, L.2    Regeur, L.3    Glad, A.4
  • 54
    • 78649973286 scopus 로고    scopus 로고
    • Rasagiline: Effectiveness and protection in Parkinson's disease
    • Pagonabarraga J, Kulisevsky J. Rasagiline: effectiveness and protection in Parkinson's disease. Rev Neurol. 2010;51(9):535-541.
    • (2010) Rev Neurol , vol.51 , Issue.9 , pp. 535-541
    • Pagonabarraga, J.1    Kulisevsky, J.2
  • 55
    • 0035826089 scopus 로고    scopus 로고
    • Transplantation of embryonic dopamine neurons for severe Parkinson's disease
    • Freed CR, Greene PE, Breeze RE, etal. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med. 2001;344(10):710-719.
    • (2001) N Engl J Med , vol.344 , Issue.10 , pp. 710-719
    • Freed, C.R.1    Greene, P.E.2    Breeze, R.E.3
  • 56
    • 0033001416 scopus 로고    scopus 로고
    • A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease
    • Shults CW, Haas RH, Beal MF. A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease. Biofactors. 1999;9(2-4):267-272.
    • (1999) Biofactors , vol.9 , Issue.2-4 , pp. 267-272
    • Shults, C.W.1    Haas, R.H.2    Beal, M.F.3
  • 57
    • 0000385299 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled study to assess safety and efficacy of riluzole as a neuroprotective drug in patients with early untreated Parkinson's disease
    • Hunter C, Jankovic J. Double-blind, placebo-controlled study to assess safety and efficacy of riluzole as a neuroprotective drug in patients with early untreated Parkinson's disease. Neurology. 1999;52:214-221.
    • (1999) Neurology , vol.52 , pp. 214-221
    • Hunter, C.1    Jankovic, J.2
  • 58
    • 0032850453 scopus 로고    scopus 로고
    • Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease
    • Kordower JH, Palfi S, Chen EY, etal. Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Ann Neurol. 1999;46(3): 419-434.
    • (1999) Ann Neurol , vol.46 , Issue.3 , pp. 419-434
    • Kordower, J.H.1    Palfi, S.2    Chen, E.Y.3
  • 59
    • 33749039453 scopus 로고    scopus 로고
    • Risk factors for ischemic stroke subtypes: The atherosclerosis risk in communities study
    • Ohira T, Shahar E, Chambless LE, Rosamond WD, Mosley TH Jr, Folsom AR. Risk factors for ischemic stroke subtypes: the atherosclerosis risk in communities study. Stroke. 2006;37(10):2493-2498.
    • (2006) Stroke , vol.37 , Issue.10 , pp. 2493-2498
    • Ohira, T.1    Shahar, E.2    Chambless, L.E.3    Rosamond, W.D.4    Mosley Jr., T.H.5    Folsom, A.R.6
  • 60
    • 42149104435 scopus 로고    scopus 로고
    • Inhibition of neurogenic inflammation as a novel treatment for ischemic stroke
    • Turner R, Vink R. Inhibition of neurogenic inflammation as a novel treatment for ischemic stroke. Timely Top Med Cardiovasc Dis. 2007;11:E24.
    • (2007) Timely Top Med Cardiovasc Dis , vol.11
    • Turner, R.1    Vink, R.2
  • 61
    • 65249107183 scopus 로고    scopus 로고
    • Brain temperature elevation and anaerobic metabolism in human acute ischaemic stroke
    • Karaszewski B, Wardlaw JM, Marshall I, etal. Brain temperature elevation and anaerobic metabolism in human acute ischaemic stroke. Brain. 2009;32(Pt 4):955-964.
    • (2009) Brain , vol.32 , Issue.PART 4 , pp. 955-964
    • Karaszewski, B.1    Wardlaw, J.M.2    Marshall, I.3
  • 62
    • 65549107439 scopus 로고    scopus 로고
    • Neuroprotection by the NR3A subunit of the NMDA receptor
    • Nakanishi N, Tu S, Shin Y, etal. Neuroprotection by the NR3A subunit of the NMDA receptor. J Neurosci. 2009;29(16):5260-5265.
    • (2009) J Neurosci , vol.29 , Issue.16 , pp. 5260-5265
    • Nakanishi, N.1    Tu, S.2    Shin, Y.3
  • 63
    • 0035967169 scopus 로고    scopus 로고
    • Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
    • Joza N, Susin SA, Daugas E, etal. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001; 410(6828):549-554.
    • (2001) Nature , vol.410 , Issue.6828 , pp. 549-554
    • Joza, N.1    Susin, S.A.2    Daugas, E.3
  • 64
    • 20444426695 scopus 로고    scopus 로고
    • Apoptosis in neurodegenerative disorders
    • Ekshyyan O, Aw TY. Apoptosis in neurodegenerative disorders. Curr Neurovasc Res. 2004;1(4):355-371.
    • (2004) Curr Neurovasc Res , vol.1 , Issue.4 , pp. 355-371
    • Ekshyyan, O.1    Aw, T.Y.2
  • 66
    • 48249103532 scopus 로고    scopus 로고
    • Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: Therapeutic strategies
    • Adibhatla RM, Hatcher JF. Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies. CNS Neurol Disord Drug Targets. 2008;7(3):243-253.
    • (2008) CNS Neurol Disord Drug Targets , vol.7 , Issue.3 , pp. 243-253
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 67
    • 64649096165 scopus 로고    scopus 로고
    • Targeting the inflammatory response in secondary stroke prevention: A role for combining aspirin and extended-release dipyridamole
    • Weyrich AS, Skalabrin EJ, Kraiss LW. Targeting the inflammatory response in secondary stroke prevention: a role for combining aspirin and extended-release dipyridamole. Am J Ther. 2009;16(2):164-170.
    • (2009) Am J Ther , vol.16 , Issue.2 , pp. 164-170
    • Weyrich, A.S.1    Skalabrin, E.J.2    Kraiss, L.W.3
  • 68
    • 0032076753 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitor therapy and stroke risk reduction: An analysis of clinical trials data
    • Crouse JR, Byington RP, Furberg CD. HMG-CoA reductase inhibitor therapy and stroke risk reduction: an analysis of clinical trials data. Atherosclerosis. 1998;138(1):11-24.
    • (1998) Atherosclerosis , vol.138 , Issue.1 , pp. 11-24
    • Crouse, J.R.1    Byington, R.P.2    Furberg, C.D.3
  • 69
    • 0032530659 scopus 로고    scopus 로고
    • Abciximab (ReoPro, chimeric 7E3 Fab) demonstrates equivalent affinity and functional blockade of glycoprotein IIb/IIIa and avb3integrins
    • Tam SH, Sassoli PM, Jordan RE, Nakada MT. Abciximab (ReoPro, chimeric 7E3 Fab) demonstrates equivalent affinity and functional blockade of glycoprotein IIb/IIIa and avb3integrins. Circulation. 1998;98(11):1085-1091.
    • (1998) Circulation , vol.98 , Issue.11 , pp. 1085-1091
    • Tam, S.H.1    Sassoli, P.M.2    Jordan, R.E.3    Nakada, M.T.4
  • 70
    • 26444510219 scopus 로고    scopus 로고
    • Extending reperfusion therapy for acute ischemic stroke. Emerging pharmacological, mechanical and imaging strategies
    • Molina CA, Saver JL. Extending reperfusion therapy for acute ischemic stroke. Emerging pharmacological, mechanical and imaging strategies. Stroke. 2005;36(10):2311-2320.
    • (2005) Stroke , vol.36 , Issue.10 , pp. 2311-2320
    • Molina, C.A.1    Saver, J.L.2
  • 71
    • 0035902456 scopus 로고    scopus 로고
    • Current concepts of the pathogenesis of the acute coronary syndromes
    • Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation. 2001;104(3):365-372.
    • (2001) Circulation , vol.104 , Issue.3 , pp. 365-372
    • Libby, P.1
  • 72
    • 63849342113 scopus 로고    scopus 로고
    • Neuroprotective therapy for ischemic stroke with free radical scavenger and gene-stem cell therapy
    • Japanese
    • Abe K. Neuroprotective therapy for ischemic stroke with free radical scavenger and gene-stem cell therapy. Rinsho Shinkeigaku. 2008;48(11):896-898. Japanese.
    • (2008) Rinsho Shinkeigaku , vol.48 , Issue.11 , pp. 896-898
    • Abe, K.1
  • 73
    • 0037107919 scopus 로고    scopus 로고
    • Citicoline mechanisms and clinical efficacy in cerebral ischemia
    • Adibhatla RM, Hatcher JF. Citicoline mechanisms and clinical efficacy in cerebral ischemia. J Neurosci Res. 2002;70(2):133-139.
    • (2002) J Neurosci Res , vol.70 , Issue.2 , pp. 133-139
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 74
    • 0034055662 scopus 로고    scopus 로고
    • Evaluating the efficacy of citicoline in embolic ischemic stroke in rats: Neuroprotective effects when used alone or in combination with urokinase
    • Shuaib A, Yang Y, Li Q. Evaluating the efficacy of citicoline in embolic ischemic stroke in rats: neuroprotective effects when used alone or in combination with urokinase. Exp Neurol. 2000;161(2):733-739.
    • (2000) Exp Neurol , vol.161 , Issue.2 , pp. 733-739
    • Shuaib, A.1    Yang, Y.2    Li, Q.3
  • 75
    • 33745938490 scopus 로고    scopus 로고
    • The lipophilic transition modulator DP-b99 attenuates matrix metalloproteinase activity in a rat MCAO ischaemic model. (Abstract)
    • Angel I, Strein S, Schatz G, etal. The lipophilic transition modulator DP-b99 attenuates matrix metalloproteinase activity in a rat MCAO ischaemic model. (Abstract). Soc Neurosci. 2004;100:3.
    • (2004) Soc Neurosci , vol.100 , pp. 3
    • Angel, I.1    Strein, S.2    Schatz, G.3
  • 76
    • 21744454032 scopus 로고    scopus 로고
    • Clinical pharmacology of DP-b99 in healthy volunteers: First administration to humans
    • Rosenberg G, Angel I, Kozak A. Clinical pharmacology of DP-b99 in healthy volunteers: first administration to humans. Br J Clin Pharmacol. 2005;60(1):7-16.
    • (2005) Br J Clin Pharmacol , vol.60 , Issue.1 , pp. 7-16
    • Rosenberg, G.1    Angel, I.2    Kozak, A.3
  • 77
    • 34248530339 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: Multiple mechanisms of action
    • Kim HJ, Rowe M, Ren M, Hong JS, Chen PS, Chuang DM. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J Pharmacol Exp Ther. 2007;321(3):892-901.
    • (2007) J Pharmacol Exp Ther , vol.321 , Issue.3 , pp. 892-901
    • Kim, H.J.1    Rowe, M.2    Ren, M.3    Hong, J.S.4    Chen, P.S.5    Chuang, D.M.6
  • 78
    • 84871527252 scopus 로고    scopus 로고
    • Drugs. com [homepage on the Internet], [press release]. Available from, Accessed September 6,
    • Drugs. com [homepage on the Internet]. ReNeuron gives uptake on stroke clinical trial. [press release]. Available from: http://www.drugs.com/clinical_trials/reneuron-gives-update-stroke-clinical-trial-11261.html. Accessed September 6, 2011.
    • (2011) ReNeuron gives uptake on stroke clinical trial
  • 79
    • 0033067355 scopus 로고    scopus 로고
    • Differential T cell response in central and peripheral nerve injury: Connection with immune privilege
    • Moalem G, Monsonego A, Shani Y, Cohen IR, Schwartz M. Differential T cell response in central and peripheral nerve injury: connection with immune privilege. FASEB J. 1999;13(10):1207-1217.
    • (1999) FASEB J. , vol.13 , Issue.10 , pp. 1207-1217
    • Moalem, G.1    Monsonego, A.2    Shani, Y.3    Cohen, I.R.4    Schwartz, M.5
  • 80
    • 0029396261 scopus 로고
    • The brain's immune system
    • Streit WJ, Kincaid-Colton CA. The brain's immune system. Sci Am. 1995;273(5):54-61.
    • (1995) Sci Am , vol.273 , Issue.5 , pp. 54-61
    • Streit, W.J.1    Kincaid-Colton, C.A.2
  • 81
    • 0037665153 scopus 로고    scopus 로고
    • Rats and mice exhibit distinct inflammatory reactions after spinal cord injury
    • Sroga JM, Jones TB, Kigerl KA, McGaughy VM, Popovich PG. Rats and mice exhibit distinct inflammatory reactions after spinal cord injury. J Comp Neurol. 2003;462(2):223-240.
    • (2003) J Comp Neurol , vol.462 , Issue.2 , pp. 223-240
    • Sroga, J.M.1    Jones, T.B.2    Kigerl, K.A.3    McGaughy, V.M.4    Popovich, P.G.5
  • 82
    • 0031815256 scopus 로고    scopus 로고
    • Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis
    • Streit WJ, Semple-Rowland SL, Hurley SD, Miller RC, Popovich PG, Stokes BT. Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis. Exp Neurol. 1998;152(1):74-87.
    • (1998) Exp Neurol , vol.152 , Issue.1 , pp. 74-87
    • Streit, W.J.1    Semple-Rowland, S.L.2    Hurley, S.D.3    Miller, R.C.4    Popovich, P.G.5    Stokes, B.T.6
  • 83
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol. 2000;47(6):707-717.
    • (2000) Ann Neurol , vol.47 , Issue.6 , pp. 707-717
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 84
    • 32144454172 scopus 로고    scopus 로고
    • The many roles of chemokines and chemokine receptors in inflammation
    • Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006;354(6):610-621.
    • (2006) N Engl J Med , vol.354 , Issue.6 , pp. 610-621
    • Charo, I.F.1    Ransohoff, R.M.2
  • 85
    • 20044376483 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis repressed by microglial paralysis
    • Heppner FL, Greter M, Marino D, etal. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med. 2005; 11(2):146-152.
    • (2005) Nat Med , vol.11 , Issue.2 , pp. 146-152
    • Heppner, F.L.1    Greter, M.2    Marino, D.3
  • 86
    • 84855964379 scopus 로고    scopus 로고
    • Multiple sclerosis: New insights in pathogenesis and novel therapeutics
    • Ontaneda D, Hyland M, Cohen JA. Multiple sclerosis: new insights in pathogenesis and novel therapeutics. Annu Rev Med. 18, 2011; 63:389-404.
    • (2011) Annu Rev Med 18 , vol.63 , pp. 389-404
    • Ontaneda, D.1    Hyland, M.2    Cohen, J.A.3
  • 87
    • 21944448962 scopus 로고    scopus 로고
    • Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis
    • Cepok S, Rosche, Grummel V, etal. Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis. Brain. 2005;128(Pt 7):1667-1676.
    • (2005) Brain , vol.128 , Issue.PART 7 , pp. 1667-1676
    • Cepok, S.1    Rosche2    Grummel, V.3
  • 88
    • 0029965137 scopus 로고    scopus 로고
    • A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry
    • Steinman L. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry. Proc Natl Acad Sci U S A. 2002;93(6):2253-2256.
    • (2002) Proc Natl Acad Sci U S A , vol.93 , Issue.6 , pp. 2253-2256
    • Steinman, L.1
  • 89
    • 84871494910 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Accessed September 5
    • Multiple sclerosis. Available from: http://www.mayoclinic.org/multiple-sclerosis. Accessed September 5, 2011.
    • (2011) Available from
  • 90
    • 79959967979 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein: A potential biomarker for progression in multiple sclerosis
    • Axelsson M, Malmeström C, Nilsson S, Haghighi S, Rosengren L, Lycke J. Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis. J Neurol. 2011;258(5):882-888.
    • (2011) J Neurol. , vol.258 , Issue.5 , pp. 882-888
    • Axelsson, M.1    Malmeström, C.2    Nilsson, S.3    Haghighi, S.4    Rosengren, L.5    Lycke, J.6
  • 91
    • 79951519138 scopus 로고    scopus 로고
    • Plasma pentosidine:A potential biomarker in the management of multiple sclerosis
    • Hennies C, Sternberg D, Bistulfi GL, etal. Plasma pentosidine:a potential biomarker in the management of multiple sclerosis. Mult Scler. 2011;17(2):157-163.
    • (2011) Mult Scler , vol.17 , Issue.2 , pp. 157-163
    • Hennies, C.1    Sternberg, D.2    Bistulfi, G.L.3
  • 92
    • 34047101767 scopus 로고    scopus 로고
    • Interferon-beta1a for the treatment of multiple sclerosis
    • Clerico M, Contessa G, Durelli L. Interferon-beta1a for the treatment of multiple sclerosis. Expert Opin Biol Ther. 2007;7(4):535-542.
    • (2007) Expert Opin Biol Ther , vol.7 , Issue.4 , pp. 535-542
    • Clerico, M.1    Contessa, G.2    Durelli, L.3
  • 93
    • 5144233487 scopus 로고    scopus 로고
    • Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications
    • Arnon R, Aharoni R. Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications. Proc Natl Acad Sci U S A. 2004;101 Suppl 2:14593-14598.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.SUPPL. 2 , pp. 14593-14598
    • Arnon, R.1    Aharoni, R.2
  • 94
    • 84871513966 scopus 로고    scopus 로고
    • The Merck Manual Home Health Handbook
    • Available from, Accessed April 26,
    • The Merck Manual Home Health Handbook. Multiple sclerosis. Available from: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/multiple_sclerosis_ms_and_related_disorders/multiple_sclerosis_ms.html?qt=&sc=&alt=. Accessed April 26, 2012.
    • (2012) Multiple sclerosis
  • 95
    • 11244349904 scopus 로고    scopus 로고
    • Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients
    • Chan A, Weilbach FX, Toyka KV, Gold R. Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients. Clin Exp Immunol. 2005;139(1):152-158.
    • (2005) Clin Exp Immunol , vol.139 , Issue.1 , pp. 152-158
    • Chan, A.1    Weilbach, F.X.2    Toyka, K.V.3    Gold, R.4
  • 96
    • 0015246542 scopus 로고
    • Effect of cyclophosphamide upon the immune response in Wegener's granulomatosis
    • Fauci AS, Wolff SM, Johnson JS. Effect of cyclophosphamide upon the immune response in Wegener's granulomatosis. N Engl J Med. 1971;285(27):1493-1496.
    • (1971) N Engl J Med , vol.285 , Issue.27 , pp. 1493-1496
    • Fauci, A.S.1    Wolff, S.M.2    Johnson, J.S.3
  • 97
    • 77956323733 scopus 로고    scopus 로고
    • Preclinical studies of methylthioadenosine for the treatment of multiple sclerosis
    • Moreno B, Fernandez-Diez B, Di Penta A, Villoslada P. Preclinical studies of methylthioadenosine for the treatment of multiple sclerosis. Mult Scler. 2010;16(9):1102-1108.
    • (2010) Mult Scler , vol.16 , Issue.9 , pp. 1102-1108
    • Moreno, B.1    Fernandez-Diez, B.2    Di Penta, A.3    Villoslada, P.4
  • 98
    • 79953325739 scopus 로고    scopus 로고
    • Midkine: A promising molecule for drug development to treat diseases of the central nervous system
    • Muramatsu T. Midkine: a promising molecule for drug development to treat diseases of the central nervous system. Curr Pharm Des. 2011;17(5):410-423.
    • (2011) Curr Pharm Des , vol.17 , Issue.5 , pp. 410-423
    • Muramatsu, T.1
  • 99
    • 0347296187 scopus 로고    scopus 로고
    • Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps
    • Dasgupta S, Zhou Y, Jana M, Banik NL, Paha K. Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps. J Immunol. 2003;170(7):3874-3882.
    • (2003) J Immunol , vol.170 , Issue.7 , pp. 3874-3882
    • Dasgupta, S.1    Zhou, Y.2    Jana, M.3    Banik, N.L.4    Paha, K.5
  • 100
    • 79957954734 scopus 로고    scopus 로고
    • The therapeutic potential of HDAC inhibitors in the treatment of multiple sclerosis
    • Faraco G, Cavone L, Chiarugi A. The therapeutic potential of HDAC inhibitors in the treatment of multiple sclerosis. Mol Med. 2011;17(5-6):442-447.
    • (2011) Mol Med , vol.17 , Issue.5-6 , pp. 442-447
    • Faraco, G.1    Cavone, L.2    Chiarugi, A.3
  • 101
    • 80052642615 scopus 로고    scopus 로고
    • Matrine suppresses production of IL-23/IL-17 and ameliorates experimental autoimmune encephalomyelitis
    • Zhao X, Kan Q, Zhu L, Zhang GX. Matrine suppresses production of IL-23/IL-17 and ameliorates experimental autoimmune encephalomyelitis. Am J Chin Med. 2011;39(5):933-941.
    • (2011) Am J Chin Med , vol.39 , Issue.5 , pp. 933-941
    • Zhao, X.1    Kan, Q.2    Zhu, L.3    Zhang, G.X.4
  • 102
    • 79960562580 scopus 로고    scopus 로고
    • Advances in multiple sclerosis therapy: New oral disease-modifying agents, CML
    • Lutterotti A, Berger T. Advances in multiple sclerosis therapy: new oral disease-modifying agents, CML. Mult Scler. 2010;2:1-10.
    • (2010) Mult Scler , vol.2 , pp. 1-10
    • Lutterotti, A.1    Berger, T.2
  • 103
    • 4744340401 scopus 로고    scopus 로고
    • Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats
    • Yang JS, Xu LY, Xiao BG, Hedlund G, Link H. Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats. J Neuroimmunol. 2004;156(1-2):3-9.
    • (2004) J Neuroimmunol , vol.156 , Issue.1-2 , pp. 3-9
    • Yang, J.S.1    Xu, L.Y.2    Xiao, B.G.3    Hedlund, G.4    Link, H.5
  • 105
    • 84856223165 scopus 로고    scopus 로고
    • Dalfampridine in multiple sclerosis: From symptomatic treatment to immunomodulation
    • Espejo C, Montalba X. Dalfampridine in multiple sclerosis: from symptomatic treatment to immunomodulation. Clin Immunol. 2011;142(1):84-92.
    • (2011) Clin Immunol , vol.142 , Issue.1 , pp. 84-92
    • Espejo, C.1    Montalba, X.2
  • 106
    • 60149087275 scopus 로고    scopus 로고
    • Buzz around Campath proof-of-concept trial in MS
    • Osborne R. Buzz around Campath proof-of-concept trial in MS. Nat Biotechnol. 2009;27(1):6-8.
    • (2009) Nat Biotechnol , vol.27 , Issue.1 , pp. 6-8
    • Osborne, R.1
  • 107
    • 78650490588 scopus 로고    scopus 로고
    • Antibodies against CD20 (rituximab) for treating multiple sclerosis: US20100233121
    • Taupin P. Antibodies against CD20 (rituximab) for treating multiple sclerosis: US20100233121. Expert Opin Ther Pat. 2011;21(1):111-114.
    • (2011) Expert Opin Ther Pat , vol.21 , Issue.1 , pp. 111-114
    • Taupin, P.1
  • 108
  • 109
    • 0034101787 scopus 로고    scopus 로고
    • New horizons in the treatment of autoimmune diseases: Immunoablation and stem cell transplantation
    • Marmont AM. New horizons in the treatment of autoimmune diseases: immunoablation and stem cell transplantation. Annu Rev Med. 2000;51:115-134.
    • (2000) Annu Rev Med , vol.51 , pp. 115-134
    • Marmont, A.M.1
  • 110
    • 84860255699 scopus 로고    scopus 로고
    • Nanoparticles in the treatment and diagnosis of neurological disorders: Untamed dragon with fire power to heal
    • Kanwar JR, Sun X, Punj V, etal. Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal. Nanomedicine. 2012;8(4):399-414.
    • (2012) Nanomedicine , vol.8 , Issue.4 , pp. 399-414
    • Kanwar, J.R.1    Sun, X.2    Punj, V.3
  • 111
    • 2442665084 scopus 로고    scopus 로고
    • Brain tumours: Incidence, survival, and aetiology
    • McKinney PA. Brain tumours: incidence, survival, and aetiology. J Neurol Neurosurg Psychiatry. 2004;75:ii12-ii17.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75
    • McKinney, P.A.1
  • 112
    • 0024708248 scopus 로고
    • Intracranial neoplasms. An overview
    • Baumann CK, Zumwalt CB. Intracranial neoplasms. An overview. AORN J. 1989;50(2):240-242.
    • (1989) AORN J. , vol.50 , Issue.2 , pp. 240-242
    • Baumann, C.K.1    Zumwalt, C.B.2
  • 113
    • 8444240128 scopus 로고    scopus 로고
    • Brain tumor treatment: Chemotherapy and other new developments
    • Graham CA, Cloughesy TF. Brain tumor treatment: chemotherapy and other new developments. Semin Oncol Nurs. 2004;20(4): 260-272.
    • (2004) Semin Oncol Nurs , vol.20 , Issue.4 , pp. 260-272
    • Graham, C.A.1    Cloughesy, T.F.2
  • 114
    • 33745262087 scopus 로고    scopus 로고
    • Central Brain Tumor Registry of the United States, Chicago, IL: Central Brain Tumor Registry of the United States;
    • Central Brain Tumor Registry of the United States. Statistical Report: Primary Brain Tumors in the United States, 1992-1997. Chicago, IL: Central Brain Tumor Registry of the United States; 2000.
    • (2000) Statistical Report: Primary Brain Tumors in the United States, 1992-1997
  • 115
    • 0026653255 scopus 로고
    • Non-Hodgkin's lymphoma of the brain: Can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the Radiation Therapy Oncology Group (RTOG): RTOG 8315
    • Nelson DF, Martz KL, Bonner H, etal. Non-Hodgkin's lymphoma of the brain: can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the Radiation Therapy Oncology Group (RTOG): RTOG 8315. Int J Radiat Oncol Biol Phys. 1992;23(1):9-17.
    • (1992) Int J Radiat Oncol Biol Phys , vol.23 , Issue.1 , pp. 9-17
    • Nelson, D.F.1    Martz, K.L.2    Bonner, H.3
  • 116
    • 0037115536 scopus 로고    scopus 로고
    • Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: Radiation Therapy Oncology Group Study 93-10
    • DeAngelis LM, Seiferheld W, Schold SC, Fisher B, Schultz CJ. Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: Radiation Therapy Oncology Group Study 93-10. J Clin Oncol. 2002;20(4):4643-4648.
    • (2002) J Clin Oncol. , vol.20 , Issue.4 , pp. 4643-4648
    • DeAngelis, L.M.1    Seiferheld, W.2    Schold, S.C.3    Fisher, B.4    Schultz, C.J.5
  • 118
    • 0030792993 scopus 로고    scopus 로고
    • Effective chemotherapy for advanced CNS embryonal tumors in adults
    • Galanis E, Buckner J, Schomberg P. Effective chemotherapy for advanced CNS embryonal tumors in adults. J Clin Oncol. 1997;15(8):2939-2944.
    • (1997) J Clin Oncol , vol.15 , Issue.8 , pp. 2939-2944
    • Galanis, E.1    Buckner, J.2    Schomberg, P.3
  • 119
    • 0018112252 scopus 로고
    • Intracranial metastases from systemic cancer
    • Posner JB, Chernik NL. Intracranial metastases from systemic cancer. Adv Neurol. 1978;19:579-592.
    • (1978) Adv Neurol , vol.19 , pp. 579-592
    • Posner, J.B.1    Chernik, N.L.2
  • 120
    • 0037245929 scopus 로고    scopus 로고
    • Targeted molecular therapy of GBM
    • Mischel PS, Cloughesy TF. Targeted molecular therapy of GBM. Brain Pathol. 2003;13(1):52-61.
    • (2003) Brain Pathol , vol.13 , Issue.1 , pp. 52-61
    • Mischel, P.S.1    Cloughesy, T.F.2
  • 121
    • 0347659463 scopus 로고    scopus 로고
    • Advances in molecular therapies in patients with brain tumors
    • Tremonts-Lukats IW, Gilbert MR. Advances in molecular therapies in patients with brain tumors. Cancer Control. 2003;10(2): 125-137.
    • (2003) Cancer Control , vol.10 , Issue.2 , pp. 125-137
    • Tremonts-Lukats, I.W.1    Gilbert, M.R.2
  • 122
    • 55749084890 scopus 로고    scopus 로고
    • The targeted delivery of cancer drugs across the blood-brain barrier: Chemical modifications of drugs or drug-nanoparticles?
    • Juillerat-Jeanneret L. The targeted delivery of cancer drugs across the blood-brain barrier: chemical modifications of drugs or drug-nanoparticles? Drug Discov Today. 2008;13(23-24):1099-1106.
    • (2008) Drug Discov Today , vol.13 , Issue.23-24 , pp. 1099-1106
    • Juillerat-Jeanneret, L.1
  • 123
    • 0042899083 scopus 로고    scopus 로고
    • Blood-brain barrier drug targeting: The future of brain drug development
    • Pardridge WM. Blood-brain barrier drug targeting: the future of brain drug development. Mol Interv. 2003;3(2):90-105.
    • (2003) Mol Interv , vol.3 , Issue.2 , pp. 90-105
    • Pardridge, W.M.1
  • 124
    • 0042468096 scopus 로고    scopus 로고
    • Impact of drug transporter studies on drug discovery and development
    • Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y. Impact of drug transporter studies on drug discovery and development. Pharmacol Rev. 2003;55(3):425-461.
    • (2003) Pharmacol Rev , vol.55 , Issue.3 , pp. 425-461
    • Mizuno, N.1    Niwa, T.2    Yotsumoto, Y.3    Sugiyama, Y.4
  • 125
    • 12344319635 scopus 로고    scopus 로고
    • Development of neuropeptide drugs that cross the blood-brain barrier
    • Egleton RD, Davis TP. Development of neuropeptide drugs that cross the blood-brain barrier. Neuro Rx. 2005;2(1):44-53.
    • (2005) Neuro Rx , vol.2 , Issue.1 , pp. 44-53
    • Egleton, R.D.1    Davis, T.P.2
  • 126
    • 33748452503 scopus 로고    scopus 로고
    • Molecular Trojan horses for blood-brain barrier drug delivery
    • Pardridge WM. Molecular Trojan horses for blood-brain barrier drug delivery. Curr Opin Pharmacol. 2006;6(5):494-500.
    • (2006) Curr Opin Pharmacol , vol.6 , Issue.5 , pp. 494-500
    • Pardridge, W.M.1
  • 127
    • 33748175984 scopus 로고    scopus 로고
    • PEG-modified gold nanorods with a stealth character for in vivo applications
    • Niidome T, Yamagata M, Okamoto Y, et al. PEG-modified gold nanorods with a stealth character for in vivo applications. J Control Release. 2006;114:343-347.
    • (2006) J Control Release , vol.114 , pp. 343-347
    • Niidome, T.1    Yamagata, M.2    Okamoto, Y.3
  • 128
    • 61349139614 scopus 로고    scopus 로고
    • Drug delivery and nanoparticles: Applications and hazards
    • De JongWH, Borm PJ. Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine. 2008;3(2):133-149.
    • (2008) Int J Nanomedicine , vol.3 , Issue.2 , pp. 133-149
    • de Jong, W.H.1    Borm, P.J.2
  • 129
    • 0036205158 scopus 로고    scopus 로고
    • Nanoparticle technology for drug delivery across the blood-brain barrier
    • Lockman PR, Mumper RJ, Khan MA, Allen DD. Nanoparticle technology for drug delivery across the blood-brain barrier. Drug Dev Ind Pharm. 2002;28(1):1-13.
    • (2002) Drug Dev Ind Pharm , vol.28 , Issue.1 , pp. 1-13
    • Lockman, P.R.1    Mumper, R.J.2    Khan, M.A.3    Allen, D.D.4
  • 130
    • 0017852803 scopus 로고
    • Regional cerebrovascular permeability to [14C] sucrose after osmotic opening of the blood-brain barrier
    • Rapoport SI, Ohno K, Fredericks WR, Pettigrew KD. Regional cerebrovascular permeability to [14C] sucrose after osmotic opening of the blood-brain barrier. Brain Res. 1978;150(3):653-657.
    • (1978) Brain Res , vol.150 , Issue.3 , pp. 653-657
    • Rapoport, S.I.1    Ohno, K.2    Fredericks, W.R.3    Pettigrew, K.D.4
  • 131
    • 77956647113 scopus 로고    scopus 로고
    • Targeted nanodelivery of drugs and diagnostics
    • Phillips MA, Gran ML, Peppas NA. Targeted nanodelivery of drugs and diagnostics. Nano Today. 2010;5(2):143-159.
    • (2010) Nano Today , vol.5 , Issue.2 , pp. 143-159
    • Phillips, M.A.1    Gran, M.L.2    Peppas, N.A.3
  • 132
    • 0022764022 scopus 로고
    • Receptor-mediated peptide transport through the blood-brain barrier
    • Pardridge WM. Receptor-mediated peptide transport through the blood-brain barrier. Endocr Rev. 1986;7(3):314-330.
    • (1986) Endocr Rev , vol.7 , Issue.3 , pp. 314-330
    • Pardridge, W.M.1
  • 133
    • 0029009048 scopus 로고
    • Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid trans-cytosis through the blood-brain barrier in vivo in the primate
    • Pardridge WM, Kang YS, Buciak JL, Yang J. Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid trans-cytosis through the blood-brain barrier in vivo in the primate. Pharm Res. 1995;12(6):807-816.
    • (1995) Pharm Res , vol.12 , Issue.6 , pp. 807-816
    • Pardridge, W.M.1    Kang, Y.S.2    Buciak, J.L.3    Yang, J.4
  • 135
    • 0031901771 scopus 로고    scopus 로고
    • Combined use of carboxyldirected protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration
    • Pardridge WM, Wu D, Sakane T. Combined use of carboxyldirected protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration. Pharm Res. 1998;15(4):576-582.
    • (1998) Pharm Res , vol.15 , Issue.4 , pp. 576-582
    • Pardridge, W.M.1    Wu, D.2    Sakane, T.3
  • 137
    • 0030930364 scopus 로고    scopus 로고
    • Drug targeting of a peptide radio pharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor
    • Wu D, Yang J, Pardridge WM. Drug targeting of a peptide radio pharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor. J Clin Invest. 1997;100(7):1804-1812.
    • (1997) J Clin Invest , vol.100 , Issue.7 , pp. 1804-1812
    • Wu, D.1    Yang, J.2    Pardridge, W.M.3
  • 140
    • 59049097859 scopus 로고    scopus 로고
    • Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: In vitro and in vivo evaluations
    • Hu K, Li J, Shen Y, etal. Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations. J Control Release. 2009;134(1):55-61.
    • (2009) J Control Release , vol.134 , Issue.1 , pp. 55-61
    • Hu, K.1    Li, J.2    Shen, Y.3
  • 141
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev. 2001;47(1):65-81.
    • (2001) Adv Drug Deliv Rev , vol.47 , Issue.1 , pp. 65-81
    • Kreuter, J.1
  • 142
    • 12144288634 scopus 로고    scopus 로고
    • Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles
    • Steiniger SC, Kreuter J, Khalansky AS, etal. Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles. Int J Cancer. 2004;109(5):759-767.
    • (2004) Int J Cancer , vol.109 , Issue.5 , pp. 759-767
    • Steiniger, S.C.1    Kreuter, J.2    Khalansky, A.S.3
  • 143
    • 61549106604 scopus 로고    scopus 로고
    • Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6glioma cells of a brain tumor model
    • Wang CX, Huang LS, Hou LB, etal. Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6glioma cells of a brain tumor model. Brain Res. 2009;1261:91-99.
    • (2009) Brain Res , vol.1261 , pp. 91-99
    • Wang, C.X.1    Huang, L.S.2    Hou, L.B.3
  • 144
    • 33846499122 scopus 로고    scopus 로고
    • Chemotherapy of brain tumor using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: Revisiting the role of surfactants
    • Petri B, Bootz A, Khalansky A, etal. Chemotherapy of brain tumor using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants. J Control Release. 2007;117(1):51-58.
    • (2007) J Control Release , vol.117 , Issue.1 , pp. 51-58
    • Petri, B.1    Bootz, A.2    Khalansky, A.3
  • 145
    • 75449107968 scopus 로고    scopus 로고
    • Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: Influence of the formulation parameters
    • Gelperina S, Maksimenko O, Khalansky A, etal. Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: influence of the formulation parameters. Eur J Pharm Biopharm. 2010;74(2):157-163.
    • (2010) Eur J Pharm Biopharm , vol.74 , Issue.2 , pp. 157-163
    • Gelperina, S.1    Maksimenko, O.2    Khalansky, A.3
  • 146
    • 79952606654 scopus 로고    scopus 로고
    • Effects of surface modification on delivery efficiency of biodegradable nanoparticles across the blood-brain barrier
    • Kulkarni SA, Feng SS. Effects of surface modification on delivery efficiency of biodegradable nanoparticles across the blood-brain barrier. Nanomedicine. 2011;6(2):377-394.
    • (2011) Nanomedicine , vol.6 , Issue.2 , pp. 377-394
    • Kulkarni, S.A.1    Feng, S.S.2
  • 147
    • 0347519282 scopus 로고    scopus 로고
    • Poly(dl-lactide-co-glycolide) nanoparticles based inhalable sustained drug delivery system for experimental tuberculosis
    • Pandey R, Sharma A, Zahoor A, Sharma S, Khuller GK. Poly(dl-lactide-co-glycolide) nanoparticles based inhalable sustained drug delivery system for experimental tuberculosis. J Antimicrob Chemother. 2003;52(6):981-986.
    • (2003) J Antimicrob Chemother , vol.52 , Issue.6 , pp. 981-986
    • Pandey, R.1    Sharma, A.2    Zahoor, A.3    Sharma, S.4    Khuller, G.K.5
  • 148
    • 77955769665 scopus 로고    scopus 로고
    • Transferrin-conjugated nanoparticlesof poly(lactide)-d-α-tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood-brain barrier
    • Gan CW, Feng SS. Transferrin-conjugated nanoparticlesof poly(lactide)-d-α-tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood-brain barrier. Biomaterials. 2010;31(30):7748-7757.
    • (2010) Biomaterials , vol.31 , Issue.30 , pp. 7748-7757
    • Gan, C.W.1    Feng, S.S.2
  • 149
    • 77951773926 scopus 로고    scopus 로고
    • Brain-targeted deliveryof Tempol-loaded nanoparticlesfor neurological disorders
    • Carroll RT, Bhatia D, Geldenhuys W, etal. Brain-targeted deliveryof Tempol-loaded nanoparticlesfor neurological disorders. J Drug Target. 2010;18(9):665-674.
    • (2010) J Drug Target , vol.18 , Issue.9 , pp. 665-674
    • Carroll, R.T.1    Bhatia, D.2    Geldenhuys, W.3
  • 150
    • 76749159851 scopus 로고    scopus 로고
    • Lactoferrin-modified nanoparticles could mediate efficient gene deliveryto the brainin vivo
    • Huang R, Ke W, Han L, Liu Y, Shao K, Jiang C. Lactoferrin-modified nanoparticles could mediate efficient gene deliveryto the brainin vivo. Brain Res Bull. 2010;81(6):600-604.
    • (2010) Brain Res Bull , vol.81 , Issue.6 , pp. 600-604
    • Huang, R.1    Ke, W.2    Han, L.3    Liu, Y.4    Shao, K.5    Jiang, C.6
  • 151
    • 53849097674 scopus 로고    scopus 로고
    • Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy
    • Agyare EK, Curran GL, Ramakrishnan M, Yu CC, Poduslo JF, Kandimalla KK. Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy. Pharm Res. 2008;25(11):2674-2684.
    • (2008) Pharm Res , vol.25 , Issue.11 , pp. 2674-2684
    • Agyare, E.K.1    Curran, G.L.2    Ramakrishnan, M.3    Yu, C.C.4    Poduslo, J.F.5    Kandimalla, K.K.6
  • 152
    • 70649114473 scopus 로고    scopus 로고
    • Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain
    • Wang ZH, Wang ZY, Sun CS, Wang CY, Jiang TY, Wang SL. Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain. Biomaterials. 2010;31(5): 908-915.
    • (2010) Biomaterials , vol.31 , Issue.5 , pp. 908-915
    • Wang, Z.H.1    Wang, Z.Y.2    Sun, C.S.3    Wang, C.Y.4    Jiang, T.Y.5    Wang, S.L.6
  • 153
    • 70349504021 scopus 로고    scopus 로고
    • Ultrasensitive and highly selective detection of Alzheimer's disease biomarker using two-photon Rayleigh scattering properties of gold nanoparticle
    • Neely A, Perry C, Varisli B, etal. Ultrasensitive and highly selective detection of Alzheimer's disease biomarker using two-photon Rayleigh scattering properties of gold nanoparticle. ACS Nano. 2009;3(9):2834-2840.
    • (2009) ACS Nano , vol.3 , Issue.9 , pp. 2834-2840
    • Neely, A.1    Perry, C.2    Varisli, B.3
  • 154
    • 79960561767 scopus 로고    scopus 로고
    • Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticlesfor glcoma
    • Huang S, Li J, Han L, etal. Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticlesfor glcoma. Biomaterials. 2011;32(38):6832-6838.
    • (2011) Biomaterials , vol.32 , Issue.38 , pp. 6832-6838
    • Huang, S.1    Li, J.2    Han, L.3
  • 155
    • 78751702565 scopus 로고    scopus 로고
    • Targeted delivery of chlorotoxin-modified DNA-loaded nanoparticlesto glioma via intravenous administration
    • Huang R, Ke W, Han L, Li J, Liu S, Jiang C. Targeted delivery of chlorotoxin-modified DNA-loaded nanoparticlesto glioma via intravenous administration. Biomaterials. 2011;32(9):2399-2406.
    • (2011) Biomaterials , vol.32 , Issue.9 , pp. 2399-2406
    • Huang, R.1    Ke, W.2    Han, L.3    Li, J.4    Liu, S.5    Jiang, C.6
  • 156
    • 80052961350 scopus 로고    scopus 로고
    • A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein
    • Huile G, Shuaiqi P, Zhi Y, etal. A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein. Biomaterials. 2011;32(33):8669-8675.
    • (2011) Biomaterials , vol.32 , Issue.33 , pp. 8669-8675
    • Huile, G.1    Shuaiqi, P.2    Zhi, Y.3
  • 157
    • 79960297652 scopus 로고    scopus 로고
    • Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles
    • Tian XH, Lin XN, Wei F, etal. Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles. Int J Nanomedicine. 2011;6:445-452.
    • (2011) Int J Nanomedicine , vol.6 , pp. 445-452
    • Tian, X.H.1    Lin, X.N.2    Wei, F.3
  • 158
    • 80051817418 scopus 로고    scopus 로고
    • Aptamer-functionalized PEG-PLGA nanoparticlesfor enhanced anti-glioma drug delivery
    • Guo J, Gao X, Su L, etal. Aptamer-functionalized PEG-PLGA nanoparticlesfor enhanced anti-glioma drug delivery. Biomaterials. 2011;32(31):8010-8020.
    • (2011) Biomaterials , vol.32 , Issue.31 , pp. 8010-8020
    • Guo, J.1    Gao, X.2    Su, L.3
  • 159
    • 79955626215 scopus 로고    scopus 로고
    • Conjugation of functionalized gadolinium metallofullerenes with IL-13 peptides for targeting and imaging glial tumors
    • Fillmore HL, Shultz MD, Henderson SC, etal. Conjugation of functionalized gadolinium metallofullerenes with IL-13 peptides for targeting and imaging glial tumors. Nanomedicine (Lond). 2011;6(3):449-458.
    • (2011) Nanomedicine (Lond) , vol.6 , Issue.3 , pp. 449-458
    • Fillmore, H.L.1    Shultz, M.D.2    Henderson, S.C.3
  • 160
    • 79955784689 scopus 로고    scopus 로고
    • Targeting the brain with PEG-PLGA nanoparticles modified with phage-displayed peptides
    • Li J, Feng L, Fan L, etal. Targeting the brain with PEG-PLGA nanoparticles modified with phage-displayed peptides. Biomaterials. 2011;32(21):4943-4950.
    • (2011) Biomaterials , vol.32 , Issue.21 , pp. 4943-4950
    • Li, J.1    Feng, L.2    Fan, L.3
  • 161
    • 79952934026 scopus 로고    scopus 로고
    • Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery
    • Park J, Gao W, Whiston R, Strom TB, Metcalfe S, Fahmy TM. Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery. Mol Pharm. 2011;8(1): 143-152.
    • (2011) Mol Pharm , vol.8 , Issue.1 , pp. 143-152
    • Park, J.1    Gao, W.2    Whiston, R.3    Strom, T.B.4    Metcalfe, S.5    Fahmy, T.M.6
  • 164
    • 79959919390 scopus 로고    scopus 로고
    • A fibrin-specific thrombolytic nanomedicine approach to acute ischemic stroke
    • Marsh JN, Hu G, Scott MJ, etal. A fibrin-specific thrombolytic nanomedicine approach to acute ischemic stroke. Nanomedicine (Lond). 2011;6(4):605-615.
    • (2011) Nanomedicine (Lond) , vol.6 , Issue.4 , pp. 605-615
    • Marsh, J.N.1    Hu, G.2    Scott, M.J.3
  • 165
    • 79251555929 scopus 로고    scopus 로고
    • Survivin mutant protects differentiated dopaminergic SK-N-SH cells against oxidative stress
    • Baratchi S, Kanwar RK, Kanwar JR. Survivin mutant protects differentiated dopaminergic SK-N-SH cells against oxidative stress. PLoS One. 2011;6(1):e15865.
    • (2011) PLoS One , vol.6 , Issue.1
    • Baratchi, S.1    Kanwar, R.K.2    Kanwar, J.R.3
  • 166
    • 77956648003 scopus 로고    scopus 로고
    • Proliferative and protective effects of SurR9-C84A on differentiated neural cells
    • Baratchi S, Kanwar RK, Antonio Cheung CH, Kanwar JR. Proliferative and protective effects of SurR9-C84A on differentiated neural cells. J Neuroimmunol. 2010;227(1-2):120-132.
    • (2010) J Neuroimmunol , vol.227 , Issue.1-2 , pp. 120-132
    • Baratchi, S.1    Kanwar, R.K.2    Antonio Cheung, C.H.3    Kanwar, J.R.4
  • 167
    • 78549289531 scopus 로고    scopus 로고
    • Recent advances on the possible neuroprotective activities of Epstein-Barr virus oncogene BARF1 protein in chronic inflammatory disorders of central nervous system
    • Wynne A, Kanwar RK, Khanna R, Kanwar JR. Recent advances on the possible neuroprotective activities of Epstein-Barr virus oncogene BARF1 protein in chronic inflammatory disorders of central nervous system. Curr Neuropharmacol. 2010;8(3):268-275.
    • (2010) Curr Neuropharmacol , vol.8 , Issue.3 , pp. 268-275
    • Wynne, A.1    Kanwar, R.K.2    Khanna, R.3    Kanwar, J.R.4
  • 168
    • 2942620628 scopus 로고    scopus 로고
    • Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis
    • Kanwar JR, Kanwar RK, Krissansen GW. Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis. Brain. 2004;127(Pt 6):1313-1331.
    • (2004) Brain , vol.127 , Issue.PART 6 , pp. 1313-1331
    • Kanwar, J.R.1    Kanwar, R.K.2    Krissansen, G.W.3
  • 169
    • 0033667644 scopus 로고    scopus 로고
    • Prevention of a chronic progressive form of experimental autoimmune encephalomyelitis by an antibody against mucosal addressin cell adhesion molecule-1, given early in the course of disease progression
    • Kanwar JR, Kanwar RK, Wang D, Krissansen GW. Prevention of a chronic progressive form of experimental autoimmune encephalomyelitis by an antibody against mucosal addressin cell adhesion molecule-1, given early in the course of disease progression. Immunol Cell Biol. 2000;78(6):641-645.
    • (2000) Immunol Cell Biol , vol.78 , Issue.6 , pp. 641-645
    • Kanwar, J.R.1    Kanwar, R.K.2    Wang, D.3    Krissansen, G.W.4
  • 170
    • 0033622029 scopus 로고    scopus 로고
    • b7integrins contribute to demyelinating disease of the central nervous system
    • Kanwar JR, Harrison JEB, Wang D, etal. b7integrins contribute to demyelinating disease of the central nervous system. J Neuroimmunol. 2000;103(2):146-152.
    • (2000) J Neuroimmunol , vol.103 , Issue.2 , pp. 146-152
    • Kanwar, J.R.1    Harrison, J.E.B.2    Wang, D.3
  • 171
    • 0032909507 scopus 로고    scopus 로고
    • Synthesis of 3'-C-and 4'-C-branched oligonucleotides and the development of locked nucleic acid (LNA)
    • Wengel J. Synthesis of 3'-C-and 4'-C-branched oligonucleotides and the development of locked nucleic acid (LNA). Acc Chem Res. 1999;32:301-310.
    • (1999) Acc Chem Res , vol.32 , pp. 301-310
    • Wengel, J.1


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