메뉴 건너뛰기




Volumn 26, Issue 2, 1999, Pages 77-88

ApolipoproteinE and Alzheimer's disease: A genetic, molecular and neuroimaging review

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; AMYLOID; APOLIPOPROTEIN E;

EID: 0032587772     PISSN: 03171671     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (30)

References (190)
  • 1
    • 0030185877 scopus 로고    scopus 로고
    • Focal cortical atrophy syndromes
    • Black SE. Focal cortical atrophy syndromes. Brain and Cognition 1996; 31: 188-229.
    • (1996) Brain and Cognition , vol.31 , pp. 188-229
    • Black, S.E.1
  • 2
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch Neurol 1985; 42: 1097-1105.
    • (1985) Arch Neurol , vol.42 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 3
    • 0028296884 scopus 로고
    • Canadian study of health and aging: Study methods and prevalence of dementia
    • Canadian Study of Health and Aging Working Group. Canadian study of health and aging: study methods and prevalence of dementia. Can Med Assoc J 1994; 150: 899-913.
    • (1994) Can Med Assoc J , vol.150 , pp. 899-913
  • 4
    • 0028030867 scopus 로고
    • Prevalence and types of dementia in the very old: Results from the Canadian study of health and aging
    • Ebly EM, Parhad IM, Hogan DB, Fung TS. Prevalence and types of dementia in the very old: results from the Canadian Study of Health and Aging. Neurology 1994; 44: 1593-1600.
    • (1994) Neurology , vol.44 , pp. 1593-1600
    • Ebly, E.M.1    Parhad, I.M.2    Hogan, D.B.3    Fung, T.S.4
  • 5
    • 0028567287 scopus 로고
    • Net economic costs of dementia in Canada
    • Ostbye T, Crosse E. Net economic costs of dementia in Canada. Can Med Assoc J 1994; 151: 1457-1464.
    • (1994) Can Med Assoc J , vol.151 , pp. 1457-1464
    • Ostbye, T.1    Crosse, E.2
  • 6
    • 0028080315 scopus 로고
    • The canadian study of health and aging: Risk factors for Alzheimer's disease in Canada
    • Canadian Study of Health and Aging Working Group. The Canadian Study of Health and Aging: risk factors for Alzheimer's disease in Canada. Neurology 1994; 44: 2073-2080.
    • (1994) Neurology , vol.44 , pp. 2073-2080
  • 7
    • 0032551222 scopus 로고    scopus 로고
    • Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: The Rotterdam study
    • Ott A, Slooter AJ, Hofman A, et al. Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study. Lancet 1998; 351: 1840-1843.
    • (1998) Lancet , vol.351 , pp. 1840-1843
    • Ott, A.1    Slooter, A.J.2    Hofman, A.3
  • 8
    • 0029160270 scopus 로고
    • Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs
    • Breitner JC, Welsh KA, Helms MJ, et al. Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs. Neurobiol Aging 1995; 16: 523-530.
    • (1995) Neurobiol Aging , vol.16 , pp. 523-530
    • Breitner, J.C.1    Welsh, K.A.2    Helms, M.J.3
  • 9
    • 0030591669 scopus 로고    scopus 로고
    • Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease
    • Tang MX, Jacobs D, Stern Y, et al. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 1996; 348: 429-432.
    • (1996) Lancet , vol.348 , pp. 429-432
    • Tang, M.X.1    Jacobs, D.2    Stern, Y.3
  • 10
    • 0030942683 scopus 로고    scopus 로고
    • The role of estrogen in the treatment of Alzheimer's disease
    • Birge SJ. The role of estrogen in the treatment of Alzheimer's disease. Neurology 1997; 48 (Suppl. 7): S36-S41.
    • (1997) Neurology , vol.48 , Issue.SUPPL. 7
    • Birge, S.J.1
  • 11
    • 0029877490 scopus 로고    scopus 로고
    • Apolipoprotein E polymorphism is associated with both senile plaque load and Alzheimer-type neurofibrillary tangle formation
    • Marz W, Scharnagl H, Kirca M, et al. Apolipoprotein E polymorphism is associated with both senile plaque load and Alzheimer-type neurofibrillary tangle formation. Ann NY Acad Sci 1996; 777: 276-280.
    • (1996) Ann NY Acad Sci , vol.777 , pp. 276-280
    • Marz, W.1    Scharnagl, H.2    Kirca, M.3
  • 12
    • 0029056590 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer's disease
    • Gearing M, Mirra SS, Hedreen JC, et al. The consortium to establish a registry for Alzheimer's disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer's disease. Neurology 1995; 45: 461-466.
    • (1995) Neurology , vol.45 , pp. 461-466
    • Gearing, M.1    Mirra, S.S.2    Hedreen, J.C.3
  • 13
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 14
    • 0031754388 scopus 로고    scopus 로고
    • New neuropathological criteria for Alzheimer disease
    • Hyman, BT. New Neuropathological criteria for Alzheimer disease. Arch Neurol 1998; 55: 1174-1176.
    • (1998) Arch Neurol , vol.55 , pp. 1174-1176
  • 15
    • 0031781795 scopus 로고    scopus 로고
    • Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease
    • Funato H, Yoshimura M, Kusui K, et al. Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease. Am J Pathol 1998; 152: 1633-1640.
    • (1998) Am J Pathol , vol.152 , pp. 1633-1640
    • Funato, H.1    Yoshimura, M.2    Kusui, K.3
  • 16
    • 0031038918 scopus 로고    scopus 로고
    • Alzheimer's disease: Genotypes, phenotypes, and treatments
    • Selkoe DJ. Alzheimer's disease: genotypes, phenotypes, and treatments. Science 1997; 275: 630-631.
    • (1997) Science , vol.275 , pp. 630-631
    • Selkoe, D.J.1
  • 18
    • 0028899724 scopus 로고
    • Quantitative analysis of senile plaques in Alzheimer disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome)
    • Hyman BT, West HL, Rebeck GW, et al. Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome). Proc Natl Acad Sci USA 1995; 92: 3586-3590.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3586-3590
    • Hyman, B.T.1    West, H.L.2    Rebeck, G.W.3
  • 19
    • 0028173205 scopus 로고
    • Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments
    • Ma J, Yee A, Brewer HB, Jr., Das S, Potter H. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature 1994; 372: 92-94.
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yee, A.2    Brewer, H.B.3    Das, S.4    Potter, H.5
  • 20
    • 0021145680 scopus 로고
    • Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
    • Hyman BT, Van Horsen GW, Damasio AR, Barnes CL. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 1984; 225: 1168-1170.
    • (1984) Science , vol.225 , pp. 1168-1170
    • Hyman, B.T.1    Van Horsen, G.W.2    Damasio, A.R.3    Barnes, C.L.4
  • 21
    • 0344653664 scopus 로고    scopus 로고
    • Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
    • Gomez-Isla T, Hollister R, West H, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 1997; 41: 17-24.
    • (1997) Ann Neurol , vol.41 , pp. 17-24
    • Gomez-Isla, T.1    Hollister, R.2    West, H.3
  • 22
    • 0030050286 scopus 로고    scopus 로고
    • Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease
    • Gomez-Isla T, West HL, Rebeck GW, et al. Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease. Ann Neurol 1996; 39: 62-70.
    • (1996) Ann Neurol , vol.39 , pp. 62-70
    • Gomez-Isla, T.1    West, H.L.2    Rebeck, G.W.3
  • 23
    • 0007438447 scopus 로고    scopus 로고
    • Clinicopathological study in Alzheimer's disease: Senile plaques correlate with profiles of cognitive impairment
    • Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM, eds. Chichester: John Wiley & Sons Ltd.
    • Caramelli P, Robitaille Y, Cholette AL, et al. Clinicopathological study in Alzheimer's disease: senile plaques correlate with profiles of cognitive impairment. In: Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM, eds. Alzheimer's Disease: Biology, Diagnosis and Therapeutics. Chichester: John Wiley & Sons Ltd., 1997: 267-274.
    • (1997) Alzheimer's Disease: Biology, Diagnosis and Therapeutics , pp. 267-274
    • Caramelli, P.1    Robitaille, Y.2    Cholette, A.L.3
  • 25
    • 0027490614 scopus 로고
    • Staging of Alzheimer-related cortical destruction
    • Braak H, Braak E, Bohl J. Staging of Alzheimer-related cortical destruction. Eur Neurol 1993; 33: 403-408.
    • (1993) Eur Neurol , vol.33 , pp. 403-408
    • Braak, H.1    Braak, E.2    Bohl, J.3
  • 26
    • 0029013727 scopus 로고
    • Staging of Alzheimer's disease-related neurofibrillary changes
    • Braak H, Braak E. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 1995; 16: 271-284.
    • (1995) Neurobiol Aging , vol.16 , pp. 271-284
    • Braak, H.1    Braak, E.2
  • 27
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30: 572-580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3
  • 28
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
    • DeKosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 1990; 27: 457-464.
    • (1990) Ann Neurol , vol.27 , pp. 457-464
    • DeKosky, S.T.1    Scheff, S.W.2
  • 29
    • 0017048577 scopus 로고
    • Distribution of cerebral degeneration in Alzheimer's disease. A clinico-pathological study
    • Brun A, Gustafson L. Distribution of cerebral degeneration in Alzheimer's disease. A clinico-pathological study. Arch Psychiat Nervenkr 1976; 223: 15-33.
    • (1976) Arch Psychiat Nervenkr , vol.223 , pp. 15-33
    • Brun, A.1    Gustafson, L.2
  • 30
    • 0019410162 scopus 로고
    • Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
    • Whitehouse PJ, Price DL, Clark AW, Coyle JT, DeLong MR. Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 1981; 10: 122-126.
    • (1981) Ann Neurol , vol.10 , pp. 122-126
    • Whitehouse, P.J.1    Price, D.L.2    Clark, A.W.3    Coyle, J.T.4    DeLong, M.R.5
  • 31
    • 0020072221 scopus 로고
    • Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
    • Whitehouse PJ, Price DL, Struble RG, et al. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 1981; 215: 1237-1239.
    • (1981) Science , vol.215 , pp. 1237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Struble, R.G.3
  • 32
    • 0031883716 scopus 로고    scopus 로고
    • A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil study group
    • Rogers SL, Farlow MR, Doody RS, Mohs R, Friedhoff LT. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group. Neurology 1998; 50: 136-145.
    • (1998) Neurology , vol.50 , pp. 136-145
    • Rogers, S.L.1    Farlow, M.R.2    Doody, R.S.3    Mohs, R.4    Friedhoff, L.T.5
  • 33
    • 0031842293 scopus 로고    scopus 로고
    • Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease
    • Morris JC, Cyrus PA, Orazem J, et al. Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease. Neurology 1998; 50: 1222-1230.
    • (1998) Neurology , vol.50 , pp. 1222-1230
    • Morris, J.C.1    Cyrus, P.A.2    Orazem, J.3
  • 34
    • 0031983322 scopus 로고    scopus 로고
    • Long-term efficacy and safety of denepezil in the treatment of Alzheimer's disease: An interim analysis of the results of a US multicenter open label extension study
    • Rogers SL, Friedhoff LT. Long-term efficacy and safety of denepezil in the treatment of Alzheimer's disease: an interim analysis of the results of a US multicenter open label extension study. Eur Neuropsychopharmacol 1998; 8(1): 67-75.
    • (1998) Eur Neuropsychopharmacol , vol.8 , Issue.1 , pp. 67-75
    • Rogers, S.L.1    Friedhoff, L.T.2
  • 35
    • 0030818062 scopus 로고    scopus 로고
    • Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease
    • Simpkins JW, Green PS, Gridley KE, et al. Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease. Am J Med 1997; 103: 19S-25S.
    • (1997) Am J Med , vol.103
    • Simpkins, J.W.1    Green, P.S.2    Gridley, K.E.3
  • 36
    • 0029886801 scopus 로고    scopus 로고
    • Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer's disease
    • Schneider LS, Farlow MR, Henderson VW, Pogoda JM. Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer's disease. Neurology 1996; 46: 1580-1584.
    • (1996) Neurology , vol.46 , pp. 1580-1584
    • Schneider, L.S.1    Farlow, M.R.2    Henderson, V.W.3    Pogoda, J.M.4
  • 37
    • 0030942682 scopus 로고    scopus 로고
    • The epidemiology of estrogen replacement therapy and Alzheimer's disease
    • Henderson VW. The epidemiology of estrogen replacement therapy and Alzheimer's disease. Neurology 1997; 48 (Suppl. 7): S27-S35.
    • (1997) Neurology , vol.48 , Issue.SUPPL. 7
    • Henderson, V.W.1
  • 38
    • 0030879207 scopus 로고    scopus 로고
    • A 12-month, randomized, placebo-controlled trial of propentofylline (HWA 285) in patients with dementia according to DSM III-R
    • Marcusson J, Rother M, Kittner B, et al. A 12-month, randomized, placebo-controlled trial of propentofylline (HWA 285) in patients with dementia according to DSM III-R. Dement Geriatr Cogn Disord 1997; 8: 320-328.
    • (1997) Dement Geriatr Cogn Disord , vol.8 , pp. 320-328
    • Marcusson, J.1    Rother, M.2    Kittner, B.3
  • 40
    • 0030061020 scopus 로고    scopus 로고
    • Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer's disease: Clinicopathologic correlations using three sets of pathologic diagnostic criteria
    • Nagy Z, Jobst KA, Esiri MM, et al. Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer's disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria. Dementia 1996; 7: 76-81.
    • (1996) Dementia , vol.7 , pp. 76-81
    • Nagy, Z.1    Jobst, K.A.2    Esiri, M.M.3
  • 41
    • 0029926216 scopus 로고    scopus 로고
    • Clustering of pathological features in Alzheimer's disease: Clinical and neuroanatomical aspects
    • Nagy Z, Esiri MM, Jobst KA, et al. Clustering of pathological features in Alzheimer's disease: clinical and neuroanatomical aspects. Dementia 1996; 7: 121-127.
    • (1996) Dementia , vol.7 , pp. 121-127
    • Nagy, Z.1    Esiri, M.M.2    Jobst, K.A.3
  • 42
    • 0028831582 scopus 로고
    • Relative roles of plaques and tangles in the dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria
    • Nagy Z, Esiri MM, Jobst KA, et al. Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria. Dementia 1995; 6: 21-31.
    • (1995) Dementia , vol.6 , pp. 21-31
    • Nagy, Z.1    Esiri, M.M.2    Jobst, K.A.3
  • 43
    • 0028794544 scopus 로고
    • Close-meshed prevalence rates of different stages as a tool to uncover the rate of Alzheimer's disease-related neurofibrillary changes
    • Ohm TG, Muller H, Braak H, Bohl J. Close-meshed prevalence rates of different stages as a tool to uncover the rate of Alzheimer's disease-related neurofibrillary changes. Neuroscience 1995; 64: 209-217.
    • (1995) Neuroscience , vol.64 , pp. 209-217
    • Ohm, T.G.1    Muller, H.2    Braak, H.3    Bohl, J.4
  • 44
    • 0002089018 scopus 로고
    • Clinical genetics of familial alzheimer's disease
    • Terry RD, Katzman R, Bick KL, eds. New York: Raven Press Ltd.
    • Bird TD. Clinical genetics of familial alzheimer's disease. In: Terry RD, Katzman R, Bick KL, eds. Alzheimer Disease. New York: Raven Press Ltd., 1994: 65-74.
    • (1994) Alzheimer Disease , pp. 65-74
    • Bird, T.D.1
  • 45
    • 0029827790 scopus 로고    scopus 로고
    • Reduced survival of apolipoprotein E4 homozygotes in Down's syndrome?
    • Holder JL, Habbak RA, Pearlson GD, et al. Reduced survival of apolipoprotein E4 homozygotes in Down's syndrome? Neuroreport 1996; 7: 2455-2456.
    • (1996) Neuroreport , vol.7 , pp. 2455-2456
    • Holder, J.L.1    Habbak, R.A.2    Pearlson, G.D.3
  • 46
    • 0031057837 scopus 로고    scopus 로고
    • Exploring the etiology of Alzheimer disease using molecular genetics
    • Lendon CL, Ashall F, Goate AM. Exploring the etiology of Alzheimer disease using molecular genetics. JAMA 1997; 277: 825-831.
    • (1997) JAMA , vol.277 , pp. 825-831
    • Lendon, C.L.1    Ashall, F.2    Goate, A.M.3
  • 47
    • 0028305380 scopus 로고
    • Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
    • Corder EH, Saunders AM, Risch NJ, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 1994; 7: 180-184.
    • (1994) Nat Genet , vol.7 , pp. 180-184
    • Corder, E.H.1    Saunders, A.M.2    Risch, N.J.3
  • 48
    • 8944241774 scopus 로고    scopus 로고
    • Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant
    • Sherrington R, Froelich S, Sorbi S, et al. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum Mol Genet 1996; 5: 985-988.
    • (1996) Hum Mol Genet , vol.5 , pp. 985-988
    • Sherrington, R.1    Froelich, S.2    Sorbi, S.3
  • 49
    • 0029968528 scopus 로고    scopus 로고
    • Three different mutations of presenilin 1 gene in early-onset Alzheimer's disease families
    • Kamino K, Sato S, Sakaki Y, et al. Three different mutations of presenilin 1 gene in early-onset Alzheimer's disease families. Neurosci Lett 1996; 208: 195-198.
    • (1996) Neurosci Lett , vol.208 , pp. 195-198
    • Kamino, K.1    Sato, S.2    Sakaki, Y.3
  • 50
    • 10544239098 scopus 로고    scopus 로고
    • Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease
    • Murphy GM, Jr., Forno LS, Ellis WG, et al. Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease. Am J Pathol 1996; 149: 1839-1846.
    • (1996) Am J Pathol , vol.149 , pp. 1839-1846
    • Murphy G.M., Jr.1    Forno, L.S.2    Ellis, W.G.3
  • 51
    • 0007691164 scopus 로고
    • Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease
    • Poirier J, Delisle MC, Quirion R, et al. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. Proc Natl Acad Sci USA 1995; 92: 12260-12264.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12260-12264
    • Poirier, J.1    Delisle, M.C.2    Quirion, R.3
  • 52
    • 0028172930 scopus 로고
    • Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease
    • Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 1994; 17: 525-530.
    • (1994) Trends Neurosci , vol.17 , pp. 525-530
    • Poirier, J.1
  • 53
    • 0027282035 scopus 로고
    • Apolipoprotein e polymorphism and Alzheimer's disease
    • Poirier J, Davignon J, Bouthillier D, et al. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993; 342: 697-699.
    • (1993) Lancet , vol.342 , pp. 697-699
    • Poirier, J.1    Davignon, J.2    Bouthillier, D.3
  • 54
    • 0027327267 scopus 로고
    • Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993; 43: 1467-1472.
    • (1993) Neurology , vol.43 , pp. 1467-1472
    • Saunders, A.M.1    Strittmatter, W.J.2    Schmechel, D.3
  • 55
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261: 921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 56
    • 0029981819 scopus 로고    scopus 로고
    • Clinical and neuropathological correlates of apolipoprotein E genotype in Alzheimer's disease. Window on molecular epidemiology
    • Hyman BT, Gomez-Isla T, West H, et al. Clinical and neuropathological correlates of apolipoprotein E genotype in Alzheimer's disease. Window on molecular epidemiology. Ann NY Acad Sci 1996; 777: 158-165.
    • (1996) Ann NY Acad Sci , vol.777 , pp. 158-165
    • Hyman, B.T.1    Gomez-Isla, T.2    West, H.3
  • 57
    • 8044230698 scopus 로고    scopus 로고
    • Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease
    • Hyman BT, Gomez-Isla T, Rebeck GW, et al. Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease. Ann NY Acad Sci 1996; 802: 1-5.
    • (1996) Ann NY Acad Sci , vol.802 , pp. 1-5
    • Hyman, B.T.1    Gomez-Isla, T.2    Rebeck, G.W.3
  • 58
    • 0030006546 scopus 로고    scopus 로고
    • Alzheimer's disease: Interaction of apolipoprotein E genotype, family history of dementia, gender, education, ethnicity, and age of onset
    • Duara R, Barker WW, Lopez-Alberola R, et al. Alzheimer's disease: interaction of apolipoprotein E genotype, family history of dementia, gender, education, ethnicity, and age of onset. Neurology 1996; 46: 1575-1579.
    • (1996) Neurology , vol.46 , pp. 1575-1579
    • Duara, R.1    Barker, W.W.2    Lopez-Alberola, R.3
  • 59
    • 0028282762 scopus 로고
    • Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease
    • West HL, Rebeck GW, Hyman BT. Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease. Neurosci Lett 1994; 175: 46-48.
    • (1994) Neurosci Lett , vol.175 , pp. 46-48
    • West, H.L.1    Rebeck, G.W.2    Hyman, B.T.3
  • 60
    • 0029664414 scopus 로고    scopus 로고
    • Apolipoprotein e epsilon4 association with dementia in a population-based study: The Framingham study
    • Myers RH, Schaefer EJ, Wilson PW, et al. Apolipoprotein E epsilon4 association with dementia in a population-based study: the Framingham study. Neurology 1996; 46: 673-677.
    • (1996) Neurology , vol.46 , pp. 673-677
    • Myers, R.H.1    Schaefer, E.J.2    Wilson, P.W.3
  • 61
    • 0030005627 scopus 로고    scopus 로고
    • Apolipoprotein E alleles as risk factors in Alzheimer's disease
    • Roses AD. Apolipoprotein E alleles as risk factors in Alzheimer's disease. Ann Rev Med 1996; 47: 387-400.
    • (1996) Ann Rev Med , vol.47 , pp. 387-400
    • Roses, A.D.1
  • 62
    • 0027946816 scopus 로고
    • Predictive value of apolipoprotein E genotyping in Alzheimer's disease: Results of an autopsy series and an analysis of several combined studies
    • Nalbantoglu J, Gilfix BM, Bertrand P, et al. Predictive value of apolipoprotein E genotyping in Alzheimer's disease: results of an autopsy series and an analysis of several combined studies. Ann Neurol 1994; 36: 889-895.
    • (1994) Ann Neurol , vol.36 , pp. 889-895
    • Nalbantoglu, J.1    Gilfix, B.M.2    Bertrand, P.3
  • 63
    • 0027407565 scopus 로고
    • Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
    • Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993; 90: 1977-1981.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.M.2    Schmechel, D.3
  • 64
    • 2642711806 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer disease: Genotype-specific risks by age and sex
    • Bickeboller H, Campion D, Brice A, et al. Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. Am J Hum Genet 1997; 60: 439-446.
    • (1997) Am J Hum Genet , vol.60 , pp. 439-446
    • Bickeboller, H.1    Campion, D.2    Brice, A.3
  • 65
    • 19144373595 scopus 로고    scopus 로고
    • Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City
    • Tang MX, Maestre G, Tsai WY, et al. Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City. Am J Hum Genet 1996; 58: 574-584.
    • (1996) Am J Hum Genet , vol.58 , pp. 574-584
    • Tang, M.X.1    Maestre, G.2    Tsai, W.Y.3
  • 66
    • 0028843391 scopus 로고
    • Apolipoprotein E4 allele and Alzheimer disease: Examination of allelic association and effect on age at onset in both early- and late-onset cases
    • Locke PA, Conneally PM, Tanzi RE, Gusella JF, Haines JL. Apolipoprotein E4 allele and Alzheimer disease: examination of allelic association and effect on age at onset in both early- and late-onset cases. Genet Epidemiol 1995; 12: 83-92.
    • (1995) Genet Epidemiol , vol.12 , pp. 83-92
    • Locke, P.A.1    Conneally, P.M.2    Tanzi, R.E.3    Gusella, J.F.4    Haines, J.L.5
  • 67
    • 0027339923 scopus 로고
    • The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease
    • Mayeux R, Stern Y, Ottman R, et al. The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease. Ann Neurol 1993; 34: 752-754.
    • (1993) Ann Neurol , vol.34 , pp. 752-754
    • Mayeux, R.1    Stern, Y.2    Ottman, R.3
  • 68
    • 0028167193 scopus 로고
    • Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease
    • Brousseau T, Legrain S, Berr C, et al. Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease. Neurology 1994; 44: 342-344.
    • (1994) Neurology , vol.44 , pp. 342-344
    • Brousseau, T.1    Legrain, S.2    Berr, C.3
  • 69
    • 0028167195 scopus 로고
    • ApoE epsilon 4 allelic association with Alzheimer's disease: Independent confirmation using denaturing gradient gel electrophoresis
    • Peacock ML, Fink JK. ApoE epsilon 4 allelic association with Alzheimer's disease: independent confirmation using denaturing gradient gel electrophoresis. Neurology 1994; 44: 339-341.
    • (1994) Neurology , vol.44 , pp. 339-341
    • Peacock, M.L.1    Fink, J.K.2
  • 70
    • 0028301820 scopus 로고
    • Apolipoprotein E: Risk factor for Alzheimer disease
    • Tsai MS, Tangalos EG, Petersen RC, et al. Apolipoprotein E: risk factor for Alzheimer disease. Am J Hum Genet 1994; 54: 643-649.
    • (1994) Am J Hum Genet , vol.54 , pp. 643-649
    • Tsai, M.S.1    Tangalos, E.G.2    Petersen, R.C.3
  • 71
    • 0028951080 scopus 로고
    • Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: Implications for disease pathogenesis
    • Richey PL, Siedlak SL, Smith MA, Perry G. Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis. Biochem Biophys Res Commun 1995; 208: 657-663.
    • (1995) Biochem Biophys Res Commun , vol.208 , pp. 657-663
    • Richey, P.L.1    Siedlak, S.L.2    Smith, Ma.3    Perry, G.4
  • 72
    • 12044254746 scopus 로고
    • Binding of human apolipoprotein E to synthetic amyloid beta peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
    • Strittmatter WJ, Weisgraber KH, Huang DY, et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993; 90: 8098-8102.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8098-8102
    • Strittmatter, W.J.1    Weisgraber, K.H.2    Huang, D.Y.3
  • 73
    • 0028080483 scopus 로고
    • Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the alzheimer beta-amyloid deposition
    • Yamaguchi H, Ishiguro K, Sugihara S, et al. Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition. Acta Neuropathol (Berl) 1994; 88: 413-419.
    • (1994) Acta Neuropathol (Berl) , vol.88 , pp. 413-419
    • Yamaguchi, H.1    Ishiguro, K.2    Sugihara, S.3
  • 74
    • 0029757510 scopus 로고    scopus 로고
    • Apolipoprotein E distribution among different plaque types in Alzheimer's disease: Implications for its role in plaque progression
    • Sheng JG, Mrak RE, Griffin WS. Apolipoprotein E distribution among different plaque types in Alzheimer's disease: implications for its role in plaque progression. Neuropathol Appl Neurobiol 1996; 22: 334-341.
    • (1996) Neuropathol Appl Neurobiol , vol.22 , pp. 334-341
    • Sheng, J.G.1    Mrak, R.E.2    Griffin, W.S.3
  • 75
    • 0028822219 scopus 로고
    • Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neunte outgrowth in a central nervous system-derived neuronal cell line
    • Holtzman DM, Pitas RE, Kilbridge J, et al. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neunte outgrowth in a central nervous system-derived neuronal cell line. Proc Natl Acad Sci USA 1995; 92: 9480-9484.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9480-9484
    • Holtzman, D.M.1    Pitas, R.E.2    Kilbridge, J.3
  • 76
    • 0028026587 scopus 로고
    • Apolipoprotein e associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3
    • Sanan DA, Weisgraber KH, Russell SJ, et al. Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. J Clin Invest 1994; 94: 860-869.
    • (1994) J Clin Invest , vol.94 , pp. 860-869
    • Sanan, D.A.1    Weisgraber, K.H.2    Russell, S.J.3
  • 77
    • 0027931854 scopus 로고
    • Isoform-specific binding of apolipoprotein E to beta-amyloid
    • LaDu MJ, Falduto MT, Manelli AM, et al. Isoform-specific binding of apolipoprotein E to beta-amyloid. J Biol Chem 1994; 269: 23403-23406.
    • (1994) J Biol Chem , vol.269 , pp. 23403-23406
    • LaDu, M.J.1    Falduto, M.T.2    Manelli, A.M.3
  • 78
    • 0027365822 scopus 로고
    • Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
    • Schmechel DE, Saunders AM, Strittmatter WJ, et al. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993; 90: 9649-9653.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9649-9653
    • Schmechel, D.E.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 79
    • 0028841027 scopus 로고
    • Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein
    • Polvikoski T, Sulkava R, Haltia M, et al. Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein. N Engl J Med 1995; 333: 1242-1247.
    • (1995) N Engl J Med , vol.333 , pp. 1242-1247
    • Polvikoski, T.1    Sulkava, R.2    Haltia, M.3
  • 80
    • 0028787064 scopus 로고
    • Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease
    • Nagy Z, Esiri MM, Jobst KA, et al. Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease. Neuroscience 1995; 69: 757-761.
    • (1995) Neuroscience , vol.69 , pp. 757-761
    • Nagy, Z.1    Esiri, M.M.2    Jobst, K.A.3
  • 81
    • 0028872558 scopus 로고
    • Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer disease
    • Evans KC, Berger EP, Cho CG, Weisgraber KH, Lansbury PT, Jr. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease. Proc Natl Acad Sci USA 1995; 92: 763-767.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 763-767
    • Evans, K.C.1    Berger, E.P.2    Cho, C.G.3    Weisgraber, K.H.4    Lansbury P.T., Jr.5
  • 82
    • 0029754637 scopus 로고    scopus 로고
    • Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein E
    • Zhou Z, Smith JD, Greengard P, Gandy S. Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein E. Mol Med 1996; 2: 175-180.
    • (1996) Mol Med , vol.2 , pp. 175-180
    • Zhou, Z.1    Smith, J.D.2    Greengard, P.3    Gandy, S.4
  • 83
    • 0031037086 scopus 로고    scopus 로고
    • Specific modulation of the fusogenic properties of the Alzheimer beta-amyloid peptide by apolipoprotein E isoforms
    • Pillot T, Goethals M, Vanloo B, et al. Specific modulation of the fusogenic properties of the Alzheimer beta-amyloid peptide by apolipoprotein E isoforms. Eur J Biochem 1997; 243: 650-659.
    • (1997) Eur J Biochem , vol.243 , pp. 650-659
    • Pillot, T.1    Goethals, M.2    Vanloo, B.3
  • 84
    • 0027994092 scopus 로고
    • Apolipoprotein E is localized to the cytoplasm of human cortical neurons: A light and electron microscopic study
    • Han SH, Einstein G, Weisgraber KH, et al. Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. J Neuropathol Exp Neurol 1994; 53: 535-544.
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 535-544
    • Han, S.H.1    Einstein, G.2    Weisgraber, K.H.3
  • 85
    • 0028018114 scopus 로고
    • Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls
    • Han SH, Hulette C, Saunders AM, et al. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Exp Neurol 1994; 128: 13-26.
    • (1994) Exp Neurol , vol.128 , pp. 13-26
    • Han, S.H.1    Hulette, C.2    Saunders, A.M.3
  • 86
    • 0030599039 scopus 로고    scopus 로고
    • Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein E allele epsilon 4 during 14 months follow-up
    • Blomberg M, Jensen M, Basun H, Lannfelt L, Wahlund LO. Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein E allele epsilon 4 during 14 months follow-up. Neurosci Lett 1996; 214: 163-166.
    • (1996) Neurosci Lett , vol.214 , pp. 163-166
    • Blomberg, M.1    Jensen, M.2    Basun, H.3    Lannfelt, L.4    Wahlund, L.O.5
  • 87
    • 0028035306 scopus 로고
    • Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer disease
    • Strittmatter WJ, Saunders AM, Goedert M, et al. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc Natl Acad Sci USA 1994; 91: 11183-11186.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11183-11186
    • Strittmatter, W.J.1    Saunders, A.M.2    Goedert, M.3
  • 88
    • 0028033804 scopus 로고
    • Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: Implications for Alzheimer's disease
    • Huang DY, Goedert M, Jakes R, et al. Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neurosci Lett 1994; 182: 55-58.
    • (1994) Neurosci Lett , vol.182 , pp. 55-58
    • Huang, D.Y.1    Goedert, M.2    Jakes, R.3
  • 89
    • 0030801045 scopus 로고    scopus 로고
    • Cerebrospinal fluid apolipoprotein E (apoE) levels in Alzheimer's disease patients are increased at follow up and show a correlation with levels of tau protein
    • Lindh M, Blomberg M, Jensen M, et al. Cerebrospinal fluid apolipoprotein E (apoE) levels in Alzheimer's disease patients are increased at follow up and show a correlation with levels of tau protein. Neurosci Lett 1997; 229: 85-88.
    • (1997) Neurosci Lett , vol.229 , pp. 85-88
    • Lindh, M.1    Blomberg, M.2    Jensen, M.3
  • 90
    • 0030989926 scopus 로고    scopus 로고
    • Apolipoprotein E genotyping and cerebrospinal fluid tau protein: Implications for the clinical diagnosis of Alzheimer's disease
    • Arai H, Higuchi S, Sasaki H. Apolipoprotein E genotyping and cerebrospinal fluid tau protein: implications for the clinical diagnosis of Alzheimer's disease. Gerontology 1997; 43 (Suppl 1): 2-10.
    • (1997) Gerontology , vol.43 , Issue.SUPPL. 1 , pp. 2-10
    • Arai, H.1    Higuchi, S.2    Sasaki, H.3
  • 91
    • 0031907459 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype
    • Craft S, Peskind E, Schwartz MW, et al. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. Neurology 1998; 50: 164-168.
    • (1998) Neurology , vol.50 , pp. 164-168
    • Craft, S.1    Peskind, E.2    Schwartz, M.W.3
  • 92
    • 0030464403 scopus 로고    scopus 로고
    • Alterations in apolipoprotein E expression during aging and neurodegeneration
    • Masliah E, Mallory M, Veinbergs I, Miller A, Samuel W. Alterations in apolipoprotein E expression during aging and neurodegeneration. Prog Neurobiol 1996; 50: 493-503.
    • (1996) Prog Neurobiol , vol.50 , pp. 493-503
    • Masliah, E.1    Mallory, M.2    Veinbergs, I.3    Miller, A.4    Samuel, W.5
  • 93
    • 0028232662 scopus 로고
    • Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro
    • Nathan B, Bellosta S, Sanan DA, et al. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 1994; 264: 850-852.
    • (1994) Science , vol.264 , pp. 850-852
    • Nathan, B.1    Bellosta, S.2    Sanan, D.A.3
  • 94
    • 0029893405 scopus 로고    scopus 로고
    • Apolipoprotein E, memory and Alzheimer's disease
    • Soininen HS, Riekkinen PJ, Sr. Apolipoprotein E, memory and Alzheimer's disease. Trends Neurosci 1996; 19: 224-228.
    • (1996) Trends Neurosci , vol.19 , pp. 224-228
    • Soininen, H.S.1    Riekkinen, P.J.2
  • 95
    • 0030751161 scopus 로고    scopus 로고
    • Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury
    • Chen Y, Lomnitski L, Michaelson DM, Shohami E. Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury. Neuroscience 1997; 80: 1255-1262.
    • (1997) Neuroscience , vol.80 , pp. 1255-1262
    • Chen, Y.1    Lomnitski, L.2    Michaelson, D.M.3    Shohami, E.4
  • 96
    • 0031933654 scopus 로고    scopus 로고
    • Specific neurochemical derangements of brain projecting neurons in apolipoprotein E-deficient mice
    • Chapman S, Michaelson DM. Specific neurochemical derangements of brain projecting neurons in apolipoprotein E-deficient mice. J Neurochem 1998; 70: 708-714.
    • (1998) J Neurochem , vol.70 , pp. 708-714
    • Chapman, S.1    Michaelson, D.M.2
  • 97
    • 0029043032 scopus 로고
    • Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation
    • Ohm TG, Kirca M, Bohl J, et al. Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation. Neuroscience 1995; 66: 583-587.
    • (1995) Neuroscience , vol.66 , pp. 583-587
    • Ohm, T.G.1    Kirca, M.2    Bohl, J.3
  • 98
    • 0029565324 scopus 로고
    • Increased acetylcholinesterase activity in the CSF of Alzheimer patients carrying apolipoprotein epsilon4 allele
    • Soininen H, Lehtovirta M, Helisalmi S, et al. Increased acetylcholinesterase activity in the CSF of Alzheimer patients carrying apolipoprotein epsilon4 allele. Neuroreport 1995; 6: 2518-2520.
    • (1995) Neuroreport , vol.6 , pp. 2518-2520
    • Soininen, H.1    Lehtovirta, M.2    Helisalmi, S.3
  • 99
    • 0028904432 scopus 로고
    • A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele
    • Soininen H, Kosunen O, Helisalmi S, et al. A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele. Neurosci Lett 1995; 187: 79-82.
    • (1995) Neurosci Lett , vol.187 , pp. 79-82
    • Soininen, H.1    Kosunen, O.2    Helisalmi, S.3
  • 100
    • 0030910311 scopus 로고    scopus 로고
    • Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease
    • Iyo M, Namba H, Fukushi K, et al. Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease. Lancet 1997; 349: 1805-1809.
    • (1997) Lancet , vol.349 , pp. 1805-1809
    • Iyo, M.1    Namba, H.2    Fukushi, K.3
  • 101
    • 0030476825 scopus 로고    scopus 로고
    • Apolipoprotein E genotype and gender influence response to tacrine therapy
    • Farlow MR, Lahiri DK, Poirier J, Davignon J, Hui S. Apolipoprotein E genotype and gender influence response to tacrine therapy. Ann NY Acad Sci 1996; 802: 101-110.
    • (1996) Ann NY Acad Sci , vol.802 , pp. 101-110
    • Farlow, M.R.1    Lahiri, D.K.2    Poirier, J.3    Davignon, J.4    Hui, S.5
  • 102
    • 0030855949 scopus 로고    scopus 로고
    • Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes
    • Svensson AL, Warpman U, Hellstrom-Lindahl E, et al. Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes. Neurosci Lett 1997; 232: 37-40.
    • (1997) Neurosci Lett , vol.232 , pp. 37-40
    • Svensson, A.L.1    Warpman, U.2    Hellstrom-Lindahl, E.3
  • 103
    • 25744457920 scopus 로고    scopus 로고
    • Apolipoprotein genotype does not predict choline acetyltransferase activity or synaptic loss in Alzheimer's disease
    • Corey-Bloom J, Tiraboachi P, Sabbagh MN, et al. Apolipoprotein genotype does not predict choline acetyltransferase activity or synaptic loss in Alzheimer's disease. Neurology 1998; 50 (Suppl. 4): A60-A61.
    • (1998) Neurology , vol.50 , Issue.SUPPL. 4
    • Corey-Bloom, J.1    Tiraboachi, P.2    Sabbagh, M.N.3
  • 104
    • 0028859880 scopus 로고
    • Apolipoprotein E genotype and Lewy body disease
    • Lippa CF, Smith TW, Saunders AM, et al. Apolipoprotein E genotype and Lewy body disease. Neurology 1995; 45: 97-103.
    • (1995) Neurology , vol.45 , pp. 97-103
    • Lippa, C.F.1    Smith, T.W.2    Saunders, A.M.3
  • 105
    • 0030590067 scopus 로고    scopus 로고
    • The apolipoprotein E epsilon 4 allele in Parkinson's disease with Alzheimer lesions
    • Egensperger R, Bancher C, Kosel S, et al. The apolipoprotein E epsilon 4 allele in Parkinson's disease with Alzheimer lesions. Biochem Biophys Res Commun 1996; 224: 484-486.
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 484-486
    • Egensperger, R.1    Bancher, C.2    Kosel, S.3
  • 106
    • 0028168115 scopus 로고
    • The apolipoprotein epsilon 4 allele in Parkinson's disease with and without dementia
    • Marder K, Maestre G, Cote L, et al. The apolipoprotein epsilon 4 allele in Parkinson's disease with and without dementia. Neurology 1994; 44: 1330-1331.
    • (1994) Neurology , vol.44 , pp. 1330-1331
    • Marder, K.1    Maestre, G.2    Cote, L.3
  • 107
    • 0031017951 scopus 로고    scopus 로고
    • Depression, delusions, and hallucinations in Alzheimer's disease: No relationship to apolipoprotein E genotype
    • Lyketsos CG, Baker L, Warren A, et al. Depression, delusions, and hallucinations in Alzheimer's disease: no relationship to apolipoprotein E genotype. J Neuropsychiatry Clin Neurosci 1997; 9: 64-67.
    • (1997) J Neuropsychiatry Clin Neurosci , vol.9 , pp. 64-67
    • Lyketsos, C.G.1    Baker, L.2    Warren, A.3
  • 108
    • 0029658476 scopus 로고    scopus 로고
    • APOE-epsilon 4 in patients with Alzheimer disease and vascular dementia
    • Treves TA, Bornstein NM, Chapman J, et al. APOE-epsilon 4 in patients with Alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord 1996; 10: 189-191.
    • (1996) Alzheimer Dis Assoc Disord , vol.10 , pp. 189-191
    • Treves, T.A.1    Bornstein, N.M.2    Chapman, J.3
  • 109
    • 0030614814 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation
    • Slooter AJ, Tang MX, van Duijn CM, et al. Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation. JAMA 1997; 277: 818-821.
    • (1997) JAMA , vol.277 , pp. 818-821
    • Slooter, A.J.1    Tang, M.X.2    Van Duijn, C.M.3
  • 110
    • 0031971434 scopus 로고    scopus 로고
    • A population study of apoE genotype at the age of 85: Relation to dementia, cerebrovascular disease, and mortality
    • Skoog I, Hesse C, Aevarsson O, et al. A population study of apoE genotype at the age of 85: relation to dementia, cerebrovascular disease, and mortality. J Neurol Neurosurg Psychiatry 1998; 64: 37-43.
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , pp. 37-43
    • Skoog, I.1    Hesse, C.2    Aevarsson, O.3
  • 111
    • 8044235632 scopus 로고    scopus 로고
    • Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease
    • Tang MX, Maestre G, Tsai WY, et al. Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease. Ann NY Acad Sci 1996; 802: 6-15.
    • (1996) Ann NY Acad Sci , vol.802 , pp. 6-15
    • Tang, M.X.1    Maestre, G.2    Tsai, W.Y.3
  • 112
    • 0029018224 scopus 로고
    • Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease
    • Mayeux R, Ottman R, Maestre G, et al. Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology 1995; 45: 555-557.
    • (1995) Neurology , vol.45 , pp. 555-557
    • Mayeux, R.1    Ottman, R.2    Maestre, G.3
  • 113
    • 8544232115 scopus 로고    scopus 로고
    • Head injury and risk of Alzheimer's disease by apolipoprotein E genotype
    • O'Meara ES, Kukull WA, Sheppard L, et al. Head injury and risk of Alzheimer's disease by apolipoprotein E genotype. Am J Epidemiol 1997; 146: 373-384.
    • (1997) Am J Epidemiol , vol.146 , pp. 373-384
    • O'Meara, E.S.1    Kukull, W.A.2    Sheppard, L.3
  • 114
    • 0029844434 scopus 로고    scopus 로고
    • Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome
    • Schupf N, Kapell D, Lee JH, et al. Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome. Ann Neurol 1996; 40: 799-801.
    • (1996) Ann Neurol , vol.40 , pp. 799-801
    • Schupf, N.1    Kapell, D.2    Lee, J.H.3
  • 115
    • 0029791629 scopus 로고    scopus 로고
    • Neurotropic viruses and Alzheimer disease. Interaction of herpes simplex type 1 virus and apolipoprotein E in the etiology of the disease
    • Lin WR, Shang D, Itzhaki RF. Neurotropic viruses and Alzheimer disease. Interaction of herpes simplex type 1 virus and apolipoprotein E in the etiology of the disease. Mol Chem Neuropathol 1996; 28: 135-141.
    • (1996) Mol Chem Neuropathol , vol.28 , pp. 135-141
    • Lin, W.R.1    Shang, D.2    Itzhaki, R.F.3
  • 116
    • 0031023443 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 in brain and risk of Alzheimer's disease
    • Itzhaki RF, Lin WR, Shang D, et al. Herpes simplex virus type 1 in brain and risk of Alzheimer's disease. Lancet 1997; 349: 241-244.
    • (1997) Lancet , vol.349 , pp. 241-244
    • Itzhaki, R.F.1    Lin, W.R.2    Shang, D.3
  • 117
    • 0029610819 scopus 로고
    • APOE genotype influences functional status among elderly without dementia
    • Albert SM, Gurland B, Maestre G, et al. APOE genotype influences functional status among elderly without dementia. Am J Med Genet 1995; 60: 583-587.
    • (1995) Am J Med Genet , vol.60 , pp. 583-587
    • Albert, S.M.1    Gurland, B.2    Maestre, G.3
  • 118
    • 0027973579 scopus 로고
    • Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele
    • Reed T, Carmelli D, Swan GE, et al. Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele. Arch Neurol 1994; 51: 1189-1192.
    • (1994) Arch Neurol , vol.51 , pp. 1189-1192
    • Reed, T.1    Carmelli, D.2    Swan, G.E.3
  • 119
    • 0030009523 scopus 로고    scopus 로고
    • High apolipoprotein E epsilon 4 allele frequency in age-related memory decline
    • Blesa R, Adroer R, Santacruz P, et al. High apolipoprotein E epsilon 4 allele frequency in age-related memory decline. Ann Neurol 1996; 39: 548-551.
    • (1996) Ann Neurol , vol.39 , pp. 548-551
    • Blesa, R.1    Adroer, R.2    Santacruz, P.3
  • 120
    • 0030870127 scopus 로고    scopus 로고
    • Apolipoprotein E phenotype and cognitive decline in a prospective study of elderly community women
    • Yaffe K, Cauley J, Sands L, Browner W. Apolipoprotein E phenotype and cognitive decline in a prospective study of elderly community women. Arch Neurol 1997; 54: 1110-1114.
    • (1997) Arch Neurol , vol.54 , pp. 1110-1114
    • Yaffe, K.1    Cauley, J.2    Sands, L.3    Browner, W.4
  • 121
    • 0031910347 scopus 로고    scopus 로고
    • Relationship between ApoE, MRI findings, and cognitive function in the cardiovascular health study
    • Kuller LH, Shemanski L, Manolio T. et al. Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study. Stroke 1998; 29: 388-398.
    • (1998) Stroke , vol.29 , pp. 388-398
    • Kuller, L.H.1    Shemanski, L.2    Manolio, T.3
  • 122
    • 0029440749 scopus 로고
    • Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults
    • Bondi MW, Salmon DP, Monsch AU, et al. Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults. Neurology 1995; 45: 2203-2206.
    • (1995) Neurology , vol.45 , pp. 2203-2206
    • Bondi, M.W.1    Salmon, D.P.2    Monsch, A.U.3
  • 123
    • 0031454240 scopus 로고    scopus 로고
    • Quantitative MR volumetry in Alzheimer's disease - Topographic markers and the effects of sex and education
    • Kidron D, Black SE, Stanchev P, et al. Quantitative MR volumetry in Alzheimer's disease - topographic markers and the effects of sex and education. Neurology 1997; 49: 1504-1512.
    • (1997) Neurology , vol.49 , pp. 1504-1512
    • Kidron, D.1    Black, S.E.2    Stanchev, P.3
  • 124
    • 0029864267 scopus 로고    scopus 로고
    • Noninvasive quantification of dopamine D2 receptors with iodine-123-IBF-SPECT
    • Ichise M, Ballinger JR, Golan H, et al. Noninvasive quantification of dopamine D2 receptors with iodine-123-IBF-SPECT. J Nucl Med 1996; 37: 513-520.
    • (1996) J Nucl Med , vol.37 , pp. 513-520
    • Ichise, M.1    Ballinger, J.R.2    Golan, H.3
  • 125
    • 0030338459 scopus 로고    scopus 로고
    • SPECT measurements of brain function in dementia; a review
    • Ryding E. SPECT measurements of brain function in dementia; a review. Acta Neurol Scand Suppl 1996; 168: 54-58.
    • (1996) Acta Neurol Scand Suppl , vol.168 , pp. 54-58
    • Ryding, E.1
  • 126
    • 0030330323 scopus 로고    scopus 로고
    • Application of PET in dementia disorders
    • Nordberg A. Application of PET in dementia disorders. Acta Neurol Scand Suppl 1996; 168: 71-76.
    • (1996) Acta Neurol Scand Suppl , vol.168 , pp. 71-76
    • Nordberg, A.1
  • 127
    • 0028950856 scopus 로고
    • Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease
    • Small GW, Mazziotta JC, Collins MT, et al. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. JAMA 1995; 273: 942-947.
    • (1995) JAMA , vol.273 , pp. 942-947
    • Small, G.W.1    Mazziotta, J.C.2    Collins, M.T.3
  • 128
    • 0029886171 scopus 로고    scopus 로고
    • SPECT and MRI analysis in Alzheimer's disease: Relation to apolipoprotein E epsilon 4 allele
    • Lehtovirta M, Soininen H, Laakso MP, et al. SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele. J Neurol Neurosurg Psychiatry 1996; 60: 644-649.
    • (1996) J Neurol Neurosurg Psychiatry , vol.60 , pp. 644-649
    • Lehtovirta, M.1    Soininen, H.2    Laakso, M.P.3
  • 129
    • 0031056972 scopus 로고    scopus 로고
    • White CL3. Brain blood flow in the dementias: SPECT with histopathologic correlation in 54 patients
    • Bonte FJ, Weiner MF, Bigio EH, White CL3. Brain blood flow in the dementias: SPECT with histopathologic correlation in 54 patients. Radiology 1997; 202: 793-797.
    • (1997) Radiology , vol.202 , pp. 793-797
    • Bonte, F.J.1    Weiner, M.F.2    Bigio, E.H.3
  • 130
    • 0031747565 scopus 로고    scopus 로고
    • Preclinical prediction of Alzheimer's disease using SPECT
    • Johnson KA, Jones K, Holman BL, et al. Preclinical prediction of Alzheimer's disease using SPECT. Neurology 1998; 50: 1563-1571.
    • (1998) Neurology , vol.50 , pp. 1563-1571
    • Johnson, K.A.1    Jones, K.2    Holman, B.L.3
  • 131
    • 0030344762 scopus 로고    scopus 로고
    • Magnetic resonance imaging and computed tomography in Alzheimer's disease
    • Wahlund LO. Magnetic resonance imaging and computed tomography in Alzheimer's disease. Acta Neurol Scand Suppl 1996; 168: 50-53.
    • (1996) Acta Neurol Scand Suppl , vol.168 , pp. 50-53
    • Wahlund, L.O.1
  • 132
    • 1842404825 scopus 로고    scopus 로고
    • Quantitative magnetic resonance imaging and neuropsychological functions in dementia of the Alzheimer type
    • Pantel J, Schroder J, Schad LR, et al. Quantitative magnetic resonance imaging and neuropsychological functions in dementia of the Alzheimer type. Psychol Med 1997; 27: 221-229.
    • (1997) Psychol Med , vol.27 , pp. 221-229
    • Pantel, J.1    Schroder, J.2    Schad, L.R.3
  • 133
    • 0343416812 scopus 로고    scopus 로고
    • Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
    • Jack CR, Petersen RC, Xu YC, et al. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology 1997; 49: 786-794.
    • (1997) Neurology , vol.49 , pp. 786-794
    • Jack, C.R.1    Petersen, R.C.2    Xu, Y.C.3
  • 134
    • 0029758192 scopus 로고    scopus 로고
    • Use of structural imaging to study the progression of Alzheimer's disease
    • Smith AD, Jobst KA. Use of structural imaging to study the progression of Alzheimer's disease. Br Med Bull 1996; 52: 575-586.
    • (1996) Br Med Bull , vol.52 , pp. 575-586
    • Smith, A.D.1    Jobst, K.A.2
  • 135
    • 0028269935 scopus 로고
    • Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease
    • Jobst KA, Smith AD, Szatmari M, et al. Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease. Lancet 1994; 343: 829-830.
    • (1994) Lancet , vol.343 , pp. 829-830
    • Jobst, K.A.1    Smith, A.D.2    Szatmari, M.3
  • 136
    • 0028076175 scopus 로고
    • The diagnosis of Alzheimer's disease: A question of image?
    • Jobst KA, Hindley NJ, King E, Smith AD. The diagnosis of Alzheimer's disease: a question of image?. J Clin Psychiatry 1994; 55 (Suppl.): 22-31.
    • (1994) J Clin Psychiatry , vol.55 , Issue.SUPPL. , pp. 22-31
    • Jobst, K.A.1    Hindley, N.J.2    King, E.3    Smith, A.D.4
  • 137
    • 2642673613 scopus 로고    scopus 로고
    • Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease
    • Jack Jr. CR, Petersen RC, Xu YC, et al. Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease. Ann Neurol 1998; 43(3): 303-310.
    • (1998) Ann Neurol , vol.43 , Issue.3 , pp. 303-310
    • Jack C.R., Jr.1    Petersen, R.C.2    Xu, Y.C.3
  • 138
    • 8044246570 scopus 로고    scopus 로고
    • Early detection of Alzheimer's disease by combining apolipoprotein E and neuroimaging
    • Small GW, Komo S, La Rue A, et al. Early detection of Alzheimer's disease by combining apolipoprotein E and neuroimaging. Ann NY Acad Sci 1996; 802: 70-78.
    • (1996) Ann NY Acad Sci , vol.802 , pp. 70-78
    • Small, G.W.1    Komo, S.2    La Rue, A.3
  • 139
    • 0029970342 scopus 로고    scopus 로고
    • Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E
    • Reiman EM, Caselli RJ, Yun LS, et al. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 1996; 334: 752-758.
    • (1996) N Engl J Med , vol.334 , pp. 752-758
    • Reiman, E.M.1    Caselli, R.J.2    Yun, L.S.3
  • 140
    • 0030907745 scopus 로고    scopus 로고
    • No difference in cerebral glucose metabolism in patients with Alzheimer disease and differing apolipoprotein E genotypes
    • Corder EH, Jelic V, Basun H, et al. No difference in cerebral glucose metabolism in patients with Alzheimer disease and differing apolipoprotein E genotypes. Arch Neurol 1997; 54: 273-277.
    • (1997) Arch Neurol , vol.54 , pp. 273-277
    • Corder, E.H.1    Jelic, V.2    Basun, H.3
  • 141
    • 0031778456 scopus 로고    scopus 로고
    • Longitudinal sPECT study in Alzheimer's disease: Relation to apolipoprotein E polymorphism
    • Lehtovirta M, Kuikka J, Helisalmi S, et al. Longitudinal SPECT study in Alzheimer's disease: relation to apolipoprotein E polymorphism. J Neurol Neurosurg Psychiatry 1998; 64: 742-746.
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , pp. 742-746
    • Lehtovirta, M.1    Kuikka, J.2    Helisalmi, S.3
  • 142
    • 0344416106 scopus 로고    scopus 로고
    • Sex and mental status, but not apolipoprotein E, correlate with parietal and temporal hypoperfusion on SPECT in Alzheimer's disease
    • Swartz RH, Black SE, Leibovitch FS, et al. Sex and mental status, but not apolipoprotein E, correlate with parietal and temporal hypoperfusion on SPECT in Alzheimer's disease. Neurology 1998; 50 (Suppl. 4): A159.
    • (1998) Neurology , vol.50 , Issue.SUPPL. 4
    • Swartz, R.H.1    Black, S.E.2    Leibovitch, F.S.3
  • 143
    • 0028898784 scopus 로고
    • Apolipoproiein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals
    • Petersen RC, Smith GE, Ivnik RJ, et al. Apolipoproiein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. JAMA 1995; 273: 1274-1278.
    • (1995) JAMA , vol.273 , pp. 1274-1278
    • Petersen, R.C.1    Smith, G.E.2    Ivnik, R.J.3
  • 144
    • 0028988735 scopus 로고
    • Gene dose of the epsilon 4 allele of apolipoprotein E and disease progression in sporadic late-onset Alzheimer's disease
    • Frisoni GB, Govoni S, Geroldi C, et al. Gene dose of the epsilon 4 allele of apolipoprotein E and disease progression in sporadic late-onset Alzheimer's disease. Ann Neurol 1995; 37: 596-604.
    • (1995) Ann Neurol , vol.37 , pp. 596-604
    • Frisoni, G.B.1    Govoni, S.2    Geroldi, C.3
  • 145
    • 0030610520 scopus 로고    scopus 로고
    • The absence of an apolipoprotein epsilon4 allele is associated with a more aggressive form of Alzheimer's disease
    • Stern Y, Brandt J, Albert M, et al. The absence of an apolipoprotein epsilon4 allele is associated with a more aggressive form of Alzheimer's disease. Ann Neurol 1997; 41: 615-620.
    • (1997) Ann Neurol , vol.41 , pp. 615-620
    • Stern, Y.1    Brandt, J.2    Albert, M.3
  • 146
    • 0029665363 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon 4 allele, cognitive decline, and deterioration of everyday performance in Alzheimer's disease
    • Kurz A, Egensperger R, Haupt M, et al. Apolipoprotein E epsilon 4 allele, cognitive decline, and deterioration of everyday performance in Alzheimer's disease. Neurology 1996; 47: 440-443.
    • (1996) Neurology , vol.47 , pp. 440-443
    • Kurz, A.1    Egensperger, R.2    Haupt, M.3
  • 147
    • 0029789379 scopus 로고    scopus 로고
    • Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease
    • Growdon JH, Locascio JJ, Corkin S, Gomez-Isla T, Hyman BT. Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease. Neurology 1996; 47: 444-448.
    • (1996) Neurology , vol.47 , pp. 444-448
    • Growdon, J.H.1    Locascio, J.J.2    Corkin, S.3    Gomez-Isla, T.4    Hyman, B.T.5
  • 148
    • 0030210424 scopus 로고    scopus 로고
    • ApoE epsilon 4 allele and cognitive decline in patients with Aizheimer's disease
    • Asada T, Kariya T, Yamagata Z, Kinoshita T, Asaka A. ApoE epsilon 4 allele and cognitive decline in patients with Aizheimer's disease. Neurology 1996; 47: 603.
    • (1996) Neurology , vol.47 , pp. 603
    • Asada, T.1    Kariya, T.2    Yamagata, Z.3    Kinoshita, T.4    Asaka, A.5
  • 149
    • 0029931412 scopus 로고    scopus 로고
    • A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment
    • Tierney MC, Szalai JP, Snow WG, et al. A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment. Neurology 1996; 46: 149-154.
    • (1996) Neurology , vol.46 , pp. 149-154
    • Tierney, M.C.1    Szalai, J.P.2    Snow, W.G.3
  • 150
    • 1842298766 scopus 로고    scopus 로고
    • No association between apolipoprotein E epsilon 4 allele and rate of decline in Alzheimer's disease
    • Murphy GM, Jr., Taylor J, Kraemer HC, Yesavage J, Tinklenberg JR. No association between apolipoprotein E epsilon 4 allele and rate of decline in Alzheimer's disease. Am J Psychiatry 1997; 154: 603-608.
    • (1997) Am J Psychiatry , vol.154 , pp. 603-608
    • Murphy G.M., Jr.1    Taylor, J.2    Kraemer, H.C.3    Yesavage, J.4    Tinklenberg, J.R.5
  • 151
    • 0029987155 scopus 로고    scopus 로고
    • Apolipoprotein E genotype and rate of decline in probable Alzheimer's disease
    • Dal Fomo G, Rasmusson DX, Brandt J, et al. Apolipoprotein E genotype and rate of decline in probable Alzheimer's disease. Arch Neurol 1996; 53: 345-350.
    • (1996) Arch Neurol , vol.53 , pp. 345-350
    • Dal Fomo, G.1    Rasmusson, D.X.2    Brandt, J.3
  • 152
    • 0029798104 scopus 로고    scopus 로고
    • Apolipoprotein E genotype and the rate of decline in probable Alzheimer disease
    • Corder EH, Lannfelt L, Basun H. Apolipoprotein E genotype and the rate of decline in probable Alzheimer disease [letter; comment]. Arch Neurol 1996; 53: 1094-1095.
    • (1996) Arch Neurol , vol.53 , pp. 1094-1095
    • Corder, E.H.1    Lannfelt, L.2    Basun, H.3
  • 153
    • 17744410836 scopus 로고    scopus 로고
    • ApoE-4 and age at onset of Alzheimer's disease: The NIMH genetics initiative
    • Blacker D, Haines JL, Rodes L, et al. ApoE-4 and age at onset of Alzheimer's disease: The NIMH Genetics Initiative. Neurology 1997; 48: 139-147.
    • (1997) Neurology , vol.48 , pp. 139-147
    • Blacker, D.1    Haines, J.L.2    Rodes, L.3
  • 154
    • 0030988503 scopus 로고    scopus 로고
    • A prospective study of cognitive health in the elderly (oregon brain aging study): Effects of family history and apolipoprotein E genotype
    • Payami H, Grimslid H, Oken B, et al. A prospective study of cognitive health in the elderly (Oregon Brain Aging Study): effects of family history and apolipoprotein E genotype. Am J Hum Genet 1997; 60: 948-956.
    • (1997) Am J Hum Genet , vol.60 , pp. 948-956
    • Payami, H.1    Grimslid, H.2    Oken, B.3
  • 155
    • 0030210475 scopus 로고    scopus 로고
    • Apolipoprotein E and cognitive decline in Alzheimer's disease
    • Plassman BL, Breitner JC. Apolipoprotein E and cognitive decline in Alzheimer's disease. Neurology 1996; 47: 317-320.
    • (1996) Neurology , vol.47 , pp. 317-320
    • Plassman, B.L.1    Breitner, J.C.2
  • 156
    • 0031226839 scopus 로고    scopus 로고
    • Brain reserve and the clinical expression of Alzheimer's disease
    • Mortimer JA. Brain reserve and the clinical expression of Alzheimer's disease. Geriatrics 1997; 52: S50-S53.
    • (1997) Geriatrics , vol.52
    • Mortimer, J.A.1
  • 157
    • 0029926462 scopus 로고    scopus 로고
    • Gender difference in apolipoprotein E - Associated risk for familial Alzheimer disease: A possible clue to the higher incidence of Alzheimer disease in women
    • Payami H, Zareparsi S, Montee KR, et al. Gender difference in apolipoprotein E - associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women. Am J Hum Genet 1996; 58: 803-811.
    • (1996) Am J Hum Genet , vol.58 , pp. 803-811
    • Payami, H.1    Zareparsi, S.2    Montee, K.R.3
  • 158
    • 19244362467 scopus 로고    scopus 로고
    • Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprolein E epsilon 4
    • Rao VS, Cupples A, van Duijn CM, et al. Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprolein E epsilon 4. Am J Hum Genet 1996; 59: 664-675.
    • (1996) Am J Hum Genet , vol.59 , pp. 664-675
    • Rao, V.S.1    Cupples, A.2    Van Duijn, C.M.3
  • 159
    • 0028831614 scopus 로고
    • The apolipoprotein E E4 allele and sex-specific risk of Alzheimer's disease
    • Corder EH, Saunders AM, Strittmatter WJ, et al. The apolipoprotein E E4 allele and sex-specific risk of Alzheimer's disease. JAMA 1995; 273: 373-374.
    • (1995) JAMA , vol.273 , pp. 373-374
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 160
    • 0028958639 scopus 로고
    • Apolipoprotein E4 allele frequency in Spanish Alzheimer and control cases
    • Adroer R, Santacruz P, Blesa R, et al. Apolipoprotein E4 allele frequency in Spanish Alzheimer and control cases. Neurosci Lett 1995; 189: 182-186.
    • (1995) Neurosci Lett , vol.189 , pp. 182-186
    • Adroer, R.1    Santacruz, P.2    Blesa, R.3
  • 161
    • 0031032999 scopus 로고    scopus 로고
    • Distribution of apolipoprotein E gene polymorphisms in Japanese patients with Alzheimer's disease and in Japanese centenarians
    • Yamagata Z, Asada T, Kinoshita A, Zhang Y, Asaka A. Distribution of apolipoprotein E gene polymorphisms in Japanese patients with Alzheimer's disease and in Japanese centenarians. Human Heredity 1997; 47: 22-26.
    • (1997) Human Heredity , vol.47 , pp. 22-26
    • Yamagata, Z.1    Asada, T.2    Kinoshita, A.3    Zhang, Y.4    Asaka, A.5
  • 162
    • 17644430796 scopus 로고    scopus 로고
    • Effects of apolipoprotein E on dementia and aging in the Shanghai Survey of Dementia
    • Katzman R, Zhang MY, Chen PJ, et al. Effects of apolipoprotein E on dementia and aging in the Shanghai Survey of Dementia. Neurology 1997; 49: 779-785.
    • (1997) Neurology , vol.49 , pp. 779-785
    • Katzman, R.1    Zhang, M.Y.2    Chen, P.J.3
  • 163
    • 0028961402 scopus 로고
    • Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans
    • Hendrie HC, Hall KS, Hui S, et al. Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans. Ann Neurol 1995; 37: 118-120.
    • (1995) Ann Neurol , vol.37 , pp. 118-120
    • Hendrie, H.C.1    Hall, K.S.2    Hui, S.3
  • 164
    • 10244241901 scopus 로고    scopus 로고
    • Genetic factors for the development of Alzheimer disease in the Cherokee Indian
    • Rosenberg RN, Richter RW, Risser RC, et al. Genetic factors for the development of Alzheimer disease in the Cherokee Indian. Arch Neurol 1996; 53: 997-1000.
    • (1996) Arch Neurol , vol.53 , pp. 997-1000
    • Rosenberg, R.N.1    Richter, R.W.2    Risser, R.C.3
  • 165
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease - A meta-analysis
    • Farrer LA, Cupples LA, Haines JL, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease - a meta-analysis. JAMA 1997; 278: 1349-1356.
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3
  • 166
    • 0030869025 scopus 로고    scopus 로고
    • Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype dependent
    • Sahota A, Yang M, Gao S, et al. Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype dependent. Ann Neurol 1997; 42: 659-661.
    • (1997) Ann Neurol , vol.42 , pp. 659-661
    • Sahota, A.1    Yang, M.2    Gao, S.3
  • 167
    • 0028816355 scopus 로고
    • Apolipoprotein E and Alzheimer's disease: Ethnic variation in genotypic risks
    • Maestre G, Ottman R, Stern Y, et al. Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks. Ann Neurol 1995; 37: 254-259.
    • (1995) Ann Neurol , vol.37 , pp. 254-259
    • Maestre, G.1    Ottman, R.2    Stern, Y.3
  • 168
    • 0028278060 scopus 로고
    • Protection against Alzheimer's disease with apoe epsilon 2
    • Talbot C, Lendon C, Craddock N, et al. Protection against Alzheimer's disease with apoE epsilon 2. Lancet 1994; 343: 1432-1433.
    • (1994) Lancet , vol.343 , pp. 1432-1433
    • Talbot, C.1    Lendon, C.2    Craddock, N.3
  • 169
    • 0029866167 scopus 로고    scopus 로고
    • Apolipoprotein E genotype in the prediction of cognitive decline and dementia in a prospectively studied elderly population
    • Brayne C, Harrington CR, Wischik CM, et al. Apolipoprotein E genotype in the prediction of cognitive decline and dementia in a prospectively studied elderly population. Dementia 1996; 7: 169-174.
    • (1996) Dementia , vol.7 , pp. 169-174
    • Brayne, C.1    Harrington, C.R.2    Wischik, C.M.3
  • 170
    • 0030614668 scopus 로고    scopus 로고
    • Apolipoprotein E-epsilon 2 and Alzheimer's disease: Genotype influences pathologic phenotype
    • Lippa CF, Smith TW, Saunders AM, et al. Apolipoprotein E-epsilon 2 and Alzheimer's disease: genotype influences pathologic phenotype. Neurology 1997; 48: 515-519.
    • (1997) Neurology , vol.48 , pp. 515-519
    • Lippa, C.F.1    Smith, T.W.2    Saunders, A.M.3
  • 171
    • 0028988736 scopus 로고
    • The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival
    • van Duijn CM, de Knijff P, Wehnert A, et al. The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. Ann Neurol 1995; 37: 605-610.
    • (1995) Ann Neurol , vol.37 , pp. 605-610
    • Van Duijn, C.M.1    De Knijff, P.2    Wehnert, A.3
  • 172
    • 0028973776 scopus 로고
    • Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know
    • Seshadri S, Drachman DA, Lippa CF. Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know. Arch Neurol 1995; 52: 1074-1079.
    • (1995) Arch Neurol , vol.52 , pp. 1074-1079
    • Seshadri, S.1    Drachman, D.A.2    Lippa, C.F.3
  • 173
    • 0030614816 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons
    • Evans DA, Beckett LA, Field TS, et al. Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons. JAMA 1997; 277: 822-824.
    • (1997) JAMA , vol.277 , pp. 822-824
    • Evans, D.A.1    Beckett, L.A.2    Field, T.S.3
  • 174
    • 0029982042 scopus 로고    scopus 로고
    • Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study
    • Tierney MC, Szalai JP, Snow WG, et al. Prediction of probable Alzheimer's disease in memory-impaired patients: a prospective longitudinal study. Neurology 1996; 46: 661-665.
    • (1996) Neurology , vol.46 , pp. 661-665
    • Tierney, M.C.1    Szalai, J.P.2    Snow, W.G.3
  • 175
    • 0030481305 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences
    • Roses AD. Apolipoprotein E and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences. Ann NY Acad Sci 1996; 802: 50-57.
    • (1996) Ann NY Acad Sci , vol.802 , pp. 50-57
    • Roses, A.D.1
  • 176
    • 0030450732 scopus 로고    scopus 로고
    • The national institute on aging/alzheimer's association recommendations on the application of apolipoprotein E genotyping to Alzheimer's disease
    • Relkin NR, Kwon YJ, Tsai J, Gandy S. The National Institute on Aging/Alzheimer's Association recommendations on the application of apolipoprotein E genotyping to Alzheimer's disease. Ann NY Acad Sci 1996; 802: 149-176.
    • (1996) Ann NY Acad Sci , vol.802 , pp. 149-176
    • Relkin, N.R.1    Kwon, Y.J.2    Tsai, J.3    Gandy, S.4
  • 177
    • 0028997817 scopus 로고
    • Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer's disease
    • Roses AD. Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer's disease. Ann Neurol 1995; 38: 6-14.
    • (1995) Ann Neurol , vol.38 , pp. 6-14
    • Roses, A.D.1
  • 178
    • 0031043470 scopus 로고    scopus 로고
    • Prediction for unimpaired subjects is different from diagnosis of demented patients
    • Roses AD, Saunders AM. Prediction for unimpaired subjects is different from diagnosis of demented patients. Ann Neurol 1997; 41: 414-416.
    • (1997) Ann Neurol , vol.41 , pp. 414-416
    • Roses, A.D.1    Saunders, A.M.2
  • 179
    • 0030801138 scopus 로고    scopus 로고
    • Apolipoprotein E genotypes in a neuropathological series from the consortium to establish a registry for Alzheimer's disease
    • Welsh-Bohmer KA, Gearing M, Saunders AM, Roses AD, Mirra S. Apolipoprotein E genotypes in a neuropathological series from the Consortium to Establish a Registry for Alzheimer's Disease. Ann Neurol 1997; 42: 319-325.
    • (1997) Ann Neurol , vol.42 , pp. 319-325
    • Welsh-Bohmer, K.A.1    Gearing, M.2    Saunders, A.M.3    Roses, A.D.4    Mirra, S.5
  • 180
    • 0030776694 scopus 로고    scopus 로고
    • Genetic testing for Alzheimer disease - Practical and ethical issues
    • Roses AD. Genetic testing for Alzheimer disease - practical and ethical issues. Arch Neurol 1997; 54: 1226-1229.
    • (1997) Arch Neurol , vol.54 , pp. 1226-1229
    • Roses, A.D.1
  • 181
    • 0032545939 scopus 로고    scopus 로고
    • Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's disease centers consortium on apolipoprotein E and Alzheimer's disease
    • Mayeux R, Saunders AM, Shea S, et al. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. N Engl J Med 1998; 338: 506-511.
    • (1998) N Engl J Med , vol.338 , pp. 506-511
    • Mayeux, R.1    Saunders, A.M.2    Shea, S.3
  • 182
    • 0030768620 scopus 로고    scopus 로고
    • Association between medial temporal lobe atrophy on CT and parietotemporal uptake decrease on SPECT in Alzheimer's disease
    • Lavenu J, Pasquier F, Lebert F, Jacob B, Petit H. Association between medial temporal lobe atrophy on CT and parietotemporal uptake decrease on SPECT in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1997; 63: 441-445.
    • (1997) J Neurol Neurosurg Psychiatry , vol.63 , pp. 441-445
    • Lavenu, J.1    Pasquier, F.2    Lebert, F.3    Jacob, B.4    Petit, H.5
  • 183
    • 0028889485 scopus 로고
    • Statement on use of apolipoprotein E testing for Alzheimer disease. American college of medical genetics/american society of human genetics working group on ApoE and Alzheimer disease
    • Anonymous. Statement on use of apolipoprotein E testing for Alzheimer disease. American College of Medical Genetics/American Society of Human Genetics Working Group on ApoE and Alzheimer disease. JAMA 1995; 274: 1627-1629.
    • (1995) JAMA , vol.274 , pp. 1627-1629
  • 184
    • 0001547777 scopus 로고    scopus 로고
    • The clinical introduction of genetic testing for Alzheimer disease. An ethical perspective
    • Post SG, Whitehouse PJ, Binstock RH, et al. The clinical introduction of genetic testing for Alzheimer disease. An ethical perspective. JAMA 1997; 277: 832-836.
    • (1997) JAMA , vol.277 , pp. 832-836
    • Post, S.G.1    Whitehouse, P.J.2    Binstock, R.H.3
  • 185
    • 0029151776 scopus 로고
    • Apolipoprotein E and Alzheimer's disease: The implications of progress in molecular medicine
    • Mayeux R, Schupf N. Apolipoprotein E and Alzheimer's disease: the implications of progress in molecular medicine. Am J Public Health 1995; 85: 1280-1284.
    • (1995) Am J Public Health , vol.85 , pp. 1280-1284
    • Mayeux, R.1    Schupf, N.2
  • 186
    • 0029944411 scopus 로고    scopus 로고
    • Apolipoprotein E genotyping in Alzheimer's disease. National institute on aging/alzheimer's association working group
    • Anonymous. Apolipoprotein E genotyping in Alzheimer's disease. National Institute on Aging/Alzheimer's Association Working Group. Lancet 1996; 347: 1091-1095.
    • (1996) Lancet , vol.347 , pp. 1091-1095
  • 187
    • 0031597583 scopus 로고    scopus 로고
    • The prevalence of apoe-epsilon4 in Alzheimer's disease is age dependent
    • Frisoni GB, Manfredi M, Geroldi C, et al. The prevalence of apoE-epsilon4 in Alzheimer's disease is age dependent. J Neurol Neurosurg Psychiatry 1998; 65: 103-106.
    • (1998) J Neurol Neurosurg Psychiatry , vol.65 , pp. 103-106
    • Frisoni, G.B.1    Manfredi, M.2    Geroldi, C.3
  • 188
    • 0031046146 scopus 로고    scopus 로고
    • Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains
    • Pirttila T, Soininen H, Mehta PD, et al. Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains. Neurobiol Aging 1997; 18: 121-127.
    • (1997) Neurobiol Aging , vol.18 , pp. 121-127
    • Pirttila, T.1    Soininen, H.2    Mehta, P.D.3
  • 189
    • 0030770726 scopus 로고    scopus 로고
    • Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12
    • Pericak-Vance MA, Bass MP, Yamaoka LH, et al. Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. JAMA 1997; 278: 1237-1241.
    • (1997) JAMA , vol.278 , pp. 1237-1241
    • Pericak-Vance, M.A.1    Bass, M.P.2    Yamaoka, L.H.3
  • 190
    • 0019967975 scopus 로고
    • The global deterioration scale for assessment of primary degenerative dementia
    • Reisberg B. The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiat 1982; 139: 1136-1139.
    • (1982) Am J Psychiat , vol.139 , pp. 1136-1139
    • Reisberg, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.