Neuroprotective therapy for ischemic stroke with free radical scavenger and gene-stem cell therapy

Clinical Neurology

Volumn 48, Issue 11, 2008, Pages 896-898

  Abe, Koji ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Cerebral infarction; Edaravone; Gene therapy; Neuroprotection; Restorative therapy

Indexed keywords

NORPHENAZONE; SCAFFOLD PROTEIN; TISSUE PLASMINOGEN ACTIVATOR; DRUG DERIVATIVE; PHENAZONE; PHENYLMETHYLPYRAZOLONE; SCAVENGER;

CELL ACTIVATION; CELL INVASION; CELL MIGRATION; CEREBROVASCULAR ACCIDENT; CONFERENCE PAPER; FIBRINOLYTIC THERAPY; GENE THERAPY; HUMAN; JAPAN; NEURAL STEM CELL; NEUROPROTECTION; STEM CELL TRANSPLANTATION; ANIMAL; BIOLOGICAL THERAPY; DRUG COMBINATION; REGENERATIVE MEDICINE; REVIEW; STROKE;

ANIMALS; ANTIPYRINE; DRUG THERAPY, COMBINATION; FREE RADICAL SCAVENGERS; GENE THERAPY; HUMANS; REGENERATIVE MEDICINE; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TISSUE THERAPY;

EID: 63849342113     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: 10.5692/clinicalneurol.48.896     Document Type: Conference Paper

References (6)

1. The Edaravone Acute Brain Infarction Study Group (Chair: Otomo E): Effect of a novel free radical scavenger, Edaravone (MCI-186) on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 2003; 15: 222-229
2. Toyoda K, et al: Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion. J Neurol Sci 2004; 221: 11-17 (Pubitemid 38721285)
3. Abe K, Yuki S, Kogure K: Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 1988; 19: 480-485 (Pubitemid 18121101)
4. Sendai virus-mediated gene transfer of GDNF reduces AIF translocation and ameliorates ischemic cerebral injury. Neurol Res. 2008 Jun 30. [Epub ahead of print] Jin G, Inoue M, Hayashi T, Deguchi K, Nagotani S, Zhang H, Wang X, Shoji M, Hasegawa M, Abe K
5. Zhao MZ, Nonoguchi N, Ikeda N, et al: Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector. J Cereb Blood Flow Metab 2006; 26: 1176-1188 (Pubitemid 44268180)
6. Kameda M, Shingo T, Takahashi K, et al: Adult neural stem and progenitor cells modified to secrete GDNF can protect, migrate and integrate after intracerebral transplantation in rats with transient forebrain ischemia. Eur J Neurosci 2007; 26: 1462-1478 (Pubitemid 47416525)