메뉴 건너뛰기




Volumn 161, Issue 2, 2000, Pages 733-739

Evaluating the efficacy of citicoline in embolic ischemic stroke in rats: Neuroprotective effects when used alone or in combination with urokinase

Author keywords

[No Author keywords available]

Indexed keywords

CITICOLINE; UROKINASE;

EID: 0034055662     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1999.7314     Document Type: Article
Times cited : (54)

References (54)
  • 1
    • 0030479855 scopus 로고    scopus 로고
    • Citicholine for the treatment of experimental cerebral ischemia: Histological and behavioral outcome
    • Aronowski J., Strong R., Grotta J. C. Citicholine for the treatment of experimental cerebral ischemia: Histological and behavioral outcome. Neurol. Res. 18:1996;570-574.
    • (1996) Neurol. Res. , vol.18 , pp. 570-574
    • Aronowski, J.1    Strong, R.2    Grotta, J.C.3
  • 2
    • 0031214879 scopus 로고    scopus 로고
    • Nitric oxide reverses aspirin antagonism of t-PA thrombolysis in a rabbit model of thromboembolic stroke
    • Bednar M. M., Gross C. E., Howard D. B., Russel S. R., Thomas G. R. Nitric oxide reverses aspirin antagonism of t-PA thrombolysis in a rabbit model of thromboembolic stroke. Exp. Neurol. 146:1997;513-517.
    • (1997) Exp. Neurol. , vol.146 , pp. 513-517
    • Bednar, M.M.1    Gross, C.E.2    Howard, D.B.3    Russel, S.R.4    Thomas, G.R.5
  • 3
    • 0029984751 scopus 로고    scopus 로고
    • The effect of oral antiplatelet agents on tissue plasminogen activator-mediated thrombolysis in a rabbit model of thromboembolic stroke
    • Bednar M. M., Ouilley J., Russel S. R., Fuller S. P., Booth C., Howard D. B., Gross C. E. The effect of oral antiplatelet agents on tissue plasminogen activator-mediated thrombolysis in a rabbit model of thromboembolic stroke. Neurosurgery. 39:1996;352-359.
    • (1996) Neurosurgery , vol.39 , pp. 352-359
    • Bednar, M.M.1    Ouilley, J.2    Russel, S.R.3    Fuller, S.P.4    Booth, C.5    Howard, D.B.6    Gross, C.E.7
  • 4
    • 0029839695 scopus 로고    scopus 로고
    • Middle cerebral artery occlusion in the rat by intraluminal suture
    • Belayve L., Alonso O. F., Busto R., Zhao W., Ginsberg M. D. Middle cerebral artery occlusion in the rat by intraluminal suture. Stroke. 27:1996;1616-1623.
    • (1996) Stroke , vol.27 , pp. 1616-1623
    • Belayve, L.1    Alonso, O.F.2    Busto, R.3    Zhao, W.4    Ginsberg, M.D.5
  • 5
    • 0031883801 scopus 로고    scopus 로고
    • Facilitatory effects of chronically administered citicholine on learning and memory processes in the dog
    • Bruhwyler J., Liegeois J. F., Geczy J. Facilitatory effects of chronically administered citicholine on learning and memory processes in the dog. Prog. NeuroPharmacol. Biol. Psych. 22:1998;115-128.
    • (1998) Prog. NeuroPharmacol. Biol. Psych. , vol.22 , pp. 115-128
    • Bruhwyler, J.1    Liegeois, J.F.2    Geczy, J.3
  • 6
    • 0026508278 scopus 로고
    • A new model of temporary focal neocortical ischemia in the rat
    • Buchan A. M., Xue D., Slivka A. A new model of temporary focal neocortical ischemia in the rat. Stroke. 23:1992;273-279.
    • (1992) Stroke , vol.23 , pp. 273-279
    • Buchan, A.M.1    Xue, D.2    Slivka, A.3
  • 7
    • 0025438029 scopus 로고
    • Methods of antagonizing glutamate neurotoxicity
    • Choi D. W. Methods of antagonizing glutamate neurotoxicity. Cerebrovac. Brain Metab. Rev. 2:1990;105-147.
    • (1990) Cerebrovac. Brain Metab. Rev. , vol.2 , pp. 105-147
    • Choi, D.W.1
  • 8
    • 0025265926 scopus 로고
    • The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death
    • Choi D. W., Rothman S. M. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurosci. 13:1990;171-182.
    • (1990) Annu. Rev. Neurosci. , vol.13 , pp. 171-182
    • Choi, D.W.1    Rothman, S.M.2
  • 9
    • 0030760430 scopus 로고    scopus 로고
    • Randomized dose-response trial of citicholine in acute ischemic stroke
    • Clark W. M. Randomized dose-response trial of citicholine in acute ischemic stroke. Neurology. 49:1997;671-677.
    • (1997) Neurology , vol.49 , pp. 671-677
    • Clark, W.M.1
  • 10
    • 0031984356 scopus 로고    scopus 로고
    • PROCT: A phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute cerebral artery stroke
    • Del Zoppo G. J., Higashida R. T., Furlan A. J., Pessin M. S., Rowley H. A., Gent M. PROCT: A phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute cerebral artery stroke. Stroke. 29:1998;11.
    • (1998) Stroke , vol.29 , pp. 11
    • Del Zoppo, G.J.1    Higashida, R.T.2    Furlan, A.J.3    Pessin, M.S.4    Rowley, H.A.5    Gent, M.6
  • 11
    • 0004284061 scopus 로고
    • Thrombolytic therapy in acute stroke: Recent experience
    • Del Zoppo G. J. Thrombolytic therapy in acute stroke: Recent experience. Cerebrovasc. Dis. 3:1993;256-263.
    • (1993) Cerebrovasc. Dis. , vol.3 , pp. 256-263
    • Del Zoppo, G.J.1
  • 12
    • 0030907699 scopus 로고    scopus 로고
    • Effects of CDP-choline treatment on neurobehavioral deficits after TBI and on hippocampal and neocortical acetylcholine release
    • Dixon C. E., Ma X., Marion D. W. Effects of CDP-choline treatment on neurobehavioral deficits after TBI and on hippocampal and neocortical acetylcholine release. J. Neurotrauma. 14:1997;161-169.
    • (1997) J. Neurotrauma , vol.14 , pp. 161-169
    • Dixon, C.E.1    Ma, X.2    Marion, D.W.3
  • 14
    • 0031886652 scopus 로고    scopus 로고
    • Duration of neuroprotective treatment for ischemic stroke
    • Dyker A. G., Lees K. R. Duration of neuroprotective treatment for ischemic stroke. Stroke. 29:1998;535-542.
    • (1998) Stroke , vol.29 , pp. 535-542
    • Dyker, A.G.1    Lees, K.R.2
  • 16
    • 0030758897 scopus 로고    scopus 로고
    • Survival rate improvement in a rat ischemia model by long circulating liposomes containing cytidine 5I diphosphate choline
    • Fresta M., Puglisi G. Survival rate improvement in a rat ischemia model by long circulating liposomes containing cytidine 5I diphosphate choline. Life Sci. 61:1999;1227-1235.
    • (1999) Life Sci. , vol.61 , pp. 1227-1235
    • Fresta, M.1    Puglisi, G.2
  • 17
    • 0029582905 scopus 로고
    • Enhances therapeutic effect of cytidine-5-diphosphate choline when associated with GM1 containing small liposomes as demonstrated in a rat ischemia model
    • Fresta M., Wehrli E., Puglishi G. Enhances therapeutic effect of cytidine-5-diphosphate choline when associated with GM1 containing small liposomes as demonstrated in a rat ischemia model. Pharmacol. Res. 12:1995;769-774.
    • (1995) Pharmacol. Res. , vol.12 , pp. 769-774
    • Fresta, M.1    Wehrli, E.2    Puglishi, G.3
  • 18
    • 0342527539 scopus 로고    scopus 로고
    • PROCAT II: Recombinant prourokinase in acute stroke
    • Furlan A. J. PROCAT II: Recombinant prourokinase in acute stroke. Stroke. 30:1999.
    • (1999) Stroke , vol.30
    • Furlan, A.J.1
  • 20
    • 0030635707 scopus 로고    scopus 로고
    • Techniques for examining neuroprotective drugs in vivo
    • A. R. Green, & A. L. Cross. New York: Academic Press
    • Green A. R., Cross A. J. Techniques for examining neuroprotective drugs in vivo. Green A. R., Cross A. L. Neuroprotective Agents and Cerebral Ischemia. 1997;47-68 Academic Press, New York.
    • (1997) Neuroprotective Agents and Cerebral Ischemia , pp. 47-68
    • Green, A.R.1    Cross, A.J.2
  • 21
    • 0027731312 scopus 로고
    • Precision and variability in postsynaptic target selection of inhibitory cells in the hippocampal CA3 region
    • Gulyás A. I., Miles R., Hájos N., Freund T. F. Precision and variability in postsynaptic target selection of inhibitory cells in the hippocampal CA3 region. Eur. J. Neurosci. 5:1993;1729-1751.
    • (1993) Eur. J. Neurosci. , vol.5 , pp. 1729-1751
    • Gulyás, A.I.1    Miles, R.2    Hájos, N.3    Freund, T.F.4
  • 22
    • 0029796651 scopus 로고    scopus 로고
    • Thrombolysis in stroke between the promise and the peril
    • Hachinski V. Thrombolysis in stroke between the promise and the peril. J. Am. Med. Assoc. 276:1996;995-996.
    • (1996) J. Am. Med. Assoc. , vol.276 , pp. 995-996
    • Hachinski, V.1
  • 24
    • 0003111593 scopus 로고
    • Animal models of cerebral ischemia. 1. Review of literature
    • Hossmann K.-A. Animal models of cerebral ischemia. 1. Review of literature. Cerebrovasc. Dis. 1:1991;2-15.
    • (1991) Cerebrovasc. Dis. , vol.1 , pp. 2-15
    • Hossmann, K.-A.1
  • 25
    • 0029884161 scopus 로고    scopus 로고
    • Glucose induced decrease in glutamate levels in ischemic human brain by microdialysis
    • Kanthan R., Shuaib A., Griebel A., Miyashita H. Glucose induced decrease in glutamate levels in ischemic human brain by microdialysis. Neurosci. Lett. 209:1996;207-209.
    • (1996) Neurosci. Lett. , vol.209 , pp. 207-209
    • Kanthan, R.1    Shuaib, A.2    Griebel, A.3    Miyashita, H.4
  • 26
    • 0033600277 scopus 로고    scopus 로고
    • The changing landscape of ischemic brain injury mechanisms
    • Lee J. M., Zipfel G. J., Choi D. W. The changing landscape of ischemic brain injury mechanisms. Nature. 399:1999;A7-A14.
    • (1999) Nature , vol.399
    • Lee, J.M.1    Zipfel, G.J.2    Choi, D.W.3
  • 27
    • 0032537392 scopus 로고    scopus 로고
    • Does neuroprotection improve stroke outcome
    • Lees K. R. Does neuroprotection improve stroke outcome. Lancet. 351:1998;1448.
    • (1998) Lancet , vol.351 , pp. 1448
    • Lees, K.R.1
  • 28
    • 0032504696 scopus 로고    scopus 로고
    • Posttreatment with low molecular weight heparin reduces brain edema and infarction volume in rats subjected to thrombotic middle cerebral artery occlusion
    • Li P.-A., Shuaib A., Li Q., Siddiqui M. M. Posttreatment with low molecular weight heparin reduces brain edema and infarction volume in rats subjected to thrombotic middle cerebral artery occlusion. Brain Res. 801:1998;220-223.
    • (1998) Brain Res. , vol.801 , pp. 220-223
    • Li, P.-A.1    Shuaib, A.2    Li, Q.3    Siddiqui, M.M.4
  • 29
    • 0343397119 scopus 로고    scopus 로고
    • Extended protection using combination therapy of urokinase and topiramate in embolic stroke of rat
    • Li Q., Yang Y., Shuaib A. Extended protection using combination therapy of urokinase and topiramate in embolic stroke of rat. Can. J. Neurol. Sci. 25:1998;S81.
    • (1998) Can. J. Neurol. Sci. , vol.25 , pp. 81
    • Li, Q.1    Yang, Y.2    Shuaib, A.3
  • 30
    • 0028218676 scopus 로고
    • Over addictive protective effect of dizocilpine and NBQX antagonist against neuronal damage
    • Lippert K., Welsch M., Krieglstein J. Over addictive protective effect of dizocilpine and NBQX antagonist against neuronal damage. Eur. J. Pharmacol. 253:1994;207-213.
    • (1994) Eur. J. Pharmacol. , vol.253 , pp. 207-213
    • Lippert, K.1    Welsch, M.2    Krieglstein, J.3
  • 31
    • 33845228767 scopus 로고    scopus 로고
    • GABA and neuroprotection
    • R. J. Bradley, R. A. Harris, & P. Jenner. Rochester: Astra Arcus
    • Lyden P. D. GABA and neuroprotection. Bradley R. J., Harris R. A., Jenner P. Neurobiology. 1997;233-258 Astra Arcus, Rochester.
    • (1997) Neurobiology , pp. 233-258
    • Lyden, P.D.1
  • 32
    • 0028032122 scopus 로고
    • Combination therapy protects ischemic brain in rats: A glutamate antagonist plus a GABA agonist
    • Lyden P. D., Lonzo L. Combination therapy protects ischemic brain in rats: A glutamate antagonist plus a GABA agonist. Stroke. 25:1994;189-196.
    • (1994) Stroke , vol.25 , pp. 189-196
    • Lyden, P.D.1    Lonzo, L.2
  • 33
    • 0027562635 scopus 로고
    • Hemorrhagic transformation after cerebral ischemia: Mechanisms and incidence
    • Lyden P. D., Zivin J. A. Hemorrhagic transformation after cerebral ischemia: Mechanisms and incidence. Cerebrovasc. Brain Metab. Rev. 5:1993;1-16.
    • (1993) Cerebrovasc. Brain Metab. Rev. , vol.5 , pp. 1-16
    • Lyden, P.D.1    Zivin, J.A.2
  • 35
    • 0032908247 scopus 로고    scopus 로고
    • Neuroprotection for acute stroke: Making clinical trials work
    • Muir K. W., Grosset D. G. Neuroprotection for acute stroke: Making clinical trials work. Stroke. 30:1999;180-184.
    • (1999) Stroke , vol.30 , pp. 180-184
    • Muir, K.W.1    Grosset, D.G.2
  • 36
    • 0030852998 scopus 로고    scopus 로고
    • Stroke. 28:1997;1530-1540.
    • (1997) Stroke , vol.28 , pp. 1530-1540
  • 37
    • 0343118114 scopus 로고    scopus 로고
    • Stroke. 28:1997;2109-2118.
    • (1997) Stroke , vol.28 , pp. 2109-2118
  • 38
    • 0343052709 scopus 로고    scopus 로고
    • Synergistic effects of citicholine and MK 801 in temporary experimental focal ischemia in rats
    • Onal M. Z., Tatlisumak T., Sandage B. W., Fisher M. Synergistic effects of citicholine and MK 801 in temporary experimental focal ischemia in rats. Stroke. 28:1997;1065.
    • (1997) Stroke , vol.28 , pp. 1065
    • Onal, M.Z.1    Tatlisumak, T.2    Sandage, B.W.3    Fisher, M.4
  • 39
    • 0028866496 scopus 로고
    • Influence of a 'brain protector drug' 21-amino steroid on the effects of experimental embolic treated by thrombolysis
    • Orozco J., Mendal R., Hahn MR G. A. C. L. Influence of a 'brain protector drug' 21-amino steroid on the effects of experimental embolic treated by thrombolysis. Neurol. Res. 17:1995;423-425.
    • (1995) Neurol. Res. , vol.17 , pp. 423-425
    • Orozco, J.1    Mendal, R.2    Hahn, M.R.G.A.C.L.3
  • 40
    • 0027360045 scopus 로고
    • Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke model
    • Overgaard K., Sereghy T., Pedersen H., Boysen G. Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke model. Neurol. Res. 15:1993;344-349.
    • (1993) Neurol. Res. , vol.15 , pp. 344-349
    • Overgaard, K.1    Sereghy, T.2    Pedersen, H.3    Boysen, G.4
  • 42
    • 0345561549 scopus 로고    scopus 로고
    • Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia
    • Schabitz W. R., Li F., Irie K., Sandage B. W., Locke K. W., Fisher M. Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia. Stroke. 30:1999;427-432.
    • (1999) Stroke , vol.30 , pp. 427-432
    • Schabitz, W.R.1    Li, F.2    Irie, K.3    Sandage, B.W.4    Locke, K.W.5    Fisher, M.6
  • 43
    • 0342936464 scopus 로고    scopus 로고
    • The effects of prolonged treatment with citicoline in temporary experimental focal ischemia
    • Schabitz W. R., Weber J., Takano K., Sandage B. W., Locke K. W., Fisher M. The effects of prolonged treatment with citicoline in temporary experimental focal ischemia. J. Neurol. Sci. 138:1999;21-25.
    • (1999) J. Neurol. Sci. , vol.138 , pp. 21-25
    • Schabitz, W.R.1    Weber, J.2    Takano, K.3    Sandage, B.W.4    Locke, K.W.5    Fisher, M.6
  • 44
    • 0342527535 scopus 로고    scopus 로고
    • Neuroprotection and thrombolysis: Alone or in combination in a focal embolic ischemia model
    • Shuaib A., Yang Y., Li Q. Neuroprotection and thrombolysis: Alone or in combination in a focal embolic ischemia model. Can. J. Neurol. Sci. 25:1998;S13.
    • (1998) Can. J. Neurol. Sci. , vol.25 , pp. 13
    • Shuaib, A.1    Yang, Y.2    Li, Q.3
  • 45
    • 0032437457 scopus 로고    scopus 로고
    • Thrombolysis with urokinase in a focal embolic rat model
    • Shuaib A., Yang Y., Li Q., Siddiqui M. M. Thrombolysis with urokinase in a focal embolic rat model. Exp. Neurol. 154:1998;330-335.
    • (1998) Exp. Neurol. , vol.154 , pp. 330-335
    • Shuaib, A.1    Yang, Y.2    Li, Q.3    Siddiqui, M.M.4
  • 46
    • 0028932511 scopus 로고
    • Glutamate, calcium and free radicals as mediators of ischemic brain damage
    • Siesjo B. K., Zhao Q., Pahlmark K. Glutamate, calcium and free radicals as mediators of ischemic brain damage. Ann. Thorac. Surg. 59:1995;1316-1320.
    • (1995) Ann. Thorac. Surg. , vol.59 , pp. 1316-1320
    • Siesjo, B.K.1    Zhao, Q.2    Pahlmark, K.3
  • 47
    • 0026782517 scopus 로고
    • Pathophysiology and treatment of focal cerebral ischemia. II. Mechanisms of damage and treatment
    • Siesjö B. K. Pathophysiology and treatment of focal cerebral ischemia. II. Mechanisms of damage and treatment. J. Neurosurg. 77:1992;337-354.
    • (1992) J. Neurosurg. , vol.77 , pp. 337-354
    • Siesjö, B.K.1
  • 48
    • 0012863560 scopus 로고
    • Animal models of cerebral ischemia. 2. Rat models
    • Takizawa S., Hakim A. M. Animal models of cerebral ischemia. 2. Rat models. Cerebrovasc. Dis. 1:1991;16-21.
    • (1991) Cerebrovasc. Dis. , vol.1 , pp. 16-21
    • Takizawa, S.1    Hakim, A.M.2
  • 49
    • 0028783948 scopus 로고
    • New Engl. J. Med. 333:1995;1581-1587.
    • (1995) New Engl. J. Med. , vol.333 , pp. 1581-1587
  • 51
    • 0026440559 scopus 로고
    • Thrombolysis in acute ischemic stroke: Does it work
    • Wardlaw J. M., Warlow C. P. Thrombolysis in acute ischemic stroke: Does it work. Stroke. 23:1992;1826-1839.
    • (1992) Stroke , vol.23 , pp. 1826-1839
    • Wardlaw, J.M.1    Warlow, C.P.2
  • 52
    • 0032192326 scopus 로고    scopus 로고
    • Quantification of infarct size on focal cerebral ischemia model of rats using a simple and economical method
    • Yang Y., Shuaib A., Li Q. Quantification of infarct size on focal cerebral ischemia model of rats using a simple and economical method. J. Neurosci. Methods. 84:1998;9-16.
    • (1998) J. Neurosci. Methods , vol.84 , pp. 9-16
    • Yang, Y.1    Shuaib, A.2    Li, Q.3
  • 53
    • 0032494239 scopus 로고    scopus 로고
    • Neuroprotection by delayed administration of topiramate in a rat brain model of middle cerebral artery embolization
    • Yang Y., Shuaib A., Li Q., Siddiqui M. M. Neuroprotection by delayed administration of topiramate in a rat brain model of middle cerebral artery embolization. Brain Res. 804:1998;169-176.
    • (1998) Brain Res. , vol.804 , pp. 169-176
    • Yang, Y.1    Shuaib, A.2    Li, Q.3    Siddiqui, M.M.4
  • 54
    • 0028102479 scopus 로고
    • Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat
    • Zhang R., Chopp M., Chen H., Garcia J. H. Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat. J. Neurol. Sci. 125:1994;3-10.
    • (1994) J. Neurol. Sci. , vol.125 , pp. 3-10
    • Zhang, R.1    Chopp, M.2    Chen, H.3    Garcia, J.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.