Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis

PLoS Medicine

Volumn 9, Issue 11, 2012, Pages

  Recknagel, Peter ^a,b   Gonnert, Falk A ^a   Westermann, Martin ^a   Lambeck, Sandro ^a   Lupp, Amelie ^a   Rudiger, Alain ^b   Dyson, Alex ^b   Carré, Jane E ^b   Kortgen, Andreas ^a   Krafft, Christoph ^c   Popp, Jürgen ^c   Sponholz, Christoph ^a   Fuhrmann, Valentin ^d   Hilger, Ingrid ^a   Claus, Ralf A ^a   Riedemann, Niels C ^a   Wetzker, Reinhard ^a   Singer, Mervyn ^b   Trauner, Michael ^d   Bauer, Michael ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c LEIBNIZ INSTITUTE OF PHOTONIC TECHNOLOGY   (Germany)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

5 (6 QUINOXALINYLMETHYLENE) 2, 4 THIAZOLIDINEDIONE; ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; BILE ACID; BILIRUBIN; CARBOXYFLUORESCEIN; CHENODEOXYCHOLIC ACID; COLLAGENASE; CYTOCHROME P450 1A; CYTOCHROME P450 2A; CYTOCHROME P450 2B; CYTOCHROME P450 2C; CYTOCHROME P450 3A; ESTERASE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; INDOCYANINE GREEN; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER; PHOSPHATIDYLINOSITOL 3 KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TAURODEOXYCHOLIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WORTMANNIN;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE FLOW; BIOTRANSFORMATION; CELL INTERACTION; CHOLESTASIS; CLINICAL ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DISEASE SEVERITY; EPIFLUORESCENCE MICROSCOPY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HEART STROKE VOLUME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LIVER DYSFUNCTION; MALE; MASS SPECTROMETRY; METABOLOMICS; MICROCIRCULATION; MOUSE; NONHUMAN; PERITONITIS; RAT; RECEIVER OPERATING CHARACTERISTIC; SCANNING ELECTRON MICROSCOPY; SENSITIVITY AND SPECIFICITY; SEPSIS; SIGNAL TRANSDUCTION; TRANSTHORACIC ECHOCARDIOGRAPHY; WESTERN BLOTTING;

ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CHOLESTASIS; COINFECTION; FECES; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LIVER; LIVER DISEASES; LIVER FUNCTION TESTS; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, SCANNING; PERITONITIS; PHOSPHATIDYLINOSITOL 3-KINASE; RATS; RATS, WISTAR; SEPSIS; SIGNAL TRANSDUCTION; SPECTRUM ANALYSIS, RAMAN; XENOBIOTICS;

EID: 84870284063     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1001338     Document Type: Article

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