Short-term regulation of canalicular transport

Seminars in Liver Disease

Volumn 20, Issue 3, 2000, Pages 307-321

  Haussinger, D ^a   Schmitt, M ^a   Weiergraber, O ^a   Kubitz, R ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

ABC transporter; Bile secretion; Cell volume; Transporter targeting

Indexed keywords

ABC TRANSPORTER; BILE ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOPROTEIN P; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MULTIDRUG RESISTANCE PROTEIN; PHALLOIDIN; PROTEIN KINASE C; TAUROURSODEOXYCHOLIC ACID;

BILE SECRETION; CELL SWELLING; CELL VOLUME; CHOLESTASIS; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HYDRATION; INTRAHEPATIC BILE DUCT; NONHUMAN; OSMOREGULATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TRANSPORT KINETICS;

ANIMALS; ANION TRANSPORT PROTEINS; BILE; BILE ACIDS AND SALTS; BILE CANALICULI; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CHOLESTASIS; HUMANS; RATS; SIGNAL TRANSDUCTION; WATER-ELECTROLYTE BALANCE;

EID: 0033736184     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (130)

1. ATP-dependent transport systems in the canalicular membrane of the hepatocyte
2. Hepatobiliary secretion of organic compounds: Molecular mechanisms of membrane transport
3. Molecular mechanisms of hepatic bile salt transport from the sinusoidal blood into bile
4. Transport across the hepatocyte canalicular membrane
5. Molecular aspects of hepatobiliary transport
6. Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver
7. Hepatobiliary elimination of cationic drugs: The role of P-glycoproteins and other ATP-dependent transporters
8. Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
9. Molecular regulation of hepatocellular transport systems in cholestasis
10. Hepatobiliary secretion of organic compounds: Molecular mechanisms of membrane transport
11. Substrate specifity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
12. Bile acid uptake via the human apical sodium-bile acid cotransporter is electrogenic
13. Regulation of organic anion and drug transporters of the sinusoidal membrane
14. Identification of a novel gene family encoding human liver -specific organic anion transporter LST-1
15. 4 as a substrate for oatpl, the hepatic sinusoidal organic solute transporter
16. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
17. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
18. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
19. Genetic analysis of the multidrug transporter
20. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
21. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
22. Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis
23. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
24. Molecular mechanisms of cholestasis: Causes and consequences of impaired bile formation
25. Differential interaction of bile acids from patients with inborn errors of bile acid synthesis with hepatocellular bile acid transporters
26. Intracellular events in bile acid transport by the liver
27. The biology of the bile canaliculus
28. Control of metabolic fluxes
29. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents
30. Ethinylestradiol cholestasis involves alterations in expression of liver sinusoidal transporters
31. Hepatocyte transport of bile acids and organic anions in endotoxemixc rats: Impaired uptake and secretion
32. +/taurocholate cotransport by cyclic AMP
33. Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate
34. +-taurocholate cotransport by translocating transporter to plasma membrane
35. +/taurocholate cotransport
36. Short-term regulation of bile acid uptake by microfilament-dependent translocation of rat ntcp to the plasma membrane
37. Glutathione S-conjugate transport in hepatocytes entering the cell cycle is preserved by a switch in expression from the apical MRP2 to the basolateral MRP1 transporting protein
38. Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by t-BOOH and CDNB
39. Biochemistry of multidrug resistance mediated by the multidrug transporter
40. Phosphorylation of P-glycoprotein by PKA and PKC modulates swelling-activated C1-currents
41. Role of membrane trafficking in plasma membrane solute transport
42. Cellular mechanisms of proximal tubular acidification
43. Osmodependent dynamic localization of the multidrug resistence protein-2 in the rat hepatocyte canalicular membrane
44. Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver
45. Regulation and translocation of ATP-dependent apical membrane proteins in rat liver
46. 3- exchanger in rat hepatocytes
47. Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets
48. Regulation of the mrp2 gene-encoded conjugate export pump in the hepatocyte canalicular membrane by lipopolysaccharide, dexamethasone and osmolarity
49. Regulation and functional significance of liver cell volume
50. The role of cellular hydration in the regulation of cell function
51. Osmotic induction of signalling cascades: Role in regulation of cell function
52. Cell volume and bile acid excretion
53. Regulatory volume decrease stimulates bile flow, bile acid excretion and exocytosis in isolated perfused rat liver
54. Activation of extracellular signal-regulated kinases Erk-1 and Erk-2 by cell swelling in H4IIE hepatoma cells
55. Regulation of taurocholate excretion by a hypoosmolarity-activated signal transduction pathway in rat liver
56. The mitogen-activated protein kinase signal transduction pathway
57. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
58. Characterization of the swelling-induced alkalinization of endocytotic vesicles in fluorescein isothiocyanate-dextran loaded rat hepatocytes
59. Activation of mitogen-activated protein kinases Erk-1 and Erk-2 mediates the stimulation of bile acid excretion by tauroursodeoxycholate
60. Osmosignalling in the liver
61. Involvement of p38(MAPK) in the regulation of proteolysis by liver cell hydration
62. Cell hydration controls autophagosome formation in rat liver in a microtubule-dependent way downstream from p38(MAPK) activation
63. Modulation of actin dynamics during stress and physiological stimulation by a signalling pathway involving p38 MAP kinase and heat shock protein 27
64. Microtubule stabilization and induction of tubulin mRNA by cell swelling in isolated rat hepatocytes
65. Effects of anisotonicity on intracellular pH in isolated rat hepatocytes as assessed by BCECF and FITC-dextran fluorescence
66. pH regulation of intracellular membrane flow
67. + conductance
68. Regulation of bile salt export pump mRNA levels by dexamethasone and osmolarity in cultured rat hepatocytes
69. Effect of anisotonic cell volume modulation on glutathione-S-conugate release, t-butylhydroperoxide metabolism and the pentose phosphate shunt in perfused rat liver
70. Osmotic regulation of the heat shock response in H4IIE rat hepatoma cells
71. Metabolism of cysteinyl leukotrienes in the perfused rat liver: The influence of endotoxin pretreatment and the cellular hydration state
72. Electronmicroscopic demonstration of Mrp2 retrieval from the canalicular membrane in response to hyperosmolarity and LPS
73. Dexamethasone- and osmolarity-dependent expression of the multidrug resistence protein 2 in cultured rat hepatocytes
74. Impaired hepatocanalicular organic anion transport in endotoxinemic rats
75. The rat canalicular conjugate export pump (Mrp2) is downregulated in intrahepatic and obstructive cholestasis
76. Upregulation of the multidrug resistance genes mrpl and mdrlb and downregulation of the organic anion transporter Mrp2 and the bile salt transporter Spgp in endotoxinemic rat liver
77. Hepatobiliary effects of tertiary-butylhydroperoxide (tBOOH) in isolated rat hepatocyte couplets
78. Prevention of nitrofurantoin-induced cytotoxicity in isolated hepatocytes by fructose
79. Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis
80. Bile formation in the rat: The role of the paracellular shunt pathway
81. Effects of chronic choleretic infusions of bile acids on the membrane of the bile canaliculus
82. +/bile acid cotransporter in extrahepatic cholestasis
83. Regulation of sterol 27-hydroxylase and its role in the regulation of acidic pathway of bile acid biosynthesis
84. Mechanisms and functional features of polarized membrane traffic in epithelial and hepatic cells
85. Factors determining the maximal rate of organic anion secretion by the liver and further evidence of the hepatic site of action of the hormone secretin
86. The effect of sodium taurocholate on the hepatic metabolism of sulfobromophtalein (BSP). The role of bile flow
87. Choleresis and hepatic transport mechanisms
88. Taurocholate stimulates transcytotic vesicular pathways labelled by horse radish peroxidase in the isolated perfused rat liver
89. 2+, mechanisms defective in cholestasis
90. 3-kinase dependent Ras activation by tauroursodeoxycholate in rat liver
91. Inhibition by cAMP of Ras-dependent activation of Raf
92. Stimulation of bile acid secretion by tauroursodeoxycholate and cell swelling involves mitogen-activated protein kinases
93. 2+ signals in isolated rat hepatocytes
94. Signal transduction and hepatocellular bile acid transport: Cross talk between bile acids and second messenger systems
95. Regulated exocytosis
96. Activation of MAP-kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor
97. Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes
98. Hepatocellular protein kinase C activation by bile acids: Implications for regulation of cholesterol 7α-hydroxylase
99. The bile acid analogue fusidic acid can replace phosphatidylserine in the activation of protein kinase C by 12-O-tetradecanoylphorbol-13-acetate in vitro
100. Activation of protein kinase C α and delta by bile acids: Correlation with bile acid structure and diacylglycerol formation
101. Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: A role for PKC
102. Glucagon-induced expression of the MAP kinase phosphatase MKP-1 in rat hepatocytes
103. Cell volume and hormone action
104. Cell volume signalling and insulin resistance in perfused rat liver
105. The effect of glucagon-induced adenosine 3',5'-monophosphate concentrations on bile acid synthesis in isolated rat liver cells
106. Effect of glucagon on hepatic taurocholate uptake: Relationship to membrane portential
107. Effects of dibutyryl cyclic AMP and papaverine on intrahepatocytic bile acid transport. Role of vesicular transport
108. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
109. DBcAMP stimulates vesicle transport and HRP excretion in isolated perfused rat liver
110. Mechanism of glucagon-induced choleresis in guinea pigs
111. Nitric oxide and guanosine 3',5'-cyclic monophosphate stimulate bile secretion in isolated rat hepatocyte couplets, but not in isolated bile duct units
112. Modulation of biliary lipid secretion by forskolin and cyclic AMP analogues
113. The effect of cyclic AMP on the biliary secretion of taurocholic acid in the perfused rat liver
114. Regulation of liver cell volume by hormones
115. Concomitant stimulation by vasopressin of biliary and perfusate calcium fluxes in the perfused rat liver
116. 2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver
117. Regulation of canalicular bile formation by α-adrenergic action and external ATP in the perfused rat liver
118. Direct regulation of bile secretion by prostaglandins in perfused rat liver
119. Regulation of bile secretion by sympathetic nerves in perfused rat liver
120. Endothelin-1 stimulates bile acid secretion and vesicular transport in the isolated perfused rat liver
121. 2+ on exocytosis in the isolated perfused rat liver
122. 2+-mobilizing agents
123. 2+ causes active contraction of bile canaliculi: Direct evidence from microinjection studies
124. Vasopressin-induced disruption of actin cytoskeletal organization and canalicular function in isolated rat hepatocyte couplets: Possible involvement of protein kinase C
125. Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the perfused rat liver
126. Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets
127. Hepatocanalicular organic anion transport is regulated by protein kinase C
128. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
129. Sphingolipid transport to the apical plasma membrane domain in human hepatoma cells is controlled by PKC and PKA activity: A correlation with cell polarity in HepG2 cells