Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets

Journal of Biological Chemistry

Volumn 278, Issue 20, 2003, Pages 17810-17818

  Beuers, Ulrich ^a   Denk, Gerald U ^a   Soroka, Carol J ^b   Wimmer, Ralf ^a   Rust, Christian ^a   Paumgartner, Gustav ^a   Boyer, James L ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; ENZYME INHIBITION; ORGANIC ACIDS; PROTEINS;

CHOLESTATIC AGENT;

BIOCHEMISTRY;

2,4 DINITROPHENYLGLUTATHIONE; BILE ACID; CHOLYLGLYCYLAMIDOFLUORESCEIN; GLUTATHIONE DERIVATIVE; HORSERADISH PEROXIDASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE C EPSILON; TAUROLITHOCHOLIC ACID; UNCLASSIFIED DRUG; WORTMANNIN; ANDROSTANE DERIVATIVE; ANION; CHOLAGOGUE; ENZYME INHIBITOR; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; TAUROCHENODEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILE SECRETION; CHOLESTASIS; CONTROLLED STUDY; ENZYME ACTIVITY; EXOCYTOSIS; ISOLATED LIVER; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL MEMBRANE; CHEMISTRY; ENZYME ACTIVATION; ENZYMOLOGY; KINETICS; LIVER; LIVER CELL; MALE; METABOLISM; PERFUSION; PROTEIN BINDING; PROTEIN TRANSPORT; SERODIAGNOSIS; SPRAGUE DAWLEY RAT; TIME;

ANIMALIA; ARMORACIA RUSTICANA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; ANIONS; BILE ACIDS AND SALTS; CELL MEMBRANE; CHOLAGOGUES AND CHOLERETICS; ENZYME ACTIVATION; ENZYME INHIBITORS; EXOCYTOSIS; HEPATOCYTES; HORSERADISH PEROXIDASE; KINETICS; LIVER; MALE; PERFUSION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; TAUROCHENODEOXYCHOLIC ACID; TAUROLITHOCHOLIC ACID; TIME FACTORS;

EID: 0038381474     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209898200     Document Type: Article

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