Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells

Journal of Hepatology

Volumn 53, Issue 5, 2010, Pages 918-926

  Hohenester, Simon ^a,b   Gates, Anna ^b   Wimmer, Ralf ^c   Beuers, Ulrich ^a   Anwer, M Sawkat ^b   Rust, Christian ^c   Webster, Cynthia R L ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b TUFTS UNIVERSITY   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Akt; Apoptosis; Cholestasis; Glycochenodeoxycholate; JNK; PI3K; Taurolithocholate; Tauroursodeoxycholate

Indexed keywords

AS 604850; BILE SALT; CALCIUM ION; CASPASE 3; CASPASE 7; CYCLIC AMP; ENZYME INHIBITOR; FAS ANTIGEN; GLYCOCHENODEOXYCHOLIC ACID; JANUS KINASE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEIN KINASE B; PROTEIN P110; PROTEIN P110 GAMMA; SMALL INTERFERING RNA; TAUROLITHOCHOLIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; HEPATOMA CELL; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; IMMUNOBLOTTING; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; APOPTOSIS; BILE ACIDS AND SALTS; CARCINOMA, HEPATOCELLULAR; CELLS, CULTURED; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; DIOXOLES; ENZYME ACTIVATION; GLYCOCHENODEOXYCHOLIC ACID; HEP G2 CELLS; HEPATOCYTES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; THIAZOLIDINEDIONES;

EID: 77957338101     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.05.015     Document Type: Article

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