Immune responses in dogs with cutaneous adverse food reactions

Veterinary Quarterly

Volumn 32, Issue 2, 2012, Pages 87-98

  Veenhof, E Z ^a   Knol, E F ^b   Willemsea, T ^a,c   Rutten, V P M G ^c,d  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Adverse food reaction; Allergy; Dog; IgE; Intestine; Skin

Indexed keywords

CD23 ANTIGEN; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CCR4; CUTANEOUS T CELL ATTRACTING CHEMOKINE; FOOD ALLERGEN; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ADVERSE OUTCOME; ALLERGIC REACTION; ANTIGEN PRESENTING CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL FUNCTION; CELL HOMING; DOG DISEASE; EFFECTOR CELL; EXPERIMENTAL DOG; FOOD ALLERGY; HUMAN; IMMUNE RESPONSE; INTESTINE EPITHELIUM CELL; NONHUMAN; NUTRITIONAL INTOLERANCE; REGULATORY T LYMPHOCYTE; REVIEW; SKIN MANIFESTATION; SKIN PENETRATION; SKIN PERMEABILITY; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; TH2 CELL;

ALLERGENS; ANIMALS; DOG DISEASES; DOGS; FOOD HYPERSENSITIVITY; INTESTINES; SKIN; T-LYMPHOCYTES;

CANIS FAMILIARIS;

EID: 84870279243     PISSN: 01652176     EISSN: 18755941     Source Type: Journal    
DOI: 10.1080/01652176.2012.713170     Document Type: Review

References (139)

1. Admyre C, Bohle B, Johansson SM, Focke-Tejkl M, Valenta R, Scheynius A, Gabrielsson S. 2007. B cell-derived exosomes can present allergen peptides and acti-vate allergen-specific T cells to proliferate and produce TH2-like cytokines. J Allergy Clin Immunol. 120:1418-1424.
2. Akdis CA, Blesken T, Akdis M, Wüthrich B, Blaser K. 1998. Role of interleukin 10 in specific immunotherapy. J Clin Invest. 102:98-106.
3. Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, Crameri R, Thunberg S, Deniz G, Valenta R, Fiebig H, et al. 2004. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med. 199:1567-1575.
4. Akimzhanov AM, Yang ZO, Dong C. 2007. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem. 282:5969-5972.
5. Armitage RJ, Macduff BM, Spriggs MK, Fanslow WC. 1993. Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines. J Immunol. 150:3671-3680.
6. Avery DT, Bryant VL, Ma GS, de Waal Malefyt R, Tangye SG. 2008. IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4. J Immunol. 181:1767-1779.
7. Berlin C, Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, Weissman IL, Hamann A, Butcher EC. 1993. α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell. 74:185-195.
8. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. 2006. Reciprocal developmen-tal pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 441:235-238.
9. Bevilacqua C, Montagnac G, Benmerah A, Candalh C, Brousse N, Cerf-Bensussan N, Perdue MH, Heyman M. 2004. Food allergens are protected from degradation during CD23-mediated transepithelial transport. Int Arch Allergy Immunol. 135:108-116.
10. Beyer K, Castro R, Birnbaum A, Benkov K, Pittman N, Sampson HA. 2002. Human milk-specific mucosal lym-phocytes of the gastrointestinal tract display a TH2 cytokine profile. J Allergy Clin Immunol. 109:707-713.
11. Borghesan F, Mistrello G, Roncarolo D, Amato S, Plebani M, Asero R. 2008. Respiratory allergy to lipid transfer protein. Int Arch Allergy Immunol. 147:161-165.
12. Briere F, Servet-Delprat C, Bridon JM, Saint-Remy JM, Banchereau J. 1994. Human interleukin 10 induces naïve surface immunoglobulin D +(sIgD +) B cells to secrete IgG1 and IgG3. J Exp Med. 179:757-762.
13. Carlotti DN, Remy I, Prost C. 1990. Food allergy in dogs and cats. A review and report of 43 cases. Vet Dermatol. 1:55-62.
14. Chehade M, Mayer L. 2005. Oral tolerance and its relation to food hypersensitivities. J Allergy Clin Immunol. 115:3-12.
15. -naive T cells to CD4 +CD25 +regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med. 198:1875-1886.
16. Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL. 2008. Latency-associated peptide identifies a novel CD4 +CD25 + regulatory T cell subset with TGFβ-mediated function and enhanced suppression of experi-mental autoimmune encephalomyelitis. J Immunol. 180:7327-7337.
17. Chervet L, Galichet A, McLean WH, Chen H, Suter MM, Roosje PJ, Müller EJ. 2010. Missing C-terminal filaggrin expression, NFkappaB activation and hyperproliferation identify the dog as a putative model to study epidermal dysfunction in atopic dermatitis. Exp Dermatol. 19:343-346.
18. Chesney CJ. 2002. Food hypersensitivity in the dog: a quantitative study. J Small Anim Pract. 43:203-207.
19. Clarke L, McQueen J. 1996. The dietary management of food allergy and food intolerance in children and adults. Aust J Nutr Diet. 53:89-98.
20. Constant S, Bottomly K. 1997. Induction of Th1 and Th2 CD4 + T cell responses: the alternative approaches. Ann Rev Immunol. 15:297-322.
21. Cork MJ, Robinson DA, Vasilopoulos Y, Ferguson A, Moustafa M, MacGowan A, Duff GW, Ward SJ, Tazi-Ahnini R. 2006. New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment inter-actions. J Allergy Clin Immunol. 118:3-21.
22. Das J, Chen CH, Yang L, Cohn L, Ray P, Ray A. 2001. A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol. 2:45-50.
23. de Jong E, Suddason T, Lord GM. 2009. Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells. Clin Exp Immunol. 159:148-158.
24. Defrance T, Vanbervliet B, Briere F, Durand I, Rousset F, Banchereau J. 1992. Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J Exp Med. 175:671-682.
25. Elser B, Lohoff M, Kock S, Giaisi M, Kirchhoff S, Krammer PH, Li-Weber M. 2002. IFN-γ represses IL-4 expression via IRF-1 and IRF-2. Immunity. 1:703-712.
26. Frossard CP, Tropia L, Hauser C, Eigenmann PA. 2004. Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy. J Allergy Clin Immunol. 113:958-964.
27. Fujieda S, Zhang K, Saxon A. 1995. IL-4 plus CD40 monoclonal antibody induces human B cells gamma subclass-specific isotype switch: switching to gamma 1, gamma 3, and gamma 4, but not gamma 2. J Immunol. 155:2318-2328.
28. Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS. 1997. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed in skin-homing T cells. Nature. 389:978-981.
29. Gascan H, Gauchat JF, Aversa G, Van Vlasselaer P, de Vries JE. 1991. Anti-CD40 monoclonal antibodies or CD4 +T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways. J Immunol. 147:8-13.
30. Geha RS, Jabara HH, Brodeur SR. 2003. The regulation of immunoglobulin E class-switch recombination. Nat Rev Immunol. 3:721-732.
31. German AJ, Hall EJ, Day MJ. 1999. Analysis of leucocyte subsets in the canine intestine. J Comp Pathol. 120:129-145.
32. German AJ, Hall EJ, Moore PJ, Ringler DJ, Newman W, Day MJ. 1999. The distribution of lymphocytes expressing αβ and γδ T-cell receptors, and the expression of mucosal address in cell adhesion molecule-1 in the canine intestine. J Comp Pathol. 121:249-263.
33. Hamid Q, Boguniewicz M, Leung DY. 1994. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest. 94:870-876.
34. Hammad H, Smits HH, Ratajczak C, Nithiananthan A, Wierenga EA, Stewart GA, Jacquet A, Tonnel AB, Pestel J. 2003. Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22. Eur Cytokine Netw. 14:219-228.
35. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. 2005. Interleukin 17-producing CD4 +effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 6:1123-1132.
36. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, et al. 2002. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med. 8:157-165.
37. Hosken NA, Shibuya K, Heath AW, Murphy KM, O'Garra A. 1995. The effect of antigen dose on CD4 +T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J Exp Med. 182:1579-1584.
38. Howell MD, Kim BE, Gao P, Grant AV, Boquniewicz M, Debenedetto A, Schneider L, Beck LA, Barnes KC, Leung DY. 2007. Cytokine modulation of atopic derma-titis filaggrin skin expression. J Allergy Clin Immunol. 120:150-155.
39. Hsieh KY, Tsai CC, Wu CH, Lin RH. 2003. Epicutaneous exposure to protein antigen and food allergy. Clin Exp Allergy. 33:1067-1075.
40. Hunt J, Beavil RL, Calvert RA, Gould HJ, Sutton BJ, Beavil AJ. 2005. Disulfide linkage controls the affinity and stoichiometry of IgE Fcepsilon3-4 binding to FcepsilonRI. J Biol Chem. 280:16808-16814.
41. Hussain R, Kifayet A, Dojki M, Dockrell HM. 1999. Selective correlation of interferon-gamma, tumour necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor with immunoglobulin G1 and immunoglobulin G3 subclass antibody in leprosy. Immunology. 98:238-243.
42. Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. 2005. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 307:430-433.
43. Imai T, Nagira M, Takagi S, Kakizaki M, Nishimura M, Wang J, Gray PW, Matsushima K, Yoshie O. 1999. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunity. 11:81-88.
44. Jackson HA, Jackson MW, Coblentz L, Hammerberg B. 2003. Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with corn-starch, corn, soy and a soy hydrolysate diet in dogs with spontaneous food allergy. Vet Dermatol. 14:181-187.
45. James SP. 1993. The gastrointestinal mucosal immune system. Dig Dis Sci. 11:146-156.
46. Jeannin P, Lecoanet S, Delneste Y, Gauchat JF, Bonnefoy JY. 1998. IgE versus IgG4 production can be differentially regulated by IL-10. J Immunol. 160:3555-3561.
47. Jeffers JG, Meyer EK, Sosis EJ. 1996. Responses of dogs with food allergies to single-ingredient dietary provoca-tion. J Am Vet Med Assoc. 209:608-611.
48. Johansson-Lindbom B, Agace WW. 2007. Generation of gut-homing T cells and their localization to the small intestinal mucosa. Immunol Rev. 215:226-242.
49. Jump RL, Levine AD. 2004. Mechanisms of natural toler-ance in the intestine. Implications for inflammatory bowel disease. Inflamm Bowel Dis. 10:462-478.
50. Kanari H, Kagami S, Kashiwakuma D, Oya Y, Furuta S, Ikeda K, Suto A, Suzuki K, Hirose K, Watanabe N, et al. 2010. Role of Th2 cells in IgG4-related lacrimal gland enlargement. Int Arch Allergy Immunol. 152(Suppl 1):47-53.
51. Kaplan MH, Schindler U, Smiley ST, Grusby MJ. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity. 4:313-319.
52. Kawano Y, Noma T, Kou K, Yoshizawa I, Yata J. 1995. Regulation of human IgG subclass production by cyto-kines: human IgG subclass production enhanced differen-tially by interleukin-6. Immunology. 84:278-284.
53. Kim J, Ho IC, Grusby M, Glimcher LH. 1999. The transcription factor c-maf controls the production of IL-4 but not other Th2 cytokines. Immunity. 10:745-751.
54. King CL, Nutman TB. 1993. IgE and IgG subclass regula-tion by IL4 and IFN gamma in human helminth infec-tions. J Immunol. 150:458-465.
55. Kitts D, Yuan Y, Joneja J, Scott F, Szilagyi A, Amiot J, Zarkadas M. 1997. Adverse reactions to food constituents: allergy, intolerance, and autoimmunity. Can J Physiol Pharmacol. 75:241-254.
56. Leser C, Hartmann AL, Prami G, Wuthrich B. 2001. The 'egg-egg' syndrome: occupational respiratory allergy to airborne egg proteins with consecutive ingestive egg allergy in the bakery and confectionery industry. J Invest Allergol Clin Immunol. 11:89-93.
57. Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. 2004. New insights into atopic dermatitis. J Clin Invest. 113:651-657.
58. Leung DYM. 2009. Our evolving understanding of the functional role of filaggrin in atopic dermatitis. J Allergy Clin Immunol. 124:494-495.
59. Li H, Nowak-Wegrzyn A, Charlop-Powers Z, Shreffler W, Chehade M, Thomas S, Roda G, Dahan S, Sperber K, Berlin MC. 2006. Transcytosis of IgE-antigen complexes by CD23a in human intestinal epithelial cells and its role in food allergy. Gastroenterology. 131:47-58.
60. Liang SC, Long AJ, Bennett F, Whitters MJ, Karim R, Collins M, Goldman SJ, Dunussi-Joannopoulos K, Williams CM, Wright JF, Fouser LA. 2007. An IL-17F/ A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J Immunol. 179:7791-7799.
61. Lighvani AA, Frucht DM, Jankovic D, Yamane H, Aliberti J, Hissong BD, Nguyen BV, Gadina M, Sher A, Paul WE, O'Shea JJ. 2001. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci. USA. 98:15137-15142.
62. Lin XP, Almqvist N, Telemo E. 2005. Human small intestinal epithelial cells constitutively express the key elements for antigen processing and the production of exosomes. Blood Cells Mol Dis. 35:122-128.
63. Lundqvist C, Baranov V, Hammarström S, Athlin L, Hammarström ML. 1995. Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. Int Immunol. 7:1473-1487.
64. Maeda S, Fujiwara S, Omori K, Kawano K, Kurata K, Masuda K, Ohno K, Tsujimoto H. 2002. Lesional expres-sion of thymus and activation-regulated chemokine in canine atopic dermatitis. Vet Immunol Immunopathol. 88:79-87.
65. Maeda S, Ohmori K, Yasuda N, Kurata K, Sakaguchi M, Masuda K, Ohno K, Tsujimoto H. 2004. Increase of CC chemokine receptor 4-positive cells in the peripheral CD4 cells in dogs with atopic dermatitis or experimentally sensitized to Japanese cedar pollen. Clin Exp Allergy. 34:1467-1473.
66. Maeda S, Tsukui T, Saze K, Masuda K, Ohno K, Tsujimoto H, Iwabuchi S. 2005. Production of a mono-clonal antibody to canine thymus and activation regulated chemokine (TARC) and detection of TARC in lesional skin from dogs with atopic dermatitis. Vet Immunol Immunopathol. 103:83-92.
67. Maeda S, Tsuchida H, Shibata S, Kawakami T, Tsukui T, Ohba Y, Fukata T, Kitagawa H. 2008. Expression analysis of CCL27 and CCL28 mRNA in lesional and non-lesional skin of dogs with atopic dermatitis. J Vet Med Sci. 70:51-55.
68. Marsella R, Olivry T, Maeda S. 2006. Cellular and cytokine kinetics after epicutaneous allergen challenge (atopy patch testing) with house dust mites in high-IgE beagles. Vet Dermatol. 17:111-120.
69. Marsella R, Olivry T, Carlotti DN, Task Force on Canine Atopic Dermatitis International. 2011. Current evidence of skin barrier dysfunction in human and canine atopic dermatitis. Vet Dermatol. 22:239-248.
70. Martin A, Sierra MP, Gonzales JL, Arevalo MA. 2004. Identification of allergens responsible for canine cutaneous adverse food reactions to lamb, beef and cow's milk. Vet Dermatol. 15:349-356.
71. Mowat AM. 2003. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol. 3:331-341.
72. Molenaar R, Greuter M, van der Marel AP, Roozendaal R, Martin SF, Edele F, Huehn J, Förster R, O'Toole T, Jansen W, et al. 2009. Lymph node stromal cells support dendritic cell-induced gut-homing of T cells. J Immunol. 183:6395-6402.
73. Moser M, Murphy KM. 2000. Dendritic cell regulation of TH1-TH2 development. Nat Immunol. 1:199-205.
74. Mullen AC, Hutchins AS, High FA, Lee HW, Sykes KJ, Chodosh LA, Reiner SL. 2002. Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nat Immunol. 3:652-658.
75. Murphy K, Travers P, Walport M, Ehrenstein M, Mauri C. 2008. Janeway's immunobiology. 7th ed. New York: Garland Sciences.
76. Nakahira M, Ahn HJ, Park WR, Gao P, Tomura M, Park CS, Hamaoka T, Ohta T, Kurimoto M, Fujiwara H. 2002. Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1. J Immunol. 168:1146-1153.
77. Nakamura K, Kitani A, Strober W. 2001. Cell contact-dependent immunosuppression by CD4 +CD25 +regula-tory T cells is mediated by cell surface-bound transforming growth factor β. J Exp Med. 194:629-644.
78. van Niel G, Raposo G, Candalh C, Boussac M, Hershberg R, Cerf-Bensussan N, Heyman M. 2001. Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterol. 121:337-349.
79. Novak N, Kraft S, Bieber T. 2003. Unraveling the mission of FceRI on antigen-presenting cells. J Allergy Clin Immunol. 111:38-44.
80. Nuttall TJ, Knight PA, McAleese SM, Lamb JR, Hill PB. 2002. Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis. Clin Exp Allergy. 32:789-795.
81. Oida T, Zhang X, Goto M, Hachimura S, Totsuka M, Kaminogawa S, Weiner HL. 2003. CD4 +CD25-T cells that express latency-associated peptide on the surface suppress CD4 +CD45RB high-induced colitis by a TGF-β-dependent mechanism. J Immunol. 170:2516-2522.
82. Olivry T, Moore PF, Affolter VK, Naydan DK. 1996. Langerhans cell hyperplasia and IgE expression in canine atopic dermatitis. Arch Dermatol Res. 288:579-585.
83. Olivry T, Naydan DK, Moore PF. 1997. Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis. Am J Dermatopathol. 19:477-486.
84. Olivry T, Dean GA, Tompkins MB, Dow JL, Moore PF. 1999. Toward a canine model of atopic dermatitis: amplification of cytokine-gene transcripts in the skin of atopic dogs. Exp Dermatol. 8:204-211.
85. Ou LS, Huang JL. 2007. Cellular aspects of atopic dermatitis. Clin Rev Allergy Immunol. 33:191-198.
86. Ouyang W, Ranganath SH, Weindel K, Bhattacharya D, Murphy TL, Sha WC, Murphy KM. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity. 9:745-755.
87. Ouyang W, Löhning M, Gao Z, Assenmacher M, Ranganath S, Murphy KM. 2000. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity. 12:27-37.
88. Ouyang W, Kolls JK, Zheng Y. 2008. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity. 28:454-467.
89. Ozdemir O, Mete E, Catal F, Ozol D. 2009. Food intolerances and eosinophilic esophagitis in childhood. Dig Dis Sci. 54:8-14.
90. Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, et al. 2006. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 38:441-446.
91. Pene J, Gauchat JF, Lecart S, Drouet E, Guglielmi P, Boulay V, Delwail A, Foster D, Lecron JC, Yssel H. 2004. Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells. J Immunol. 172:5154-5157.
92. Pérez-Machado MA, Ashwood P, Thomson MA, Latcham F, Sim R, WalkerSmith JA, Murch SH. 2003. Reduced transforming growth factor-beta1-producing T cells in the duodenal mucosa of children with food allergy. Eur J Immunol. 33:2307-2315.
93. Peters IR, Helps CR, Calvert EL, Hall EJ, Day MJ. 2005. Cytokine mRNA quantification in histologically normal canine duodenal mucosa by real-time RT-PCR. Vet Immunol Immunopathol. 103:101-111.
94. Picco F, Zini E, Nett C, Naegeli C, Bigler B, Rüfenacht S, Roosje P, Gutzwiller ME, Wilhelm S, Pfister J, et al. 2008. A prospective study on canine atopic dermatitis and food-induced allergic dermatitis in Switzerland. Vet Dermatol. 19:150-155.
95. Proksch E, Fölster-Holst R, Jensen JM. 2006. Skin barrier function, epidermal proliferation and differentiation in eczema. J Dermatol Sci. 43:156-169.
96. Pucheu-Haston CM, Jackson HA, Olivry T, Dunston SM, Hammerberg B. 2008. Epicutaneous sensitization with dermatophagoides farinae induces generalized allergic dermatitis and elevated mite-specific immunoglobulin E levels in a canine model of atopic dermatitis. Clin Exp Allergy. 38:667-679.
97. Puigdemont A, Brazis P, Serra M, Fondati A. 2006. Immunologic responses against hydrolysed soy protein in dogs with experimentally induced soy hypersensitivity. Am J Vet Res. 67:484-488.
98. Punnonen J, Aversa G, Cocks BG, McKenzie AN, Menon S, Zurawski G, de Waal Malefyt R, de Vries JE. 1993. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA. 90:3730-3734.
99. Rautava S, Isolauri E. 2004. Cow's milk allergy in infants with atopic eczema is associated with aberrant production of interleukin-4 during oral cow's milk challenge. J Pediatr Gastroenterol Nutr. 39:529-535.
100. Reiss Y, Proudfoot AE, Power CA, Campbell JJ, Butcher EC. 2001. CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J Exp Med. 194:1541-1547.
101. Rescigno M, Urbano M, Valzasina B, Francolini M, Rotta G, Bonasio R, Granucci F, Kraehenbuhl JP, Ricciardi-Castagnoli P. 2001. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol. 2:361-367.
102. Reynolds DS, Boom WH, Abbas AK. 1987. Inhibition of B lymphocyte activation by interferon-γ. J Immunol. 139:767-773.
103. Rogler G, Andus T. 1998. Cytokines in inflammatory bowel disease. World J Surg. 22:382-389.
104. Rosser Jr EJ. 1993. Diagnosis of food allergy in dogs. J Am Vet Med Assoc. 203:259-262.
105. Sanchez-Munoz F, Dominguez-Lopez A, Yamamoto-Furusho JK. 2008. Role of cytokines in inflammatory bowel disease. World J Gastroenterol. 14:4280-4288.
106. Sandilands A, Terron-Kwiatkowski A, Hull PR, O'Regan GM, Clayton TH, Watson RM, Carrick T, Evans AT, Liao H, Zhao Y, et al. 2007. Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in Ichthyosis vulgaris and atopic eczema. Nat Genet. 39:650-654.
107. Saraiva M, O'Garra A. 2010. The regulation of IL-10 production by immune cells. Nat Rev Immunol. 10:170-181.
108. Schade RP, Van Ieperen-Van Dijk AG, Van Reijsen FC, Versluis C, Kimpen JLL, Knol EF, Bruijnzeel-Koomen CAFM, Van Hoffen E. 2000. Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow's milk allergy: Relevance of TH2 cytokines. J Allergy Clin Immunol. 106:1155-1162.
109. Sinke JD, Thepen T, Bihari IC, Rutten VP, Willemse T. 1997. Immunophenotyping of skin-infiltrating T-cell sub-sets in dogs with atopic dermatitis. Vet Immunol Immunopathol. 57:13-23.
110. Sloan-Lancaster J, Steinberg TH, Allen PM. 1997. Selective loss of the calcium ion signaling pathway in T cells maturing toward a T helper 2 phenotype. J Immunol. 159:1160-1168.
111. Sonea IM, Harkins K, Wannemuehler MJ, Jergens AE, Merten EA, Sacco RE, Cunnick JE. 1999. Flow cytometric analysis of canine colonic mucosal lymphocytes from endoscopically obtained biopsy specimens. Am J Vet Res. 60:236-353.
112. Sonea IM, Jergens AE, Sacco RE, Niyo Y, Merten E, Kauffman LK, Moore PF. 2000. Flow cytometric analysis of colonic and small intestinal mucosal lymphocytes obtained by endoscopic biopsy in the healthy dog. Vet Immunol Immunopathol. 77:103-119.
113. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science. 295:338-342.
114. Thepen T, Langeveld-Wildschut EG, Bihari IC, van Wichen DF, van Reijsen FC, Mudde GC, Bruijnzeel-Koomen CA. 1996. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochem-ical study. J Allergy Clin Immunol. 97:828-837.
115. Thornton AM, Shevach EM. 2000. Suppressor effector function of CD4 +CD25 +immunoregulatory T cells is antigen nonspecific. J Immunol. 164:183-190.
116. Tiemessen MM, Van Ieperen-Van Dijk AG, Bruijnzeel-Koomen CAFM, Garssen J, Knol EF, Van Hoffen E. 2004. Cow's milk-specific T-cell reactivity of children with and without persistent cow's milk allergy: Key role for IL-10. J Allergy Clin Immunol. 113:932-939.
117. Tsuge I, Kondo Y, Tokuda R, Kakami M, Kawamura M, Nakajima Y, Komatsubara R, Yamada K, Urisu A. 2006. Allergen-specific helper T cell response in patients with cow's milk allergy: Simultaneous analysis of proliferation and cytokine production by carboxyfluorescein succinimi-dyl ester dilution assay. Clin Exp Allergy. 36:1538-1545.
118. Turcanu V, Maleki SJ, Lack G. 2003. Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J Clin Invest. 111:1056-1072.
119. Untersmayr E, Jensen-Jarolim E. 2008. The role of protein digestibility and antacids on food allergy outcomes. J Allergy Clin Immunol. 121:1301-1308.
120. Untersmayr E, Bises G, Starkl P, Bevins CL, Scheiner O, Boltz-Nitulescu G, Wrba F, Jensen-Jarolim E. 2010. The high affinity IgE receptor Fc epsilonRI is expressed by human intestinal epithelial cells. PloS One. 5:e9023.
121. Usui T, Nishikomori R, Kitani A, Strober W. 2003. GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet. Immunity. 18:415-428.
122. Usui T, Preiss JC, Kanno Y, Yao ZJ, Bream JH, O'Shea JJ, Strober W. 2006. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J Exp Med. 203:755-766.
123. Vaden SL, Hammerberg B, Davenport DJ, Orton SM, Trogdon MM, Melgarejo LT, VanCamp SD, Williams DA. 2000. Food hypersensitivity reactions in Soft Coated Wheaten Terriers with protein-losing entero-pathy or protein-losing nephropathy or both: gastroscopic food sensitivity testing, dietary provocation, and fecal immunoglobulin E. J Vet Intern Med. 14:60-67.
124. Veenhof EZ, Rutten VP, van Noort R, Knol EF, Willemse T. 2010. Evaluation of T-cell activation in the duodenum of dogs with cutaneous food hypersensitivity. Am J Vet Res. 71:441-446.
125. Veenhof EZ, Knol EF, Schlotter YM, Vernooij JC, Rutten VP, Willemse T. 2011. Characterisation of T cell phenotypes, cytokines and transcription factors in the skin of dogs with cutaneous adverse food reactions. Vet J. 187:320-324.
126. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. 2006. TGFβ in the context of an inflamma-tory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 24:179-189.
127. Wang X, Fujita M, Prado R, Tousson A, Hsu HC, Schottelius A, Kelly DR, Yang PA, Wu Q, Chen J, et al. 2010. Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model. Brit J Dermatol. 162:487-496.
128. Weiner HL. 2001. Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells. Immunol Rev. 182:207-214.
129. Werfel T. 2009. The Role of Leukocytes, Keratinocytes, and Allergen-Specific IgE in the Development of Atopic Dermatitis. J Invest Dermatol. 129:1878-1891.
130. Westendorf AM, Bruder D, Hansen W, Buer J. 2006. Intestinal epithelial antigen induces CD4 +T cells with regulatory phenotype in a transgenic autoimmune mouse model. Ann N Y Acad Sci USA. 1072:401-406.
131. White SD. 1986. Food hypersensitivity in 30 dogs. J Am Vet Med Assoc. 188:695-698.
132. Wills J, Harvey R. 1994. Diagnosis and management of food allergy and intolerance in dogs and cats. Aust Vet J. 71:322-326.
133. -T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol. 178:6725-6729.
134. Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C. 2007. STAT3 regulates cytokine mediated generation of inflammatory helper T cells. J Biol Chem. 282:9358-9363.
135. Yu LCH, Yang PC, Berin MC, Di Leo V, Conrad DH, McKay DM, Satoskar AR, Perdue MH. 2001. Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by inter-leukin-4. Gastroenterology. 121:370-381.
136. Zan H, Cerutti A, Dramitinos P, Schaffer A, Casali P. 1998. CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-β: evidence for TGF-β but not IL-10-dependent direct Sμ →Sα and sequential Sμ→Sγ, Sμ→Sα DNA recombi-nation. J Immunol. 161:5217-5225.
137. Zheng X, Nakamura K, Furukawa H, Nishibu A, Takahashi M, Tojo M, Kaneko F, Kakinuma T, Tamaki K. 2003. Demonstration of TARC and CCR4 mRNA expression and distribution using in situ RT-PCR in the lesional skin of atopic dermatitis. J Dermatol. 30:26-32.
138. Zhu J, Min B, Hu-Li J, Watson CJ, Grinberg A, Wang Q, Killeen N, Urban Jr JF, Guo L, Paul WE. 2004. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol. 5:1157-1165.
139. Zhu J, Yamane H, Paul WE. 2010. Differentiation of effector CD4 T cell populations. Ann Rev Immunol. 28:445-489.