The importance of SRS-1 residues in catalytic specificity of human cytochrome P450 3A4

Archives of Biochemistry and Biophysics

Volumn 374, Issue 2, 2000, Pages 269-278

  Roussel, Fabienne ^a   Khan, Kishore K ^a   Halpert, James R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

CYP3A4; Cytochrome P450; Heterologous expression; Site directed mutagenesis; Steroid hydroxylation

Indexed keywords

CYTOCHROME P450;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEROID HYDROXYLATION;

EID: 0034652348     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1999.1599     Document Type: Article

References (56)

1. Nelson D. R., Koymans L., Kamataki T., Stegeman J. J., Feyereisen R., Waxman D. J., Waterman M. R., Gotoh O., Coon M. J., Estabrook R. W., Gunsalus I. C., Nebert D. W. Pharmacogenetics. 6:1996;1-42.
2. Guengerich F. P. FASEB J. 6:1992;745-748.
3. Guengerich F. P. Chem. Res. Toxicol. 3:1990;363-371.
4. Guengerich F. P. Ortiz de Montellano P. R. Cytochromes P450: Structure, Mechanism, and Biochemistry. 1995;473-535 Plenum, New York.
5. Thummel K. E., Wilkinson G. R. Annu. Rev. Pharmacol. Toxicol. 38:1998;389-430.
6. Kronbach T., Mathys D., Umeno M., Gonzalez F. J., Meyer U. A. Mol. Pharmacol. 36:1989;89-96.
7. Yamazaki H., Shimada T. Arch. Biochem. Biophys. 346:1997;161-169.
8. Waxman D. J., Lapenson D. P., Aoyama T., Gelboin H. V., Gonzalez F. J., Korzekwa K. R. Arch. Biochem. Biophys. 290:1991;160-166.
9. Korzekwa K. R., Krishnamachary N., Shou M., Ogai A., Parise R. A., Rettie A. E., Gonzalez F. J., Tracy T. S. Biochemistry. 37:1998;4137-4147.
10. Harlow G. R., Halpert J. R. Proc. Natl. Acad. Sci. USA. 95:1998;6636-6641.
11. Koley A., Buters J. T. M., Robinson R. C., Markowitz A., Friedman F. K. J. Biol. Chem. 272:1997;3149-3152.
12. Shou M., Grogan J., Mancewicz J. A., Krausz K. W., Gonzalez F. J., Gelboin H. V., Korzekwa K. R. Biochemistry. 33:1994;6450-6453.
13. Ueng Y.-F., Kuwabara T., Chun Y.-J., Guengerich F. P. Biochemistry. 36:1997;370-381.
14. Johnson E. F. Trends Pharmacol. Sci. 13:1992;122-131.
15. Von Wachenfeldt C., Johnson E. F. Ortiz de Montellano P. R. Cytochrome P450: Structure, Mechanism, and Biochemistry. 1995;183-223 Plenum, New York.
16. Gotoh O. J. Biol. Chem. 267:1992;83-90.
17. He Y.-A., Luo Z., Klekotka P. A., Burnett V. L., Halpert J. R. Biochemistry. 33:1994;4419-4424.
18. He Y.-Q., He Y.-A., Halpert J. R. Chem. Res. Toxicol. 8:1995;574-579.
19. Strobel S. M., Halpert J. R. Biochemistry. 36:1998;11697-11706.
20. He Y.-Q., Harlow G. R., Szklarz G. D., Halpert J. R. Arch. Biochem. Biophys. 350:1998;333-339.
21. He Y.-Q., Szklarz G. D., Halpert J. R. Arch. Biochem. Biophys. 335:1996;152-160.
22. Hasler J. A., Harlow G R., Szklarz G D., John G. H., Kedzie K. M., Burnett V. L., He Y.-A., Kaminsky L. S., Halpert J. R. Mol. Pharmacol. 46:1994;338-345.
23. Szklarz G. D., Halpert J. R. J. Comput. Aided Mol. Design. 11:1997;265-272.
24. Harlow G. R., Halpert J. R. J. Biol. Chem. 272:1997;5396-5402.
25. Domanski T. L., Liu J., Harlow G. R., Halpert J. R. Arch. Biochem. Biophys. 350:1998;223-232.
26. He Y.-A., He Y.-Q., Szklarz G. D, Halpert J. R. Biochemistry. 36:1997;8831-8839.
27. Wang H., Dick R., Yin H., Licad-Coles E., Kroetz D. L., Szklarz G., Harlow G., Halpert J. R., Correia A. Biochemistry. 37:1998;12536-12545.
28. Stresser D. M., Kupfer D. Biochemistry. 36:1997;2203-2210.
29. Smith D. A., Jones B. C. Biochem. Pharmacol. 44:1992;2089-2098.
30. Smith D. A. Eur. J. Drug Metab. Disp. 19:1994;193-199.
31. Lewis D. F., Eddershaw P. J., Goldfarb P. S., Tarbit M. H. Xenobiotica. 26:1996;1067-1086.
32. Halpert J. R., He Y.-A. J. Biol. Chem. 268:1993;4453-4457.
33. Poulos T. L., Finzel B. C., Gunsalus I. C., Wagner G. C., Kraut J. J. Biol. Chem. 260:1985;16122-16130.
34. Kronbach T., Johnson E. F. J. Biol. Chem. 266:1991;6215-6220.
35. Straub P., Lloyd M., Johnson E. F., Kemper B. J. Biol. Chem. 268:1993;21997-22003.
36. Lindberg R. L. P., Negishi M. Nature. 339:1989;632-634.
37. Harlow G. R., Halpert J. R. Arch. Biochem. Biophys. 326:1996;85-92.
38. John G. H., Hasler J. Q., Halpert J. R. Arch. Biochem. Biophys. 314:1994;367-375.
39. Laemmli U. K. Nature. 339:1970;632-634.
40. Ciaccio P. J., Halpert J. R. Arch. Biochem. Biophys. 271:1989;284-299.
41. Kedzie K. M., Balfour C. A., Escobar G. Y., Grimm S. W., He Y.-A., Pepperl D. J., Regan J. W., Stevens J. C., Halpert J. R. J. Biol. Chem. 266:1991;22515-22521.
42. Kobayashi Y., Fang Y., Szklarz G. D., Halpert J. R. Biochemistry. 37:1998;6679-6688.
43. Cunningham B. C., Wells J. A. Science. 244:1989;1081-1085.
44. Hasemann C. A., Kurumbail R. G., Boddupalli S. S., Peterson J. A., Deisenhofer J. Structure. 2:1995;41-62.
45. Ravichandran K. G., Boddupalli S. S., Hasemann C. A., Peterson J. A., Deisenhofer J. Science. 261:1993;731-736.
46. Cupp-Vickery J. R., Poulos T. L. Nature Struct. Biol. 2:1995;144-153.
47. Hasemann C. A., Ravichandran K. G., Peterson J. A., Deisenhofer J. J. Mol. Biol. 236:1994;1169-1185.
48. Kronbach T., Kemper B., Johnson E. F. Biochemistry. 30:1991;6097-6102.
49. Haining R. L., Jones J. P., Henne K. R., Fisher M. B., Koop D. R., Trager W. F., Rettie A. E. Biochemistry. 38:1999;3285-3292.
50. Kronbach T., Larabee T. M., Johnson E. F. Proc. Natl. Acad. Sci. USA. 86:1989;8262-8265.
51. Juvonen R. O., Iwasaki M., Negishi M. J. Biol. Chem. 266:1991;16431-16435.
52. Iwazaki M., Lindberg R. L. P., Juvonen R. O., Negishi M. Biochem. J. 291:1993;569-573.
53. Oliver C. F., Modi S., Sutcliffe M. J., Primose W. U., Lian L.-Y., Roberts G. C. K. Biochemistry. 36:1997;1567-1572.
54. Graham-Lorence S., Truan G., Peterson J. A., Falck J. R., Wei S., Helvig C., Capdevila J. H. J. Biol. Chem. 272:1997;1127-1135.
55. Li H., Poulos T. L. Nature Struct. Biol. 4:1997;140-146.
56. Dierks E. A., Zhang Z., Johnson E. F., Ortiz de Montellano P. R. J. Biol. Chem. 273:1998;23055-23061.