Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes

Biochemical Pharmacology

Volumn 52, Issue 2, 1996, Pages 301-309

  Yamazaki, Hiroshi ^a   Nakano, Masami ^a   Gillam, Elizabeth M J ^b   Bell, L Chastine ^c   Guengerich, F Peter ^c   Shimada, Tsutomu ^a  

^a OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

7 ethoxycoumarin; aniline; chlorzoxazone; cytochrome b5; elec tron transfer; N nitrosodimethylamine; P450 2E1; reconstitution

Indexed keywords

7 ETHOXYCOUMARIN DEETHYLASE; ANILINE; CHLORZOXAZONE; CYTOCHROME B5; CYTOCHROME B5 REDUCTASE; CYTOCHROME P450 ISOENZYME; CYTOCHROME P450 REDUCTASE; DIMETHYLNITROSAMINE; ENZYME ANTIBODY; IMMUNOGLOBULIN G; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; 7 ETHOXYCOUMARIN; 7-ETHOXYCOUMARIN; ANILINE DERIVATIVE; COUMARIN DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; N DEMETHYLASE; OXIDOREDUCTASE; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ARTICLE; CONTROLLED STUDY; DRUG HYDROXYLATION; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME RECONSTITUTION; HUMAN; HUMAN TISSUE; LIVER MICROSOME METABOLISM; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RABBIT; RAT; DRUG ANTAGONISM; KINETICS; LIVER MICROSOME; METABOLISM; OXIDATION REDUCTION REACTION;

ANILINE COMPOUNDS; CHLORZOXAZONE; COUMARINS; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES B5; DIMETHYLNITROSAMINE; HUMANS; KINETICS; MICROSOMES, LIVER; NADH, NADPH OXIDOREDUCTASES; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; OXIDOREDUCTASES; OXIDOREDUCTASES, N-DEMETHYLATING; RECOMBINANT PROTEINS;

EID: 0030602654     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00208-0     Document Type: Article

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