Cytochrome b5 increases the rate of product formation by cytochrome P450 2B4 and competes with cytochrome P450 reductase for a binding site on cytochrome P450 2B4

Journal of Biological Chemistry

Volumn 282, Issue 41, 2007, Pages 29766-29776

  Zhang, Haoming ^a   Im, Sang Choul ^a   Waskell, Lucy ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b 3495 Bailey Ave Buffalo N   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYST ACTIVITY; DRUG PRODUCTS; RATE CONSTANTS;

CATALYTIC CYCLE; CYTOCHROME; MOLAR RATIO;

ENZYMES;

CYTOCHROME B5; CYTOCHROME P450 2B4; CYTOCHROME P450 REDUCTASE; BENZPHETAMINE; CYCLOHEXANOL DERIVATIVE; CYTOCHROME P 450 CYP2B4 (RABBIT); CYTOCHROME P-450 CYP2B4 (RABBIT); DRUG DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NORBENZPHETAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BINDING SITE; CATALYSIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME SUBSTRATE; ENZYME SYNTHESIS; PRIORITY JOURNAL; STEADY STATE; ANIMAL; BINDING COMPETITION; CHEMISTRY; ENZYME SPECIFICITY; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; RABBIT; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZPHETAMINE; BINDING SITES; BINDING, COMPETITIVE; CHROMATOGRAPHY, LIQUID; CYCLOHEXANOLS; CYTOCHROMES B5; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MASS SPECTROMETRY; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; RABBITS; RATS; SUBSTRATE SPECIFICITY;

EID: 35648963202     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703845200     Document Type: Article

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