Allosteric activation of cytochrome P450 3A4 by α-naphthoflavone: Branch point regulation revealed by isotope dilution analysis

Biochemistry

Volumn 50, Issue 46, 2011, Pages 10041-10051

  Woods, Caleb M ^a   Fernandez, Cristina ^a   Kunze, Kent L ^a   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC ACTIVATION; ALLOSTERIC EFFECT; ALLOSTERIC EFFECTORS; BRANCH POINTS; COOPERATIVITY; COUPLING EFFICIENCY; CYTOCHROME P450-3A4; IN-VITRO; ISOTOPE DILUTION ANALYSIS; KINETIC MODELS; NILE RED; RAPID EQUILIBRIUM; SPECTROSCOPIC INVESTIGATIONS;

ACTIVATION ANALYSIS; CATALYSIS; DEUTERIUM; ENZYMES; METABOLISM; METABOLITES; PHYSIOLOGY;

SUBSTRATES;

ALPHA NAPHTHOFLAVONE; CYTOCHROME P450 3A4; DEUTERIUM; DYE; NILE RED; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DILUTION; METABOLISM; PRIORITY JOURNAL;

ALLOSTERIC REGULATION; CYTOCHROME P-450 CYP3A; DEUTERIUM; HUMANS; INDICATOR DILUTION TECHNIQUES; KINETICS; OXAZINES;

EID: 81255195359     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2013454     Document Type: Article

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