Enhanced interferon-β production by CHO cells through elevated osmolality and reduced culture temperature

Biotechnology Progress

Volumn 25, Issue 5, 2009, Pages 1440-1447

  Han, Young Kue ^a   Koo, Tai Young ^b   Lee, Gyun Min ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Daewoong Pharmaceutical Co Ltd   (South Korea)

Author keywords

CHO cells; Hyperosmolality; Hypothermia; Interferon ; Molecular aggregation

Indexed keywords

BIPHASIC; CELL CONCENTRATIONS; CHO CELL; CHO CELLS; CONTROL BATCH; CULTURE TEMPERATURE; EFFICIENT PRODUCTION; GROWTH SUPPRESSIONS; HYPEROSMOLALITY; MOLECULAR AGGREGATION; OSMOLALITY;

ANTIBIOTICS; BATCH CELL CULTURE; CELL MEMBRANES; GLYCOPROTEINS; HYPOTHERMIA;

CELL CULTURE;

BETA INTERFERON; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; CELL FREE SYSTEM; CELL PROLIFERATION; CELL SURVIVAL; CHO CELL; CRICETULUS; CULTURE TECHNIQUE; GENETICS; HAMSTER; HUMAN; METABOLISM; METHODOLOGY; OSMOLARITY; PROTEIN MULTIMERIZATION; TEMPERATURE;

ANIMALS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELL SURVIVAL; CELL-FREE SYSTEM; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; INTERFERON-BETA; OSMOLAR CONCENTRATION; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; TEMPERATURE;

BACTERIA (MICROORGANISMS);

EID: 70350141643     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1002/btpr.234     Document Type: Article

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