메뉴 건너뛰기




Volumn 9, Issue , 2012, Pages

Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord

Author keywords

Extracellular signal regulated kinase; Inflammation; Metabotropic glutamate receptor 5; Tongue pain; Trigeminal subnucleus caudalis; Upper cervical spinal cord

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; METABOTROPIC RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 84869888652     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-258     Document Type: Article
Times cited : (22)

References (81)
  • 1
    • 0034948349 scopus 로고    scopus 로고
    • Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation. Implications for persistent temporomandibular pain
    • 10.1159/000047887, 11455119
    • Imbe H, Iwata K, Zhou QQ, Zou S, Dubner R, Ren K. Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation. Implications for persistent temporomandibular pain. Cells Tissues Organs 2001, 169:238-247. 10.1159/000047887, 11455119.
    • (2001) Cells Tissues Organs , vol.169 , pp. 238-247
    • Imbe, H.1    Iwata, K.2    Zhou, Q.Q.3    Zou, S.4    Dubner, R.5    Ren, K.6
  • 2
    • 8844255512 scopus 로고    scopus 로고
    • Brainstem mechanisms of persistent pain following injury
    • Dubner R, Ren K. Brainstem mechanisms of persistent pain following injury. J Orofac Pain 2004, 18:299-305.
    • (2004) J Orofac Pain , vol.18 , pp. 299-305
    • Dubner, R.1    Ren, K.2
  • 3
    • 0033140059 scopus 로고    scopus 로고
    • Central nervous system plasticity and persistent pain
    • Ren K, Dubner R. Central nervous system plasticity and persistent pain. J Orofac Pain 1999, 13:155-163.
    • (1999) J Orofac Pain , vol.13 , pp. 155-163
    • Ren, K.1    Dubner, R.2
  • 4
    • 0033588931 scopus 로고    scopus 로고
    • Persistent Fos protein expression after orofacial deep or cutaneous tissue inflammation in rats: implications for persistent orofacial pain
    • 10.1002/(SICI)1096-9861(19990920)412:2<276::AID-CNE7>3.0.CO;2-9, 10441756
    • Zhou Q, Imbe H, Dubner R, Ren K. Persistent Fos protein expression after orofacial deep or cutaneous tissue inflammation in rats: implications for persistent orofacial pain. J Comp Neurol 1999, 412:276-291. 10.1002/(SICI)1096-9861(19990920)412:2<276::AID-CNE7>3.0.CO;2-9, 10441756.
    • (1999) J Comp Neurol , vol.412 , pp. 276-291
    • Zhou, Q.1    Imbe, H.2    Dubner, R.3    Ren, K.4
  • 5
    • 0032872123 scopus 로고    scopus 로고
    • Medullary dorsal horn neuronal activity in rats with persistent temporomandibular joint and perioral inflammation
    • Iwata K, Tashiro A, Tsuboi Y, Imai T, Sumino R, Morimoto T, Dubner R, Ren K. Medullary dorsal horn neuronal activity in rats with persistent temporomandibular joint and perioral inflammation. J Neurophysiol 1999, 82:1244-1253.
    • (1999) J Neurophysiol , vol.82 , pp. 1244-1253
    • Iwata, K.1    Tashiro, A.2    Tsuboi, Y.3    Imai, T.4    Sumino, R.5    Morimoto, T.6    Dubner, R.7    Ren, K.8
  • 6
    • 77649291914 scopus 로고    scopus 로고
    • Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors
    • 10.1186/1744-8069-5-75, 2806354, 20025765
    • Shimizu K, Guo W, Wang H, Zou S, LaGraize SC, Iwata K, Wei F, Dubner R, Ren K. Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors. Mol Pain 2009, 5:75. 10.1186/1744-8069-5-75, 2806354, 20025765.
    • (2009) Mol Pain , vol.5 , pp. 75
    • Shimizu, K.1    Guo, W.2    Wang, H.3    Zou, S.4    LaGraize, S.C.5    Iwata, K.6    Wei, F.7    Dubner, R.8    Ren, K.9
  • 7
    • 18244387226 scopus 로고    scopus 로고
    • Peripheral and central mechanisms of orofacial pain and their clinical correlates
    • Sessle BJ. Peripheral and central mechanisms of orofacial pain and their clinical correlates. Minerva Anestesiol 2005, 71:117-136.
    • (2005) Minerva Anestesiol , vol.71 , pp. 117-136
    • Sessle, B.J.1
  • 8
    • 67649097093 scopus 로고    scopus 로고
    • Effects of systemic bicuculline or morphine on formalin-evoked pain-related behaviour and c-Fos expression in trigeminal nuclei after formalin injection into the lip or tongue in rats
    • 10.1007/s00221-009-1842-1, 19462165
    • Sugiyo S, Uehashi D, Satoh F, Abe T, Yonehara N, Kobayashi M, Takemura M. Effects of systemic bicuculline or morphine on formalin-evoked pain-related behaviour and c-Fos expression in trigeminal nuclei after formalin injection into the lip or tongue in rats. Exp Brain Res 2009, 196:229-237. 10.1007/s00221-009-1842-1, 19462165.
    • (2009) Exp Brain Res , vol.196 , pp. 229-237
    • Sugiyo, S.1    Uehashi, D.2    Satoh, F.3    Abe, T.4    Yonehara, N.5    Kobayashi, M.6    Takemura, M.7
  • 9
    • 0022500752 scopus 로고
    • Cell size analysis of trigeminal primary afferent neurons comprizing individual peripheral branches of the rat mandibular nerve
    • 10.1016/0014-4886(86)90176-7, 3743702
    • Sugimoto T, Takemura M, Sakai A, Ishimaru M. Cell size analysis of trigeminal primary afferent neurons comprizing individual peripheral branches of the rat mandibular nerve. Exp Neurol 1986, 93:565-573. 10.1016/0014-4886(86)90176-7, 3743702.
    • (1986) Exp Neurol , vol.93 , pp. 565-573
    • Sugimoto, T.1    Takemura, M.2    Sakai, A.3    Ishimaru, M.4
  • 10
    • 0025975302 scopus 로고
    • Difference in central projection of primary afferents innervating facial and intraoral structures in the rat
    • 10.1016/0014-4886(91)90099-X, 1705521
    • Takemura M, Sugimoto T, Shigenaga Y. Difference in central projection of primary afferents innervating facial and intraoral structures in the rat. Exp Neurol 1991, 111:324-331. 10.1016/0014-4886(91)90099-X, 1705521.
    • (1991) Exp Neurol , vol.111 , pp. 324-331
    • Takemura, M.1    Sugimoto, T.2    Shigenaga, Y.3
  • 11
    • 80053352350 scopus 로고    scopus 로고
    • Involvement of peripheral ionotropic glutamate receptors in orofacial thermal hyperalgesia in rats
    • 10.1186/1744-8069-7-75, 3216263, 21952000
    • Honda K, Noma N, Shinoda M, Miyamoto M, Katagiri A, Kita D, Liu MG, Sessle BJ, Yasuda M, Iwata K. Involvement of peripheral ionotropic glutamate receptors in orofacial thermal hyperalgesia in rats. Mol Pain 2011, 7:75. 10.1186/1744-8069-7-75, 3216263, 21952000.
    • (2011) Mol Pain , vol.7 , pp. 75
    • Honda, K.1    Noma, N.2    Shinoda, M.3    Miyamoto, M.4    Katagiri, A.5    Kita, D.6    Liu, M.G.7    Sessle, B.J.8    Yasuda, M.9    Iwata, K.10
  • 12
    • 40949110122 scopus 로고    scopus 로고
    • Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats
    • 10.1002/cne.21620, 18196540
    • Noma N, Tsuboi Y, Kondo M, Matsumoto M, Sessle BJ, Kitagawa J, Saito K, Iwata K. Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats. J Comp Neurol 2008, 507:1428-1440. 10.1002/cne.21620, 18196540.
    • (2008) J Comp Neurol , vol.507 , pp. 1428-1440
    • Noma, N.1    Tsuboi, Y.2    Kondo, M.3    Matsumoto, M.4    Sessle, B.J.5    Kitagawa, J.6    Saito, K.7    Iwata, K.8
  • 13
    • 2342441834 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases as potential targets for pain killers
    • Ji RR. Mitogen-activated protein kinases as potential targets for pain killers. Curr Opin Investig Drugs 2004, 5:71-75.
    • (2004) Curr Opin Investig Drugs , vol.5 , pp. 71-75
    • Ji, R.R.1
  • 14
    • 63449113568 scopus 로고    scopus 로고
    • MAP kinase and pain
    • 10.1016/j.brainresrev.2008.12.011, 2666786, 19150373
    • Ji RR, Gereau RW, Malcangio M, Strichartz GR. MAP kinase and pain. Brain Res Rev 2009, 60:135-148. 10.1016/j.brainresrev.2008.12.011, 2666786, 19150373.
    • (2009) Brain Res Rev , vol.60 , pp. 135-148
    • Ji, R.R.1    Gereau, R.W.2    Malcangio, M.3    Strichartz, G.R.4
  • 15
    • 14044252008 scopus 로고    scopus 로고
    • ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    • 10.1016/j.pain.2004.12.022, 15733640
    • Zhuang ZY, Gerner P, Woolf CJ, Ji RR. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 2005, 114:149-159. 10.1016/j.pain.2004.12.022, 15733640.
    • (2005) Pain , vol.114 , pp. 149-159
    • Zhuang, Z.Y.1    Gerner, P.2    Woolf, C.J.3    Ji, R.R.4
  • 16
    • 34548069198 scopus 로고    scopus 로고
    • Region- or state-related differences in expression and activation of extracellular signal-regulated kinases (ERKs) in naive and pain-experiencing rats
    • 10.1186/1471-2202-8-53, 1949833, 17650295
    • Guo SW, Liu MG, Long YL, Ren LY, Lu ZM, Yu HY, Hou JF, Li H, Gao CY, Cui XY, An YY, Li J, Zhao LF, Chen J. Region- or state-related differences in expression and activation of extracellular signal-regulated kinases (ERKs) in naive and pain-experiencing rats. BMC Neurosci 2007, 8:53. 10.1186/1471-2202-8-53, 1949833, 17650295.
    • (2007) BMC Neurosci , vol.8 , pp. 53
    • Guo, S.W.1    Liu, M.G.2    Long, Y.L.3    Ren, L.Y.4    Lu, Z.M.5    Yu, H.Y.6    Hou, J.F.7    Li, H.8    Gao, C.Y.9    Cui, X.Y.10    An, Y.Y.11    Li, J.12    Zhao, L.F.13    Chen, J.14
  • 17
    • 79952533846 scopus 로고    scopus 로고
    • Differential roles of ERK, JNK and p38 MAPK in pain-related spatial and temporal enhancement of synaptic responses in the hippocampal formation of rats: multi-electrode array recordings
    • Liu MG, Wang RR, Chen XF, Zhang FK, Cui XY, Chen J. Differential roles of ERK, JNK and p38 MAPK in pain-related spatial and temporal enhancement of synaptic responses in the hippocampal formation of rats: multi-electrode array recordings. Brain Res 2011, 1382:57-69.
    • (2011) Brain Res , vol.1382 , pp. 57-69
    • Liu, M.G.1    Wang, R.R.2    Chen, X.F.3    Zhang, F.K.4    Cui, X.Y.5    Chen, J.6
  • 18
    • 41549147221 scopus 로고    scopus 로고
    • Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia
    • 10.1016/j.neuroscience.2007.12.038, 18329815
    • Hao J, Liu MG, Yu YQ, Cao FL, Li Z, Lu ZM, Chen J. Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia. Neuroscience 2008, 152:1067-1075. 10.1016/j.neuroscience.2007.12.038, 18329815.
    • (2008) Neuroscience , vol.152 , pp. 1067-1075
    • Hao, J.1    Liu, M.G.2    Yu, Y.Q.3    Cao, F.L.4    Li, Z.5    Lu, Z.M.6    Chen, J.7
  • 20
    • 63549132991 scopus 로고    scopus 로고
    • Mechanisms involved in an increment of multimodal excitability of medullary and upper cervical dorsal horn neurons following cutaneous capsaicin treatment
    • 10.1186/1744-8069-4-59, 2661045, 19019214
    • Honda K, Kitagawa J, Sessle BJ, Kondo M, Tsuboi Y, Yonehara Y, Iwata K. Mechanisms involved in an increment of multimodal excitability of medullary and upper cervical dorsal horn neurons following cutaneous capsaicin treatment. Mol Pain 2008, 4:59. 10.1186/1744-8069-4-59, 2661045, 19019214.
    • (2008) Mol Pain , vol.4 , pp. 59
    • Honda, K.1    Kitagawa, J.2    Sessle, B.J.3    Kondo, M.4    Tsuboi, Y.5    Yonehara, Y.6    Iwata, K.7
  • 21
    • 80053265875 scopus 로고    scopus 로고
    • Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis, upper cervical cord, NTS and Pa5 following capsaicin injection into masticatory and swallowing-related muscles in rats
    • Tsujimura T, Shinoda M, Honda K, Hitomi S, Kiyomoto M, Matsuura S, Katagiri A, Tsuji K, Inoue M, Shiga Y, Iwata K. Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis, upper cervical cord, NTS and Pa5 following capsaicin injection into masticatory and swallowing-related muscles in rats. Brain Res 2011, 1417:45-54.
    • (2011) Brain Res , vol.1417 , pp. 45-54
    • Tsujimura, T.1    Shinoda, M.2    Honda, K.3    Hitomi, S.4    Kiyomoto, M.5    Matsuura, S.6    Katagiri, A.7    Tsuji, K.8    Inoue, M.9    Shiga, Y.10    Iwata, K.11
  • 22
    • 84859919621 scopus 로고    scopus 로고
    • Organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis and upper cervical spinal cord associated with orofacial neuropathic pain
    • Shibuta K, Suzuki I, Shinoda M, Tsuboi Y, Honda K, Shimizu N, Sessle BJ, Iwata K. Organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis and upper cervical spinal cord associated with orofacial neuropathic pain. Brain Res 2012, 1451:74-86.
    • (2012) Brain Res , vol.1451 , pp. 74-86
    • Shibuta, K.1    Suzuki, I.2    Shinoda, M.3    Tsuboi, Y.4    Honda, K.5    Shimizu, N.6    Sessle, B.J.7    Iwata, K.8
  • 23
    • 79751529383 scopus 로고    scopus 로고
    • Mechanisms involved in extraterritorial facial pain following cervical spinal nerve injury in rats
    • 10.1186/1744-8069-7-12, 3048571, 21310020
    • Kobayashi A, Shinoda M, Sessle BJ, Honda K, Imamura Y, Hitomi S, Tsuboi Y, Okada-Ogawa A, Iwata K. Mechanisms involved in extraterritorial facial pain following cervical spinal nerve injury in rats. Mol Pain 2011, 7:12. 10.1186/1744-8069-7-12, 3048571, 21310020.
    • (2011) Mol Pain , vol.7 , pp. 12
    • Kobayashi, A.1    Shinoda, M.2    Sessle, B.J.3    Honda, K.4    Imamura, Y.5    Hitomi, S.6    Tsuboi, Y.7    Okada-Ogawa, A.8    Iwata, K.9
  • 24
    • 32844458553 scopus 로고    scopus 로고
    • Phosphorylation of extracellular signal-regulated kinase in medullary and upper cervical cord neurons following noxious tooth pulp stimulation
    • 10.1016/j.brainres.2005.12.040, 16442086
    • Shimizu K, Asano M, Kitagawa J, Ogiso B, Ren K, Oki H, Matsumoto M, Iwata K. Phosphorylation of extracellular signal-regulated kinase in medullary and upper cervical cord neurons following noxious tooth pulp stimulation. Brain Res 2006, 1072:99-109. 10.1016/j.brainres.2005.12.040, 16442086.
    • (2006) Brain Res , vol.1072 , pp. 99-109
    • Shimizu, K.1    Asano, M.2    Kitagawa, J.3    Ogiso, B.4    Ren, K.5    Oki, H.6    Matsumoto, M.7    Iwata, K.8
  • 25
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn PJ, Pin JP. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev PharmacolToxicol 1997, 37:205-237.
    • (1997) Annu Rev PharmacolToxicol , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.P.2
  • 26
    • 5644256896 scopus 로고    scopus 로고
    • Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia
    • 10.1523/JNEUROSCI.3422-04.2004, 15483135
    • Guo W, Wei F, Zou S, Robbins MT, Sugiyo S, Ikeda T, Tu JC, Worley PF, Dubner R, Ren K. Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia. J Neurosci 2004, 24:9161-9173. 10.1523/JNEUROSCI.3422-04.2004, 15483135.
    • (2004) J Neurosci , vol.24 , pp. 9161-9173
    • Guo, W.1    Wei, F.2    Zou, S.3    Robbins, M.T.4    Sugiyo, S.5    Ikeda, T.6    Tu, J.C.7    Worley, P.F.8    Dubner, R.9    Ren, K.10
  • 27
    • 71649094290 scopus 로고    scopus 로고
    • Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain
    • 10.1111/j.1471-4159.2009.06437.x, 2900839, 19840219
    • Li JQ, Chen SR, Chen H, Cai YQ, Pan HL. Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain. J Neurochem 2010, 112:162-172. 10.1111/j.1471-4159.2009.06437.x, 2900839, 19840219.
    • (2010) J Neurochem , vol.112 , pp. 162-172
    • Li, J.Q.1    Chen, S.R.2    Chen, H.3    Cai, Y.Q.4    Pan, H.L.5
  • 28
    • 63349093027 scopus 로고    scopus 로고
    • Imbalance between excitatory and inhibitory amino acids at spinal level is associated with maintenance of persistent pain-related behaviors
    • 10.1016/j.phrs.2009.01.012, 19416628
    • Yan LH, Hou JF, Liu MG, Li MM, Cui XY, Lu ZM, Zhang FK, An YY, Shi L, Chen J. Imbalance between excitatory and inhibitory amino acids at spinal level is associated with maintenance of persistent pain-related behaviors. Pharmacol Res 2009, 59:290-299. 10.1016/j.phrs.2009.01.012, 19416628.
    • (2009) Pharmacol Res , vol.59 , pp. 290-299
    • Yan, L.H.1    Hou, J.F.2    Liu, M.G.3    Li, M.M.4    Cui, X.Y.5    Lu, Z.M.6    Zhang, F.K.7    An, Y.Y.8    Shi, L.9    Chen, J.10
  • 29
    • 0029834434 scopus 로고    scopus 로고
    • Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists
    • 10.1097/00001756-199611040-00067, 8981459
    • Fisher K, Coderre TJ. Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists. Neuroreport 1996, 7:2743-2747. 10.1097/00001756-199611040-00067, 8981459.
    • (1996) Neuroreport , vol.7 , pp. 2743-2747
    • Fisher, K.1    Coderre, T.J.2
  • 30
    • 0032550134 scopus 로고    scopus 로고
    • Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats
    • 10.1097/00001756-199804200-00038, 9601688
    • Fisher K, Coderre TJ. Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats. Neuroreport 1998, 9:1169-1172. 10.1097/00001756-199804200-00038, 9601688.
    • (1998) Neuroreport , vol.9 , pp. 1169-1172
    • Fisher, K.1    Coderre, T.J.2
  • 31
    • 27644469440 scopus 로고    scopus 로고
    • Role of peripheral group I and II metabotropic glutamate receptors in IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats
    • 10.1016/j.pain.2005.07.017, 16154694
    • Ahn DK, Kim KH, Jung CY, Choi HS, Lim EJ, Youn DH, Bae YC. Role of peripheral group I and II metabotropic glutamate receptors in IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats. Pain 2005, 118:53-60. 10.1016/j.pain.2005.07.017, 16154694.
    • (2005) Pain , vol.118 , pp. 53-60
    • Ahn, D.K.1    Kim, K.H.2    Jung, C.Y.3    Choi, H.S.4    Lim, E.J.5    Youn, D.H.6    Bae, Y.C.7
  • 32
    • 34247543018 scopus 로고    scopus 로고
    • Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms
    • 10.1016/j.neuroscience.2007.01.015, 17306466
    • Lee JS, Ro JY. Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms. Neuroscience 2007, 146:375-383. 10.1016/j.neuroscience.2007.01.015, 17306466.
    • (2007) Neuroscience , vol.146 , pp. 375-383
    • Lee, J.S.1    Ro, J.Y.2
  • 33
    • 15244346364 scopus 로고    scopus 로고
    • Characterization of long-term potentiation of primary afferent transmission at trigeminal synapses of juvenile rats: essential role of subtype 5 metabotropic glutamate receptors
    • 10.1016/j.pain.2005.01.008, 15777867
    • Liang YC, Huang CC, Hsu KS. Characterization of long-term potentiation of primary afferent transmission at trigeminal synapses of juvenile rats: essential role of subtype 5 metabotropic glutamate receptors. Pain 2005, 114:417-428. 10.1016/j.pain.2005.01.008, 15777867.
    • (2005) Pain , vol.114 , pp. 417-428
    • Liang, Y.C.1    Huang, C.C.2    Hsu, K.S.3
  • 34
    • 4344648261 scopus 로고    scopus 로고
    • Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation
    • 10.1016/j.pain.2004.06.009, 15327816
    • Adwanikar H, Karim F, Gereau RW. Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation. Pain 2004, 111:125-135. 10.1016/j.pain.2004.06.009, 15327816.
    • (2004) Pain , vol.111 , pp. 125-135
    • Adwanikar, H.1    Karim, F.2    Gereau, R.W.3
  • 35
    • 36849083576 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons
    • 10.1523/JNEUROSCI.0269-07.2007, 18045912
    • Hu HJ, Alter BJ, Carrasquillo Y, Qiu CS, Gereau RW. Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. J Neurosci 2007, 27:13181-13191. 10.1523/JNEUROSCI.0269-07.2007, 18045912.
    • (2007) J Neurosci , vol.27 , pp. 13181-13191
    • Hu, H.J.1    Alter, B.J.2    Carrasquillo, Y.3    Qiu, C.S.4    Gereau, R.W.5
  • 36
    • 0035371317 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
    • Karim F, Wang CC, Gereau RW. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J Neurosci 2001, 21:3771-3779.
    • (2001) J Neurosci , vol.21 , pp. 3771-3779
    • Karim, F.1    Wang, C.C.2    Gereau, R.W.3
  • 37
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • 10.1016/0304-3959(83)90201-4, 6877845
    • Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110. 10.1016/0304-3959(83)90201-4, 6877845.
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1
  • 38
    • 0029166667 scopus 로고
    • A synthetic inhibitor of the mitogen-activated protein kinase cascade
    • 10.1073/pnas.92.17.7686, 41210, 7644477
    • Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A 1995, 92:7686-7689. 10.1073/pnas.92.17.7686, 41210, 7644477.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 7686-7689
    • Dudley, D.T.1    Pang, L.2    Decker, S.J.3    Bridges, A.J.4    Saltiel, A.R.5
  • 40
    • 0033763535 scopus 로고    scopus 로고
    • MGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia
    • 10.1016/S0028-3908(00)00114-3, 11077066
    • Walker K, Reeve A, Bowes M, Winter J, Wotherspoon G, Davis A, Schmid P, Gasparini F, Kuhn R, Urban L. mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia. Neuropharmacology 2001, 40:10-19. 10.1016/S0028-3908(00)00114-3, 11077066.
    • (2001) Neuropharmacology , vol.40 , pp. 10-19
    • Walker, K.1    Reeve, A.2    Bowes, M.3    Winter, J.4    Wotherspoon, G.5    Davis, A.6    Schmid, P.7    Gasparini, F.8    Kuhn, R.9    Urban, L.10
  • 41
    • 47549118674 scopus 로고    scopus 로고
    • Modulation of trigeminal spinal subnucleus caudalis neuronal activity following regeneration of transected inferior alveolar nerve in rats
    • 10.1152/jn.00794.2007, 18337368
    • Saito K, Hitomi S, Suzuki I, Masuda Y, Kitagawa J, Tsuboi Y, Kondo M, Sessle BJ, Iwata K. Modulation of trigeminal spinal subnucleus caudalis neuronal activity following regeneration of transected inferior alveolar nerve in rats. J Neurophysiol 2008, 99:2251-2263. 10.1152/jn.00794.2007, 18337368.
    • (2008) J Neurophysiol , vol.99 , pp. 2251-2263
    • Saito, K.1    Hitomi, S.2    Suzuki, I.3    Masuda, Y.4    Kitagawa, J.5    Tsuboi, Y.6    Kondo, M.7    Sessle, B.J.8    Iwata, K.9
  • 43
    • 43949146604 scopus 로고    scopus 로고
    • Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury
    • 10.1016/j.neuroscience.2008.03.041, 18440713
    • Terayama R, Omura S, Fujisawa N, Yamaai T, Ichikawa H, Sugimoto T. Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury. Neuroscience 2008, 153:1245-1255. 10.1016/j.neuroscience.2008.03.041, 18440713.
    • (2008) Neuroscience , vol.153 , pp. 1245-1255
    • Terayama, R.1    Omura, S.2    Fujisawa, N.3    Yamaai, T.4    Ichikawa, H.5    Sugimoto, T.6
  • 45
    • 0036710955 scopus 로고    scopus 로고
    • Sensory dysfunction in burning mouth syndrome
    • 10.1016/S0304-3959(02)00052-0, 12237182
    • Forssell H, Jaaskelainen S, Tenovuo O, Hinkka S. Sensory dysfunction in burning mouth syndrome. Pain 2002, 99:41-47. 10.1016/S0304-3959(02)00052-0, 12237182.
    • (2002) Pain , vol.99 , pp. 41-47
    • Forssell, H.1    Jaaskelainen, S.2    Tenovuo, O.3    Hinkka, S.4
  • 46
    • 4444227231 scopus 로고    scopus 로고
    • The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret
    • 10.1016/j.pain.2004.07.008, 15363869
    • Yates JM, Smith KG, Robinson PP. The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret. Pain 2004, 111:261-269. 10.1016/j.pain.2004.07.008, 15363869.
    • (2004) Pain , vol.111 , pp. 261-269
    • Yates, J.M.1    Smith, K.G.2    Robinson, P.P.3
  • 47
    • 0034683187 scopus 로고    scopus 로고
    • Ectopic neural activity from myelinated afferent fibres in the lingual nerve of the ferret following three types of injury
    • 10.1016/S0006-8993(00)02547-6, 10936222
    • Yates JM, Smith KG, Robinson PP. Ectopic neural activity from myelinated afferent fibres in the lingual nerve of the ferret following three types of injury. Brain Res 2000, 874:37-47. 10.1016/S0006-8993(00)02547-6, 10936222.
    • (2000) Brain Res , vol.874 , pp. 37-47
    • Yates, J.M.1    Smith, K.G.2    Robinson, P.P.3
  • 48
    • 33751428701 scopus 로고    scopus 로고
    • Changes in vanilloid receptor 1 (TRPV1) expression following lingual nerve injury
    • 10.1016/j.ejpain.2006.02.004, 16542859
    • Biggs JE, Yates JM, Loescher AR, Clayton NM, Boissonade FM, Robinson PP. Changes in vanilloid receptor 1 (TRPV1) expression following lingual nerve injury. Eur J Pain 2007, 11:192-201. 10.1016/j.ejpain.2006.02.004, 16542859.
    • (2007) Eur J Pain , vol.11 , pp. 192-201
    • Biggs, J.E.1    Yates, J.M.2    Loescher, A.R.3    Clayton, N.M.4    Boissonade, F.M.5    Robinson, P.P.6
  • 51
    • 84859073175 scopus 로고    scopus 로고
    • Satellite glial cell P2Y12 receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats
    • 10.1186/1744-8069-8-23, 3386019, 22458630
    • Katagiri A, Shinoda M, Honda K, Toyofuku A, Sessle BJ, Iwata K. Satellite glial cell P2Y12 receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats. Mol Pain 2012, 8:23. 10.1186/1744-8069-8-23, 3386019, 22458630.
    • (2012) Mol Pain , vol.8 , pp. 23
    • Katagiri, A.1    Shinoda, M.2    Honda, K.3    Toyofuku, A.4    Sessle, B.J.5    Iwata, K.6
  • 52
    • 20444453576 scopus 로고    scopus 로고
    • Changes in P2X3 receptor expression in the trigeminal ganglion following monoarthritis of the temporomandibular joint in rats
    • 10.1016/j.pain.2005.03.042, 15936887
    • Shinoda M, Ozaki N, Asai H, Nagamine K, Sugiura Y. Changes in P2X3 receptor expression in the trigeminal ganglion following monoarthritis of the temporomandibular joint in rats. Pain 2005, 116:42-51. 10.1016/j.pain.2005.03.042, 15936887.
    • (2005) Pain , vol.116 , pp. 42-51
    • Shinoda, M.1    Ozaki, N.2    Asai, H.3    Nagamine, K.4    Sugiura, Y.5
  • 53
    • 70449527665 scopus 로고    scopus 로고
    • Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons
    • 10.1016/j.neuroscience.2009.09.058, 2813765, 19786077
    • Tashiro A, Okamoto K, Bereiter DA. Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons. Neuroscience 2009, 164:1813-1820. 10.1016/j.neuroscience.2009.09.058, 2813765, 19786077.
    • (2009) Neuroscience , vol.164 , pp. 1813-1820
    • Tashiro, A.1    Okamoto, K.2    Bereiter, D.A.3
  • 54
    • 56349156480 scopus 로고    scopus 로고
    • Modulation of paratrigeminal nociceptive neurons following temporomandibular joint inflammation in rats
    • 10.1016/j.expneurol.2008.08.005, 2684032, 18778706
    • Yamazaki Y, Ren K, Shimada M, Iwata K. Modulation of paratrigeminal nociceptive neurons following temporomandibular joint inflammation in rats. Exp Neurol 2008, 214:209-218. 10.1016/j.expneurol.2008.08.005, 2684032, 18778706.
    • (2008) Exp Neurol , vol.214 , pp. 209-218
    • Yamazaki, Y.1    Ren, K.2    Shimada, M.3    Iwata, K.4
  • 55
    • 35448947941 scopus 로고    scopus 로고
    • Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression
    • 10.1016/j.neuroscience.2007.07.058, 2196131, 17928159
    • Ambalavanar R, Yallampalli C, Yallampalli U, Dessem D. Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression. Neuroscience 2007, 149:650-659. 10.1016/j.neuroscience.2007.07.058, 2196131, 17928159.
    • (2007) Neuroscience , vol.149 , pp. 650-659
    • Ambalavanar, R.1    Yallampalli, C.2    Yallampalli, U.3    Dessem, D.4
  • 56
    • 28844437127 scopus 로고    scopus 로고
    • Trigeminal transition zone/rostral ventromedial medulla connections and facilitation of orofacial hyperalgesia after masseter inflammation in rats
    • 10.1002/cne.20797, 16304628
    • Sugiyo S, Takemura M, Dubner R, Ren K. Trigeminal transition zone/rostral ventromedial medulla connections and facilitation of orofacial hyperalgesia after masseter inflammation in rats. J Comp Neurol 2005, 493:510-523. 10.1002/cne.20797, 16304628.
    • (2005) J Comp Neurol , vol.493 , pp. 510-523
    • Sugiyo, S.1    Takemura, M.2    Dubner, R.3    Ren, K.4
  • 57
    • 79956299813 scopus 로고    scopus 로고
    • Nerve growth factor contribution via transient receptor potential vanilloid 1 to ectopic orofacial pain
    • 10.1523/JNEUROSCI.0481-11.2011, 21562277
    • Shinoda M, Asano M, Omagari D, Honda K, Hitomi S, Katagiri A, Iwata K. Nerve growth factor contribution via transient receptor potential vanilloid 1 to ectopic orofacial pain. J Neurosci 2011, 31:7145-7155. 10.1523/JNEUROSCI.0481-11.2011, 21562277.
    • (2011) J Neurosci , vol.31 , pp. 7145-7155
    • Shinoda, M.1    Asano, M.2    Omagari, D.3    Honda, K.4    Hitomi, S.5    Katagiri, A.6    Iwata, K.7
  • 58
    • 44249111187 scopus 로고    scopus 로고
    • Characterization of a model of chronic orofacial hyperalgesia in the rat: contribution of NA(V) 1.8
    • 10.1016/j.jpain.2008.01.326, 18337185
    • Morgan JR, Gebhart GF. Characterization of a model of chronic orofacial hyperalgesia in the rat: contribution of NA(V) 1.8. J Pain 2008, 9:522-531. 10.1016/j.jpain.2008.01.326, 18337185.
    • (2008) J Pain , vol.9 , pp. 522-531
    • Morgan, J.R.1    Gebhart, G.F.2
  • 59
    • 4644324408 scopus 로고    scopus 로고
    • Thermosensation and pain
    • 10.1002/neu.20079, 15362149
    • Tominaga M, Caterina MJ. Thermosensation and pain. J Neurobiol 2004, 61:3-12. 10.1002/neu.20079, 15362149.
    • (2004) J Neurobiol , vol.61 , pp. 3-12
    • Tominaga, M.1    Caterina, M.J.2
  • 60
    • 55349122592 scopus 로고    scopus 로고
    • TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats
    • 10.1113/jphysiol.2008.159731, 2652143, 18755744
    • De Schepper HU, De Winter BY, Van Nassauw L, Timmermans JP, Herman AG, Pelckmans PA, De Man JG. TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats. J Physiol 2008, 586:5247-5258. 10.1113/jphysiol.2008.159731, 2652143, 18755744.
    • (2008) J Physiol , vol.586 , pp. 5247-5258
    • De Schepper, H.U.1    De Winter, B.Y.2    Van Nassauw, L.3    Timmermans, J.P.4    Herman, A.G.5    Pelckmans, P.A.6    De Man, J.G.7
  • 61
    • 58149200910 scopus 로고    scopus 로고
    • Transient receptor potential channels: targeting pain at the source
    • 10.1038/nrd2757, 2755576, 19116627
    • Patapoutian A, Tate S, Woolf CJ. Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov 2009, 8:55-68. 10.1038/nrd2757, 2755576, 19116627.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 55-68
    • Patapoutian, A.1    Tate, S.2    Woolf, C.J.3
  • 62
    • 34447331071 scopus 로고    scopus 로고
    • Differential involvement of TRPV1 receptors at the central and peripheral nerves in CFA-induced mechanical and thermal hyperalgesia
    • Kanai Y, Hara T, Imai A, Sakakibara A. Differential involvement of TRPV1 receptors at the central and peripheral nerves in CFA-induced mechanical and thermal hyperalgesia. J Pharm Pharmacol 2007, 59:733-738.
    • (2007) J Pharm Pharmacol , vol.59 , pp. 733-738
    • Kanai, Y.1    Hara, T.2    Imai, A.3    Sakakibara, A.4
  • 64
    • 23044501630 scopus 로고    scopus 로고
    • Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice
    • 10.1124/jpet.104.082487, 15831443
    • Szabo A, Helyes Z, Sandor K, Bite A, Pinter E, Nemeth J, Banvolgyi A, Bolcskei K, Elekes K, Szolcsanyi J. Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice. J Pharmacol Exp Ther 2005, 314:111-119. 10.1124/jpet.104.082487, 15831443.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 111-119
    • Szabo, A.1    Helyes, Z.2    Sandor, K.3    Bite, A.4    Pinter, E.5    Nemeth, J.6    Banvolgyi, A.7    Bolcskei, K.8    Elekes, K.9    Szolcsanyi, J.10
  • 65
    • 0036938785 scopus 로고    scopus 로고
    • Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn
    • 10.1006/mcne.2002.1205, 12504600
    • Pezet S, Malcangio M, Lever IJ, Perkinton MS, Thompson SW, Williams RJ, McMahon SB. Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn. Mol Cell Neurosci 2002, 21:684-695. 10.1006/mcne.2002.1205, 12504600.
    • (2002) Mol Cell Neurosci , vol.21 , pp. 684-695
    • Pezet, S.1    Malcangio, M.2    Lever, I.J.3    Perkinton, M.S.4    Thompson, S.W.5    Williams, R.J.6    McMahon, S.B.7
  • 66
    • 0033490464 scopus 로고    scopus 로고
    • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    • 10.1038/16040, 10570489
    • Ji RR, Baba H, Brenner GJ, Woolf CJ. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 1999, 2:1114-1119. 10.1038/16040, 10570489.
    • (1999) Nat Neurosci , vol.2 , pp. 1114-1119
    • Ji, R.R.1    Baba, H.2    Brenner, G.J.3    Woolf, C.J.4
  • 67
    • 0036758662 scopus 로고    scopus 로고
    • Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization
    • Dai Y, Iwata K, Fukuoka T, Kondo E, Tokunaga A, Yamanaka H, Tachibana T, Liu Y, Noguchi K. Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization. J Neurosci 2002, 22:7737-7745.
    • (2002) J Neurosci , vol.22 , pp. 7737-7745
    • Dai, Y.1    Iwata, K.2    Fukuoka, T.3    Kondo, E.4    Tokunaga, A.5    Yamanaka, H.6    Tachibana, T.7    Liu, Y.8    Noguchi, K.9
  • 68
    • 0025073139 scopus 로고
    • Contralateral projections of trigeminal mandibular primary afferents in the guinea pig as seen by transganglionic transport of horseradish peroxidase
    • 10.1016/0006-8993(90)91261-E, 2302566
    • Segade LA, Suarez Quintanilla J, Cobos AR. Contralateral projections of trigeminal mandibular primary afferents in the guinea pig as seen by transganglionic transport of horseradish peroxidase. Brain Res 1990, 506:267-280. 10.1016/0006-8993(90)91261-E, 2302566.
    • (1990) Brain Res , vol.506 , pp. 267-280
    • Segade, L.A.1    Suarez Quintanilla, J.2    Cobos, A.R.3
  • 69
    • 0028826021 scopus 로고
    • Brainstem neurons expressing c-Fos immunoreactivity following irritant chemical stimulation of the rat's tongue
    • 10.1016/0306-4522(95)00297-V, 8596661
    • Carstens E, Saxe I, Ralph R. Brainstem neurons expressing c-Fos immunoreactivity following irritant chemical stimulation of the rat's tongue. Neuroscience 1995, 69:939-953. 10.1016/0306-4522(95)00297-V, 8596661.
    • (1995) Neuroscience , vol.69 , pp. 939-953
    • Carstens, E.1    Saxe, I.2    Ralph, R.3
  • 70
    • 33744511186 scopus 로고    scopus 로고
    • The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint
    • 10.1016/j.pain.2006.02.032, 16616417
    • Seino D, Tokunaga A, Tachibana T, Yoshiya S, Dai Y, Obata K, Yamanaka H, Kobayashi K, Noguchi K. The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint. Pain 2006, 123:193-203. 10.1016/j.pain.2006.02.032, 16616417.
    • (2006) Pain , vol.123 , pp. 193-203
    • Seino, D.1    Tokunaga, A.2    Tachibana, T.3    Yoshiya, S.4    Dai, Y.5    Obata, K.6    Yamanaka, H.7    Kobayashi, K.8    Noguchi, K.9
  • 71
    • 0037080003 scopus 로고    scopus 로고
    • ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    • Ji RR, Befort K, Brenner GJ, Woolf CJ. ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci 2002, 22:478-485.
    • (2002) J Neurosci , vol.22 , pp. 478-485
    • Ji, R.R.1    Befort, K.2    Brenner, G.J.3    Woolf, C.J.4
  • 72
    • 0037704450 scopus 로고    scopus 로고
    • Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury
    • Obata K, Yamanaka H, Dai Y, Tachibana T, Fukuoka T, Tokunaga A, Yoshikawa H, Noguchi K. Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury. J Neurosci 2003, 23:4117-4126.
    • (2003) J Neurosci , vol.23 , pp. 4117-4126
    • Obata, K.1    Yamanaka, H.2    Dai, Y.3    Tachibana, T.4    Fukuoka, T.5    Tokunaga, A.6    Yoshikawa, H.7    Noguchi, K.8
  • 73
    • 0035478759 scopus 로고    scopus 로고
    • Peripheral metabotropic glutamate receptors: fight the pain where it hurts
    • 10.1016/S0166-2236(00)02007-5, 11576647
    • Neugebauer V. Peripheral metabotropic glutamate receptors: fight the pain where it hurts. Trends Neurosci 2001, 24:550-552. 10.1016/S0166-2236(00)02007-5, 11576647.
    • (2001) Trends Neurosci , vol.24 , pp. 550-552
    • Neugebauer, V.1
  • 74
    • 0036295881 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors-important modulators of nociception and pain behavior
    • 10.1016/S0304-3959(02)00140-9, 12098611
    • Neugebauer V. Metabotropic glutamate receptors-important modulators of nociception and pain behavior. Pain 2002, 98:1-8. 10.1016/S0304-3959(02)00140-9, 12098611.
    • (2002) Pain , vol.98 , pp. 1-8
    • Neugebauer, V.1
  • 75
    • 0001050064 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics
    • 10.2174/1568007023339300, 12769620
    • Varney MA, Gereau RW. Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics. Curr Drug Targets CNS Neurol Disord 2002, 1:283-296. 10.2174/1568007023339300, 12769620.
    • (2002) Curr Drug Targets CNS Neurol Disord , vol.1 , pp. 283-296
    • Varney, M.A.1    Gereau, R.W.2
  • 76
    • 63449115392 scopus 로고    scopus 로고
    • Metabotropic receptors for glutamate and GABA in pain
    • 10.1016/j.brainresrev.2008.12.007, 19146876
    • Goudet C, Magnaghi V, Landry M, Nagy F, Gereau RW, Pin JP. Metabotropic receptors for glutamate and GABA in pain. Brain Res Rev 2009, 60:43-56. 10.1016/j.brainresrev.2008.12.007, 19146876.
    • (2009) Brain Res Rev , vol.60 , pp. 43-56
    • Goudet, C.1    Magnaghi, V.2    Landry, M.3    Nagy, F.4    Gereau, R.W.5    Pin, J.P.6
  • 77
    • 0026681594 scopus 로고
    • Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction
    • Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. J Biol Chem 1992, 267:13361-13368.
    • (1992) J Biol Chem , vol.267 , pp. 13361-13368
    • Abe, T.1    Sugihara, H.2    Nawa, H.3    Shigemoto, R.4    Mizuno, N.5    Nakanishi, S.6
  • 78
    • 0027378595 scopus 로고
    • Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain
    • 10.1016/0304-3940(93)90227-C, 8295733
    • Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci Lett 1993, 163:53-57. 10.1016/0304-3940(93)90227-C, 8295733.
    • (1993) Neurosci Lett , vol.163 , pp. 53-57
    • Shigemoto, R.1    Nomura, S.2    Ohishi, H.3    Sugihara, H.4    Nakanishi, S.5    Mizuno, N.6
  • 79
    • 0026634872 scopus 로고
    • Neural changes in acute arthritis in monkeys. IV. Time-course of amino acid release into the lumbar dorsal horn
    • Sorkin LS, Westlund KN, Sluka KA, Dougherty PM, Willis WD. Neural changes in acute arthritis in monkeys. IV. Time-course of amino acid release into the lumbar dorsal horn. Brain Res Brain Res Rev 1992, 17:39-50.
    • (1992) Brain Res Brain Res Rev , vol.17 , pp. 39-50
    • Sorkin, L.S.1    Westlund, K.N.2    Sluka, K.A.3    Dougherty, P.M.4    Willis, W.D.5
  • 80
    • 4644312225 scopus 로고    scopus 로고
    • Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    • 10.1523/JNEUROSCI.2396-04.2004, 15385614
    • Kawasaki Y, Kohno T, Zhuang ZY, Brenner GJ, Wang H, Van Der Meer C, Befort K, Woolf CJ, Ji RR. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci 2004, 24:8310-8321. 10.1523/JNEUROSCI.2396-04.2004, 15385614.
    • (2004) J Neurosci , vol.24 , pp. 8310-8321
    • Kawasaki, Y.1    Kohno, T.2    Zhuang, Z.Y.3    Brenner, G.J.4    Wang, H.5    Van Der Meer, C.6    Befort, K.7    Woolf, C.J.8    Ji, R.R.9
  • 81
    • 0035996507 scopus 로고    scopus 로고
    • Antisense oligonucleotide knockdown of mGluR1 alleviates hyperalgesia and allodynia associated with chronic inflammation
    • 10.1016/S0091-3057(02)00831-6, 12117595
    • Fundytus ME, Osborne MG, Henry JL, Coderre TJ, Dray A. Antisense oligonucleotide knockdown of mGluR1 alleviates hyperalgesia and allodynia associated with chronic inflammation. Pharmacol Biochem Behav 2002, 73:401-410. 10.1016/S0091-3057(02)00831-6, 12117595.
    • (2002) Pharmacol Biochem Behav , vol.73 , pp. 401-410
    • Fundytus, M.E.1    Osborne, M.G.2    Henry, J.L.3    Coderre, T.J.4    Dray, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.