Metabotropic glutamate receptors - Important modulators of nociception and pain behavior

Pain

Volumn 98, Issue 1-2, 2002, Pages 1-8

  Neugebauer, Volker ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Analgesics; Electrophysiology; Metabotropic glutamate receptors; Neuroplasticity; Nociception; Pain

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; 4 CARBOXY 2 METHYLPHENYLGLYCINE; 6 METHYL 2 PHENYLAZO 3 PYRIDINOL; 6A NAPHTHALEN 2 YLMETHYL 5 METHYLIDENHEXAHYDROCYCLOPENTAN[C]FURAN 1 ON; BAY 36 7620; EGLUMETAD; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

BEHAVIOR; BRAIN; HUMAN; NOCICEPTION; PAIN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SPINAL CORD; SYNAPTIC TRANSMISSION;

ANIMALS; BEHAVIOR; HUMANS; NOCICEPTORS; PAIN; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0036295881     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(02)00140-9     Document Type: Review

References (39)

1. Metabotropic glutamate receptors: Electrophysiological properties and role in plasticity
2. Peripheral group I metabotropic glutamate receptors modulate nociception in mice
3. Group I metabotropic glutamate receptors: Implications for brain diseases
4. Involvement of mGluR(5) on acute nociceptive transmission
5. The involvement of metabotropic glutamate receptors in sensory transmission in dorsal horn of the rat spinal cord
6. Peripheral excitatory amino acids
7. Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat
8. Regulation of neurotransmitter release by metabotropic glutamate receptors
9. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR5) antagonist, in experimental neuropathic pain in rats
10. Behavioural evidence supporting a differential role for groups I and II metabotropic glutamate receptors in spinal nociceptive transmission
11. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception
12. Intrathecal administration of the mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats
13. Glutamate receptors and nociception. Implications for the drug treatment of pain
14. In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats
15. Knockdown of spinal metabotropic glutamate receptor 1 (mGluR1) alleviates pain and restores opioid efficacy after nerve injury in rats
16. Allosteric modulators of group I metabotropic glutamate receptors: Novel subtype-selective ligands and therapeutic perspectives
17. Groups II and III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn
18. Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics
19. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
20. Metabotropic glutamate receptors: Novel targets for pain relief
21. Peripheral metabotropic glutamate receptors: Fight the pain where it hurts
22. Peripheral metabotropic glutamate receptors as drug targets for pain relief
23. Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons
24. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells
25. Groups II and III metabotropic glutamate receptors differentially modulate brief and prolonged nociception in primate STT cells
26. Long-term depression induced by postsynaptic group II metabotropic glutamate receptors linked to phospholipase C and intracellular calcium rises in rat prefrontal cortex
27. Interaction between vanilloid and glutamate receptors in the central modulation of nociception
28. The effect of trans-ACPD, a metabotropic excitatory amino acid receptor agonist, on the responses of primate spinothalamic tract neurons
29. Metabotropic G-protein-coupled glutamate receptors as therapeutic targets
30. Contributions of mGlu1 and mGlu5 receptors to interactions with N-methyl-D-aspartate receptor-mediated responses and nociceptive sensory responses of rat thalamic neurons
31. Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine
32. Characterization of the metabotropic glutamate receptors (mGluRs) which modulate GABA-mediated inhibition in the ventrobasal thalamus
33. Pharmacological agents acting at subtypes of metabotropic glutamate receptors
34. Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders
35. Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurons
36. MGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia
37. Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons
38. Antisense ablation of type I metabotropic glutamate receptor mGluR1 inhibits spinal nociceptive transmission
39. Metabotropic glutamate 1α receptors on peripheral primary afferent fibers: Their role in nociception