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Volumn 52, Issue 1, 2013, Pages 51-61

Manipulating molecular switches in brown adipocytes and their precursors: A therapeutic potential

Author keywords

Adipocyte; Brown adipose; Obesity; PRDM16; UCP1

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CAPSAICIN; CATECHOLAMINE; CYCLOOXYGENASE 2; MELANOCORTIN; MELANOCORTIN RECEPTOR AGONIST; MONOACYLGLYCEROL; OSTEOGENIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; THYROID HORMONE; UNCOUPLING PROTEIN 1; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1;

EID: 84869882221     PISSN: 01637827     EISSN: 18732194     Source Type: Journal    
DOI: 10.1016/j.plipres.2012.08.001     Document Type: Review
Times cited : (32)

References (115)
  • 1
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • G.M. Reaven Banting lecture 1988. Role of insulin resistance in human disease Diabetes 37 12 1988 1595 1607
    • (1988) Diabetes , vol.37 , Issue.12 , pp. 1595-1607
    • Reaven, G.M.1
  • 2
    • 55849114349 scopus 로고    scopus 로고
    • Adipocytokines and the metabolic complications of obesity
    • N. Rasouli, and P.A. Kern Adipocytokines and the metabolic complications of obesity J. Clin. Endocrinol. Metab. 93 2008 S64 S73
    • (2008) J. Clin. Endocrinol. Metab. , vol.93
    • Rasouli, N.1    Kern, P.A.2
  • 3
    • 34047160412 scopus 로고    scopus 로고
    • Adipokines and melanocortins in the hepatic manifestation of metabolic syndrome: Nonalcoholic fatty liver disease
    • A. Baranova, M. Randhawa, M. Jarrar, and Z.M. Younossi Adipokines and melanocortins in the hepatic manifestation of metabolic syndrome: nonalcoholic fatty liver disease Expert Rev. Mol. Diagn. 7 2007 195 205
    • (2007) Expert Rev. Mol. Diagn. , vol.7 , pp. 195-205
    • Baranova, A.1    Randhawa, M.2    Jarrar, M.3    Younossi, Z.M.4
  • 5
    • 84857685253 scopus 로고    scopus 로고
    • Incident cardiovascular disease events in metabolically benign obese individuals
    • 101038/oby2011243
    • A.D. Ogorodnikova, M. Kim, A.P. McGinn, P. Muntner, U. Khan, and R.P. Wildman Incident cardiovascular disease events in metabolically benign obese individuals Obesity 2011 101038/oby2011243
    • (2011) Obesity
    • Ogorodnikova, A.D.1    Kim, M.2    McGinn, A.P.3    Muntner, P.4    Khan, U.5    Wildman, R.P.6
  • 7
    • 79953254189 scopus 로고    scopus 로고
    • Relationship between obesity and diabetes in a US adult population: Findings from the National Health and Nutrition Examination Survey, 1999-2006
    • N.T. Nguyen, X.M. Nguyen, J. Lane, and P. Wang Relationship between obesity and diabetes in a US adult population: findings from the National Health And Nutrition Examination Survey, 1999-2006 Obes. Surg. 21 2011 351 355
    • (2011) Obes. Surg. , vol.21 , pp. 351-355
    • Nguyen, N.T.1    Nguyen, X.M.2    Lane, J.3    Wang, P.4
  • 8
    • 79960025383 scopus 로고    scopus 로고
    • Gene-lifestyle and gene-pharmacotherapy interactions in obesity and its cardiovascular consequences
    • P.W. Franks, and A. Poveda Gene-lifestyle and gene-pharmacotherapy interactions in obesity and its cardiovascular consequences Curr. Vasc. Pharmacol. 9 2011 401 456
    • (2011) Curr. Vasc. Pharmacol. , vol.9 , pp. 401-456
    • Franks, P.W.1    Poveda, A.2
  • 9
    • 69249208526 scopus 로고    scopus 로고
    • Gene-environment interactions and obesity-further aspects of genomewide association studies
    • C.H. Andreasen, and G. Andersen Gene-environment interactions and obesity-further aspects of genomewide association studies Nutrition 25 2009 998 1003
    • (2009) Nutrition , vol.25 , pp. 998-1003
    • Andreasen, C.H.1    Andersen, G.2
  • 11
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • B. Cannon, and J. Nedergaard Brown adipose tissue: function and physiological significance J. Physiol. Rev. 84 2004 277 359
    • (2004) J. Physiol. Rev. , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 13
    • 79951560291 scopus 로고    scopus 로고
    • Between brown and white: Novel aspects of adipocyte differentiation
    • S. Cinti Between brown and white: novel aspects of adipocyte differentiation Ann. Med. 43 2 2011 104 115
    • (2011) Ann. Med. , vol.43 , Issue.2 , pp. 104-115
    • Cinti, S.1
  • 14
    • 77952623888 scopus 로고    scopus 로고
    • The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
    • G. Barbatelli, I. Murano, L. Madsen, Q. Hao, M. Jimenez, and K. Kristiansen The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation Am. J. Physiol. Endocrinol. Metab. 298 6 2010 E1244 E1253
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298 , Issue.6
    • Barbatelli, G.1    Murano, I.2    Madsen, L.3    Hao, Q.4    Jimenez, M.5    Kristiansen, K.6
  • 15
    • 46349110454 scopus 로고    scopus 로고
    • Human skeletal muscle mitochondrial uncoupling is associated with cold induced adaptive thermogenesis
    • S.L. Wijers, P. Schrauwen, W.H. Saris, and W.D. van Marken Lichtenbelt Human skeletal muscle mitochondrial uncoupling is associated with cold induced adaptive thermogenesis PLoS ONE 3 3 2008 e1777
    • (2008) PLoS ONE , vol.3 , Issue.3 , pp. 1777
    • Wijers, S.L.1    Schrauwen, P.2    Saris, W.H.3    Van Marken Lichtenbelt, W.D.4
  • 17
    • 65349151258 scopus 로고    scopus 로고
    • Have we entered the brown adipose tissue renaissance?
    • E. Ravussin, and L.P. Kozak Have we entered the brown adipose tissue renaissance? Obes. Rev. 10 2009 265 268
    • (2009) Obes. Rev. , vol.10 , pp. 265-268
    • Ravussin, E.1    Kozak, L.P.2
  • 18
    • 78649693193 scopus 로고    scopus 로고
    • Hot fat in a cool man: Infrared thermography and brown adipose tissue
    • P. Lee, K.K.Y. Ho, and J.R. Greenfield Hot fat in a cool man: infrared thermography and brown adipose tissue Diabetes Obes. Metab. 13 2011 92 93
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 92-93
    • Lee, P.1    Ho, K.K.Y.2    Greenfield, J.R.3
  • 19
    • 84858341775 scopus 로고    scopus 로고
    • Changes in brown adipose tissue in boys and girls during childhood and puberty
    • V. Gilsanz, M.L. Smith, F. Goodarzian, M. Kim, T.A. Wren, and H.H. Hu Changes in brown adipose tissue in boys and girls during childhood and puberty J. Pediatr. 160 4 2012 604 609
    • (2012) J. Pediatr. , vol.160 , Issue.4 , pp. 604-609
    • Gilsanz, V.1    Smith, M.L.2    Goodarzian, F.3    Kim, M.4    Wren, T.A.5    Hu, H.H.6
  • 21
    • 79959961564 scopus 로고    scopus 로고
    • Association between the presence of brown adipose tissue and non-alcoholic fatty liver disease in adult humans
    • Y. Yilmaz, T. Ones, T. Purnak, S. Ozguven, R. Kurt, and O. Atug Association between the presence of brown adipose tissue and non-alcoholic fatty liver disease in adult humans Aliment. Pharmacol. Ther. 34 2011 318 323
    • (2011) Aliment. Pharmacol. Ther. , vol.34 , pp. 318-323
    • Yilmaz, Y.1    Ones, T.2    Purnak, T.3    Ozguven, S.4    Kurt, R.5    Atug, O.6
  • 22
    • 0022578991 scopus 로고
    • Brown adipose tissue thermogenesis in neonatal and cold-adapted animals
    • B. Cannon, and J. Nedergaard Brown adipose tissue thermogenesis in neonatal and cold-adapted animals Biochem. Soc. Trans. 14 2 1986 233 236
    • (1986) Biochem. Soc. Trans. , vol.14 , Issue.2 , pp. 233-236
    • Cannon, B.1    Nedergaard, J.2
  • 24
    • 0026635508 scopus 로고
    • Cellular and molecular aspects of adipose tissue development
    • G. Ailhaud, P. Grimaldi, and R. Négrel Cellular and molecular aspects of adipose tissue development Annu. Rev. Nutr. 12 1992 207 233
    • (1992) Annu. Rev. Nutr. , vol.12 , pp. 207-233
    • Ailhaud, G.1    Grimaldi, P.2    Négrel, R.3
  • 25
    • 33745966038 scopus 로고    scopus 로고
    • Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse
    • R. Atit, S.K. Sgaier, O.A. Mohamed, M.M. Taketo, D. Dufort, and A.L. Joyner Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse Dev. Biol. 296 1 2006 164 176
    • (2006) Dev. Biol. , vol.296 , Issue.1 , pp. 164-176
    • Atit, R.1    Sgaier, S.K.2    Mohamed, O.A.3    Taketo, M.M.4    Dufort, D.5    Joyner, A.L.6
  • 26
    • 50049122271 scopus 로고    scopus 로고
    • PRDM16 controls a brown fat/skeletal muscle switch
    • P. Seale, B. Bjork, W. Yang, S. Kajimura, S. Chin, and S. Kuang PRDM16 controls a brown fat/skeletal muscle switch Nature 454 7207 2008 961 967
    • (2008) Nature , vol.454 , Issue.7207 , pp. 961-967
    • Seale, P.1    Bjork, B.2    Yang, W.3    Kajimura, S.4    Chin, S.5    Kuang, S.6
  • 27
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • N. Petrovic, T.B. Walden, I.G. Shabalina, J.A. Timmons, B. Cannon, and J. Nedergaard Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes J. Biol. Chem. 285 10 2010 7153 7164
    • (2010) J. Biol. Chem. , vol.285 , Issue.10 , pp. 7153-7164
    • Petrovic, N.1    Walden, T.B.2    Shabalina, I.G.3    Timmons, J.A.4    Cannon, B.5    Nedergaard, J.6
  • 28
    • 83355163350 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: Involvement of PRDM16
    • E. Hondares, M. Rosell, J. Díaz-Delfín, Y. Olmos, M. Monsalve, and R. Iglesias Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16 J. Biol. Chem. 286 50 2011 43112 43122
    • (2011) J. Biol. Chem. , vol.286 , Issue.50 , pp. 43112-43122
    • Hondares, E.1    Rosell, M.2    Díaz-Delfín, J.3    Olmos, Y.4    Monsalve, M.5    Iglesias, R.6
  • 29
    • 27344442242 scopus 로고    scopus 로고
    • Transforming growth factor beta1 release by human adipose tissue is enhanced in obesity
    • J.N. Fain, D.S. Tichansky, and A.K. Madan Transforming growth factor beta1 release by human adipose tissue is enhanced in obesity Metabolism 54 2005 1546 1551
    • (2005) Metabolism , vol.54 , pp. 1546-1551
    • Fain, J.N.1    Tichansky, D.S.2    Madan, A.K.3
  • 30
    • 84866159140 scopus 로고    scopus 로고
    • Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissue
    • Feb 15
    • Eringa EC, Bakker W, van Hinsbergh VW. Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissue. Vascul Pharmacol 2012; Feb 15.
    • (2012) Vascul Pharmacol
    • Eringa, E.C.1    Bakker, W.2    Van Hinsbergh, V.W.3
  • 31
    • 69949110064 scopus 로고    scopus 로고
    • Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: Epicardial fat functioning as brown fat
    • H.S. Sacks, J.N. Fain, B. Holman, P. Cheema, A. Chary, and F. Parks Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: epicardial fat functioning as brown fat J. Clin. Endocrinol. Metab. 94 9 2009 3611 3615
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , Issue.9 , pp. 3611-3615
    • Sacks, H.S.1    Fain, J.N.2    Holman, B.3    Cheema, P.4    Chary, A.5    Parks, F.6
  • 32
    • 0031985802 scopus 로고    scopus 로고
    • Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes
    • J.E. Digby, C.T. Montague, C.P. Sewter, L. Sanders, W.O. Wilkison, and S. O'Rahilly Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes Diabetes 47 1 1998 138 141
    • (1998) Diabetes , vol.47 , Issue.1 , pp. 138-141
    • Digby, J.E.1    Montague, C.T.2    Sewter, C.P.3    Sanders, L.4    Wilkison, W.O.5    O'Rahilly, S.6
  • 33
    • 34447263808 scopus 로고    scopus 로고
    • 18FDG uptake in brown fat: Potential for false positives
    • K.D. Evans, T.A. Tulloss, and N. Hall 18FDG uptake in brown fat: potential for false positives Radiol. Technol. 78 5 2007 361 366
    • (2007) Radiol. Technol. , vol.78 , Issue.5 , pp. 361-366
    • Evans, K.D.1    Tulloss, T.A.2    Hall, N.3
  • 35
    • 84855877835 scopus 로고    scopus 로고
    • Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes
    • A. Krings, S. Rahman, S. Huang, Y. Lu, P.J. Czernik, and B. Lecka-Czernik Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes Bone 50 2 2012 546 552
    • (2012) Bone , vol.50 , Issue.2 , pp. 546-552
    • Krings, A.1    Rahman, S.2    Huang, S.3    Lu, Y.4    Czernik, P.J.5    Lecka-Czernik, B.6
  • 36
    • 79960109805 scopus 로고    scopus 로고
    • Temperatures rising: Brown fat and bone
    • K.J. Motyl, and C.J. Rosen Temperatures rising: brown fat and bone Discov. Med. 11 58 2011 179 185
    • (2011) Discov. Med. , vol.11 , Issue.58 , pp. 179-185
    • Motyl, K.J.1    Rosen, C.J.2
  • 37
    • 77949327079 scopus 로고    scopus 로고
    • Reversible physiological transdifferentiation in the adipose organ
    • S. Cinti Reversible physiological transdifferentiation in the adipose organ Proc. Nutr. Soc. 68 4 2009 340 349
    • (2009) Proc. Nutr. Soc. , vol.68 , Issue.4 , pp. 340-349
    • Cinti, S.1
  • 38
    • 14544303179 scopus 로고    scopus 로고
    • PPARγ, 10 years later
    • M.A. Lazar PPARγ, 10 years later Biochimie 87 1 2005 9 13
    • (2005) Biochimie , vol.87 , Issue.1 , pp. 9-13
    • Lazar, M.A.1
  • 39
    • 33748942837 scopus 로고    scopus 로고
    • Transcriptional control of adipocyte formation
    • S.R. Farmer Transcriptional control of adipocyte formation Cell Metab. 4 2006 263 273
    • (2006) Cell Metab. , vol.4 , pp. 263-273
    • Farmer, S.R.1
  • 40
    • 69349088117 scopus 로고    scopus 로고
    • Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-b transcriptional complex
    • S. Kajimura, P. Seale, K. Kubota, E. Lunsford, J.V. Frangioni, and S.P. Gygi Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-b transcriptional complex Nature 460 2009 1154 1159
    • (2009) Nature , vol.460 , pp. 1154-1159
    • Kajimura, S.1    Seale, P.2    Kubota, K.3    Lunsford, E.4    Frangioni, J.V.5    Gygi, S.P.6
  • 44
    • 80053143671 scopus 로고    scopus 로고
    • Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways
    • A.M. Cypess, H. Zhang, T.J. Schulz, T.L. Huang, D.O. Espinoza, and K. Kristiansen Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways Endocrinology 152 10 2011 3680
    • (2011) Endocrinology , vol.152 , Issue.10 , pp. 3680
    • Cypess, A.M.1    Zhang, H.2    Schulz, T.J.3    Huang, T.L.4    Espinoza, D.O.5    Kristiansen, K.6
  • 45
    • 20444417035 scopus 로고    scopus 로고
    • Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin
    • Y.H. Tseng, A.J. Butte, E. Kokkotou, V.K. Yechoor, C.M. Taniguchi, and K.M. Kriauciunas Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin Nat. Cell Biol. 7 2005 601 611
    • (2005) Nat. Cell Biol. , vol.7 , pp. 601-611
    • Tseng, Y.H.1    Butte, A.J.2    Kokkotou, E.3    Yechoor, V.K.4    Taniguchi, C.M.5    Kriauciunas, K.M.6
  • 46
    • 25144489034 scopus 로고    scopus 로고
    • Metabolic and cellular plasticity in white adipose tissue I: Effects of beta3-adrenergic receptor activation
    • J.G. Granneman, P. Li, Z. Zhu, and Y. Lu Metabolic and cellular plasticity in white adipose tissue I: effects of beta3-adrenergic receptor activation Am. J. Physiol. Endocrinol. Metab. 289 4 2005 E608 E616
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289 , Issue.4
    • Granneman, J.G.1    Li, P.2    Zhu, Z.3    Lu, Y.4
  • 48
    • 0025828908 scopus 로고
    • Molecular studies of the uncoupling protein
    • D. Ricquier, L. Casteilla, and F. Bouillaud Molecular studies of the uncoupling protein FASEB J 5 9 1991 2237 2242
    • (1991) FASEB J , vol.5 , Issue.9 , pp. 2237-2242
    • Ricquier, D.1    Casteilla, L.2    Bouillaud, F.3
  • 49
    • 79959190178 scopus 로고    scopus 로고
    • Could increased time spent in a thermal comfort zone contribute to population increases in obesity?
    • F. Johnson, A. Mavrogianni, M. Ucci, A. Vidal-Puig, and J. Wardle Could increased time spent in a thermal comfort zone contribute to population increases in obesity? Obes. Rev. 12 7 2011 543 551
    • (2011) Obes. Rev. , vol.12 , Issue.7 , pp. 543-551
    • Johnson, F.1    Mavrogianni, A.2    Ucci, M.3    Vidal-Puig, A.4    Wardle, J.5
  • 50
    • 77951622607 scopus 로고    scopus 로고
    • Impact of ecology on development of NIDDM
    • D.A. Dayaratne Impact of ecology on development of NIDDM Med. Hypotheses 74 6 2010 986 988
    • (2010) Med. Hypotheses , vol.74 , Issue.6 , pp. 986-988
    • Dayaratne, D.A.1
  • 52
    • 79952414304 scopus 로고    scopus 로고
    • Type 2 iodothyronine deiodinase is expressed in human preadipocytes
    • E. Nomura, N. Toyoda, A. Harada, K. Nishimura, C. Ukita, and S. Morimoto Type 2 iodothyronine deiodinase is expressed in human preadipocytes Thyroid 21 3 2011 305 310
    • (2011) Thyroid , vol.21 , Issue.3 , pp. 305-310
    • Nomura, E.1    Toyoda, N.2    Harada, A.3    Nishimura, K.4    Ukita, C.5    Morimoto, S.6
  • 53
    • 79952313244 scopus 로고    scopus 로고
    • Bioenergetic impact of tissue-specific regulation of iodothyronine deiodinases during nutritional imbalance
    • R.L. Araujo, and D.P. Carvalho Bioenergetic impact of tissue-specific regulation of iodothyronine deiodinases during nutritional imbalance J. Bioenerg. Biomembr. 43 1 2011 59 65
    • (2011) J. Bioenerg. Biomembr. , vol.43 , Issue.1 , pp. 59-65
    • Araujo, R.L.1    Carvalho, D.P.2
  • 54
    • 0035011092 scopus 로고    scopus 로고
    • Minor alterations in thyroid-function tests associated with diabetes mellitus and obesity in outpatients without known thyroid illness
    • S. Proces, E. Delgrange, T.V. Vander Borght, J. Jamart, and J.E. Donckier Minor alterations in thyroid-function tests associated with diabetes mellitus and obesity in outpatients without known thyroid illness Acta. Clin. Belg. 56 2 2001 86 90
    • (2001) Acta. Clin. Belg. , vol.56 , Issue.2 , pp. 86-90
    • Proces, S.1    Delgrange, E.2    Vander Borght, T.V.3    Jamart, J.4    Donckier, J.E.5
  • 55
    • 34250670494 scopus 로고    scopus 로고
    • C-reactive protein in obese PCOS women and the effect of metformin therapy
    • Z. Velija-Asimi C-reactive protein in obese PCOS women and the effect of metformin therapy Bosn. J. Basic Med. Sci. 7 1 2007 90 93
    • (2007) Bosn. J. Basic Med. Sci. , vol.7 , Issue.1 , pp. 90-93
    • Velija-Asimi, Z.1
  • 57
    • 27644460920 scopus 로고    scopus 로고
    • Prevalence of subclinical hypothyroidism in a morbidly obese population and improvement after weight loss induced by Roux-en-Y gastric bypass
    • C.M. Moulin de Moraes, M.C. Mancini, M.E. de Melo, D.A. Figueiredo, S.M. Villares, and A. Rascovski Prevalence of subclinical hypothyroidism in a morbidly obese population and improvement after weight loss induced by Roux-en-Y gastric bypass Obes. Surg. 15 9 2005 1287 1291
    • (2005) Obes. Surg. , vol.15 , Issue.9 , pp. 1287-1291
    • Moulin De Moraes, C.M.1    Mancini, M.C.2    De Melo, M.E.3    Figueiredo, D.A.4    Villares, S.M.5    Rascovski, A.6
  • 58
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • M. Watanabe, S.M. Houten, C. Mataki, M.A. Christoffolete, B.W. Kim, and H. Sato Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation Nature 439 7075 2006 484 489
    • (2006) Nature , vol.439 , Issue.7075 , pp. 484-489
    • Watanabe, M.1    Houten, S.M.2    Mataki, C.3    Christoffolete, M.A.4    Kim, B.W.5    Sato, H.6
  • 59
    • 33847388961 scopus 로고    scopus 로고
    • The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation
    • W.S. da-Silva, J.W. Harney, B.W. Kim, J. Li, S.D. Bianco, and A. Crescenzi The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation Diabetes 56 3 2007 767 776
    • (2007) Diabetes , vol.56 , Issue.3 , pp. 767-776
    • Da-Silva, W.S.1    Harney, J.W.2    Kim, B.W.3    Li, J.4    Bianco, S.D.5    Crescenzi, A.6
  • 61
    • 0030179471 scopus 로고    scopus 로고
    • Increase in rT3 serum levels observed during extended Alaskan field operations of Naval personnel
    • P.D. McCormack, H.L. Reed, J.R. Thomas, and M.J. Malik Increase in rT3 serum levels observed during extended Alaskan field operations of Naval personnel Alaska Med. 38 3 1996 89 97
    • (1996) Alaska Med. , vol.38 , Issue.3 , pp. 89-97
    • McCormack, P.D.1    Reed, H.L.2    Thomas, J.R.3    Malik, M.J.4
  • 62
    • 0028918870 scopus 로고
    • Effects of high altitude and cold exposure on resting thyroid hormone concentrations
    • A.C. Hackney, S. Feith, R. Pozos, and J. Seale Effects of high altitude and cold exposure on resting thyroid hormone concentrations Aviat. Space Environ. Med. 66 4 1995 325 329
    • (1995) Aviat. Space Environ. Med. , vol.66 , Issue.4 , pp. 325-329
    • Hackney, A.C.1    Feith, S.2    Pozos, R.3    Seale, J.4
  • 63
    • 0842266865 scopus 로고    scopus 로고
    • Chronic sympathetic activation: Consequence and cause of age-associated obesity?
    • D.R. Seals, and C. Bell Chronic sympathetic activation: consequence and cause of age-associated obesity? Diabetes 53 2 2004 276 284
    • (2004) Diabetes , vol.53 , Issue.2 , pp. 276-284
    • Seals, D.R.1    Bell, C.2
  • 64
    • 0037066575 scopus 로고    scopus 로고
    • Beta(3)-Adrenoceptor agonists: Potential, pitfalls and progress
    • J.R. Arch Beta(3)-Adrenoceptor agonists: potential, pitfalls and progress Eur. J. Pharmacol. 440 2-3 2002 99 107
    • (2002) Eur. J. Pharmacol. , vol.440 , Issue.23 , pp. 99-107
    • Arch, J.R.1
  • 65
    • 0026527748 scopus 로고
    • BRL 35135, a potent and selective atypical beta-adrenoceptor agonist
    • M.A. Cawthorne, M.V. Sennitt, J.R. Arch, and S.A. Smith BRL 35135, a potent and selective atypical beta-adrenoceptor agonist Am. J. Clin. Nutr. 55 1 Suppl 1992 252S 257S
    • (1992) Am. J. Clin. Nutr. , vol.55 , Issue.1 SUPPL.
    • Cawthorne, M.A.1    Sennitt, M.V.2    Arch, J.R.3    Smith, S.A.4
  • 66
    • 0028224485 scopus 로고
    • Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats
    • J. Himms-Hagen, J. Cui, E. Danforth Jr, D.J. Taatjes, S.S. Lang, and B.L. Waters Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats Am. J. Physiol. 266 4 Pt 2 1994 R1371 R1382
    • (1994) Am. J. Physiol. , vol.266 , Issue.4 PT 2
    • Himms-Hagen, J.1    Cui, J.2    Danforth Jr., E.3    Taatjes, D.J.4    Lang, S.S.5    Waters, B.L.6
  • 67
    • 0034999667 scopus 로고    scopus 로고
    • Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
    • C. Weyer, T. Funahashi, S. Tanaka, K. Hotta, Y. Matsuzawa, and R.E. Pratley Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia J. Clin. Endocrinol. Metab. 86 5 2001 1930 1935
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , Issue.5 , pp. 1930-1935
    • Weyer, C.1    Funahashi, T.2    Tanaka, S.3    Hotta, K.4    Matsuzawa, Y.5    Pratley, R.E.6
  • 68
    • 0029761541 scopus 로고    scopus 로고
    • Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues
    • C. Deng, A. Paoloni-Giacobino, F. Kuehne, O. Boss, J.P. Revelli, and M. Moinat Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues Br. J. Pharmacol. 118 4 1996 929 934
    • (1996) Br. J. Pharmacol. , vol.118 , Issue.4 , pp. 929-934
    • Deng, C.1    Paoloni-Giacobino, A.2    Kuehne, F.3    Boss, O.4    Revelli, J.P.5    Moinat, M.6
  • 71
    • 54449101252 scopus 로고    scopus 로고
    • Note
    • M. Sato, D.S. Hutchinson, B.A. Evans, and R.J. Summers The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2- hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2- hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor Mol. Pharmacol. 74 5 2008 1417 1428
    • (2008) Mol. Pharmacol. , vol.74 , Issue.5 , pp. 1417-1428
    • Sato, M.1    Hutchinson, D.S.2    Evans, B.A.3    Summers, R.J.4
  • 72
    • 34547900257 scopus 로고    scopus 로고
    • Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity
    • J.A. Lafontaine, R.F. Day, J. Dibrino, J.R. Hadcock, D.M. Hargrove, and M. Linhares Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity Bioorg. Med. Chem. Lett. 17 18 2007 5245 5250
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , Issue.18 , pp. 5245-5250
    • Lafontaine, J.A.1    Day, R.F.2    Dibrino, J.3    Hadcock, J.R.4    Hargrove, D.M.5    Linhares, M.6
  • 73
    • 34548840602 scopus 로고    scopus 로고
    • GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog
    • A. Hicks, G.P. McCafferty, E. Riedel, N. Aiyar, M. Pullen, and C. Evans GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog J. Pharmacol. Exp. Ther. 323 1 2007 202 209
    • (2007) J. Pharmacol. Exp. Ther. , vol.323 , Issue.1 , pp. 202-209
    • Hicks, A.1    McCafferty, G.P.2    Riedel, E.3    Aiyar, N.4    Pullen, M.5    Evans, C.6
  • 74
    • 77956179997 scopus 로고    scopus 로고
    • The beta3 adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes
    • A. Tamburella, V. Micale, G.M. Leggio, and F. Drago The beta3 adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes Eur. Neuropsychopharmacol. 20 10 2010 704 713
    • (2010) Eur. Neuropsychopharmacol. , vol.20 , Issue.10 , pp. 704-713
    • Tamburella, A.1    Micale, V.2    Leggio, G.M.3    Drago, F.4
  • 77
    • 79959305513 scopus 로고    scopus 로고
    • Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity
    • Q. Wang, M. Zhang, G. Ning, W. Gu, T. Su, and M. Xu Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity PLoS ONE 6 6 2011 e21006
    • (2011) PLoS ONE , vol.6 , Issue.6 , pp. 21006
    • Wang, Q.1    Zhang, M.2    Ning, G.3    Gu, W.4    Su, T.5    Xu, M.6
  • 79
    • 82555186955 scopus 로고    scopus 로고
    • Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    • K.D. Nguyen, Y. Qiu, X. Cui, Y.P. Goh, J. Mwangi, and T. David Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis Nature 480 7375 2011 104 108
    • (2011) Nature , vol.480 , Issue.7375 , pp. 104-108
    • Nguyen, K.D.1    Qiu, Y.2    Cui, X.3    Goh, Y.P.4    Mwangi, J.5    David, T.6
  • 80
    • 79953173984 scopus 로고    scopus 로고
    • Increased levels of both Th1 and Th2 cytokines in subjects with metabolic syndrome (CURES-103)
    • J. Surendar, V. Mohan, S. Rao MM Babu, and V. Aravindhan Increased levels of both Th1 and Th2 cytokines in subjects with metabolic syndrome (CURES-103) Diabetes Technol. Ther 13 4 2011 477 482
    • (2011) Diabetes Technol. Ther , vol.13 , Issue.4 , pp. 477-482
    • Surendar, J.1    Mohan, V.2    Rao Mm Babu, S.3    Aravindhan, V.4
  • 81
    • 77954905414 scopus 로고    scopus 로고
    • Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, white, and Japanese American middle-aged men
    • A. Sekikawa, T. Kadowaki, J.D. Curb, R.W. Evans, H. Maegawa, and R.D. Abbott Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, white, and Japanese American middle-aged men J. Interferon Cytokine Res. 30 7 2010 541 548
    • (2010) J. Interferon Cytokine Res. , vol.30 , Issue.7 , pp. 541-548
    • Sekikawa, A.1    Kadowaki, T.2    Curb, J.D.3    Evans, R.W.4    Maegawa, H.5    Abbott, R.D.6
  • 82
    • 42749090390 scopus 로고    scopus 로고
    • Interleukin 4 receptor is associated with an increase in body mass index in Koreans
    • E. Ha, S.H. Yang, K.I. Yoo, I.S. Chung, M.Y. Lee, and J.H. Bae Interleukin 4 receptor is associated with an increase in body mass index in Koreans Life Sci. 82 19-20 2008 1040 1043
    • (2008) Life Sci. , vol.82 , Issue.1920 , pp. 1040-1043
    • Ha, E.1    Yang, S.H.2    Yoo, K.I.3    Chung, I.S.4    Lee, M.Y.5    Bae, J.H.6
  • 84
    • 77955333533 scopus 로고    scopus 로고
    • UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity
    • L. Madsen, L.M. Pedersen, H.H. Lillefosse, E. Fjaere, I. Bronstad, and Q. Hao UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity PLoS ONE 5 6 2010 e11391
    • (2010) PLoS ONE , vol.5 , Issue.6 , pp. 11391
    • Madsen, L.1    Pedersen, L.M.2    Lillefosse, H.H.3    Fjaere, E.4    Bronstad, I.5    Hao, Q.6
  • 86
    • 33947324058 scopus 로고    scopus 로고
    • PPARgamma activation by thiazolidinediones (TZDs) may modulate breast carcinoma outcome: The importance of interplay with TGFbeta signalling
    • M.H. Jarrar, and A. Baranova PPARgamma activation by thiazolidinediones (TZDs) may modulate breast carcinoma outcome: the importance of interplay with TGFbeta signalling J. Cell Mol. Med. 11 2007 71 87
    • (2007) J. Cell Mol. Med. , vol.11 , pp. 71-87
    • Jarrar, M.H.1    Baranova, A.2
  • 87
    • 33750378338 scopus 로고    scopus 로고
    • Insulin resistance and PPAR insulin sensitizers
    • V. Bhatia, and P. Viswanathan Insulin resistance and PPAR insulin sensitizers Curr. Opin. Investig. Drugs 7 10 2006 891 897
    • (2006) Curr. Opin. Investig. Drugs , vol.7 , Issue.10 , pp. 891-897
    • Bhatia, V.1    Viswanathan, P.2
  • 88
    • 0031985802 scopus 로고    scopus 로고
    • Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes
    • J.E. Digby, C.T. Montague, C.P. Sewter, L. Sanders, W.O. Wilkison, and S. O'Rahilly Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes Diabetes 47 1 1998 138 141
    • (1998) Diabetes , vol.47 , Issue.1 , pp. 138-141
    • Digby, J.E.1    Montague, C.T.2    Sewter, C.P.3    Sanders, L.4    Wilkison, W.O.5    O'Rahilly, S.6
  • 89
    • 84872489545 scopus 로고    scopus 로고
    • The Effects of Capsaicin and Capsiate on Energy Balance: Critical Review and Meta-analyses of Studies in Humans
    • Electronic publication ahead of print
    • Ludy MJ, Moore GE, Mattes RD. The Effects of Capsaicin and Capsiate on Energy Balance: Critical Review and Meta-analyses of Studies in Humans. Chem Senses 2011; Electronic publication ahead of print.
    • (2011) Chem Senses
    • Ludy, M.J.1    Moore, G.E.2    Mattes, R.D.3
  • 90
    • 0344413729 scopus 로고    scopus 로고
    • Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog
    • Y. Masuda, S. Haramizu, K. Oki, K. Ohnuki, T. Watanabe, and S. Yazawa Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog J. Appl. Physiol. 95 6 2003 2408 2415
    • (2003) J. Appl. Physiol. , vol.95 , Issue.6 , pp. 2408-2415
    • Masuda, Y.1    Haramizu, S.2    Oki, K.3    Ohnuki, K.4    Watanabe, T.5    Yazawa, S.6
  • 91
    • 79957793687 scopus 로고    scopus 로고
    • TRPV1 agonist monoacylglycerol increases UCP1 content in brown adipose tissue and suppresses accumulation of visceral fat in mice fed a high-fat and high-sucrose diet
    • Y. Iwasaki, Y. Tamura, K. Inayoshi, M. Narukawa, K. Kobata, and H. Chiba TRPV1 agonist monoacylglycerol increases UCP1 content in brown adipose tissue and suppresses accumulation of visceral fat in mice fed a high-fat and high-sucrose diet Biosci. Biotechnol. Biochem. 75 5 2011 904 909
    • (2011) Biosci. Biotechnol. Biochem. , vol.75 , Issue.5 , pp. 904-909
    • Iwasaki, Y.1    Tamura, Y.2    Inayoshi, K.3    Narukawa, M.4    Kobata, K.5    Chiba, H.6
  • 92
    • 34247168128 scopus 로고    scopus 로고
    • Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity
    • L.L. Zhang, D. Yan Liu, L.Q. Ma, Z.D. Luo, T.B. Cao, and J. Zhong Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity Circ. Res. 100 7 2007 1063 1070
    • (2007) Circ. Res. , vol.100 , Issue.7 , pp. 1063-1070
    • Zhang, L.L.1    Yan Liu, D.2    Ma, L.Q.3    Luo, Z.D.4    Cao, T.B.5    Zhong, J.6
  • 93
    • 50049127055 scopus 로고    scopus 로고
    • New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    • Y.H. Tseng, E. Kokkotou, T.J. Schulz, T.L. Huang, J.N. Winnay, and C.M. Taniguchi New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure Nature 454 2008 1000 1004
    • (2008) Nature , vol.454 , pp. 1000-1004
    • Tseng, Y.H.1    Kokkotou, E.2    Schulz, T.J.3    Huang, T.L.4    Winnay, J.N.5    Taniguchi, C.M.6
  • 94
    • 77956642634 scopus 로고    scopus 로고
    • Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis
    • H. Zhang, T.J. Schulz, D.O. Espinoza, T.L. Huang, B. Emanuelli, and K. Kristiansen Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis Mol. Cell Biol. 30 17 2010 4224 4233
    • (2010) Mol. Cell Biol. , vol.30 , Issue.17 , pp. 4224-4233
    • Zhang, H.1    Schulz, T.J.2    Espinoza, D.O.3    Huang, T.L.4    Emanuelli, B.5    Kristiansen, K.6
  • 96
    • 79955875196 scopus 로고    scopus 로고
    • The BMP-7-Smad1/5/8 pathway promotes kidney repair after obstruction induced renal injury
    • S.R. Manson, R.A. Niederhoff, K.A. Hruska, and P.F. Austin The BMP-7-Smad1/5/8 pathway promotes kidney repair after obstruction induced renal injury J. Urology 185 6 2011 2523 2530
    • (2011) J. Urology , vol.185 , Issue.6 , pp. 2523-2530
    • Manson, S.R.1    Niederhoff, R.A.2    Hruska, K.A.3    Austin, P.F.4
  • 97
    • 77049088688 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 (BMP-7) increases the expresion of follice-stimulating hormone (FSH) receptor in human granulosa cells
    • J. Shi, O. Yoshino, Y. Osuga, O. Nishii, T. Yano, and Y. Taketani Bone morphogenetic protein 7 (BMP-7) increases the expresion of follice-stimulating hormone (FSH) receptor in human granulosa cells Fertil. Steril. 93 4 2010 1273 1279
    • (2010) Fertil. Steril. , vol.93 , Issue.4 , pp. 1273-1279
    • Shi, J.1    Yoshino, O.2    Osuga, Y.3    Nishii, O.4    Yano, T.5    Taketani, Y.6
  • 98
    • 82455168018 scopus 로고    scopus 로고
    • Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilization and activates brown adipose tissue in diet-induced obese mice
    • M. Bajzer, M. Olivieri, M.K. Haas, P.T. Pfluger, I.J. Magrisso, and M.T. Foster Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilization and activates brown adipose tissue in diet-induced obese mice Diabetologia 54 12 2011 3121 3131
    • (2011) Diabetologia , vol.54 , Issue.12 , pp. 3121-3131
    • Bajzer, M.1    Olivieri, M.2    Haas, M.K.3    Pfluger, P.T.4    Magrisso, I.J.5    Foster, M.T.6
  • 99
    • 80053276336 scopus 로고    scopus 로고
    • The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice
    • Z. Pang, N.N. Wu, W. Zhao, D.C. Chain, E. Schaffer, and P. Yamdagni The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice Obesity 19 10 2001 1923 1934
    • (2001) Obesity , vol.19 , Issue.10 , pp. 1923-1934
    • Pang, Z.1    Wu, N.N.2    Zhao, W.3    Chain, D.C.4    Schaffer, E.5    Yamdagni, P.6
  • 100
    • 73349119690 scopus 로고    scopus 로고
    • Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes
    • N. Perwitz, J. Wenzel, I. Wagner, J. Büning, and M. Drenckhan Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes Diabetes Obes. Metab. 12 2 2010 158 166
    • (2010) Diabetes Obes. Metab. , vol.12 , Issue.2 , pp. 158-166
    • Perwitz, N.1    Wenzel, J.2    Wagner, I.3    Büning, J.4    Drenckhan, M.5
  • 101
    • 77956017429 scopus 로고    scopus 로고
    • Rimonabant for prevention of cardiovascular events (CRESCENDO): A randomised, multicentre, placebo-controlled trial
    • E.J. Topol, M.G. Bousser, K.A.A. Fox, M.A. Creager, J.P. Despres, and J.D. Easton Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial Lancet 376 9740 2010 517 523
    • (2010) Lancet , vol.376 , Issue.9740 , pp. 517-523
    • Topol, E.J.1    Bousser, M.G.2    Fox, K.A.A.3    Creager, M.A.4    Despres, J.P.5    Easton, J.D.6
  • 102
    • 33845318626 scopus 로고    scopus 로고
    • Presence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes
    • R. Roche, L. Hoareau, S. Bes-Houtman, M.P. Gontier, C. Laborde, and J.F. Baron Presence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes Histochem. Cell Biol. 126 2 2006 177 187
    • (2006) Histochem. Cell Biol. , vol.126 , Issue.2 , pp. 177-187
    • Roche, R.1    Hoareau, L.2    Bes-Houtman, S.3    Gontier, M.P.4    Laborde, C.5    Baron, J.F.6
  • 103
    • 67649159879 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis
    • V. Deveaux, T. Cadoudal, Y. Ichigotani, F. Teixeira-Clerc, A. Louvet, and S. Manin Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis PLoS ONE 4 6 2009 e5844
    • (2009) PLoS ONE , vol.4 , Issue.6 , pp. 5844
    • Deveaux, V.1    Cadoudal, T.2    Ichigotani, Y.3    Teixeira-Clerc, F.4    Louvet, A.5    Manin, S.6
  • 104
    • 75649097758 scopus 로고    scopus 로고
    • Mechanism of the anti-obesity effects induced by a novel melanin-concentrating hormone 1-receptor antagonist in mice Brit
    • M. Ito, A. Ishihara, A. Gomori, H. Matsushita, I. Makoto, and J.M. Metzger Mechanism of the anti-obesity effects induced by a novel melanin-concentrating hormone 1-receptor antagonist in mice Brit J. Pharmacol. 159 2 2010 374 383
    • (2010) J. Pharmacol. , vol.159 , Issue.2 , pp. 374-383
    • Ito, M.1    Ishihara, A.2    Gomori, A.3    Matsushita, H.4    Makoto, I.5    Metzger, J.M.6
  • 105
    • 0242552065 scopus 로고    scopus 로고
    • Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats
    • M. Pereira-da-Silva, M.A. Torsoni, H.V. Nourani, V.D. Augusto, C.T. Souza, and A.L. Gasparetti Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats Endocrinology 144 11 2003 4831
    • (2003) Endocrinology , vol.144 , Issue.11 , pp. 4831
    • Pereira-Da-Silva, M.1    Torsoni, M.A.2    Nourani, H.V.3    Augusto, V.D.4    Souza, C.T.5    Gasparetti, A.L.6
  • 106
    • 77956030149 scopus 로고    scopus 로고
    • The endogenous actions of hypothalamic peptides on brown adipose tissue in the rat
    • A.N.A. Verty, A.M. Allen, and B.J. Oldfield The endogenous actions of hypothalamic peptides on brown adipose tissue in the rat Endocrinology 151 9 2010 4236
    • (2010) Endocrinology , vol.151 , Issue.9 , pp. 4236
    • Verty, A.N.A.1    Allen, A.M.2    Oldfield, B.J.3
  • 107
    • 0242713017 scopus 로고    scopus 로고
    • Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat
    • D.L. Williams, R.R. Bowers, T.J. Bartness, J.M. Kaplan, and H.J. Grill Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat Endocrinology 144 11 2003 4692
    • (2003) Endocrinology , vol.144 , Issue.11 , pp. 4692
    • Williams, D.L.1    Bowers, R.R.2    Bartness, T.J.3    Kaplan, J.M.4    Grill, H.J.5
  • 108
    • 34347208695 scopus 로고    scopus 로고
    • Melanocortinergic activation by Melanotan II inhibits feeding and increases uncoupling protein 1 messenger ribonucleic acid in the developing rat
    • M.M. Glavas, S.E. Joachim, S.J. Draper, M.S. Smith, and K.L. Grove Melanocortinergic activation by Melanotan II inhibits feeding and increases uncoupling protein 1 messenger ribonucleic acid in the developing rat Endocrinology 148 7 2007 3279
    • (2007) Endocrinology , vol.148 , Issue.7 , pp. 3279
    • Glavas, M.M.1    Joachim, S.E.2    Draper, S.J.3    Smith, M.S.4    Grove, K.L.5
  • 110
    • 0031883753 scopus 로고    scopus 로고
    • The murine misty mutation: Phenotypic effects on melanocytes, platelets and brown fat
    • E.V. Sviderskaya, E.K. Novak, R.T. Swank, and D.C. Bennett The murine misty mutation: phenotypic effects on melanocytes, platelets and brown fat Genetics 148 1998 381 390
    • (1998) Genetics , vol.148 , pp. 381-390
    • Sviderskaya, E.V.1    Novak, E.K.2    Swank, R.T.3    Bennett, D.C.4
  • 111
    • 84857408775 scopus 로고    scopus 로고
    • Reversal of type 1 diabetes in mice by brown adipose tissue transplant
    • S.C. Gunawardana, and D.W. Piston Reversal of type 1 diabetes in mice by brown adipose tissue transplant Diabetes 61 3 2012 674 682
    • (2012) Diabetes , vol.61 , Issue.3 , pp. 674-682
    • Gunawardana, S.C.1    Piston, D.W.2
  • 112
    • 84857420142 scopus 로고    scopus 로고
    • Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction
    • A. Gómez-Hernández, Y.F. Otero, N. de Las Heras, O. Escribano, V. Cachofeiro, and V. Lahera Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction Endocrinology 153 3 2012 1242 1255
    • (2012) Endocrinology , vol.153 , Issue.3 , pp. 1242-1255
    • Gómez-Hernández, A.1    Otero, Y.F.2    De Las Heras, N.3    Escribano, O.4    Cachofeiro, V.5    Lahera, V.6
  • 113
    • 84859783965 scopus 로고    scopus 로고
    • Endothelial cell apoptosis in brown adipose tissue of rats induced by hyperinsulinaemia: The possible role of TNF-α
    • M. Markelic, K. Velickovic, I. Golic, V. Otasevic, A. Stancic, and A. Jankovic Endothelial cell apoptosis in brown adipose tissue of rats induced by hyperinsulinaemia: the possible role of TNF-α Eur. J. Histochem. 55 4 2011 e34
    • (2011) Eur. J. Histochem. , vol.55 , Issue.4 , pp. 34
    • Markelic, M.1    Velickovic, K.2    Golic, I.3    Otasevic, V.4    Stancic, A.5    Jankovic, A.6
  • 114
    • 80052373417 scopus 로고    scopus 로고
    • Evaluation of macrophage plasticity in brown and white adipose tissue
    • M.T. Ortega, L. Xie, S. Mora, and S.K. Chapes Evaluation of macrophage plasticity in brown and white adipose tissue Cell. Immunol. 271 2011 124 133
    • (2011) Cell. Immunol. , vol.271 , pp. 124-133
    • Ortega, M.T.1    Xie, L.2    Mora, S.3    Chapes, S.K.4
  • 115
    • 77955842837 scopus 로고    scopus 로고
    • Arginine-vasopressin directly promotes a thermogenic and pro-inflammatory adipokine expression profile in brown adipocytes
    • S. Küchler, N. Perwitz, R.R. Schick, J. Klein, and S. Westphal Arginine-vasopressin directly promotes a thermogenic and pro-inflammatory adipokine expression profile in brown adipocytes Regul. Pept. 164 2010 126 132
    • (2010) Regul. Pept. , vol.164 , pp. 126-132
    • Küchler, S.1    Perwitz, N.2    Schick, R.R.3    Klein, J.4    Westphal, S.5


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