Mechanism of the anti-obesity effects induced by a novel Melanin-concentrating hormone 1-receptor antagonist in mice

British Journal of Pharmacology

Volumn 159, Issue 2, 2010, Pages 374-383

  Ito, Masahiko ^a   Ishihara, Akane ^a   Gomori, A ^a   Matsushita, H ^a   Ito, Makoto ^a   Metzger, J M ^b   Marsh, D J ^b   Haga, Y ^a   Iwaasa, H ^a   Tokita, S ^a   Takenaga, N ^a   Sato, N ^a   MacNeil, D J ^b   Moriya, M ^a   Kanatani, A ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonist; Anti obesity mechanism; Melanin concentrating hormone; Pair feeding

Indexed keywords

4 (BENZYLOXY) 1 [4 (2 PYRROLIDIN 1 YLETHOXY)PHENYL]PYRIDIN 2(1H) ONE; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG; WO 2005085200;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CHO CELL; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG MECHANISM; DRUG PENETRATION; DRUG SELECTIVITY; ENERGY EXPENDITURE; FOOD INDUSTRY; HORMONE RECEPTOR INTERACTION; LIVER; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THERMOGENESIS; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; ANTI-OBESITY AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; EATING; ENERGY METABOLISM; HUMANS; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PYRIDONES; PYRROLIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, SOMATOSTATIN; RNA, MESSENGER; THERMOGENESIS;

EID: 75649097758     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00536.x     Document Type: Article

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