Hypothalamic Melanin-Concentrating Hormone Is Induced by Cold Exposure and Participates in the Control of Energy Expenditure in Rats

Endocrinology

Volumn 144, Issue 11, 2003, Pages 4831-4840

  Pereira Da Silva, Márcio ^a   Torsoni, Márcio A ^a   Nourani, Hugo V ^a   Augusto, Viviane D ^a   Souza, Cláudio T ^a   Gasparetti, Alessandra L ^a   Carvalheira, José B ^a   Ventrucci, Gislaine ^a   Marcondes, Maria Cristina C G ^a   Cruz Neto, Ariovaldo P ^b   Saad, Mário J A ^a   Boschero, Antonio C ^a   Carneiro, Everardo M ^a   Velloso, Lício A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MELANIN CONCENTRATING HORMONE; UNCOUPLING PROTEIN 1;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; COLD EXPOSURE; CONTROL SYSTEM; CONTROLLED STUDY; DNA MICROARRAY; ENERGY EXPENDITURE; FEEDING BEHAVIOR; FOOD INTAKE; GENETIC ANALYSIS; GLYCOGEN LIVER LEVEL; HYPOTHALAMUS; LEAN BODY WEIGHT; LONG TERM EXPOSURE; MALE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THERMOGENESIS;

ADAPTATION, PHYSIOLOGICAL; ADIPOSE TISSUE, BROWN; ANIMALS; BODY COMPOSITION; BODY TEMPERATURE REGULATION; BODY WEIGHT; CARRIER PROTEINS; COLD; EATING; ENERGY METABOLISM; GENE EXPRESSION PROFILING; GLYCOGEN; HYPOTHALAMIC HORMONES; HYPOTHALAMUS; ION CHANNELS; LIVER; MALE; MELANINS; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXYGEN CONSUMPTION; PITUITARY HORMONES; RATS; RATS, WISTAR;

EID: 0242552065     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0243     Document Type: Article

References (39)

1. Arancibia S, Rage F, Astier H, Tapia-Arancibia L 1996 Neuroendocrine and autonomous mechanisms underlying thermoregulation in cold environment. Neuroendocrinology 64:257-267
2. Horvath TL, Warden CH, Hajos M, Lombardi A, Goglia F, Diano S 1999 Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers. J Neurosci 19:10417-10427
3. Vinter J, Hull D, Batt RA, Tyler DD 1988 The effect of limit feeding on thermogenesis and thermoregulation in genetically obese (ob/ob) mice during cold exposure. Int J Obes 12:111-117
4. Melnyk A, Himms-Hagen J 1998 Temperature-dependent feeding: lack of role for leptin and defect in brown adipose tissue-ablated obese mice. Am J Physiol 274:R1131-R1135
5. Yahata T, Kuroshima A 1989 Metabolic cold acclimation after repetitive intermittent cold exposure in rat. Jpn J Physiol 39:215-228
6. Baffi JS, Palkovits M 2000 Fine topography of brain areas activated by cold stress. A fos immunohistochemical study in rats. Neuroendocrinology 72: 102-113
7. Chen XM, Hosono T, Yoda T, Fukuda Y, Kanosue K 1998 Efferent projection from the preoptic area for the control of non-shivering thermogenesis in rats. J Physiol 512:883-892
8. Ferreira ML, Marubayashi U, Coimbra CC 1999 The medial preoptic area modulates the increase in plasma glucose and free fatty acid mobilization induced by acute cold exposure. Brain Res Bull 49:189-193
9. Spiegelman BM, Flier JS 2001 Obesity and the regulation of energy balance. Cell 104:531-543
10. Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E 2001 Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest 107:379-386
11. Inui A 1999 Feeding and body-weight regulation by hypothalamic neuropeptides - mediation of the actions of leptin. Trends Neurosci 22:62-67
12. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek R, Kanarek R, Maratos-Flier E 1996 A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380:243-247
13. Della-Zuana O, Presse F, Ortola C, Duhault J, Nahon JL, Levens N 2002 Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats. Int J Obes Relat Metab Disord 26:1289-1295
14. Rossi M, Beak SA, Choi SJ, Small CJ, Morgan DG, Ghatei MA, Smith DM, Bloom SR 1999 Investigation of the feeding effects of melanin concentrating hormone on food intake - action independent of galanin and the melanocortin receptors. Brain Res 846:164-170
15. Marsh DJ, Weingarth DT, Novi DE, Chen HY, Trumbauer ME, Chen AS, Guan XM, Jiang MM, Feng Y, Camacho RE, Shen Z, Frazier EG, Yu H, Metzger JM, Kuca SJ, Shearman LP, Gopal-Truter S, MacNeil DJ, Strack AM, MacIntyre DE, Van der Ploeg LH, Qian S 2002 Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc Natl Acad Sci USA 99:3240-3245
16. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E 1998 Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396:670-674
17. Trinder P 1969 Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol 22:158-161
18. Scott AM, Atwater I, Rojas E 1981 A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans. Diabetologia 21:470-475
19. Pimenta WP, Saad MJ, Paccola GM, Piccinato CE, Foss MC 1989 Effect of oral glucose on peripheral muscle fuel metabolism in fasted men. Braz J Med Biol Res 22:465-476
20. Kumar MV, Shimokawa T, Nagy TR, Lane MD 2002 Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. Proc Natl Acad Sci USA 99:1921-1925
21. Thomas DW, Blondel J, Perret P, Lambrechts MM, Speakman JR 2001 Energetic and fitness costs of mismatching resource supply and demand in seasonally breeding birds. Science 291:2598-2600
22. Withers PC 1977 Measurement of VO2, VCO2, and evaporative water loss with a flow-through mask. J Appl Physiol 42:120-123
23. Araujo EP, Amaral ME, Souza CT, Bordin S, Ferreira F, Saad MJ, Boschero AC, Magalhaes EC, Velloso LA 2002 Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion. FEBS Lett 531:437-442
24. Luciano E, Carneiro EM, Carvalho CR, Carvalheira JB, Peres SB, Reis MA, Saad MJ, Boschero AC, Velloso LA 2002 Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Eur J Endocrinol 147:149-157
25. Nagy G, Szekeres G, Kvell K, Berki T, Nemeth P 2002 Development and characterisation of a monoclonal antibody family against aquaporin 1 (AQP1) and aquaporin 4 (AQP4). Pathol Oncol Res 8:115-124
26. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
27. Mondal MS, Nakazato M, Matsukura S 2002 Characterization of orexins (hypocretins) and melanin-concentrating hormone in genetically obese mice. Regul Pept 104:21-25
28. Cunningham JJ, Gulino MA, Meara PA, Bode HH 1985 Enhanced hepatic insulin sensitivity and peripheral glucose uptake in cold acclimating rats. Endocrinology 117:1585-1589
29. Vallerand AL, Perusse F, Bukowiecki LJ 1987 Cold exposure potentiates the effect of insulin on in vivo glucose uptake. Am J Physiol 253:E179-E186
30. Enerback S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP 1997 Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387:90-94
31. Cheung VG, Spielman RS 2002 The genetics of variation in gene expression. Nat Genet 32(Suppl):522-525
32. Huang Q, Viale A, Picard F, Nahon J, Richard D 1999 Effects of leptin on melanin-concentrating hormone expression in the brain of lean and obese Lep(ob)/Lep(ob) mice. Neuroendocrinology 69:145-153
33. Yamada M, Miyakawa T, Duttaroy A, Yamanaka A, Moriguchi T, Makita R, Ogawa M, Chou CJ, Xia B, Crawley JN, Felder CC, Deng CX, Wess J 2001 Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature 410:207-212
34. Clegg DJ, Air EL, Benoit SC, Sakai RS, Seeley RJ, Woods SC 2002 Intraventricular melanin concentrating hormone stimulates water intake independent of food intake. Am J Physiol Regul Integr Comp Physiol 7:7
35. Gomori A, Ishihara A, Ito M, Mashiko S, Matsushita H, Yumoto M, Tanaka T, Tokita S, Moriya M, Iwaasa H, Kanatani A 2003 Chronic intracerebro-ventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone. Am J Physiol Endocrinol Metab 284:E583-E588
36. Ito M, Gomori A, Ishihara A, Oda Z, Mashiko S, Matsushita H, Yumoto M, Sano H, Tokita S, Moriya M, Iwaasa H, Kanatani A 2003 Characterization of MCH-mediated obesity in mice. Am J Physiol Endocrinol Metab 284:E940-E945
37. Borowsky B, Durkin MM, Ogozalek K, Marzabadi MR, DeLeon J, Lagu B, Heurich R, Lichtblau H, Shaposhnik Z, Daniewska I, Blackburn TP, Branchek TA, Gerald C, Vaysse PJ, Forray C 2002 Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat Med 8:825-830
38. Oldfield BJ, Giles ME, Watson A, Anderson C, Colvill LM, McKinley MJ 2002 The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 110:515-526
39. Shimokawa T, Kumar MV, Lane MD 2002 Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. Proc Natl Acad Sci USA 99:66-71