Evidence for the ectopic synthesis of melanin in human adipose tissue

FASEB Journal

Volumn 23, Issue 3, 2009, Pages 835-843

  Randhawa, Manpreet ^a   Huff, Tom ^b   Valencia, Julio C ^c   Younossi, Zobair ^d   Chandhoke, Vikas ^a   Hearing, Vincent J ^c   Baranova, Ancha ^a,d,e  

^a Molecular and Microbiology Department   (United States)

^b GEORGE MASON UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d INOVA FAIRFAX HOSPITAL   (United States)

^e GEORGE MASON UNIVERSITY   (United States)

Author keywords

A MSH; Inflammation; Metabolic syndrome; Obesity; Pigmentation

Indexed keywords

CARBON 14; MELANIN; MESSENGER RNA; PERMANGANATE POTASSIUM; PYRROLE 2,3,5 TRICARBOXYLIC ACID; PYRROLE DERIVATIVE; TISSUE EXTRACT; TRICARBOXYLIC ACID; TYROSINE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INNER EAR; INTRAABDOMINAL FAT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MELANOCYTE; MELANOGENESIS; OBESITY; OXIDATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; ULTRAVIOLET SPECTROSCOPY;

ADIPOSE TISSUE; ANIMALS; CHROMATOGRAPHY, LIQUID; GENE EXPRESSION REGULATION; HAIR; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MASS SPECTROMETRY; MELANINS; MEMBRANE GLYCOPROTEINS; MICE; OXIDOREDUCTASES;

ANIMALIA;

EID: 61449128287     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-116327     Document Type: Article

References (22)

1. Ito, S., and Wakamatsu, K. (1989) Melanin chemistry and melanin precursors in melanoma. J. Invest. Dermatol. 92, 261S- 265S
2. Martinez-Morales, J. R., Rodrigo, I., and Bovolenta, P. (2004) Eye development: a view from the retina pigmented epithelium. Bioessays 26, 766-777
3. Mayer, T. C. (1973) The migratory pathway of neural crest cells into the skin of mouse embryos. Dev. Biol. 34, 39-46
4. Nofsinger, J. B., Liu, Y., and Simon, J. D. (2002) Aggregation of eumelanin mitigates photogeneration of reactive oxygen species. Free Radic. Biol. Med. 32, 720-730
5. Meyskens, F. L. Jr., Farmer, P., and Fruehauf, J. P. (2001) Redox regulation in human melanocytes and melanoma. Pigment Cell Res. 14, 148-154
6. Zecca, L., Zucca, F. A., Albertini, A., Rizzio, E., and Fariello, R. G. (2006) A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease. Neurology 67, S8-S11
7. Gallone, A., Guida, G., Maida, I., and Cicero, R. (2002) Spleen and liver pigmented macrophages of Rana esculenta L. A new melanogenic system? Pigment Cell Res. 15, 32-40
8. Nosanchuk, J. D., and Casadevall, A. (2003) The contribution of melanin to microbial pathogenesis. Cell. Microbiol. 5, 203-223
9. Baranova, A., Collantes, R., Gowder, S. J., Elariny, H., Schlauch, K., Younoszai, A., King, S., Randhawa, M., Pusulury, S., Alsheddi, T., Ong, J. P., Martin, L. M., Chandhoke, V., and Younossi, Z. M. (2005) Obesity-related differential gene expression in the visceral adipose tissue. Obes. Surg. 6, 758-765
10. Tadokoro, T., Kobayashi, N., Zmudzka, B. Z., Ito, S., Waka- matsu, K., Yamaguchi, Y., Korossy, K. S., Miller, S. A., Beer, J. Z., and Hearing, V. J. (2003) UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin. FASEB J. 17, 1177-11779
11. Bolt, A. G. (1967) Interaction between human melanoprotein and chlorpromazine derivatives 1. Isolation and purification of human melanin protein from hair and melanoma. Life Sci. 6, 1277-1283
12. Ito, S., and Fujita, K. (1985) Microanalysis of eumelanin and pheomelanin in hair and melanomas by chemical degradation and liquid chromatography. Anal. Biochem. 144, 527-536
13. Hearing, V. J., and Ekel, T. M. (1976) Mammalian tyrosinase. A comparison of tyrosine hydroxylation and melanin formation. Biochem. J. 157, 549-557
14. Valencia, J. C., Watabe, H., Chi, A., Rouzaud, F., Chen, K. G., Vieira, W. D., Takahashi, K., Yamaguchi, Y., Berens, W., Na- gashima, K., Shabanowitz, J., Hunt, D. F., Appella, E., and Hearing, V. J. (2006) Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes. J. Cell Sci. 119, 1080-1091
15. Kushimoto, T., Basrur, V., Valencia, J., Matsunaga, J., Vieira, W. D., Ferrans, V. J., Muller, J., Appella, E., and Hearing, V. J. (2001) A model for melanosome biogenesis based on the purification and analysis of early melanosomes. Proc. Natl. Acad. Sci. U. S. A. 98, 10698-10703
16. Szekely-Klepser, G., Wade, K., Woolson, D., Brown, R., Fountain, S., and Kindt, E. (2005) A validated LC/MS/MS method for the quantification of pyrrole-2,3,5-tricarboxylic acid (PTCA), a eumelanin specific biomarker, in human skin punch biopsies. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 826, 31-40
17. Mohagheghpour, N., Waleh, N., Garger, S. J., Dousman, L., Grill, L. K., and Tuse, D. (2000) Synthetic melanin suppresses production of proinflammatory cytokines. Cell. Immunol. 199, 25-36
18. Rozanowska, M., Sarna, T., Land, E. J., and Truscott, T. G. (1999) Free radical scavenging properties of melanin interaction of eu- and pheo-melanin models with reducing and oxidising radicals. Free Radic. Biol. Med. 26, 518-525
19. Seagle, B. L., Rezai, K. A., Gasyna, E. M., Kobori, Y., Rezaei, K. A., and Norris, J. R. Jr. (2005) Time-resolved detection of melanin free radicals quenching reactive oxygen species. J. Am. Chem. Soc. 127, 11220-11221
20. Hoggard, N., Hoggard, N., Johnstone, A. M., Faber, P., Gibney, E. R., Elia, M., Lobley, G., Rayner, V., Horgan, G., Hunter, L., Bashir, S., and Stubbs, R. J. (2004) Plasma concentrations of alpha-MSH, AgRP and leptin in lean and obese men and their relationship to differing states of energy balance perturbation. Clin. Endocrinol. (Oxf.) 61, 31-39
21. Hoch, M., Eberle, A. N., Wagner, U., Bussmann, C., Peters, T., and Peterli, R. (2007) Expression and localization of melano- cortin-1 receptor in human adipose tissues of severely obese patients. Obesity 15, 40-49
22. Soukas, A., Socci, N. D., Saatkamp, B. D., Novelli, S., Friedman, J. M. (2001) Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J. Biol. Chem. 276, 34167-34174