Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans

RNA

Volumn 18, Issue 12, 2012, Pages 2220-2235

  Lehrbach, Nicolas J ^a,b   Castro, Cecilia ^b   Murfitt, Kenneth J ^a,b   Abreu Goodger, Cei ^c   Griffin, Julian L ^b,d,e   Miska, Eric A ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Laboratorio Nacional de Genómica para la Biodiversidad Cinvestav Irapuato   (Mexico)

^d MEDICAL RESEARCH COUNCIL   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

C. Elegans; DGCR8; miRNA; PASH 1; Physiology

Indexed keywords

INSULIN; MICRORNA; SOMATOMEDIN C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DGCR8; TRANSCRIPTION FACTOR PASH 1; UNCLASSIFIED DRUG;

AGED; AGING; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CELL VIABILITY; CONTROLLED STUDY; DEVELOPMENTAL BIOLOGY; GENE DISRUPTION; GENE EXPRESSION; GENE INACTIVATION; IN VITRO STUDY; IN VIVO STUDY; LIFESPAN; LONGEVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; RNA SYNTHESIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AGING; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HELMINTH; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LONGEVITY; MICRORNAS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, INSULIN; RNA STABILITY; RNA, HELMINTH; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TEMPERATURE;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 84869853276     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.035402.112     Document Type: Article

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