메뉴 건너뛰기




Volumn 22, Issue 18, 2008, Pages 2535-2549

A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity

Author keywords

C. elegans; Feedback; MicroRNA; Network motif; Regulatory network; Transcription factor

Indexed keywords

MICRORNA; TRANSCRIPTION FACTOR;

EID: 51949087680     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1678608     Document Type: Article
Times cited : (205)

References (69)
  • 1
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • Alon, U. 2007. Network motifs: Theory and experimental approaches. Nat. Rev. Genet. 8: 450-461.
    • (2007) Nat. Rev. Genet , vol.8 , pp. 450-461
    • Alon, U.1
  • 3
    • 33846994717 scopus 로고    scopus 로고
    • EDGEdb: A transcription factor-DNA interaction database for the analysis of C. elegans differential gene expression
    • doi: 10.1186/1471-2164-8-21
    • Barrasa, M.I., Vaglio, P., Cavasino, F., Jacotot, L., and Walhout, A.J.M. 2007. EDGEdb: A transcription factor-DNA interaction database for the analysis of C. elegans differential gene expression. BMC Genomics 8: 21. doi: 10.1186/1471-2164-8-21.
    • (2007) BMC Genomics , vol.8 , pp. 21
    • Barrasa, M.I.1    Vaglio, P.2    Cavasino, F.3    Jacotot, L.4    Walhout, A.J.M.5
  • 4
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel, D.P. 2004. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 5
    • 1942435249 scopus 로고    scopus 로고
    • Micromanagers of gene expression: The potentially widespread influence of metazoan microRNAs
    • Bartel, D.P. and Chen, C.Z. 2004. Micromanagers of gene expression: The potentially widespread influence of metazoan microRNAs. Nat. Rev. Genet. 5: 396-400.
    • (2004) Nat. Rev. Genet , vol.5 , pp. 396-400
    • Bartel, D.P.1    Chen, C.Z.2
  • 6
    • 13944260434 scopus 로고    scopus 로고
    • Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes
    • Baskerville, S. and Bartel, D.P. 2005. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA 11: 241-247.
    • (2005) RNA , vol.11 , pp. 241-247
    • Baskerville, S.1    Bartel, D.P.2
  • 8
    • 4644227434 scopus 로고    scopus 로고
    • Trans-splicing and polyadenylation of let-7 microRNA primary transcripts
    • Bracht, J., Hunter, S., Eachus, R., Weeks, P., and Pasquinelli, A.E. 2004. Trans-splicing and polyadenylation of let-7 microRNA primary transcripts. RNA 10: 1586-1594.
    • (2004) RNA , vol.10 , pp. 1586-1594
    • Bracht, J.1    Hunter, S.2    Eachus, R.3    Weeks, P.4    Pasquinelli, A.E.5
  • 9
    • 4043072675 scopus 로고    scopus 로고
    • MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode
    • Chang, S., Johnston Jr., R.J., Frokjaer-Jensen, C., Lockery, S., and Hobert, O. 2004. MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode. Nature 430: 785-789.
    • (2004) Nature , vol.430 , pp. 785-789
    • Chang, S.1    Johnston Jr., R.J.2    Frokjaer-Jensen, C.3    Lockery, S.4    Hobert, O.5
  • 10
    • 7444267933 scopus 로고    scopus 로고
    • A Gateway-compatible yeast one-hybrid system
    • Deplancke, B., Dupuy, D., Vidal, M., and Walhout, A.J.M. 2004. A Gateway-compatible yeast one-hybrid system. Genome Res. 14: 2093-2101.
    • (2004) Genome Res , vol.14 , pp. 2093-2101
    • Deplancke, B.1    Dupuy, D.2    Vidal, M.3    Walhout, A.J.M.4
  • 15
    • 28344438648 scopus 로고    scopus 로고
    • A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPα regulates human granulopoiesis
    • Fazi, F., Rosa, A., Fatica, A., Gelmetti, V., De Marchis, M.L., Nervi, C., and Bozzoni, I. 2005. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPα regulates human granulopoiesis. Cell 123: 819-831.
    • (2005) Cell , vol.123 , pp. 819-831
    • Fazi, F.1    Rosa, A.2    Fatica, A.3    Gelmetti, V.4    De Marchis, M.L.5    Nervi, C.6    Bozzoni, I.7
  • 16
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • Gardner, T.S., Cantor, C.R., and Collins, J.J. 2000. Construction of a genetic toggle switch in Escherichia coli. Nature 403: 339-342.
    • (2000) Nature , vol.403 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 18
    • 50849141708 scopus 로고    scopus 로고
    • Hammell, M., Long, D., Zhang, L., Lee, A., Carmack, C.S., Han, M., Ding, Y., and Ambros, V. 2008. mirWIP: microRNA target prediction based on microRNA-containing ribonucleo-protein-enriched transcripts. Nat. Methods. doi: 10.1038/nmeth.1247.
    • Hammell, M., Long, D., Zhang, L., Lee, A., Carmack, C.S., Han, M., Ding, Y., and Ambros, V. 2008. mirWIP: microRNA target prediction based on microRNA-containing ribonucleo-protein-enriched transcripts. Nat. Methods. doi: 10.1038/nmeth.1247.
  • 20
    • 0037174669 scopus 로고    scopus 로고
    • Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop
    • Hirata, H., Yoshiura, S., Ohtsuka, T., Bessho, Y., Harada, T., Yoshikawa, K., and Kageyama, R. 2002. Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science 298: 840-843.
    • (2002) Science , vol.298 , pp. 840-843
    • Hirata, H.1    Yoshiura, S.2    Ohtsuka, T.3    Bessho, Y.4    Harada, T.5    Yoshikawa, K.6    Kageyama, R.7
  • 21
    • 34547641224 scopus 로고    scopus 로고
    • Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family
    • Hollenhorst, P.C., Shah, A.A., Hopkins, C., and Graves, B.J. 2007. Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes & Dev. 21: 1882-1894.
    • (2007) Genes & Dev , vol.21 , pp. 1882-1894
    • Hollenhorst, P.C.1    Shah, A.A.2    Hopkins, C.3    Graves, B.J.4
  • 22
    • 84984765621 scopus 로고    scopus 로고
    • Canalization of development by microRNAs
    • doi: 10.1038/ng1803
    • Hornstein, E. and Shomron, N. 2006. Canalization of development by microRNAs. Nat. Genet. 38: S20-S24. doi: 10.1038/ng1803.
    • (2006) Nat. Genet , vol.38
    • Hornstein, E.1    Shomron, N.2
  • 25
    • 0035799707 scopus 로고    scopus 로고
    • Lethality and centrality in protein networks
    • Jeong, H., Mason, S.P., Barabasi, A.-L., and Oltvai, Z.N. 2001. Lethality and centrality in protein networks. Nature 411: 41-42.
    • (2001) Nature , vol.411 , pp. 41-42
    • Jeong, H.1    Mason, S.P.2    Barabasi, A.-L.3    Oltvai, Z.N.4
  • 26
    • 0037772254 scopus 로고    scopus 로고
    • The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter
    • Johnson, S.M., Lin, S.-Y., and Slack, F.J. 2003. The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter. Dev. Biol. 259: 364-379.
    • (2003) Dev. Biol , vol.259 , pp. 364-379
    • Johnson, S.M.1    Lin, S.-Y.2    Slack, F.J.3
  • 28
    • 24144437052 scopus 로고    scopus 로고
    • MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision
    • Johnston Jr., R.J., Chang, S., Etchberger, J.F., Ortiz, C.O., and Hobert, O. 2005. MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision. Proc. Natl. Acad. Sci. 102: 12449-12454.
    • (2005) Proc. Natl. Acad. Sci , vol.102 , pp. 12449-12454
    • Johnston Jr., R.J.1    Chang, S.2    Etchberger, J.F.3    Ortiz, C.O.4    Hobert, O.5
  • 29
    • 4444268694 scopus 로고    scopus 로고
    • Efficient sampling algorithm for estimating subgraph concentrations and detecting network motifs
    • Kashtan, N., Itzkovitz, S., Milo, R., and Alon, U. 2004. Efficient sampling algorithm for estimating subgraph concentrations and detecting network motifs. Bioinformatics 20: 1746-1758.
    • (2004) Bioinformatics , vol.20 , pp. 1746-1758
    • Kashtan, N.1    Itzkovitz, S.2    Milo, R.3    Alon, U.4
  • 30
    • 18344369543 scopus 로고    scopus 로고
    • MicroRNA biogenesis: Coordinated cropping and dicing
    • Kim, V.N. 2005. MicroRNA biogenesis: Coordinated cropping and dicing. Nat. Rev. Mol. Cell Biol. 6: 376-385.
    • (2005) Nat. Rev. Mol. Cell Biol , vol.6 , pp. 376-385
    • Kim, V.N.1
  • 32
    • 0028095365 scopus 로고
    • The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zincfinger transcription factor
    • Labouesse, M., Sookhareea, S., and Horvitz, H.R. 1994. The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zincfinger transcription factor. Development 120: 2359-2368.
    • (1994) Development , vol.120 , pp. 2359-2368
    • Labouesse, M.1    Sookhareea, S.2    Horvitz, H.R.3
  • 34
    • 0346022962 scopus 로고    scopus 로고
    • Multiple regulatory elements with spatially and temporally distinct activities control the expression of the epithelial differentiation gene lin-26 in C. elegans
    • Landmann, F., Quintin, S., and Labouesse, M. 2004. Multiple regulatory elements with spatially and temporally distinct activities control the expression of the epithelial differentiation gene lin-26 in C. elegans. Dev. Biol. 265: 478-490.
    • (2004) Dev. Biol , vol.265 , pp. 478-490
    • Landmann, F.1    Quintin, S.2    Labouesse, M.3
  • 35
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee, R.C., Feinbaum, R.L., and Ambros, V. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 36
    • 8144225486 scopus 로고    scopus 로고
    • MicroRNA genes are transcribed by RNA polymerase II
    • Lee, Y., Kim, M., Han, J., Yeom, K.-H., Lee, S., Baek, S.H., and Kim, V.N. 2004. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23: 4051-4060.
    • (2004) EMBO J , vol.23 , pp. 4051-4060
    • Lee, Y.1    Kim, M.2    Han, J.3    Yeom, K.-H.4    Lee, S.5    Baek, S.H.6    Kim, V.N.7
  • 37
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis, B.P., Burge, C.B., and Bartel, D.P. 2005. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120: 15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 38
    • 24144467823 scopus 로고    scopus 로고
    • Regulatory mutations of mir-48, a C. elegans let-7 family microRNA, cause developmental timing defects
    • Li, M., Jones-Rhoades, M.W., Lau, N.C., Bartel, D.P., and Rougvie, A.E. 2005. Regulatory mutations of mir-48, a C. elegans let-7 family microRNA, cause developmental timing defects. Dev. Cell 9: 415-422.
    • (2005) Dev. Cell , vol.9 , pp. 415-422
    • Li, M.1    Jones-Rhoades, M.W.2    Lau, N.C.3    Bartel, D.P.4    Rougvie, A.E.5
  • 42
    • 51949108357 scopus 로고    scopus 로고
    • The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans
    • this issue, doi: 10.1101/gad.1678808
    • Ow, M.C., Martinez, N.J., Olsen, P.H., Silverman, S., Barrasa, M.I., Conradt, B., Walhout, A.J.M., and Ambros, V. 2008. The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans. Genes & Dev. (this issue). doi: 10.1101/gad.1678808.
    • (2008) Genes & Dev
    • Ow, M.C.1    Martinez, N.J.2    Olsen, P.H.3    Silverman, S.4    Barrasa, M.I.5    Conradt, B.6    Walhout, A.J.M.7    Ambros, V.8
  • 43
    • 0030776478 scopus 로고    scopus 로고
    • The DAF-3 Smad protein antagonizes TGF-B-related receptor signaling in the Caenorhabditis elegans dauer pathway
    • Patterson, G.I., Koweek, A., Wong, A., Liu, Y., and Ruvkun, G. 1997. The DAF-3 Smad protein antagonizes TGF-B-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes & Dev. 11: 2679-2690.
    • (1997) Genes & Dev , vol.11 , pp. 2679-2690
    • Patterson, G.I.1    Koweek, A.2    Wong, A.3    Liu, Y.4    Ruvkun, G.5
  • 44
    • 33744976395 scopus 로고    scopus 로고
    • A compendium of C. elegans regulatory transcription factors: A resource for mapping transcription regulatory networks
    • doi: 10.1186/gb-2005-6-13-r110
    • Reece-Hoyes, J.S., Deplancke, B., Shingles, J., Grove, C.A., Hope, I.A., and Walhout, A.J.M. 2005. A compendium of C. elegans regulatory transcription factors: A resource for mapping transcription regulatory networks. Genome Biol. 6: R110. doi: 10.1186/gb-2005-6-13-r110.
    • (2005) Genome Biol , vol.6
    • Reece-Hoyes, J.S.1    Deplancke, B.2    Shingles, J.3    Grove, C.A.4    Hope, I.A.5    Walhout, A.J.M.6
  • 45
    • 33846964132 scopus 로고    scopus 로고
    • Insight into transcription factor gene duplication from Caenorhabditis elegans Promoterome-driven expression patterns
    • doi: 10.1186/1471-2164-8-27
    • Reece-Hoyes, J.S., Shingles, J., Dupuy, D., Grove, C.A., Walhout, A.J., Vidal, M., and Hope, I.A. 2007. Insight into transcription factor gene duplication from Caenorhabditis elegans Promoterome-driven expression patterns. BMC Genomics 8: 27. doi: 10.1186/1471-2164-8-27.
    • (2007) BMC Genomics , vol.8 , pp. 27
    • Reece-Hoyes, J.S.1    Shingles, J.2    Dupuy, D.3    Grove, C.A.4    Walhout, A.J.5    Vidal, M.6    Hope, I.A.7
  • 46
    • 4644237189 scopus 로고    scopus 로고
    • Fast and effective prediction of microRNA/target duplexes
    • Rehmsmeier, M., Steffen, P., Hochsmann, M., and Giegerich, R. 2004. Fast and effective prediction of microRNA/target duplexes. RNA 10: 1507-1517.
    • (2004) RNA , vol.10 , pp. 1507-1517
    • Rehmsmeier, M.1    Steffen, P.2    Hochsmann, M.3    Giegerich, R.4
  • 47
    • 33845436047 scopus 로고    scopus 로고
    • Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
    • Ruby, J.G., Jan, C., Player, C., Axtell, M.J., Lee, W., Nusbaum, C., Ge, H., and Bartel, D.P. 2006. Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell 127: 1193-1207.
    • (2006) Cell , vol.127 , pp. 1193-1207
    • Ruby, J.G.1    Jan, C.2    Player, C.3    Axtell, M.J.4    Lee, W.5    Nusbaum, C.6    Ge, H.7    Bartel, D.P.8
  • 48
    • 33847271755 scopus 로고    scopus 로고
    • A core transcriptional network for early mesoderm development in Drosophila melanogaster
    • Sandmann, T., Girardot, C., Brehme, M., Tongprasit, W., Stolc, V., and Furlong, E.E. 2007. A core transcriptional network for early mesoderm development in Drosophila melanogaster. Genes & Dev. 21: 436-449.
    • (2007) Genes & Dev , vol.21 , pp. 436-449
    • Sandmann, T.1    Girardot, C.2    Brehme, M.3    Tongprasit, W.4    Stolc, V.5    Furlong, E.E.6
  • 49
    • 33750318273 scopus 로고    scopus 로고
    • A guide through present computational approaches for the identification of mammalian microRNA targets
    • Sethupathy, P., Megraw, M., and Hatzigergiou, A.G. 2006. A guide through present computational approaches for the identification of mammalian microRNA targets. Nat. Methods 3: 881-886.
    • (2006) Nat. Methods , vol.3 , pp. 881-886
    • Sethupathy, P.1    Megraw, M.2    Hatzigergiou, A.G.3
  • 50
    • 34547555796 scopus 로고    scopus 로고
    • Global and local architecture of the mammalian microRNA-transcription factor regulatory network
    • doi: 10.1371/journal.pcbi.0030131
    • Shalgi, R., Lieber, D., Oren, M., and Pilpel, Y. 2007. Global and local architecture of the mammalian microRNA-transcription factor regulatory network. PLoS Comput. Biol. 3: e131. doi: 10.1371/journal.pcbi.0030131.
    • (2007) PLoS Comput. Biol , vol.3
    • Shalgi, R.1    Lieber, D.2    Oren, M.3    Pilpel, Y.4
  • 52
    • 0036578795 scopus 로고    scopus 로고
    • Network motifs in the transcriptional regulation network of Escherichia coli
    • Shen-Orr, S.S., Milo, R., Mangan, S., and Alon, U. 2002. Network motifs in the transcriptional regulation network of Escherichia coli. Nat. Genet. 31: 64-68.
    • (2002) Nat. Genet , vol.31 , pp. 64-68
    • Shen-Orr, S.S.1    Milo, R.2    Mangan, S.3    Alon, U.4
  • 54
    • 33644499134 scopus 로고    scopus 로고
    • Cell-type-specific signatures of microRNAs on target mRNA expression
    • Sood, P., Krek, A., Zavolan, M., Macino, G., and Rajewsky, N. 2006. Cell-type-specific signatures of microRNAs on target mRNA expression. Proc. Natl. Acad. Sci. 103: 2746-2751.
    • (2006) Proc. Natl. Acad. Sci , vol.103 , pp. 2746-2751
    • Sood, P.1    Krek, A.2    Zavolan, M.3    Macino, G.4    Rajewsky, N.5
  • 55
    • 28944439309 scopus 로고    scopus 로고
    • Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3′UTR evolution
    • Stark, A., Brennecke, J., Bushati, N., Russell, R.B., and Cohen, S.M. 2005. Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3′UTR evolution. Cell 123: 1133-1146.
    • (2005) Cell , vol.123 , pp. 1133-1146
    • Stark, A.1    Brennecke, J.2    Bushati, N.3    Russell, R.B.4    Cohen, S.M.5
  • 57
    • 0032957753 scopus 로고    scopus 로고
    • The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx
    • Thatcher, J.D., Haun, C., and Okkema, P.G. 1999. The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx. Development 126: 97-107.
    • (1999) Development , vol.126 , pp. 97-107
    • Thatcher, J.D.1    Haun, C.2    Okkema, P.G.3
  • 58
    • 34249819336 scopus 로고    scopus 로고
    • MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals
    • Tsang, J., Zhu, J., and van Oudenaarden, A. 2007. MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Mol. Cell 26: 753-767.
    • (2007) Mol. Cell , vol.26 , pp. 753-767
    • Tsang, J.1    Zhu, J.2    van Oudenaarden, A.3
  • 59
    • 34548863687 scopus 로고    scopus 로고
    • microRNA miR-14 acts to modulate a positive autoregulatory loop controlling steroid hormone signaling in Drosophila
    • Varghese, J. and Cohen, S.M. 2007. microRNA miR-14 acts to modulate a positive autoregulatory loop controlling steroid hormone signaling in Drosophila. Genes & Dev. 21: 2277-2282.
    • (2007) Genes & Dev , vol.21 , pp. 2277-2282
    • Varghese, J.1    Cohen, S.M.2
  • 62
    • 0028067425 scopus 로고
    • Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans
    • Vowels, J.J. and Thomas, J.H. 1994. Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans. Genetics 138: 303-316.
    • (1994) Genetics , vol.138 , pp. 303-316
    • Vowels, J.J.1    Thomas, J.H.2
  • 63
    • 33845311536 scopus 로고    scopus 로고
    • Unraveling transcription regulatory networks by protein-DNA and protein-protein interaction mapping
    • Walhout, A.J.M. 2006. Unraveling transcription regulatory networks by protein-DNA and protein-protein interaction mapping. Genome Res. 16: 1445-1454.
    • (2006) Genome Res , vol.16 , pp. 1445-1454
    • Walhout, A.J.M.1
  • 66
    • 0038406208 scopus 로고    scopus 로고
    • Global analysis of dauer gene expression in C. elegans
    • Wang, J. and Kim, S.K. 2003. Global analysis of dauer gene expression in C. elegans. Development 130: 1621-1634.
    • (2003) Development , vol.130 , pp. 1621-1634
    • Wang, J.1    Kim, S.K.2
  • 67
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman, B., Ha, I., and Ruvkun, G. 1993. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75: 855-862.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 69
    • 28144458897 scopus 로고    scopus 로고
    • LIN-12/Notch activation leads to microRNA-mediated downregulation of Vav in C. elegans
    • Yoo, A.S. and Greenwald, I. 2005. LIN-12/Notch activation leads to microRNA-mediated downregulation of Vav in C. elegans. Science 310: 1330-1333.
    • (2005) Science , vol.310 , pp. 1330-1333
    • Yoo, A.S.1    Greenwald, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.