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Volumn 7, Issue 11, 2012, Pages

Vasculogenic Mimicry of HT1080 Tumour Cells In Vivo: Critical Role of HIF-1α-Neuropilin-1 Axis

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; MYC PROTEIN; NEUROPILIN 1; OCTAMER TRANSCRIPTION FACTOR 4; RIBOSOME RNA; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SOX2; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

EID: 84869777262     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050153     Document Type: Article
Times cited : (48)

References (79)
  • 1
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other Diseases
    • Carmeliet P, Jain RK, (2000) Angiogenesis in cancer and other Diseases. Nature. 407(6801): 249-257.
    • (2000) Nature , vol.407 , Issue.6801 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 2
    • 84975525035 scopus 로고
    • Clinical applications of research on angiogenesis
    • Folkman J, (1995) Clinical applications of research on angiogenesis. N Engl J Med. 333(26): 1757-1763.
    • (1995) N Engl J Med , vol.333 , Issue.26 , pp. 1757-1763
    • Folkman, J.1
  • 3
    • 81255188940 scopus 로고    scopus 로고
    • Tumor angiogenesis: molecular pathways and therapeutic targets
    • Weis SM, Cheresh DA, (2011) Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med. 17(11): 1359-1370.
    • (2011) Nat Med , vol.17 , Issue.11 , pp. 1359-1370
    • Weis, S.M.1    Cheresh, D.A.2
  • 4
    • 0034601455 scopus 로고    scopus 로고
    • Molecular classification of cutaneous malignant melanoma by gene expression profiling
    • Bittner M, Meltzer P, Chen Y, Jiang Y, Seftor E, et al. (2000) Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406(6795): 536-540.
    • (2000) Nature , vol.406 , Issue.6795 , pp. 536-540
    • Bittner, M.1    Meltzer, P.2    Chen, Y.3    Jiang, Y.4    Seftor, E.5
  • 5
    • 0036527585 scopus 로고    scopus 로고
    • Molecular mechanisms of lymphangiogenesis in health and disease
    • Alitalo K, Carmeliet P, (2002) Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 1(3): 219-227.
    • (2002) Cancer Cell , vol.1 , Issue.3 , pp. 219-227
    • Alitalo, K.1    Carmeliet, P.2
  • 6
    • 0032887340 scopus 로고    scopus 로고
    • Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry
    • Maniotis AJ, Folberg R, Hess A, Seftor EA, Gardner LM, et al. (1999) Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry. Am J Pathol 155(3): 739-752.
    • (1999) Am J Pathol , vol.155 , Issue.3 , pp. 739-752
    • Maniotis, A.J.1    Folberg, R.2    Hess, A.3    Seftor, E.A.4    Gardner, L.M.5
  • 7
    • 6944230090 scopus 로고    scopus 로고
    • Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells
    • Van der Schaft DW, Seftor RE, Seftor EA, Hess AR, Gruman LM, et al. (2004) Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells. J Natl Cancer Inst. 96(19): 1473-1477.
    • (2004) J Natl Cancer Inst , vol.96 , Issue.19 , pp. 1473-1477
    • van der Schaft, D.W.1    Seftor, R.E.2    Seftor, E.A.3    Hess, A.R.4    Gruman, L.M.5
  • 9
    • 84866524036 scopus 로고    scopus 로고
    • Tumor cell vasculogenic mimicry: from controversy to therapeutic promise
    • Seftor RE, Hess AR, Seftor EA, Kirschmann DA, Hardy KM, et al. (2012) Tumor cell vasculogenic mimicry: from controversy to therapeutic promise. Am J Pathol. 181(4): 1115-1125.
    • (2012) Am J Pathol , vol.181 , Issue.4 , pp. 1115-1125
    • Seftor, R.E.1    Hess, A.R.2    Seftor, E.A.3    Kirschmann, D.A.4    Hardy, K.M.5
  • 10
    • 49949152069 scopus 로고    scopus 로고
    • Mechanisms of adaptive angiogenesis to tissue hypoxia
    • Fong GH, (2008) Mechanisms of adaptive angiogenesis to tissue hypoxia. Angiogenesis 11(2): 121-140.
    • (2008) Angiogenesis , vol.11 , Issue.2 , pp. 121-140
    • Fong, G.H.1
  • 11
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-a key regulatory factor in tumour growth
    • Harris AL, (2002) Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2(1): 38-47.
    • (2002) Nat Rev Cancer , vol.2 , Issue.1 , pp. 38-47
    • Harris, A.L.1
  • 12
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, stem cells and cancer
    • Keith B, Simon MC, (2007) Hypoxia-inducible factors, stem cells and cancer. Cell. 129(3): 465-472.
    • (2007) Cell , vol.129 , Issue.3 , pp. 465-472
    • Keith, B.1    Simon, M.C.2
  • 13
    • 40949142209 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in tumorgenesis
    • Rankin EB, Giaccia AJ, (2008) The role of hypoxia-inducible factors in tumorgenesis. Cell Death Differ. 15(4): 678-685.
    • (2008) Cell Death Differ , vol.15 , Issue.4 , pp. 678-685
    • Rankin, E.B.1    Giaccia, A.J.2
  • 14
    • 79960981005 scopus 로고    scopus 로고
    • Signal transduction in vasculogenesis and developmental angiogenesis
    • Patel-Hett S, D'Amore PA, (2011) Signal transduction in vasculogenesis and developmental angiogenesis. Int J Dev Biol. 55(4-5): 353-363.
    • (2011) Int J Dev Biol , vol.55 , Issue.4-5 , pp. 353-363
    • Patel-Hett, S.1    D'Amore, P.A.2
  • 15
    • 0032710319 scopus 로고    scopus 로고
    • Clinical applications of angiogenic growth factors and their inhibitors
    • Ferrara N, Alitalo K, (1999) Clinical applications of angiogenic growth factors and their inhibitors. Nat Med. 5(12): 1359-1364.
    • (1999) Nat Med , vol.5 , Issue.12 , pp. 1359-1364
    • Ferrara, N.1    Alitalo, K.2
  • 16
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet. 40(5): 499-507.
    • (2008) Nat Genet , vol.40 , Issue.5 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5
  • 17
    • 41449118521 scopus 로고    scopus 로고
    • Module map of stem cell genes guides creation of epithelial cancer stem cells
    • Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, et al. (2008) Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell stem cell. 2(4): 333-344.
    • (2008) Cell stem cell , vol.2 , Issue.4 , pp. 333-344
    • Wong, D.J.1    Liu, H.2    Ridky, T.W.3    Cassarino, D.4    Segal, E.5
  • 18
    • 79959908506 scopus 로고    scopus 로고
    • HIF induces human embryonic stem cell markers in cancer cells
    • Mathieu J, Zhang Z, Zhou W, Wang AJ, Heddleston JM, et al. (2011) HIF induces human embryonic stem cell markers in cancer cells. Cancer Res. 71(13): 4640-4652.
    • (2011) Cancer Res , vol.71 , Issue.13 , pp. 4640-4652
    • Mathieu, J.1    Zhang, Z.2    Zhou, W.3    Wang, A.J.4    Heddleston, J.M.5
  • 19
    • 0036792667 scopus 로고    scopus 로고
    • c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
    • Baudino TA, McKay C, Pendeville-Samain H, Nilsson JA, Maclean KH, et al. (2002) c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev. 16(19): 2530-2543.
    • (2002) Genes Dev , vol.16 , Issue.19 , pp. 2530-2543
    • Baudino, T.A.1    McKay, C.2    Pendeville-Samain, H.3    Nilsson, J.A.4    Maclean, K.H.5
  • 20
    • 35649014840 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    • Kim JW, Gao P, Liu YC, Semenza GL, Dang CV, (2007) Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol. 27(21): 7381-7393.
    • (2007) Mol Cell Biol , vol.27 , Issue.21 , pp. 7381-7393
    • Kim, J.W.1    Gao, P.2    Liu, Y.C.3    Semenza, G.L.4    Dang, C.V.5
  • 21
    • 79954559053 scopus 로고    scopus 로고
    • Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migrationand signalling via p130Cas
    • Pellet-Many C, Frankel P, Evans IM, Herzog B, Jünemann-Ramírez M, et al. (2011) Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migrationand signalling via p130Cas. Biochem J. 435(3): 609-618.
    • (2011) Biochem J , vol.435 , Issue.3 , pp. 609-618
    • Pellet-Many, C.1    Frankel, P.2    Evans, I.M.3    Herzog, B.4    Jünemann-Ramírez, M.5
  • 22
    • 1542571789 scopus 로고    scopus 로고
    • Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration
    • Wang L, Zeng H, Wang P, Soker S, Mukhopadhyay D, (2003) Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration. J Biol Chem. 278(49): 48848-48860.
    • (2003) J Biol Chem , vol.278 , Issue.49 , pp. 48848-48860
    • Wang, L.1    Zeng, H.2    Wang, P.3    Soker, S.4    Mukhopadhyay, D.5
  • 23
    • 41049099329 scopus 로고    scopus 로고
    • Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis
    • Geretti E, Shimizu A, Klagsbrun M, (2008) Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis. Angiogenesis. 11(1): 31-39.
    • (2008) Angiogenesis , vol.11 , Issue.1 , pp. 31-39
    • Geretti, E.1    Shimizu, A.2    Klagsbrun, M.3
  • 24
    • 9744253054 scopus 로고    scopus 로고
    • Overproduction of VEGF concomitantly expressed with its receptors promotes growth and survival of melanoma cells through MAPK and PI3K signaling
    • Graells J, Vinyals A, Figueras A, Llorens A, Moreno A, et al. (2004) Overproduction of VEGF concomitantly expressed with its receptors promotes growth and survival of melanoma cells through MAPK and PI3K signaling. J Invest Dermatol. 123(6): 1151-1161.
    • (2004) J Invest Dermatol , vol.123 , Issue.6 , pp. 1151-1161
    • Graells, J.1    Vinyals, A.2    Figueras, A.3    Llorens, A.4    Moreno, A.5
  • 25
    • 0036009760 scopus 로고    scopus 로고
    • VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding
    • Soker S, Miao HQ, Nomi M, Takashima S, Klagsbrun M, (2002) VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding. J.Cell Biochem. 85 (2): 357-368.
    • (2002) J.Cell Biochem , vol.85 , Issue.2 , pp. 357-368
    • Soker, S.1    Miao, H.Q.2    Nomi, M.3    Takashima, S.4    Klagsbrun, M.5
  • 26
    • 0037429570 scopus 로고    scopus 로고
    • Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells
    • Akagi M, Kawaguchi M, Liu W, McCarty MF, Takeda A, et al. (2003) Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells. Br J Cancer. 88(5): 796-802.
    • (2003) Br J Cancer , vol.88 , Issue.5 , pp. 796-802
    • Akagi, M.1    Kawaguchi, M.2    Liu, W.3    McCarty, M.F.4    Takeda, A.5
  • 27
    • 18144427143 scopus 로고    scopus 로고
    • Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors
    • Gray MJ, Wey JS, Belcheva A, McCarty MF, Trevino JG, et al. (2005) Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors. Cancer Res. 65(9): 3664-3670.
    • (2005) Cancer Res , vol.65 , Issue.9 , pp. 3664-3670
    • Gray, M.J.1    Wey, J.S.2    Belcheva, A.3    McCarty, M.F.4    Trevino, J.G.5
  • 28
    • 84865141645 scopus 로고    scopus 로고
    • VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression
    • Cao Y, E G, Wang E, Pal K, Dutta SK, et al. (2012) VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression. Cancer Res. 72(16): 3912-3918.
    • (2012) Cancer Res , vol.72 , Issue.16 , pp. 3912-3918
    • Cao, Y.E.G.1    Wang, E.2    Pal, K.3    Dutta, S.K.4
  • 29
    • 0035917618 scopus 로고    scopus 로고
    • Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations
    • Nordsmark M, Alsner J, Keller J, Nielsen OS, Jensen OM, et al. (2001) Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations. Br J Cancer 84(8): 1070-1075.
    • (2001) Br J Cancer , vol.84 , Issue.8 , pp. 1070-1075
    • Nordsmark, M.1    Alsner, J.2    Keller, J.3    Nielsen, O.S.4    Jensen, O.M.5
  • 30
    • 21344445924 scopus 로고    scopus 로고
    • Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A
    • Detwiller KY, Fernando NT, Segal NH, Ryeom SW, D'Amore PA, (2005) Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A. Cancer Res. 65(13): 5881-5889.
    • (2005) Cancer Res , vol.65 , Issue.13 , pp. 5881-5889
    • Detwiller, K.Y.1    Fernando, N.T.2    Segal, N.H.3    Ryeom, S.W.4    D'Amore, P.A.5
  • 31
    • 34247382569 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor in synovial fibroblasts from human temporo mandibular joint by hypoxia
    • Ke J, Liu Y, Long X, Li J, Fang W, et al. (2007) Up-regulation of vascular endothelial growth factor in synovial fibroblasts from human temporo mandibular joint by hypoxia. J Oral Pathol Med. 36(5): 290-296.
    • (2007) J Oral Pathol Med , vol.36 , Issue.5 , pp. 290-296
    • Ke, J.1    Liu, Y.2    Long, X.3    Li, J.4    Fang, W.5
  • 32
    • 0034065028 scopus 로고    scopus 로고
    • VEGF nuclear accumulation correlates with phenotypical changes in endothelial cells
    • Li W, Keller G, (2000) VEGF nuclear accumulation correlates with phenotypical changes in endothelial cells. J Cell Sci. 113 (Pt 9): 1525-1534.
    • (2000) J Cell Sci , vol.113 , Issue.Pt 9 , pp. 1525-1534
    • Li, W.1    Keller, G.2
  • 33
    • 77949318969 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis
    • Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, et al. (2010) Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis. J Biol Chem. 285(8): 5532-5540.
    • (2010) J Biol Chem , vol.285 , Issue.8 , pp. 5532-5540
    • Nowak, D.G.1    Amin, E.M.2    Rennel, E.S.3    Hoareau-Aveilla, C.4    Gammons, M.5
  • 35
    • 29244473123 scopus 로고    scopus 로고
    • Tumor cell plasticity in ewing sarcoma, an alternative circulatory system stimulated by hypoxia
    • Van der Schaft DW, Hillen F, Pauwels P, Kirschmann DA, Castermans K, et al. (2005) Tumor cell plasticity in ewing sarcoma, an alternative circulatory system stimulated by hypoxia. Cancer Res. 65(24): 11520-11528.
    • (2005) Cancer Res , vol.65 , Issue.24 , pp. 11520-11528
    • van der Schaft, D.W.1    Hillen, F.2    Pauwels, P.3    Kirschmann, D.A.4    Castermans, K.5
  • 36
    • 77956461407 scopus 로고    scopus 로고
    • The proliferation, apoptosis, invasion of endothelial-like epithelial ovarian cancer cells induced by hypoxia
    • Zhu P, Ning Y, Yao L, Chen M, Xu C (2010) The proliferation, apoptosis, invasion of endothelial-like epithelial ovarian cancer cells induced by hypoxia. J Exp Clin Cancer Res. 29 (124).
    • (2010) J Exp Clin Cancer Res. , vol.29 , Issue.124
    • Zhu, P.1    Ning, Y.2    Yao, L.3    Chen, M.4    Xu, C.5
  • 37
    • 2442669295 scopus 로고    scopus 로고
    • Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis
    • Arsham AM, Plas DR, Thompson CB, Simon MC, (2004) Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer Res. 64(10): 3500-3507.
    • (2004) Cancer Res , vol.64 , Issue.10 , pp. 3500-3507
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 38
    • 38349019701 scopus 로고    scopus 로고
    • Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells
    • Staab A, Loeffler J, Said HM, Diehlmann D, Katzer A, et al. (2007) Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells. BMC Cancer. 7: 213.
    • (2007) BMC Cancer , vol.7 , pp. 213
    • Staab, A.1    Loeffler, J.2    Said, H.M.3    Diehlmann, D.4    Katzer, A.5
  • 39
    • 13544251374 scopus 로고    scopus 로고
    • A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia
    • Brusselmans K, Bono F, Collen D, Herbert JM, Carmeliet P, et al. (2005) A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia. J Biol Chem. 280(5): 3493-3499.
    • (2005) J Biol Chem , vol.280 , Issue.5 , pp. 3493-3499
    • Brusselmans, K.1    Bono, F.2    Collen, D.3    Herbert, J.M.4    Carmeliet, P.5
  • 40
    • 41249088330 scopus 로고    scopus 로고
    • Blocking neuropilin-2 function inhibits tumor cell metastasis
    • Caunt M, Mak J, Liang WC, Stawicki S, Pan Q, et al. (2008) Blocking neuropilin-2 function inhibits tumor cell metastasis. Cancer cell 13(4): 331-342.
    • (2008) Cancer Cell , vol.13 , Issue.4 , pp. 331-342
    • Caunt, M.1    Mak, J.2    Liang, W.C.3    Stawicki, S.4    Pan, Q.5
  • 41
    • 67649424217 scopus 로고    scopus 로고
    • Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines
    • Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, et al. (2008) Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines. Int J Oncol. 34(5): 1381-1386.
    • (2008) Int J Oncol , vol.34 , Issue.5 , pp. 1381-1386
    • Fujii, H.1    Honoki, K.2    Tsujiuchi, T.3    Kido, A.4    Yoshitani, K.5
  • 43
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: role of the HIF system
    • Pugh CW, Ratcliffe PJ, (2003) Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 9(6): 677-684.
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 44
    • 0038380470 scopus 로고    scopus 로고
    • Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors
    • Warnecke C, Griethe W, Weidemann A, Jürgensen JS, Willam C, et al. (2003) Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors. FASEB J. 17(9): 1186-1188.
    • (2003) FASEB J , vol.17 , Issue.9 , pp. 1186-1188
    • Warnecke, C.1    Griethe, W.2    Weidemann, A.3    Jürgensen, J.S.4    Willam, C.5
  • 45
    • 84863422466 scopus 로고    scopus 로고
    • Overcoming disappointing results with antiangiogenic therapy by targetinghypoxia
    • Rapisarda A, Melillo G, (2012) Overcoming disappointing results with antiangiogenic therapy by targetinghypoxia. Nat Rev Clin Oncol. 9(7): 378-390.
    • (2012) Nat Rev Clin Oncol , vol.9 , Issue.7 , pp. 378-390
    • Rapisarda, A.1    Melillo, G.2
  • 46
    • 0035700049 scopus 로고    scopus 로고
    • TNP-470 suppresses the tumorigenicity of HT1080 fibrosarcoma tumor through the inhibition of VEGF secretion from the tumor cells
    • Kaya M, Wada T, Nagoya S, Kawaguchi S, Yamashita T, et al. (2001) TNP-470 suppresses the tumorigenicity of HT1080 fibrosarcoma tumor through the inhibition of VEGF secretion from the tumor cells. Sarcoma. 5(4): 197-202.
    • (2001) Sarcoma , vol.5 , Issue.4 , pp. 197-202
    • Kaya, M.1    Wada, T.2    Nagoya, S.3    Kawaguchi, S.4    Yamashita, T.5
  • 47
    • 77957875746 scopus 로고    scopus 로고
    • Paeonol Oxime inhibits bFGF-induced angiogenesis and reduces VEGF levels in fibrosarcoma cells
    • Lee HJ, Kim SA, Lee HJ, Jeong SJ, Han I, et al. (2010) Paeonol Oxime inhibits bFGF-induced angiogenesis and reduces VEGF levels in fibrosarcoma cells. PLoS ONE 5(8): e12358.
    • (2010) PLoS ONE , vol.5 , Issue.8
    • Lee, H.J.1    Kim, S.A.2    Lee, H.J.3    Jeong, S.J.4    Han, I.5
  • 48
    • 84863110951 scopus 로고    scopus 로고
    • miR-409-3p inhibits HT1080 cell proliferation, vascularization and metastasis bytargeting angiogenin
    • Weng C, Dong H, Chen G, Zhai Y, Bai R, et al. (2012) miR-409-3p inhibits HT1080 cell proliferation, vascularization and metastasis bytargeting angiogenin. Cancer Lett. 323(2): 171-179.
    • (2012) Cancer Lett , vol.323 , Issue.2 , pp. 171-179
    • Weng, C.1    Dong, H.2    Chen, G.3    Zhai, Y.4    Bai, R.5
  • 49
    • 0033873782 scopus 로고    scopus 로고
    • Vasculogenic Mimicry: How convincing, How novel, and How Significant?
    • McDonald DM, Munn L, Jain R, (2000) Vasculogenic Mimicry: How convincing, How novel, and How Significant? Am. J. Pathology 156(2): 383-388.
    • (2000) Am. J. Pathology , vol.156 , Issue.2 , pp. 383-388
    • McDonald, D.M.1    Munn, L.2    Jain, R.3
  • 50
    • 0142042500 scopus 로고    scopus 로고
    • Generation of non-permissive basement membranes by anti-laminin antibody fragments produced by matrix-embedded gene-modified cells
    • Sanz L, Feijóo M, Blanco B, Serrano A, Alvarez-Vallina L, (2003) Generation of non-permissive basement membranes by anti-laminin antibody fragments produced by matrix-embedded gene-modified cells. Cancer Immunol Immunother. 52(10): 643-647.
    • (2003) Cancer Immunol Immunother , vol.52 , Issue.10 , pp. 643-647
    • Sanz, L.1    Feijóo, M.2    Blanco, B.3    Serrano, A.4    Alvarez-Vallina, L.5
  • 51
    • 33344474679 scopus 로고    scopus 로고
    • Neuropilins in neoplasms: expression, regulation, and function
    • Bielenberg DR, Pettaway CA, Takashima S, Klagsbrun M, (2006) Neuropilins in neoplasms: expression, regulation, and function. Exp Cell Res. 312(5): 584-593.
    • (2006) Exp Cell Res , vol.312 , Issue.5 , pp. 584-593
    • Bielenberg, D.R.1    Pettaway, C.A.2    Takashima, S.3    Klagsbrun, M.4
  • 52
    • 78650954703 scopus 로고    scopus 로고
    • Exogenous recombinant dimeric neuropilin-1 is sufficient to drive angiogenesis
    • Uniewicz KA, Cross MJ, Fernig DG, (2011) Exogenous recombinant dimeric neuropilin-1 is sufficient to drive angiogenesis. J Biol Chem. 286(1): 12-23.
    • (2011) J Biol Chem , vol.286 , Issue.1 , pp. 12-23
    • Uniewicz, K.A.1    Cross, M.J.2    Fernig, D.G.3
  • 53
    • 0033674846 scopus 로고    scopus 로고
    • Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression
    • Miao HQ, Lee P, Lin H, Soker S, Klagsbrun M, (2000) Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression. FASEB J 14(15): 2532-2539.
    • (2000) FASEB J , vol.14 , Issue.15 , pp. 2532-2539
    • Miao, H.Q.1    Lee, P.2    Lin, H.3    Soker, S.4    Klagsbrun, M.5
  • 54
    • 84865992234 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NFκB activation and tumor sphere formation
    • Glinka Y, Mohammed N, Subramaniam V, Jothy S, Prud'homme GJ, (2012) Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NFκB activation and tumor sphere formation. Biochem Biophys Res Commun. 425(4): 775-780.
    • (2012) Biochem Biophys Res Commun , vol.425 , Issue.4 , pp. 775-780
    • Glinka, Y.1    Mohammed, N.2    Subramaniam, V.3    Jothy, S.4    Prud'homme, G.J.5
  • 55
    • 84860356630 scopus 로고    scopus 로고
    • Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
    • Hamerlik P, Lathia JD, Rasmussen R, Wu Q, Bartkova J, et al. (2012) Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med. (3): 507-520.
    • (2012) J Exp Med , vol.3 , pp. 507-520
    • Hamerlik, P.1    Lathia, J.D.2    Rasmussen, R.3    Wu, Q.4    Bartkova, J.5
  • 56
    • 80055003796 scopus 로고    scopus 로고
    • A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours
    • Beck B, Driessens G, Goossens S, Youssef KK, Kuchnio A, et al. (2011) A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature. 478(7369): 399-403.
    • (2011) Nature , vol.478 , Issue.7369 , pp. 399-403
    • Beck, B.1    Driessens, G.2    Goossens, S.3    Youssef, K.K.4    Kuchnio, A.5
  • 57
    • 84867899675 scopus 로고    scopus 로고
    • T cells: Neuropilin 1- distinguishing T(Reg) cell subsets
    • doi: 10.1038/nri3323
    • Papatriantafyllou M (2012) T cells: Neuropilin 1- distinguishing T(Reg) cell subsets. Nat Rev Immunol. doi: 10.1038/nri3323.
    • (2012) Nat Rev Immunol
    • Papatriantafyllou, M.1
  • 58
    • 84869777544 scopus 로고    scopus 로고
    • Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth
    • DOI: 10.1084/jem.20111497
    • Hansen W, Hutzler M, Abel S, Alter C, Stockmann C, et al. (2012) Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J Exp Med. DOI: 10.1084/jem.20111497.
    • (2012) J Exp Med
    • Hansen, W.1    Hutzler, M.2    Abel, S.3    Alter, C.4    Stockmann, C.5
  • 59
    • 84865140752 scopus 로고    scopus 로고
    • Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment
    • Yaqoob U, Cao S, Shergill U, Jagavelu K, Geng Z, et al. (2012) Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment. Cancer Res. 72(16): 4047-4059.
    • (2012) Cancer Res , vol.72 , Issue.16 , pp. 4047-4059
    • Yaqoob, U.1    Cao, S.2    Shergill, U.3    Jagavelu, K.4    Geng, Z.5
  • 60
    • 84869211914 scopus 로고    scopus 로고
    • Neuropilin-1 dependent regulation of EGF-Receptor signaling
    • doi: 10.1158/0008-5472
    • Rizzolio S, Rabinoviz N, Rainero E, Lanzetti L, Serini G, et al. (2012) Neuropilin-1 dependent regulation of EGF-Receptor signaling. Cancer Res. doi: 10.1158/0008-5472.
    • (2012) Cancer Res
    • Rizzolio, S.1    Rabinoviz, N.2    Rainero, E.3    Lanzetti, L.4    Serini, G.5
  • 61
    • 2442639176 scopus 로고    scopus 로고
    • Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis
    • Parikh AA, Fan F, Liu WB, Ahmad SA, Stoeltzing O, et al. (2004) Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis. Am J Pathol. 164(6): 2139-2151.
    • (2004) Am J Pathol , vol.164 , Issue.6 , pp. 2139-2151
    • Parikh, A.A.1    Fan, F.2    Liu, W.B.3    Ahmad, S.A.4    Stoeltzing, O.5
  • 62
    • 80053104790 scopus 로고    scopus 로고
    • RNA interference targeting NRP-1 inhibits human glioma cell proliferation andenhances cell apoptosis
    • Li X, Tang T, Lu X, Zhou H, Huang Y, (2011) RNA interference targeting NRP-1 inhibits human glioma cell proliferation andenhances cell apoptosis. Mol Med Report. 4(6): 1261-1266.
    • (2011) Mol Med Report , vol.4 , Issue.6 , pp. 1261-1266
    • Li, X.1    Tang, T.2    Lu, X.3    Zhou, H.4    Huang, Y.5
  • 63
    • 80054792520 scopus 로고    scopus 로고
    • Neuropilin-2 mediated β-catenin signaling and survival in human gastro-intestinalcancer cell lines
    • Samuel S, Gaur P, Fan F, Xia L, Gray MJ, et al. (2011) Neuropilin-2 mediated β-catenin signaling and survival in human gastro-intestinalcancer cell lines. PLoS One. 6(10): e23208.
    • (2011) PLoS One , vol.6 , Issue.10
    • Samuel, S.1    Gaur, P.2    Fan, F.3    Xia, L.4    Gray, M.J.5
  • 64
    • 3042701598 scopus 로고    scopus 로고
    • Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells: Involvement of cytosolic phospholipase A2 activity
    • Ottino P, Finley J, Rojo E, Ottlecz A, Lambrou GN, et al. (2004) Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells: Involvement of cytosolic phospholipase A2 activity. Mol Vis. 10: 341-350.
    • (2004) Mol Vis , vol.10 , pp. 341-350
    • Ottino, P.1    Finley, J.2    Rojo, E.3    Ottlecz, A.4    Lambrou, G.N.5
  • 65
    • 1842861743 scopus 로고    scopus 로고
    • Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior
    • Jogi A, Vallon-Christersson J, Holmquist L, Axelson H, Borg A, et al. (2004) Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior. Exp Cell Res. 295 (2): 469-487.
    • (2004) Exp Cell Res , vol.295 , Issue.2 , pp. 469-487
    • Jogi, A.1    Vallon-Christersson, J.2    Holmquist, L.3    Axelson, H.4    Borg, A.5
  • 66
    • 36749058532 scopus 로고    scopus 로고
    • Combined antiangiogenic therapy is superior to single inhibitors in a model of renal cell carcinoma, J Urol
    • Bartsch G Jr, Eggert K, Soker S, Bokemeyer C, Hautmann R, et al. (2008) Combined antiangiogenic therapy is superior to single inhibitors in a model of renal cell carcinoma, J Urol. 179(1): 326-332.
    • (2008) , vol.179 , Issue.1 , pp. 326-332
    • Bartsch Jr., G.1    Eggert, K.2    Soker, S.3    Bokemeyer, C.4    Hautmann, R.5
  • 67
    • 34548064808 scopus 로고    scopus 로고
    • Targeting neuropilin 1 as an antitumor strategy in lung cancer
    • Hong TM, Chen YL, Wu YY, Yuan A, Chao YC, et al. (2007) Targeting neuropilin 1 as an antitumor strategy in lung cancer. Clin Cancer Res. 13(16): 4759-4768.
    • (2007) Clin Cancer Res , vol.13 , Issue.16 , pp. 4759-4768
    • Hong, T.M.1    Chen, Y.L.2    Wu, Y.Y.3    Yuan, A.4    Chao, Y.C.5
  • 68
    • 36148969690 scopus 로고    scopus 로고
    • Structure-function analysis of the antiangiogenic ATWLPPR peptide inhibiting VEGF(165) binding to neuropilin-1 and molecular dynamics simulations of the ATWLPPR/neuropilin-1 complex
    • Starzec A, Ladam P, Vassy R, Badache S, Bouchemal N, et al. (2007) Structure-function analysis of the antiangiogenic ATWLPPR peptide inhibiting VEGF(165) binding to neuropilin-1 and molecular dynamics simulations of the ATWLPPR/neuropilin-1 complex. Peptides. 28(12): 2397-2402.
    • (2007) Peptides , vol.28 , Issue.12 , pp. 2397-2402
    • Starzec, A.1    Ladam, P.2    Vassy, R.3    Badache, S.4    Bouchemal, N.5
  • 69
    • 33845969276 scopus 로고    scopus 로고
    • Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library
    • Liang WC, Dennis MS, Stawicki S, Chanthery Y, Pan Q, et al. (2007) Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library. J Mol Biol. 366(3): 815-829.
    • (2007) J Mol Biol , vol.366 , Issue.3 , pp. 815-829
    • Liang, W.C.1    Dennis, M.S.2    Stawicki, S.3    Chanthery, Y.4    Pan, Q.5
  • 70
    • 77949342169 scopus 로고    scopus 로고
    • Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction
    • Jarvis A, Allerston CK, Jia H, Herzog B, Garza-Garcia A, et al. (2010) Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 53(5): 2215-2226.
    • (2010) J Med Chem , vol.53 , Issue.5 , pp. 2215-2226
    • Jarvis, A.1    Allerston, C.K.2    Jia, H.3    Herzog, B.4    Garza-Garcia, A.5
  • 71
    • 33846630894 scopus 로고    scopus 로고
    • Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro
    • Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, et al. (2007) Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Mol Cell Biol. 27(3): 912-925.
    • (2007) Mol Cell Biol , vol.27 , Issue.3 , pp. 912-925
    • Pan, Y.1    Mansfield, K.D.2    Bertozzi, C.C.3    Rudenko, V.4    Chan, D.A.5
  • 72
    • 35148856751 scopus 로고    scopus 로고
    • Myeloid leukemias express a broad spectrum of VEGF receptors including neuropilin-1 (NRP-1) and NRP-2
    • Vales A, Kondo R, Aichberger KJ, Mayerhofer M, Kainz B, et al. (2007) Myeloid leukemias express a broad spectrum of VEGF receptors including neuropilin-1 (NRP-1) and NRP-2. Leuk Lymphoma. 48(10): 1997-2007.
    • (2007) Leuk Lymphoma , vol.48 , Issue.10 , pp. 1997-2007
    • Vales, A.1    Kondo, R.2    Aichberger, K.J.3    Mayerhofer, M.4    Kainz, B.5
  • 73
    • 84857041057 scopus 로고    scopus 로고
    • Neuropilin-2: a novel biomarker for malignant melanoma?
    • Rushing EC, Stine MJ, Hahn SJ, Shea S, Eller MS, et al. (2012) Neuropilin-2: a novel biomarker for malignant melanoma? Hum Pathol. 43(3): 381-389.
    • (2012) Hum Pathol , vol.43 , Issue.3 , pp. 381-389
    • Rushing, E.C.1    Stine, M.J.2    Hahn, S.J.3    Shea, S.4    Eller, M.S.5
  • 74
    • 85046979809 scopus 로고    scopus 로고
    • Hypoxia induces tumor and endothelial cell migration in a Semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor Neuropilin 2
    • Coma S, Shimizu A, Klagsbrun M, (2011) Hypoxia induces tumor and endothelial cell migration in a Semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor Neuropilin 2. Cell Adh Migr. 5 (3): 266-275.
    • (2011) Cell Adh Migr , vol.5 , Issue.3 , pp. 266-275
    • Coma, S.1    Shimizu, A.2    Klagsbrun, M.3
  • 75
    • 68949116424 scopus 로고    scopus 로고
    • Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium
    • Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, et al. (2009) Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium. J Biol Chem. 284(31): 20522-20530.
    • (2009) J Biol Chem , vol.284 , Issue.31 , pp. 20522-20530
    • Kawanami, D.1    Mahabeleshwar, G.H.2    Lin, Z.3    Atkins, G.B.4    Hamik, A.5
  • 76
    • 84863891322 scopus 로고    scopus 로고
    • miR 103/107 promote metastasis of colorectal cancer by targeting the metastasissuppressors DAPK and KLF4
    • Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, et al. (2012) miR 103/107 promote metastasis of colorectal cancer by targeting the metastasissuppressors DAPK and KLF4. Cancer Res. 72(14): 3631-3641.
    • (2012) Cancer Res , vol.72 , Issue.14 , pp. 3631-3641
    • Chen, H.Y.1    Lin, Y.M.2    Chung, H.C.3    Lang, Y.D.4    Lin, C.J.5
  • 77
    • 4644313271 scopus 로고    scopus 로고
    • c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism
    • Knies-Bamforth UE, Fox SB, Poulsom R, Evan GI, Harris AL, (2004) c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer Res 64(18): 6563-6570.
    • (2004) Cancer Res , vol.64 , Issue.18 , pp. 6563-6570
    • Knies-Bamforth, U.E.1    Fox, S.B.2    Poulsom, R.3    Evan, G.I.4    Harris, A.L.5
  • 78
    • 8144219541 scopus 로고    scopus 로고
    • Molecular mechanisms behind the dose-dependent differential activation of MAPK pathways induced by transforming growth factor-beta1 in hematopoietic cells
    • Kale VP, Vaidya AA, (2004) Molecular mechanisms behind the dose-dependent differential activation of MAPK pathways induced by transforming growth factor-beta1 in hematopoietic cells. Stem Cells Dev. 13(5): 536-547.
    • (2004) Stem Cells Dev , vol.13 , Issue.5 , pp. 536-547
    • Kale, V.P.1    Vaidya, A.A.2
  • 79
    • 31544448010 scopus 로고    scopus 로고
    • Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function
    • Williams CK, Li JL, Murga M, Harris AL, Tosato G, (2006) Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood. 107(3): 931-939.
    • (2006) Blood , vol.107 , Issue.3 , pp. 931-939
    • Williams, C.K.1    Li, J.L.2    Murga, M.3    Harris, A.L.4    Tosato, G.5


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