Fueling the flames: Mammalian programmed necrosis in inflammatory diseases

Cold Spring Harbor Perspectives in Biology

Volumn 4, Issue 11, 2012, Pages

  Chan, Francis Ka Ming ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE;

ANIMAL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL ORGANELLE; HUMAN; INFLAMMATION; MAMMAL; METABOLISM; NECROSIS; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; UBIQUITINATION;

ANIMALS; APOPTOSIS; AUTOPHAGY; CASPASE 8; HUMANS; INFLAMMATION; MAMMALS; NECROSIS; ORGANELLES; PHOSPHORYLATION; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; UBIQUITINATION;

MAMMALIA;

EID: 84868531636     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a008805     Document Type: Article

References (92)

1. Adams S, Pankow S, Werner S, Munz B. 2007. Regulation of NF-κB activity and keratinocyte differentiation by the RIP4 protein: Implications for cutaneous wound repair. J Invest Dermatol 127: 538-544.
2. Berry DL, Baehrecke EH. 2007. Growth arrest and autophagy are required for salivary gland cell degradation i Drosophila. Cell 131: 1137-1148.
3. Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, Banks S, Wang GH, Senkevich TG, Alnemri ES, Moss B, et al. 1997. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas-and TNFR1-induced apoptosis. Proc Natl Acad Sci 94: 1172-1176.
4. Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Barker PA. 2008. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 30: 689-700.
5. Biton S, Ashkenazi A. 2011. NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling. Cell 145: 92-103.
6. Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, Pasparakis M. 2011. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 35: 572-582.
7. Brune W, Menard C, Heesemann J, Koszinowski UH. 2001. A ribonucleotide reductase homolog of cytomegalovirus and endothelial cell tropism. Science 291: 303-305.
8. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B. 1975. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci 72: 3666-3670.
9. Chan FK, Shisler J, Bixby JG, Felices M, Zheng L, Appel M, Orenstein J, Moss B, Lenardo MJ. 2003. A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. J Biol Chem 278: 51613-51621.
10. Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick SM. 2008. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci 105: 17463-17468.
11. Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick SM. 2011. Mechanisms of necroptosis in T cells. J Exp Med 208: 633-641.
12. Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK. 2009. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137: 1112-1123.
13. Cho Y, McQuade T, Zhang HB, Zhang JK, Chan FKM. 2011. RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. Plos ONE 6.
14. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. 2005. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 1: 112-119.
15. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, et al. 2008. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4: 313-321.
16. Dillon CP, Oberst A, Weinlich R, Janke LJ, Kang TB, Ben-Moshe T, Mak TW, Wallach D, Green DR. 2012. Survival function of the FADD-CASPASE-8-cFLIPL complex. Cell Rep 1: 401-407.
17. Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ. 2006. Activation of IKK by TNFa requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 22: 245-257.
18. Feng S, Yang Y, Mei Y, Ma L, Zhu DE, Hoti N, Castanares M, Wu M. 2007. Cleavage of RIP3 inactivates its caspaseindependent apoptosis pathway by removal of kinase domain. Cell Signal 19: 2056-2067.
19. Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M, Cain K, MacFarlane M, Hacker G, Leverkus M. 2011. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 43: 449-463.
20. Geserick P, Hupe M, Moulin M, WongWW, Feoktistova M, Kellert B, Gollnick H, Silke J, Leverkus M. 2009. Cellular IAPs inhibit a cryptic CD95-induced cell death by limitin RIP1 kinase recruitment. J Cell Biol 187: 1037-1054.
21. Goossens V, De Vos K, Vercammen D, Steemans M, Vancompernolle K, Fiers W, Vandenabeele P, Grooten J. 1999. Redox regulation of TNF signaling. Biofactors 10: 145-156.
22. Gunther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, Waldner MJ, Hedrick SM, Tenzer S, Neurath MF, et al. 2011. Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature 477: 335-339.
23. He S, Wang L, Miao L, Du F, Zhao L, Wang X. 2009. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α. Cell 137: 1100-1111.
24. He S, Liang Y, Shao F, Wang X. 2011. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Pro Natl Acad Sci 108: 20054-20059.
25. Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J. 2008. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 135: 1311-1323.
26. Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV. 1996. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4: 387-396.
27. Hu S, Vincenz C, Buller M, Dixit VM. 1997. A novel family of viral death effector domain-containing molecules that inhibit both CD-95-and tumor necrosis factor receptor-1-induced apoptosis. J Biol Chem 272: 9621-9624.
28. Hur GM, Lewis J, Yang Q, Lin Y, Nakano H, Nedospasov S, Liu ZG. 2003. The death domain kinase RIP has an essential role in DNA damage-induced NF-κB activation. Genes Dev 17: 873-882.
29. Janssens S, Tinel A, Lippens S, Tschopp J. 2005. PIDD mediates NF-κB activation in response toDNAdamage. Cell 123: 1079-1092.
30. Kaiser WJ, Upton JW, Mocarski ES. 2008. Receptor-interacting protein homotypic interaction motif-dependent control of NF-κB activation via the DNA-dependent activator of IFN regulatory factors. J Immunol 181: 6427-6434.
31. Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R, Caspary T, Mocarski ES. 2011. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 471: 368-372.
32. Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ, Leder P. 1998. The death domain kinase RIP mediates the TNFinduced NF-κB signal. Immunity 8: 297-303.
33. Kim YS, Morgan MJ, Choksi S, Liu ZG. 2007. TNF-induced activation of theNox1NADPHoxidase and its role in the induction of necrotic cell death. Mol Cell 26: 675-687.
34. Kovalenko A, Kim JC, Kang TB, Rajput A, Bogdanov K, Dittrich-Breiholz O, Kracht M, Brenner O, Wallach D. 2009. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med 206: 2161-2177.
35. Lembo D, Donalisio M, Hofer A, Cornaglia M, Brune W, Koszinowski U, Thelander L, Landolfo S. 2004. The ribonucleotide reductase R1 homolog of murine cytomegalovirus is not a functional enzyme subunit but is required for pathogenesis. J Virol 78: 4278-4288.
36. Li M, Beg AA. 2000. Induction of necrotic-like cell death by tumor necrosis factor a and caspase inhibitors: Novel mechanism for killing virus-infected cells. J Virol 74: 7470-7477.
37. Li H, Kobayashi M, Blonska M, You Y, Lin X. 2006. Ubiquitination of RIP is required for tumor necrosis factor a-induced NF-κB activation. J Biol Chem 281: 13636-13643.
38. Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, et al. 2012. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell 150: 339-350.
39. Lim SY, Davidson SM, Mocanu MM, Yellon DM, Smith CC. 2007. The cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore. Cardiovasc Drugs Ther 21: 467-469.
40. Lin Y, Devin A, Rodriguez Y, Liu ZG. 1999. Cleavage of the death domain kinase RIP by caspase-8 prompts TNFinduced apoptosis. Genes Dev 13: 2514-2526.
41. Linkermann A, Brasen JH, Himmerkus N, Liu S, Huber TB, Kunzendorf U, Krautwald S. 2012. Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. Kidney Int 81: 751-761.
42. Lo SC, Hannink M. 2008. PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res 314: 1789-1803.
43. Lu JV, Weist BM, van Raam BJ, Marro BS, Nguyen LV, Srinivas P, Bell BD, Luhrs KA, Lane TE, Salvesen GS, et al. 2011. Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci 108: 15312-15317.
44. Majno G, Joris I. 1995. Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146: 3-15.
45. McComb S, Cheung HH, Korneluk RG, Wang S, Krishna L, Sad S. 2012. cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation. Cel Death Differ doi: 10.1038/cdd.2012.59.
46. Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M, Tschopp J. 2004. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation. Nat Immunol 5: 503-507.
47. Micheau O, Tschopp J. 2003. Induction of TNF receptor Imediated apoptosis via two sequential signaling complexes. Cell 114: 181-190.
48. Mocarski ES, Upton JW, Kaiser WJ. 2012. Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways. Nat Rev Immunol 12: 79-88.
49. Mollah S, Arnott D, Phung Q, Wertz I, Dixit V, Kayagaki N, Lill J. 2007. Targeted mass spectrometric strategy for global mapping of ubiquitination on proteins. Mol Cell Proteomics 6: 58-58.
50. Morgan MJ, Kim YS, Liu ZG. 2009. Membrane-bound Fas ligand requires RIP1 for efficient activation of caspase-8 within the death-inducing signaling complex. J Immunol 183: 3278-3284.
51. Newton K, Sun X, Dixit VM. 2004. Kinase RIP3 is dispensable for normal NF-κBs, signaling by the B-cell and Tcell receptors, tumor necrosis factor receptor 1, and Tolllike receptors 2 and 4. Mol Cell Biol 24: 1464-1469.
52. Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, et al. 2008. Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell 134: 668-678.
53. Northington FJ, Chavez-Valdez R, Graham EM, Razdan S, Gauda EB, Martin LJ. 2011. Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI. J Cereb Blood Flow Metab 31: 178-189.
54. Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR. 2011. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471: 363-367.
55. O'Donnell MA, Legarda-Addison D, Skountzos P, Yeh WC, Ting AT. 2007. Ubiquitination of RIP1 regulates an NFkB-independent cell-death switch in TNF signaling. Curr Biol 17: 418-424.
56. O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, TingAT. 2011. Caspase 8 inhibits programmed necrosis by processing CYLD. Na Cell Biol 13: 1437-1442.
57. Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J, Harran P, Wang X. 2007. Autocrine TNFa signaling renders human cancer cells susceptible to Smacmimetic-induced apoptosis. Cancer Cell 12: 445-456.
58. Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J. 2009. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB. EMBO Rep 10: 916-922.
59. Smith CC, Davidson SM, Lim SY, Simpkin JC, Hothersall JS, Yellon DM. 2007. Necrostatin: A potentially novel cardioprotective agent? Cardiovasc Drugs Ther 21: 227-233.
60. Stanger BZ, Leder P, Lee TH, Kim E, Seed B. 1995. RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81: 513-523.
61. Su HC, Lenardo MJ. 2008. Genetic defects of apoptosis and primary immunodeficiency. Immunol Allergy Clin North Am 28: 329-351, ix.
62. Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, et al. 2012. Mixed lineage kinase domainlike protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148: 213-227.
63. Takeda K, Komuro Y, Hayakawa T, Oguchi H, Ishida Y, Murakami S, Noguchi T, Kinoshita H, Sekine Y, Iemura S, et al. 2009. Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/ threonine phosphatase to activate ASK1. Proc Nat Acad Sci 106: 12301-12305.
64. Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, et al. 2011. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell 43: 432-448.
65. Thome M, Schneider P, Hofmann K, Fickenscher H, Meinl E, Neipel F, Mattmann C, Burns K, Bodmer JL, Schroter M, et al. 1997. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386: 517-521.
66. Ting AT, Pimentel-Muinos FX, Seed B. 1996. RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/APO-1-initiated apoptosis. EMBO J 15: 6189-6196.
67. Trichonas G, Murakami Y, Thanos A, Morizane Y, Kayama M, Debouck CM, Hisatomi T, Miller JW, Vavvas DG. 2010. Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Pro Natl Acad Sci 107: 21695-21700.
68. Tu HC, Ren D, Wang GX, Chen DY, Westergard TD, Kim H, Sasagawa S, Hsieh JJ, Cheng EH. 2009. The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proc Natl Acad Sci 106: 1093-1098.
69. Upton JW, Kaiser WJ, Mocarski ES. 2008. Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1. J Biol Chem 283: 16966-16970.
70. Upton JW, Kaiser WJ, Mocarski ES. 2010. Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 7: 302-313.
71. Upton JW, Kaiser WJ, Mocarski ES. 2012. DAI/ZBP1/ DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe 11: 290-297.
72. Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G. 2010. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 11: 700-714.
73. Vanden Berghe T, Vanlangenakker N, Parthoens E, Deckers W, Devos M, Festjens N, Guerin CJ, Brunk UT, Declercq W, Vandenabeele P. 2010. Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Cell Death Differ 17: 922-930.
74. Vanlangenakker N, Vanden Berghe T, Bogaert P, Laukens B, Zobel K, Deshayes K, Vucic D, Fulda S, Vandenabeele P, Bertrand MJ. 2011. cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ 18: 656-665.
75. Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, et al. 2007. IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFadependent apoptosis. Cell 131: 669-681.
76. Vercammen D, Beyaert R, Denecker G, Goossens V, Van Loo G, Declercq W, Grooten J, Fiers W, Vandenabeele P. 1998. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 187: 1477-1485.
77. Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, et al. 2007. IAP antagonists target cIAP1 to induce TNFa-dependent apoptosis. Cell 131: 682-693.
78. Vince JE, Wong WW, Gentle I, Lawlor KE, Allam R, O'Reilly L, Mason K, Gross O, Ma S, Guarda G, et al. 2012. Inhibitor of apoptosis proteins limit RIP3 kinasedependent interleukin-1 activation. Immunity 36: 215-227.
79. Vivarelli MS, McDonald D, Miller M, Cusson N, Kelliher M, Geha RS. 2004. RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J Exp Med 200: 399-404.
80. von Recklinghausen F. 1910. Untersuchungen über rachitis und osteomalazie. Verlag Gustav Fischer Jena, Stuttgart.
81. Wang L, Du F, Wang X. 2008. TNF-α induces two distinct caspase-8 activation pathways. Cell 133: 693-703.
82. Wang Z, Jiang H, Chen S, Du F, Wang X. 2012. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148: 228-243.
83. Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernandez-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M. 2011. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 477: 330-334.
84. Wong WW, Gentle IE, Nachbur U, Anderton H, Vaux DL, Silke J. 2010. RIPK1 is not essential for TNFR1-induced activation of NF-κB. Cell Death Differ 17: 482-487.
85. Xu M, Skaug B, Zeng W, Chen ZJ. 2009. Aubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFα and IL-1β. Mol Cell 36: 302-314.
86. Yang Y, Xia F, Hermance N, Mabb A, Simonson S, Morrissey S, Gandhi P, Munson M, Miyamoto S, Kelliher MA. 2011. A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-κB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. Mol Cell Biol 31: 2774-2786.
87. Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermohlen O, et al. 2009. Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature 460: 1159-1163.
88. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehreck EH, Lenardo MJ. 2004. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304: 1500-1502.
89. ZhangDW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. 2009. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325: 332-336.
90. Zhang H, Zhou X, McQuade T, Li J, Chan FK, Zhang J. 2011. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471: 373-376.
91. Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG. 2012. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci 109: 5322-5327.
92. Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen GS. 1997. Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem 272: 7797-7800.