-
1
-
-
55849130994
-
Communication between the synapse and the nucleus in neuronal development, plasticity, and disease
-
Cohen, S., and Greenberg, M. E. (2008)Communication between the synapse and the nucleus in neuronal development, plasticity, and disease. Annu. Rev. Cell Dev. Biol. 24, 183-2099
-
(2008)
Annu. Rev. Cell Dev. Biol.
, vol.24
, pp. 183-2099
-
-
Cohen, S.1
Greenberg, M.E.2
-
2
-
-
16744362714
-
Excitation-transcription coupling: Signaling by ion channels to the nucleus
-
Dolmetsch, R. (2003) Excitation-transcription coupling: Signaling by ion channels to the nucleus. Sci. STKE 2003, PE44
-
(2003)
Sci. STKE 2003
-
-
Dolmetsch, R.1
-
3
-
-
0030463470
-
CREB phosphorylation and dephosphorylation.ACa2+-and stimulus duration-dependent switch for hippocampal gene expression
-
Bito, H., Deisseroth, K., and Tsien, R. W. (1996)CREB phosphorylation and dephosphorylation.ACa2+-and stimulus duration-dependent switch for hippocampal gene expression. Cell 87, 1203-12144
-
(1996)
Cell
, vol.87
, pp. 1203-12144
-
-
Bito, H.1
Deisseroth, K.2
Tsien, R.W.3
-
4
-
-
0032510478
-
Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons
-
Deisseroth, K., Heist, E. K., and Tsien, R. W. (1998) Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature 392, 198-2022
-
(1998)
Nature
, vol.392
, pp. 198-2022
-
-
Deisseroth, K.1
Heist, E.K.2
Tsien, R.W.3
-
5
-
-
0033554699
-
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons
-
Graef, I. A., Mermelstein, P. G., Stankunas, K., Neilson, J. R., Deisseroth, K., Tsien, R. W., and Crabtree, G. R. (1999)L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature 401, 703-7088
-
(1999)
Nature
, vol.401
, pp. 703-7088
-
-
Graef, I.A.1
Mermelstein, P.G.2
Stankunas, K.3
Neilson, J.R.4
Deisseroth, K.5
Tsien, R.W.6
Crabtree, G.R.7
-
6
-
-
34447283760
-
AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling
-
Oliveria, S. F., Dell'Acqua, M. L., and Sather, W. A. (2007) AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling. Neuron 55, 261-2755
-
(2007)
Neuron
, vol.55
, pp. 261-2755
-
-
Oliveria, S.F.1
Dell'Acqua, M.L.2
Sather, W.A.3
-
7
-
-
0023821516
-
Identification of a putative regulator of early T cell activation genes
-
Shaw, J. P., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A., and Crabtree, G. R. (1988) Identification of a putative regulator of early T cell activation genes. Science 241, 202-2055
-
(1988)
Science
, vol.241
, pp. 202-2055
-
-
Shaw, J.P.1
Utz, P.J.2
Durand, D.B.3
Toole, J.J.4
Emmel, E.A.5
Crabtree, G.R.6
-
8
-
-
0027432388
-
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
-
McCaffrey, P. G., Luo, C., Kerppola, T. K., Jain, J., Badalian, T. M., Ho, A. M., Burgeon, E., Lane, W. S., Lambert, J. N., Curran, T., et al. (1993) Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 262, 750-7544
-
(1993)
Science
, vol.262
, pp. 750-7544
-
-
McCaffrey, P.G.1
Luo, C.2
Kerppola, T.K.3
Jain, J.4
Badalian, T.M.5
Ho, A.M.6
Burgeon, E.7
Lane, W.S.8
Lambert, J.N.9
Curran, T.10
-
9
-
-
0028361589
-
NF-AT components define a family of transcription factors targeted in T-cell activation
-
Northrop, J. P., Ho, S. N., Chen, L., Thomas, D. J., Timmerman, L. A., Nolan, G. P., Admon, A., and Crabtree, G. R. (1994) NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369, 497-5022
-
(1994)
Nature
, vol.369
, pp. 497-5022
-
-
Northrop, J.P.1
Ho, S.N.2
Chen, L.3
Thomas, D.J.4
Timmerman, L.A.5
Nolan, G.P.6
Admon, A.7
Crabtree, G.R.8
-
10
-
-
0037018145
-
NFAT, Ubiquitous regulator of cell differentiation and adaptation
-
Horsley, V., and Pavlath, G. K. (2002) NFAT. Ubiquitous regulator of cell differentiation and adaptation. J. Cell Biol. 156, 771-7744
-
(2002)
J. Cell Biol.
, vol.156
, pp. 771-7744
-
-
Horsley, V.1
Pavlath, G.K.2
-
11
-
-
34249673350
-
NFAT signaling and the invention of vertebrates
-
Wu, H., Peisley, A., Graef, I. A., and Crabtree, G. R. (2007) NFAT signaling and the invention of vertebrates. Trends Cell Biol. 17, 251-2600
-
(2007)
Trends Cell Biol.
, vol.17
, pp. 251-2600
-
-
Wu, H.1
Peisley, A.2
Graef, I.A.3
Crabtree, G.R.4
-
12
-
-
0032540267
-
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
-
Molkentin, J. D., Lu, J. R., Antos, C. L., Markham, B., Richardson, J., Robbins, J., Grant, S. R., and Olson, E. N. (1998) A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215-2288
-
(1998)
Cell
, vol.93
, pp. 215-2288
-
-
Molkentin, J.D.1
Lu, J.R.2
Antos, C.L.3
Markham, B.4
Richardson, J.5
Robbins, J.6
Grant, S.R.7
Olson, E.N.8
-
13
-
-
0141483523
-
Transcriptional regulation by calcium, calcineurin, and NFAT
-
Hogan, P. G., Chen, L., Nardone, J., and Rao, A. (2003) Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 17, 2205-22322
-
(2003)
Genes Dev.
, vol.17
, pp. 2205-22322
-
-
Hogan, P.G.1
Chen, L.2
Nardone, J.3
Rao, A.4
-
14
-
-
54449097010
-
NFAT-dependent excitation-transcription coupling in heart
-
Santana, L. F. (2008)NFAT-dependent excitation-transcription coupling in heart. Circ. Res. 103, 681-6833
-
(2008)
Circ. Res.
, vol.103
, pp. 681-6833
-
-
Santana, L.F.1
-
15
-
-
0035967887
-
Signals transduced by Ca2+/calcineurin and NFATc3/c4 pattern the developing vasculature
-
Graef, I. A., Chen, F., Chen, L., Kuo, A., and Crabtree, G. R. (2001) Signals transduced by Ca2+/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell 105, 863-8755
-
(2001)
Cell
, vol.105
, pp. 863-8755
-
-
Graef, I.A.1
Chen, F.2
Chen, L.3
Kuo, A.4
Crabtree, G.R.5
-
16
-
-
0038463835
-
NFATc3 and NFATc4 are required for cardiac development and mitochondrial function
-
Bushdid, P. B., Osinska, H., Waclaw, R. R., Molkentin, J. D., and Yutzey, K. E. (2003) NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circ. Res. 92, 1305-13133
-
(2003)
Circ. Res.
, vol.92
, pp. 1305-13133
-
-
Bushdid, P.B.1
Osinska, H.2
Waclaw, R.R.3
Molkentin, J.D.4
Yutzey, K.E.5
-
17
-
-
2642533432
-
NFATc3-induced reductions in voltage-gated K-currents after myocardial infarction
-
Rossow, C. F., Minami, E., Chase, E. G., Murry, C. E., and Santana, L. F. (2004) NFATc3-induced reductions in voltage-gated K-currents after myocardial infarction. Circ. Res. 94, 1340-13500
-
(2004)
Circ. Res.
, vol.94
, pp. 1340-13500
-
-
Rossow, C.F.1
Minami, E.2
Chase, E.G.3
Murry, C.E.4
Santana, L.F.5
-
18
-
-
53449084513
-
NFATc3 regulates BK channel function in murine urinary bladder smooth muscle
-
Layne, J. J., Werner, M. E., Hill-Eubanks, D. C., and Nelson, M. T. (2008)NFATc3 regulates BK channel function in murine urinary bladder smooth muscle. Am. J. Physiol. Cell Physiol. 295, C611-C6233
-
(2008)
Am. J. Physiol. Cell Physiol.
, vol.295
-
-
Layne, J.J.1
Werner, M.E.2
Hill-Eubanks, D.C.3
Nelson, M.T.4
-
19
-
-
34047265484
-
Activation of NFATc3 down-regulates the-1 subunit of large conductance, calcium-activated K-channels in arterial smooth muscle and contributes to hypertension
-
Nieves-Cintrón, M., Amberg, G. C., Nichols, C. B., Molkentin, J. D., and Santana, L. F. (2007) Activation of NFATc3 down-regulates the-1 subunit of large conductance, calcium-activated K-channels in arterial smooth muscle and contributes to hypertension. J. Biol. Chem. 282, 3231-32400
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 3231-32400
-
-
Nieves-Cintrón, M.1
Amberg, G.C.2
Nichols, C.B.3
Molkentin, J.D.4
Santana, L.F.5
-
20
-
-
13244287963
-
The transcription factor NFAT3 mediates neuronal survival
-
Benedito, A. B., Lehtinen, M., Massol, R., Lopes, U. G., Kirchhausen, T., Rao, A., and Bonni, A. (2005) The transcription factor NFAT3 mediates neuronal survival. J. Biol. Chem. 280, 2818-28255
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 2818-28255
-
-
Benedito, A.B.1
Lehtinen, M.2
Massol, R.3
Lopes, U.G.4
Kirchhausen, T.5
Rao, A.6
Bonni, A.7
-
21
-
-
72849145265
-
Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription inNMDA receptorstimulated cortical neurons
-
Vashishta, A., Habas, A., Pruunsild, P., Zheng, J. J., Timmusk, T., and Hetman, M. (2009)Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription inNMDA receptorstimulated cortical neurons. J. Neurosci. 29, 15331-153400
-
(2009)
J. Neurosci.
, vol.29
, pp. 15331-153400
-
-
Vashishta, A.1
Habas, A.2
Pruunsild, P.3
Zheng, J.J.4
Timmusk, T.5
Hetman, M.6
-
22
-
-
67650567352
-
NFAT-3 is a transcriptional repressor of the growth-associated protein 43 during neuronal maturation
-
Nguyen, T., Lindner, R., Tedeschi, A., Forsberg, K., Green, A., Wuttke, A., Gaub, P., and Di Giovanni, S. (2009)NFAT-3 is a transcriptional repressor of the growth-associated protein 43 during neuronal maturation. J. Biol. Chem. 284, 18816-188233
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 18816-188233
-
-
Nguyen, T.1
Lindner, R.2
Tedeschi, A.3
Forsberg, K.4
Green, A.5
Wuttke, A.6
Gaub, P.7
Di Giovanni, S.8
-
23
-
-
0037806030
-
Neurotrophins and netrins require calcineurin/ NFAT signaling to stimulate outgrowth of embryonic axons
-
Graef, I. A., Wang, F., Charron, F., Chen, L., Neilson, J., Tessier-Lavigne, M., and Crabtree, G. R. (2003) Neurotrophins and netrins require calcineurin/ NFAT signaling to stimulate outgrowth of embryonic axons. Cell 113, 657-6700
-
(2003)
Cell
, vol.113
, pp. 657-6700
-
-
Graef, I.A.1
Wang, F.2
Charron, F.3
Chen, L.4
Neilson, J.5
Tessier-Lavigne, M.6
Crabtree, G.R.7
-
24
-
-
70350454809
-
Cognitive decline in Alzheimer disease is associated with selective changes in calcineurin/NFAT signaling
-
Abdul, H. M., Sama, M. A., Furman, J. L., Mathis, D. M., Beckett, T. L., Weidner, A. M., Patel, E. S., Baig, I., Murphy, M. P., LeVine, H., 3rd, Kraner, S. D., and Norris, C. M. (2009)Cognitive decline in Alzheimer disease is associated with selective changes in calcineurin/NFAT signaling. J. Neurosci. 29, 12957-129699
-
(2009)
J. Neurosci.
, vol.29
, pp. 12957-129699
-
-
Abdul, H.M.1
Sama, M.A.2
Furman, J.L.3
Mathis, D.M.4
Beckett, T.L.5
Weidner, A.M.6
Patel, E.S.7
Baig, I.8
Murphy, M.P.9
Levine III, H.10
Kraner, S.D.11
Norris, C.M.12
-
25
-
-
66449131559
-
Neural activity regulates synaptic properties and dendritic structure in vivo through calcineurin/ NFAT signaling
-
Schwartz, N., Schohl, A., and Ruthazer, E. S. (2009)Neural activity regulates synaptic properties and dendritic structure in vivo through calcineurin/ NFAT signaling. Neuron 62, 655-6699
-
(2009)
Neuron
, vol.62
, pp. 655-6699
-
-
Schwartz, N.1
Schohl, A.2
Ruthazer, E.S.3
-
26
-
-
39149105604
-
NFAT signaling in neural development and axon growth
-
Nguyen, T., and Di Giovanni, S. (2008)NFAT signaling in neural development and axon growth. Int. J. Dev. Neurosci. 26, 141-1455
-
(2008)
Int. J. Dev. Neurosci.
, vol.26
, pp. 141-1455
-
-
Nguyen, T.1
Di Giovanni, S.2
-
27
-
-
84863238028
-
Inhibition of theNFATpathway alleviates amyloid-neurotoxicity in a mouse model of Alzheimer disease
-
Hudry, E., Wu, H. Y., Arbel-Ornath, M., Hashimoto, T., Matsouaka, R., Fan, Z., Spires-Jones, T. L., Betensky, R. A., Bacskai, B. J., and Hyman, B. T. (2012) Inhibition of theNFATpathway alleviates amyloid-neurotoxicity in a mouse model of Alzheimer disease. J. Neurosci. 32, 3176-31922
-
(2012)
J. Neurosci.
, vol.32
, pp. 3176-31922
-
-
Hudry, E.1
Wu, H.Y.2
Arbel-Ornath, M.3
Hashimoto, T.4
Matsouaka, R.5
Fan, Z.6
Spires-Jones, T.L.7
Betensky, R.A.8
Bacskai, B.J.9
Hyman, B.T.10
-
28
-
-
0036234543
-
NFAT signaling, Choreographing the social lives of cells
-
Crabtree, G. R., and Olson, E. N. (2002) NFAT signaling. Choreographing the social lives of cells. Cell 109, S67-S799
-
(2002)
Cell
, vol.109
-
-
Crabtree, G.R.1
Olson, E.N.2
-
29
-
-
20644466433
-
NFAT proteins, Key regulators of T-cell development and function
-
Macian, F. (2005) NFAT proteins. Key regulators of T-cell development and function. Nat. Rev. Immunol. 5, 472-4844
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 472-4844
-
-
MacIan, F.1
-
30
-
-
0034691195
-
A second calcineurinbinding site on the NFAT regulatory domain
-
Park, S., Uesugi, M., and Verdine, G. L. (2000) A second calcineurinbinding site on the NFAT regulatory domain. Proc. Natl. Acad. Sci. U.S.A. 97, 7130-71355
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 7130-71355
-
-
Park, S.1
Uesugi, M.2
Verdine, G.L.3
-
31
-
-
0032039075
-
Selective inhibition of NFAT activation by a peptide spanning the calcineurin-targeting site of NFAT
-
Aramburu, J., Garcia-Cózar, F., Raghavan, A., Okamura, H., Rao, A., and Hogan, P. G. (1998) Selective inhibition of NFAT activation by a peptide spanning the calcineurin-targeting site of NFAT. Mol. Cell 1, 627-6377
-
(1998)
Mol. Cell
, vol.1
, pp. 627-6377
-
-
Aramburu, J.1
Garcia-Cózar, F.2
Raghavan, A.3
Okamura, H.4
Rao, A.5
Hogan, P.G.6
-
32
-
-
33646564423
-
Blockade of NFAT activation by the second calcineurin-binding site
-
Martínez-Martínez, S., Rodríguez, A., López-Maderuelo, M. D., Ortega-Pérez, I., Vázquez, J., and Redondo, J. M. (2006) Blockade of NFAT activation by the second calcineurin-binding site. J. Biol. Chem. 281, 6227-62355
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 6227-62355
-
-
Martínez-Martínez, S.1
Rodríguez, A.2
López-Maderuelo, M.D.3
Ortega-Pérez, I.4
Vázquez, J.5
Redondo, J.M.6
-
33
-
-
0030706186
-
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway
-
Chow, C. W., Rincón, M., Cavanagh, J., Dickens, M., and Davis, R. J. (1997) Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science 278, 1638-16411
-
(1997)
Science
, vol.278
, pp. 1638-16411
-
-
Chow, C.W.1
Rincón, M.2
Cavanagh, J.3
Dickens, M.4
Davis, R.J.5
-
34
-
-
0040141604
-
Arole for the p38MAPkinase pathway in the nuclear shuttling of NFATp
-
Gómez del Arco, P., Martínez-Martínez, S., Maldonado, J. L., Ortega-Pérez, I., and Redondo, J. M. (2000)Arole for the p38MAPkinase pathway in the nuclear shuttling of NFATp. J. Biol. Chem. 275, 13872-138788
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 13872-138788
-
-
Gómez Del Arco, P.1
Martínez-Martínez, S.2
Maldonado, J.L.3
Ortega-Pérez, I.4
Redondo, J.M.5
-
35
-
-
0036094148
-
Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases
-
Yang, T. T., Xiong, Q., Enslen, H., Davis, R. J., and Chow, C. W. (2002) Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol. Cell. Biol. 22, 3892-39044
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3892-39044
-
-
Yang, T.T.1
Xiong, Q.2
Enslen, H.3
Davis, R.J.4
Chow, C.W.5
-
36
-
-
2942569350
-
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1
-
Okamura, H., Garcia-Rodriguez, C., Martinson, H., Qin, J., Virshup, D. M., and Rao, A. (2004) A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol. Cell Biol. 24, 4184-41955
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 4184-41955
-
-
Okamura, H.1
Garcia-Rodriguez, C.2
Martinson, H.3
Qin, J.4
Virshup, D.M.5
Rao, A.6
-
37
-
-
43249085035
-
Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4
-
Yang, T. T., Yu, R. Y., Agadir, A., Gao, G. J., Campos-Gonzalez, R., Tournier, C., and Chow, C. W. (2008)Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol. Cell. Biol. 28, 3489-35011
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 3489-35011
-
-
Yang, T.T.1
Yu, R.Y.2
Agadir, A.3
Gao, G.J.4
Campos-Gonzalez, R.5
Tournier, C.6
Chow, C.W.7
-
38
-
-
0030890234
-
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
-
Beals, C. R., Sheridan, C. M., Turck, C. W., Gardner, P., and Crabtree, G. R. (1997) Nuclear export of NF-ATc enhanced by glycogen synthase kinase-
-
(1997)
Science
, vol.275
, pp. 1930-19344
-
-
Beals, C.R.1
Sheridan, C.M.2
Turck, C.W.3
Gardner, P.4
Crabtree, G.R.5
-
39
-
-
33646559053
-
Agenomewide Drosophila RNAi screen identifies DYRK family kinases as regulators of NFAT
-
Gwack, Y., Sharma, S., Nardone, J., Tanasa, B., Iuga, A., Srikanth, S., Okamura, H., Bolton, D., Feske, S., Hogan, P. G., and Rao, A. (2006)Agenomewide Drosophila RNAi screen identifies DYRK family kinases as regulators of NFAT. Nature 441, 646-6500
-
(2006)
Nature
, vol.441
, pp. 646-6500
-
-
Gwack, Y.1
Sharma, S.2
Nardone, J.3
Tanasa, B.4
Iuga, A.5
Srikanth, S.6
Okamura, H.7
Bolton, D.8
Feske, S.9
Hogan, P.G.10
Rao, A.11
-
40
-
-
33646171446
-
NFATdysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
-
Arron, J. R., Winslow, M. M., Polleri, A., Chang, C. P., Wu, H., Gao, X., Neilson, J. R., Chen, L., Heit, J. J., Kim, S. K., Yamasaki, N., Miyakawa, T., Francke, U., Graef, I. A., and Crabtree, G. R. (2006)NFATdysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 441, 595-6000
-
(2006)
Nature
, vol.441
, pp. 595-6000
-
-
Arron, J.R.1
Winslow, M.M.2
Polleri, A.3
Chang, C.P.4
Wu, H.5
Gao, X.6
Neilson, J.R.7
Chen, L.8
Heit, J.J.9
Kim, S.K.10
Yamasaki, N.11
Miyakawa, T.12
Francke, U.13
Graef, I.A.14
Crabtree, G.R.15
-
41
-
-
2242456802
-
Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3
-
Sheridan, C. M., Heist, E. K., Beals, C. R., Crabtree, G. R., and Gardner, P. (2002) Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3. J. Biol. Chem. 277, 48664-486766
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48664-486766
-
-
Sheridan, C.M.1
Heist, E.K.2
Beals, C.R.3
Crabtree, G.R.4
Gardner, P.5
-
42
-
-
77952591821
-
Isoform-and tissue-specific regulation of the Ca2+-sensitive transcription factor NFAT in cardiac myocytes and heart failure
-
Rinne, A., Kapur, N., Molkentin, J. D., Pogwizd, S. M., Bers, D. M., Banach, K., and Blatter, L. A. (2010) Isoform-and tissue-specific regulation of the Ca2+-sensitive transcription factor NFAT in cardiac myocytes and heart failure. Am. J. Physiol. Heart Circ. Physiol. 298, H2001-H20099
-
(2010)
Am. J. Physiol. Heart Circ. Physiol.
, vol.298
-
-
Rinne, A.1
Kapur, N.2
Molkentin, J.D.3
Pogwizd, S.M.4
Bers, D.M.5
Banach, K.6
Blatter, L.A.7
-
43
-
-
33745431025
-
Activity-and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers
-
Shen, T., Liu, Y., Cseresnyés, Z., Hawkins, A., Randall, W. R., and Schneider, M. F. (2006) Activity-and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers. Mol. Biol. Cell 17, 1570-15822
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 1570-15822
-
-
Shen, T.1
Liu, Y.2
Cseresnyés, Z.3
Hawkins, A.4
Randall, W.R.5
Schneider, M.F.6
-
44
-
-
0031694618
-
Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells
-
Abbott, K. L., Friday, B. B., Thaloor, D., Murphy, T. J., and Pavlath, G. K. (1998) Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells. Mol. Biol. Cell 9, 2905-29166
-
(1998)
Mol. Biol. Cell
, vol.9
, pp. 2905-29166
-
-
Abbott, K.L.1
Friday, B.B.2
Thaloor, D.3
Murphy, T.J.4
Pavlath, G.K.5
-
45
-
-
34547193818
-
Bradykinin-induced nuclear factor of activated T-cells-dependent transcription in rat dorsal root ganglion neurons
-
Jackson, J. G., Usachev, Y. M., and Thayer, S. A. (2007) Bradykinin-induced nuclear factor of activated T-cells-dependent transcription in rat dorsal root ganglion neurons. Mol. Pharmacol. 72, 303-3100
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 303-3100
-
-
Jackson, J.G.1
Usachev, Y.M.2
Thayer, S.A.3
-
46
-
-
70349624835
-
Mitochondrial Ca2+ cycling facilitates activation of the transcription factor NFAT in sensory neurons
-
Kim, M. S., and Usachev, Y. M. (2009)Mitochondrial Ca2+ cycling facilitates activation of the transcription factor NFAT in sensory neurons. J. Neurosci. 29, 12101-121144
-
(2009)
J. Neurosci.
, vol.29
, pp. 12101-121144
-
-
Kim, M.S.1
Usachev, Y.M.2
-
47
-
-
0041835836
-
Brain-derived neurotrophic factor activation of NFAT (nuclear factor of activated T-cells)-dependent transcription: A role for the transcription factor NFATc4 in neurotrophinmediated gene expression
-
Groth, R. D., and Mermelstein, P. G. (2003) Brain-derived neurotrophic factor activation of NFAT (nuclear factor of activated T-cells)-dependent transcription: a role for the transcription factor NFATc4 in neurotrophinmediated gene expression. J. Neurosci. 23, 8125-81344
-
(2003)
J. Neurosci.
, vol.23
, pp. 8125-81344
-
-
Groth, R.D.1
Mermelstein, P.G.2
-
48
-
-
37749009688
-
D1 dopamine receptor activation of NFAT-mediated striatal gene expression
-
Groth, R. D., Weick, J. P., Bradley, K. C., Luoma, J. I., Aravamudan, B., Klug, J. R., Thomas, M. J., and Mermelstein, P. G. (2008)D1 dopamine receptor activation of NFAT-mediated striatal gene expression. Eur. J. Neurosci. 27, 31-422
-
(2008)
Eur. J. Neurosci.
, vol.27
, pp. 31-422
-
-
Groth, R.D.1
Weick, J.P.2
Bradley, K.C.3
Luoma, J.I.4
Aravamudan, B.5
Klug, J.R.6
Thomas, M.J.7
Mermelstein, P.G.8
-
49
-
-
14144251429
-
Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis
-
Jayanthi, S., Deng, X., Ladenheim, B., McCoy, M. T., Cluster, A., Cai, N. S., and Cadet, J. L. (2005) Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis. Proc. Natl. Acad. Sci. U.S.A. 102, 868-8733
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 868-8733
-
-
Jayanthi, S.1
Deng, X.2
Ladenheim, B.3
McCoy, M.T.4
Cluster, A.5
Cai, N.S.6
Cadet, J.L.7
-
50
-
-
77249158836
-
Amyloid-induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation
-
Wu, H. Y., Hudry, E., Hashimoto, T., Kuchibhotla, K., Rozkalne, A., Fan, Z., Spires-Jones, T., Xie, H., Arbel-Ornath, M., Grosskreutz, C. L., Bacskai, B. J., and Hyman, B. T. (2010) Amyloid-induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. J. Neurosci. 30, 2636-26499
-
(2010)
J. Neurosci.
, vol.30
, pp. 2636-26499
-
-
Wu, H.Y.1
Hudry, E.2
Hashimoto, T.3
Kuchibhotla, K.4
Rozkalne, A.5
Fan, Z.6
Spires-Jones, T.7
Xie, H.8
Arbel-Ornath, M.9
Grosskreutz, C.L.10
Bacskai, B.J.11
Hyman, B.T.12
-
51
-
-
41149179522
-
Deafferentiation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period. A role for NFATc4-dependent apoptosis in the CNS
-
Luoma, J. I., and Zirpel, L. (2008)Deafferentiation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period. A role for NFATc4-dependent apoptosis in the CNS. J. Neurosci. 28, 3159-31699
-
(2008)
J. Neurosci.
, vol.28
, pp. 3159-31699
-
-
Luoma, J.I.1
Zirpel, L.2
-
52
-
-
0027320760
-
A system for characterizing cellular and molecular events in programmed neuronal cell death
-
Pittman, R. N., Wang, S., DiBenedetto, A. J., and Mills, J. C. (1993) A system for characterizing cellular and molecular events in programmed neuronal cell death. J. Neurosci. 13, 3669-36800
-
(1993)
J. Neurosci.
, vol.13
, pp. 3669-36800
-
-
Pittman, R.N.1
Wang, S.2
Dibenedetto, A.J.3
Mills, J.C.4
-
53
-
-
0035793565
-
Ras regulates NFAT3 activity in cardiac myocytes
-
Ichida, M., and Finkel, T. (2001) Ras regulates NFAT3 activity in cardiac myocytes. J. Biol. Chem. 276, 3524-35300
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3524-35300
-
-
Ichida, M.1
Finkel, T.2
-
54
-
-
0042525949
-
NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation
-
Tomida, T., Hirose, K., Takizawa, A., Shibasaki, F., and Iino, M. (2003) NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. EMBO J. 22, 3825-38322
-
(2003)
EMBO J.
, vol.22
, pp. 3825-38322
-
-
Tomida, T.1
Hirose, K.2
Takizawa, A.3
Shibasaki, F.4
Iino, M.5
-
55
-
-
0033567140
-
Ca2+ influx in resting rat sensory neurones that regulates and is regulated by ryanodine-sensitive Ca2+ stores
-
Usachev, Y. M., and Thayer, S. A. (1999)Ca2+ influx in resting rat sensory neurones that regulates and is regulated by ryanodine-sensitive Ca2+ stores. J. Physiol. 519, 115-1300
-
(1999)
J. Physiol.
, vol.519
, pp. 115-1300
-
-
Usachev, Y.M.1
Thayer, S.A.2
-
56
-
-
58149302821
-
CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling
-
Wheeler, D. G., Barrett, C. F., Groth, R. D., Safa, P., and Tsien, R. W. (2008)CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling. J. Cell Biol. 183, 849-8633
-
(2008)
J. Cell Biol.
, vol.183
, pp. 849-8633
-
-
Wheeler, D.G.1
Barrett, C.F.2
Groth, R.D.3
Safa, P.4
Tsien, R.W.5
-
57
-
-
0033634846
-
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
-
Okamura, H., Aramburu, J., García-Rodríguez, C., Viola, J. P., Raghavan, A., Tahiliani, M., Zhang, X., Qin, J., Hogan, P. G., and Rao, A. (2000) Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol. Cell 6, 539-5500
-
(2000)
Mol. Cell
, vol.6
, pp. 539-5500
-
-
Okamura, H.1
Aramburu, J.2
García-Rodríguez, C.3
Viola, J.P.4
Raghavan, A.5
Tahiliani, M.6
Zhang, X.7
Qin, J.8
Hogan, P.G.9
Rao, A.10
-
58
-
-
0030899131
-
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction
-
Beals, C. R., Clipstone, N. A., Ho, S. N., and Crabtree, G. R. (1997) Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev. 11, 824-8344
-
(1997)
Genes Dev.
, vol.11
, pp. 824-8344
-
-
Beals, C.R.1
Clipstone, N.A.2
Ho, S.N.3
Crabtree, G.R.4
-
59
-
-
0036234543
-
NFAT signaling, Choreographing the social lives of cells
-
Crabtree, G. R., and Olson, E. N. (2002) NFAT signaling. Choreographing the social lives of cells. Cell 109, S67-S799
-
(2002)
Cell
, vol.109
-
-
Crabtree, G.R.1
Olson, E.N.2
-
60
-
-
1842534887
-
Inhibitors of the calcineurin/ NFAT pathway
-
Martínez-Martínez, S., and Redondo, J. M. (2004) Inhibitors of the calcineurin/ NFAT pathway. Curr. Med. Chem. 11, 997-10077
-
(2004)
Curr. Med. Chem.
, vol.11
, pp. 997-10077
-
-
Martínez-Martínez, S.1
Redondo, J.M.2
-
61
-
-
0033561538
-
Two independent calcineurin-binding regions in the N-terminal domain of murine NF-ATx1 recruit calcineurin to murine NF-ATx1
-
Liu, J., Masuda, E. S., Tsuruta, L., Arai, N., and Arai, K. (1999)Two independent calcineurin-binding regions in the N-terminal domain of murine NF-ATx1 recruit calcineurin to murine NF-ATx1. J. Immunol. 162, 4755-47611
-
(1999)
J. Immunol.
, vol.162
, pp. 4755-47611
-
-
Liu, J.1
Masuda, E.S.2
Tsuruta, L.3
Arai, N.4
Arai, K.5
-
62
-
-
0032577673
-
Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase i and MEKK1
-
Zhu, J., Shibasaki, F., Price, R., Guillemot, J. C., Yano, T., Dötsch, V., Wagner, G., Ferrara, P., and McKeon, F. (1998) Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Cell 93, 851-8611
-
(1998)
Cell
, vol.93
, pp. 851-8611
-
-
Zhu, J.1
Shibasaki, F.2
Price, R.3
Guillemot, J.C.4
Yano, T.5
Dötsch, V.6
Wagner, G.7
Ferrara, P.8
McKeon, F.9
-
63
-
-
0032849010
-
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
-
Aramburu, J., Yaffe, M. B., López-Rodríguez, C., Cantley, L. C., Hogan, P. G., and Rao, A. (1999)Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285, 2129-21333
-
(1999)
Science
, vol.285
, pp. 2129-21333
-
-
Aramburu, J.1
Yaffe, M.B.2
López-Rodríguez, C.3
Cantley, L.C.4
Hogan, P.G.5
Rao, A.6
-
64
-
-
66349086736
-
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development
-
Müller, M. R., Sasaki, Y., Stevanovic, I., Lamperti, E. D., Ghosh, S., Sharma, S., Gelinas, C., Rossi, D. J., Pipkin, M. E., Rajewsky, K., Hogan, P. G., and Rao, A. (2009)Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development. Proc. Natl. Acad. Sci. U.S.A. 106, 7034-70399
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 7034-70399
-
-
Müller, M.R.1
Sasaki, Y.2
Stevanovic, I.3
Lamperti, E.D.4
Ghosh, S.5
Sharma, S.6
Gelinas, C.7
Rossi, D.J.8
Pipkin, M.E.9
Rajewsky, K.10
Hogan, P.G.11
Rao, A.12
-
65
-
-
0033580477
-
NF-AT activation requires suppression of Crm1-dependent export by calcineurin
-
Zhu, J., and McKeon, F. (1999)NF-AT activation requires suppression of Crm1-dependent export by calcineurin. Nature 398, 256-2600
-
(1999)
Nature
, vol.398
, pp. 256-2600
-
-
Zhu, J.1
McKeon, F.2
-
66
-
-
69449105426
-
NFAT isoforms control activity-dependent muscle fiber type specification
-
Calabria, E., Ciciliot, S., Moretti, I., Garcia, M., Picard, A., Dyar, K. A., Pallafacchina, G., Tothova, J., Schiaffino, S., and Murgia, M. (2009)NFAT isoforms control activity-dependent muscle fiber type specification. Proc. Natl. Acad. Sci. U.S.A. 106, 13335-133400
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 13335-133400
-
-
Calabria, E.1
Ciciliot, S.2
Moretti, I.3
Garcia, M.4
Picard, A.5
Dyar, K.A.6
Pallafacchina, G.7
Tothova, J.8
Schiaffino, S.9
Murgia, M.10
-
68
-
-
0032562603
-
Functional interaction of an axin homolog, conductin, with-catenin, APC, and GSK3
-
Behrens, J., Jerchow, B. A., Würtele, M., Grimm, J., Asbrand, C., Wirtz, R., Kühl, M., Wedlich, D., and Birchmeier, W. (1998) Functional interaction of an axin homolog, conductin, with-catenin, APC, and GSK3. Science 280, 596-5999
-
(1998)
Science
, vol.280
, pp. 596-5999
-
-
Behrens, J.1
Jerchow, B.A.2
Würtele, M.3
Grimm, J.4
Asbrand, C.5
Wirtz, R.6
Kühl, M.7
Wedlich, D.8
Birchmeier, W.9
-
69
-
-
24644481406
-
A strategy for probing the function of noncoding RNAs finds a repressor of NFAT
-
Willingham, A. T., Orth, A. P., Batalov, S., Peters, E. C., Wen, B. G., Aza-Blanc, P., Hogenesch, J. B., and Schultz, P. G. (2005) A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science 309, 1570-15733
-
(2005)
Science
, vol.309
, pp. 1570-15733
-
-
Willingham, A.T.1
Orth, A.P.2
Batalov, S.3
Peters, E.C.4
Wen, B.G.5
Aza-Blanc, P.6
Hogenesch, J.B.7
Schultz, P.G.8
-
70
-
-
79960984904
-
Dephos-phorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex
-
Sharma, S., Findlay, G. M., Bandukwala, H. S., Oberdoerffer, S., Baust, B., Li, Z., Schmidt, V., Hogan, P. G., Sacks, D. B., and Rao, A. (2011) Dephos-phorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc. Natl. Acad. Sci. U.S.A. 108, 11381-113866
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 11381-113866
-
-
Sharma, S.1
Findlay, G.M.2
Bandukwala, H.S.3
Oberdoerffer, S.4
Baust, B.5
Li, Z.6
Schmidt, V.7
Hogan, P.G.8
Sacks, D.B.9
Rao, A.10
-
71
-
-
80054933395
-
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
-
Liu, Z., Lee, J., Krummey, S., Lu, W., Cai, H., and Lenardo, M. J. (2011) The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat. Immunol. 12, 1063-10700
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1063-10700
-
-
Liu, Z.1
Lee, J.2
Krummey, S.3
Lu, W.4
Cai, H.5
Lenardo, M.J.6
-
72
-
-
4444260305
-
Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions
-
Li, H., Rao, A., and Hogan, P. G. (2004) Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions. J. Mol. Biol. 342, 1659-16744
-
(2004)
J. Mol. Biol.
, vol.342
, pp. 1659-16744
-
-
Li, H.1
Rao, A.2
Hogan, P.G.3
-
73
-
-
2942735115
-
NGF-induced axon growth is mediated by localized inactivation of GSK-3-and functions of the microtubule plus end binding protein APC
-
Zhou, F. Q., Zhou, J., Dedhar, S., Wu, Y. H., and Snider, W. D. (2004) NGF-induced axon growth is mediated by localized inactivation of GSK-3-and functions of the microtubule plus end binding protein APC. Neuron 42, 897-9122
-
(2004)
Neuron
, vol.42
, pp. 897-9122
-
-
Zhou, F.Q.1
Zhou, J.2
Dedhar, S.3
Wu, Y.H.4
Snider, W.D.5
-
74
-
-
11844260672
-
Both the establishment and the maintenance of neuronal polarity require active mechanisms. Critical roles of GSK-3-and its upstream regulators
-
Jiang, H., Guo, W., Liang, X., and Rao, Y. (2005) Both the establishment and the maintenance of neuronal polarity require active mechanisms. Critical roles of GSK-3-and its upstream regulators. Cell 120, 123-1355
-
(2005)
Cell
, vol.120
, pp. 123-1355
-
-
Jiang, H.1
Guo, W.2
Liang, X.3
Rao, Y.4
-
75
-
-
77954874401
-
GSK3 signaling in neural development
-
Hur, E. M., and Zhou, F. Q. (2010) GSK3 signaling in neural development. Nat. Rev. Neurosci. 11, 539-5511
-
(2010)
Nat. Rev. Neurosci.
, vol.11
, pp. 539-5511
-
-
Hur, E.M.1
Zhou, F.Q.2
-
76
-
-
77954966128
-
NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy
-
Gómez-Sintes, R., and Lucas, J. J. (2010) NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J. Clin. Invest. 120, 2432-24455
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2432-24455
-
-
Gómez-Sintes, R.1
Lucas, J.J.2
-
77
-
-
84865078148
-
The effects of glycogen synthase kinase-3-in serotonin neurons
-
Zhou, W., Chen, L., Paul, J., Yang, S., Li, F., Sampson, K., Woodgett, J. R., Beaulieu, J. M., Gamble, K. L., and Li, X. (2012) The effects of glycogen synthase kinase-3-in serotonin neurons. PLoS ONE 7, e432622
-
(2012)
PLoS ONE
, vol.7
-
-
Zhou, W.1
Chen, L.2
Paul, J.3
Yang, S.4
Li, F.5
Sampson, K.6
Woodgett, J.R.7
Beaulieu, J.M.8
Gamble, K.L.9
Li, X.10
-
78
-
-
0442276554
-
The glamour and gloom of glycogen synthase kinase-3
-
Jope, R. S., and Johnson, G. V. (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem. Sci. 29, 95-1022
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 95-1022
-
-
Jope, R.S.1
Johnson, G.V.2
-
79
-
-
77958597709
-
Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain
-
Soutar, M. P., Kim, W. Y., Williamson, R., Peggie, M., Hastie, C. J., McLauchlan, H., Snider, W. D., Gordon-Weeks, P. R., and Sutherland, C. (2010) Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain. J. Neurochem. 115, 974-9833
-
(2010)
J. Neurochem.
, vol.115
, pp. 974-9833
-
-
Soutar, M.P.1
Kim, W.Y.2
Williamson, R.3
Peggie, M.4
Hastie, C.J.5
McLauchlan, H.6
Snider, W.D.7
Gordon-Weeks, P.R.8
Sutherland, C.9
-
80
-
-
0035369840
-
Trk receptors. Mediators of neurotrophin action
-
Patapoutian, A., and Reichardt, L. F. (2001) Trk receptors. Mediators of neurotrophin action. Curr. Opin. Neurobiol. 11, 272-2800
-
(2001)
Curr. Opin. Neurobiol.
, vol.11
, pp. 272-2800
-
-
Patapoutian, A.1
Reichardt, L.F.2
-
81
-
-
0037762690
-
Neurotrophins and their receptors. A convergence point for many signaling pathways
-
Chao, M. V. (2003) Neurotrophins and their receptors. A convergence point for many signaling pathways. Nat. Rev. Neurosci. 4, 299-3099
-
(2003)
Nat. Rev. Neurosci.
, vol.4
, pp. 299-3099
-
-
Chao, M.V.1
-
82
-
-
34547177480
-
Neurotrophin activation of NFAT-dependent transcription contributes to the regulation of pro-nociceptive genes
-
Groth, R. D., Coicou, L. G., Mermelstein, P. G., and Seybold, V. S. (2007) Neurotrophin activation of NFAT-dependent transcription contributes to the regulation of pro-nociceptive genes. J. Neurochem. 102, 1162-11744
-
(2007)
J. Neurochem.
, vol.102
, pp. 1162-11744
-
-
Groth, R.D.1
Coicou, L.G.2
Mermelstein, P.G.3
Seybold, V.S.4
|