Two independent calcineurin-binding regions in the N-terminal domain of murine NF-ATx1 recruit calcineurin to murine NF-ATx1

Journal of Immunology

Volumn 162, Issue 8, 1999, Pages 4755-4761

  Liu, Jie ^a,b   Masuda, Esteban S ^b   Tsuruta, Lisako ^a   Arai, Naoko ^b   Arai, Ken Ichi ^a,c  

^a THE UNIVERSITY OF TOKYO   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM; INTERLEUKIN 2; LUCIFERASE; NUCLEAR FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0033561538     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Kincaid, R. 1993. Calmodulin-dependent protein phosphatases from microorganisms to man: a study in structural conservatism and biological diversity. Adv. Second Messenger Phosphoprotein Res. 27:1.
2. Crabtree, G. R., and N. A. Clipstone. 1994. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63:1045.
3. Rao, A., C. Luo, and P. G. Hogan. 1997. Transcription factors of the NF-AT family: regulation and function. Annu. Rev. Immunol. 15:707.
4. Masuda, E. S., R. Imamura, Y. Amasaki, K. Arai, and N. Arai. 1999 Signaling into the T cell nucleus: NF-AT regulation. Cell. Signaling. In press.
5. Hoey, T., Y. L. Sun, K. Williamson, and X. Xu. 1995. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2:461.
6. Masuda, E. S., Y. Naito, H. Tokumitsu, D. Campbell, F. Saito, C. Hannum, K. Arai, and N. Arai. 1995. NF-ATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. Mol. Cell. Biol. 15:2697.
7. McCaffrey, P. G., C. Luo, T. K. Kerppola, J. Jain, T. M. Badalian, A. M. Ho, E. Burgeon, W. S. Lane, J. N. Lambert, T. Curran, et al. 1993. Isolation of the cyclosporin-sensitive T cell transcription factor NF-ATp. Science 262:750.
8. Northrop, J. P., S. N. Ho, L. Chen, D. J. Thomas, L. A. Timmerman, G. P. Nolan. A. Admon, and G. R. Crabtree. 1994. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369:497.
9. Rao, A. 1994. NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes. Immunol. Today 15:274.
10. Karen, T.-Y. S., A. M. Ho, A. Raghavan, J. Kim, J. Jain, J. Park, S. Sharma, A. Rao, and P. Hogan. 1995. Immunosuppressive drugs prevent a rapid dephosphorylalion of transcription factor NF-AT1 in stimulated immune cells. Proc. Natl. Acad. Sci. USA 92:11205.
11. Bierer, B. E. 1994. Cyclosporin A, FK506, and rapamycin: binding to immunophilins and biological action. Chem. Immunol. 59:128.
12. Jain, J., E. Burgeon, T. M. Badalian, P. G. Hogan, and A. Rao. 1995. A similar DNA-binding motif in NFAT family proteins and the Rel homology region. J. Biol. Chem. 270:4138.
13. Imamura, R., E. S. Masuda, Y. Naito, S.-i. Imai, T. Fujino, T. Takano, K.-i. Arai, and N. Arai. 1998. Carboxy-terminal 15 amino acid sequence of NFATx1 possibly created by tissue-specific splicing is conserved among NFAT family proteins and is essential for transactivation activity in T cells. J. Immunol. 161:3455.
14. Masuda, E. S., J. Liu, R. Imamura, S.-i. Imai, K.-i. Arai, and N. Arai. 1997. Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain. Mol. Cell. Biol. 17:2066.
15. Beals, C. R., N. A. Clipstone, S. N. Ho, and G. R. Crabtree. 1997. Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev. 11:824.
16. Luo, C., K. T. Y. Shaw, A. Raghavan, J. Aramburu, F. Garcia-Cozar, B. A. Perrino, P. G. Hogan, and A. Rao. 1996. Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import. Proc. Natl. Acad. Sci. USA 93:8907.
17. Liu, J., N. Koyano-Nakagawa, Y. Amasaki, F. Saito-Ohara, T. Ikeuchi, S.-i. Imai, T. Takano, N. Arai, T. Yokota, and K.-i. Arai. 1997. Calcineurin dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization. Mol. Biol. Cell. 8:157.
18. Tsuruta, L., H. J. Lee, E. Masuda, N. Koyano-Nakagawa, N. Arai, K. Arai, and T. Yokota. 1995. Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP. J. Immunol. 154:5255.
19. Shibasaki, F., E. R. Price, D. Milan, and F. McKeon. 1996. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 382:370.
20. Aramburu, J., F. Garcia-Cozar, A. Raghavan, H. Okamura, A. Rao, and P. G. Hogan. 1998. Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. Mol. Cell 1:627.
21. Zhu, J., F. Shibasaki, R. Price, J.-C. Guillemot, T. Yano, V. Dotsch, G. Wagner, P. Ferrara, and F. McKeon. 1998. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Cell 93:851.
22. Luo, C., E. Burgeon, and A. Rao. 1996. Mechanisms of transactivation by nuclear factor of activated T cells-1. J. Exp. Med. 184:141.
23. 2+ signals and immunosuppression. Nature 383:837.
24. Kallunki, T., T. Deng, M. Hibi, and M. Karin. 1996. C-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 87: 929.
25. Stahl, N., T. J. Farrugella, B. T.G., Z. Zhong, J. E. Darnell, and G. D. Yancopoulos. 1995. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349.
26. Leevers, S. J., H. F. Paterson, and C. J. Marshall. 1994. Requirement for Ras in RAF activation is overcome by targeting RAF to the plasma membrane. Nature 369:411.
27. Klemm, J. D., C. R. Beals, and G. R. Crabtree. 1997. Rapid targeting of nuclear proteins to the cytoplasm. Curr. Biol. 7:638.
28. Fruman, D. A., P. E. Mather, S. J. Burakoff, and B. E. Bierer. 1992. Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas. Eur. J. Immunol. 22:2513.
29. Urdahl, K. B., D. M. Pardoll, and M. K. Jenkins. 1992. Self-reactive T cells are present in the peripheral lymphoid tissues of cyclosporin A-treated mice. Int. Immunol. 4:1341.
30. Shi, Y. F., B. M. Sahai, and D. R. Green. 1989. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature 339:625.
31. Bierer, B. E., P. K. Somers, T. J. Wandless, S. J. Burakoff, and S. L. Schreiber. 1990. Probing immunosuppressant action with a nonnatural immunophilin ligand. Science 250:556.
32. Dumont, F. J., M. J. Staruch, S. L. Koprak, J. J. Siekierka, C. S. Lin, R. Harrison, T. Sewell, V. M. Kindt, T. R. Beattie, and M. Wyvratt. 1992. The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin. J. Exp. Med. 176:751.