Akt phosphorylates the transcriptional repressor Bmi1 to block its effects on the tumor-suppressing Ink4a-Arf locus

Science Signaling

Volumn 5, Issue 247, 2012, Pages

  Liu, Yan ^a,b   Liu, Fan ^a   Yu, Hao ^b   Zhao, Xinyang ^a   Sashida, Goro ^a   Deblasio, Anthony ^a   Harr, Michael ^a   She, Qing Bai ^a   Chen, Zhenbang ^c   Lin, Hui Kuan ^c   Di Giandomenico, Silvana ^a   Elf, Shannon E ^a   Yang, Youyang ^a   Miyata, Yasuhiko ^a   Huang, Gang ^a   Menendez, Silvia ^a   Mellinghoff, Ingo K ^a   Rosen, Neal ^a   Pandolfi, Pier Paolo ^c   Hedvat, Cyrus V ^a   Nimer, Stephen D ^a,d   more..

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HISTONE H2A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P16; PROTEIN P19; SERINE;

ARTICLE; CELL PROLIFERATION; CELL REGENERATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; GENE LOCUS; HEMATOPOIETIC STEM CELL; HISTONE UBIQUITINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ANIMALS; CHROMATIN; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE SILENCING; GENETIC LOCI; HELA CELLS; HISTONES; HUMANS; MICE; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; POLYCOMB REPRESSIVE COMPLEX 1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 84868159785     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003199     Document Type: Article

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