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Volumn 4, Issue 10, 2012, Pages 2233-2250

RNA structural elements of hepatitis C virus controlling viral RNA translation and the implications for viral pathogenesis

Author keywords

Hepatitis C; Host factors; IRES; RNA structural elements; Translation control

Indexed keywords

MESSENGER RNA; MICRORNA; RNA BINDING PROTEIN; VIRUS PROTEIN; VIRUS RNA;

EID: 84868129170     PISSN: 19994915     EISSN: None     Source Type: Journal    
DOI: 10.3390/v4102233     Document Type: Review
Times cited : (33)

References (118)
  • 1
    • 84860324912 scopus 로고    scopus 로고
    • New advances in the molecular biology of hepatitis C virus infection: Towards the identification of new treatment targets
    • Ploss, A.; Dubuisson, J. New advances in the molecular biology of hepatitis C virus infection: Towards the identification of new treatment targets. Gut 2012, 61, i25-i35.
    • (2012) Gut , vol.61
    • Ploss, A.1    Dubuisson, J.2
  • 2
    • 79953733509 scopus 로고    scopus 로고
    • Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191)
    • Imhof, I.; Simmonds, P. Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191). Hepatology 2011, 53, 1090-1099.
    • (2011) Hepatology , vol.53 , pp. 1090-1099
    • Imhof, I.1    Simmonds, P.2
  • 3
    • 0026728652 scopus 로고
    • Sequence analysis of the 5' noncoding region of hepatitis C virus
    • Bukh, J.; Purcell, R.H.; Miller, R.H. Sequence analysis of the 5' noncoding region of hepatitis C virus. Proc. Natl. Acad. Sci. U. S. A. 1992, 89, 4942-4946.
    • (1992) Proc. Natl. Acad. Sci. U. S. A , vol.89 , pp. 4942-4946
    • Bukh, J.1    Purcell, R.H.2    Miller, R.H.3
  • 5
    • 0028271727 scopus 로고
    • Dynamic behavior of hepatitis C virus quasispecies in patients undergoing orthotopic liver transplantation
    • Martell, M.; Esteban, J.I.; Quer, J.; Vargas, V.; Esteban, R.; Guardia, J.; Gomez, J. Dynamic behavior of hepatitis C virus quasispecies in patients undergoing orthotopic liver transplantation. J. Virol. 1994, 68, 3425-3436.
    • (1994) J. Virol , vol.68 , pp. 3425-3436
    • Martell, M.1    Esteban, J.I.2    Quer, J.3    Vargas, V.4    Esteban, R.5    Guardia, J.6    Gomez, J.7
  • 6
    • 7444256169 scopus 로고    scopus 로고
    • Genetic diversity and evolution of hepatitis C virus-15 years on
    • Simmonds, P. Genetic diversity and evolution of hepatitis C virus-15 years on. J. Gen. Virol. 2004, 85, 3173-3188.
    • (2004) J. Gen. Virol , vol.85 , pp. 3173-3188
    • Simmonds, P.1
  • 8
    • 79955103901 scopus 로고    scopus 로고
    • Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus
    • Pawlotsky, J.M. Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus. Hepatology 2011, 53, 1742-1751.
    • (2011) Hepatology , vol.53 , pp. 1742-1751
    • Pawlotsky, J.M.1
  • 10
    • 42449114149 scopus 로고    scopus 로고
    • New insights into internal ribosome entry site elements relevant for viral gene expression
    • Martinez-Salas, E.; Pacheco, A.; Serrano, P.; Fernandez, N. New insights into internal ribosome entry site elements relevant for viral gene expression. J. Gen. Virol. 2008, 89, 611-626.
    • (2008) J. Gen. Virol , vol.89 , pp. 611-626
    • Martinez-Salas, E.1    Pacheco, A.2    Serrano, P.3    Fernandez, N.4
  • 11
    • 71849111699 scopus 로고    scopus 로고
    • Internal translation initiation of picornaviruses and hepatitis C virus
    • Niepmann, M. Internal translation initiation of picornaviruses and hepatitis C virus. Biochim. Biophys. Acta 2009, 1789, 529-541.
    • (2009) Biochim. Biophys. Acta , vol.1789 , pp. 529-541
    • Niepmann, M.1
  • 12
    • 0033515094 scopus 로고    scopus 로고
    • In vivo analysis of the 3' untranslated region of the hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone
    • Yanagi, M.; St Claire, M.; Emerson, S.U.; Purcell, R.H.; Bukh, J. In vivo analysis of the 3' untranslated region of the hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone. Proc. Natl. Acad. Sci. U. S. A. 1999, 96, 2291-2295.
    • (1999) Proc. Natl. Acad. Sci. U. S. A , vol.96 , pp. 2291-2295
    • Yanagi, M.1    St Claire, M.2    Emerson, S.U.3    Purcell, R.H.4    Bukh, J.5
  • 13
    • 0037311233 scopus 로고    scopus 로고
    • Eukaryotic translation initiation factors and regulators
    • Sonenberg, N.; Dever, T.E. Eukaryotic translation initiation factors and regulators. Curr. Opin. Struct. Biol. 2003, 13, 56-63.
    • (2003) Curr. Opin. Struct. Biol , vol.13 , pp. 56-63
    • Sonenberg, N.1    Dever, T.E.2
  • 14
    • 42749086185 scopus 로고    scopus 로고
    • The impact of RNA structure on picornavirus IRES activity
    • Martinez-Salas, E. The impact of RNA structure on picornavirus IRES activity. Trends Microbiol. 2008, 16, 230-237.
    • (2008) Trends Microbiol , vol.16 , pp. 230-237
    • Martinez-Salas, E.1
  • 15
    • 0026513651 scopus 로고
    • Internal ribosome entry site within hepatitis C virus RNA
    • Tsukiyama-Kohara, K.; Iizuka, N.; Kohara, M.; Nomoto, A. Internal ribosome entry site within hepatitis C virus RNA. J. Virol. 1992, 66, 1476-1483.
    • (1992) J. Virol , vol.66 , pp. 1476-1483
    • Tsukiyama-Kohara, K.1    Iizuka, N.2    Kohara, M.3    Nomoto, A.4
  • 16
    • 0036305811 scopus 로고    scopus 로고
    • Quasispecies heterogeneity and constraints on the evolution of the 5' noncoding region of hepatitis C virus (HCV): Relationship with HCV resistance to interferon-alpha therapy
    • Soler, M.; Pellerin, M.; Malnou, C.E.; Dhumeaux, D.; Kean, K.M.; Pawlotsky, J.M. Quasispecies heterogeneity and constraints on the evolution of the 5' noncoding region of hepatitis C virus (HCV): Relationship with HCV resistance to interferon-alpha therapy. Virology 2002, 298, 160-173.
    • (2002) Virology , vol.298 , pp. 160-173
    • Soler, M.1    Pellerin, M.2    Malnou, C.E.3    Dhumeaux, D.4    Kean, K.M.5    Pawlotsky, J.M.6
  • 17
    • 7044228006 scopus 로고    scopus 로고
    • The pathway of HCV IRES-mediated translation initiation
    • Otto, G.A.; Puglisi, J.D. The pathway of HCV IRES-mediated translation initiation. Cell 2004, 119, 369-380.
    • (2004) Cell , vol.119 , pp. 369-380
    • Otto, G.A.1    Puglisi, J.D.2
  • 18
    • 59749085225 scopus 로고    scopus 로고
    • Structure and function of HCV IRES domains
    • Lukavsky, P.J. Structure and function of HCV IRES domains. Virus Res. 2008, 139, 166-171.
    • (2008) Virus Res , vol.139 , pp. 166-171
    • Lukavsky, P.J.1
  • 20
    • 6944246045 scopus 로고    scopus 로고
    • Picornavirus IRES: Structure function relationship
    • Martinez-Salas, E.; Fernandez-Miragall, O. Picornavirus IRES: Structure function relationship. Curr. Pharm. Des. 2004, 10, 3757-3767.
    • (2004) Curr. Pharm. Des , vol.10 , pp. 3757-3767
    • Martinez-Salas, E.1    Fernandez-Miragall, O.2
  • 21
    • 66849089596 scopus 로고    scopus 로고
    • Toward a structural understanding of IRES RNA function
    • Filbin, M.E.; Kieft, J.S. Toward a structural understanding of IRES RNA function. Curr. Opin. Struct. Biol. 2009, 19, 267-276.
    • (2009) Curr. Opin. Struct. Biol , vol.19 , pp. 267-276
    • Filbin, M.E.1    Kieft, J.S.2
  • 22
    • 59749095351 scopus 로고    scopus 로고
    • Divergent picornavirus IRES elements
    • Belsham, G.J. Divergent picornavirus IRES elements. Virus Res. 2009, 139, 183-192.
    • (2009) Virus Res , vol.139 , pp. 183-192
    • Belsham, G.J.1
  • 23
    • 59749086877 scopus 로고    scopus 로고
    • Relevance of RNA structure for the activity of picornavirus IRES elements
    • Fernandez-Miragall, O.; Lopez de Quinto, S.; Martinez-Salas, E. Relevance of RNA structure for the activity of picornavirus IRES elements. Virus Res. 2009, 139, 172-182.
    • (2009) Virus Res , vol.139 , pp. 172-182
    • Fernandez-Miragall, O.1    Lopez de Quinto, S.2    Martinez-Salas, E.3
  • 24
    • 0033988927 scopus 로고    scopus 로고
    • Mutational analysis of the GB virus B internal ribosome entry site
    • Rijnbrand, R.; Abell, G.; Lemon, S.M. Mutational analysis of the GB virus B internal ribosome entry site. J. Virol. 2000, 74, 773-783.
    • (2000) J. Virol , vol.74 , pp. 773-783
    • Rijnbrand, R.1    Abell, G.2    Lemon, S.M.3
  • 25
    • 0033032196 scopus 로고    scopus 로고
    • Natural variation in translational activities of the 5' nontranslated RNAs of hepatitis C virus genotypes 1a and 1b: Evidence for a long-range RNA-RNA interaction outside of the internal ribosomal entry site
    • Honda, M.; Rijnbrand, R.; Abell, G.; Kim, D.; Lemon, S.M. Natural variation in translational activities of the 5' nontranslated RNAs of hepatitis C virus genotypes 1a and 1b: Evidence for a long-range RNA-RNA interaction outside of the internal ribosomal entry site. J. Virol. 1999, 73, 4941-4951.
    • (1999) J. Virol , vol.73 , pp. 4941-4951
    • Honda, M.1    Rijnbrand, R.2    Abell, G.3    Kim, D.4    Lemon, S.M.5
  • 27
  • 28
    • 5144229241 scopus 로고    scopus 로고
    • Mutational and structural analysis of stem-loop IIIC of the hepatitis C virus and GB virus B internal ribosome entry sites
    • Rijnbrand, R.; Thiviyanathan, V.; Kaluarachchi, K.; Lemon, S.M.; Gorenstein, D.G. Mutational and structural analysis of stem-loop IIIC of the hepatitis C virus and GB virus B internal ribosome entry sites. J. Mol. Biol. 2004, 343, 805-817.
    • (2004) J. Mol. Biol , vol.343 , pp. 805-817
    • Rijnbrand, R.1    Thiviyanathan, V.2    Kaluarachchi, K.3    Lemon, S.M.4    Gorenstein, D.G.5
  • 29
    • 0036257140 scopus 로고    scopus 로고
    • Long-range RNA-RNA interactions between distant regions of the hepatitis C virus internal ribosome entry site element
    • Lafuente, E.; Ramos, R.; Martinez-Salas, E. Long-range RNA-RNA interactions between distant regions of the hepatitis C virus internal ribosome entry site element. J. Gen. Virol. 2002, 83, 1113-1121.
    • (2002) J. Gen. Virol , vol.83 , pp. 1113-1121
    • Lafuente, E.1    Ramos, R.2    Martinez-Salas, E.3
  • 30
    • 67349196058 scopus 로고    scopus 로고
    • Rescue of internal initiation of translation by RNA complementation provides evidence for a distribution of functions between individual IRES domains
    • Serrano, P.; Ramajo, J.; Martinez-Salas, E. Rescue of internal initiation of translation by RNA complementation provides evidence for a distribution of functions between individual IRES domains. Virology 2009, 388, 221-229.
    • (2009) Virology , vol.388 , pp. 221-229
    • Serrano, P.1    Ramajo, J.2    Martinez-Salas, E.3
  • 31
    • 0030219426 scopus 로고    scopus 로고
    • Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA
    • Honda, M.; Ping, L.H.; Rijnbrand, R.C.; Amphlett, E.; Clarke, B.; Rowlands, D.; Lemon, S.M. Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA. Virology 1996, 222, 31-42.
    • (1996) Virology , vol.222 , pp. 31-42
    • Honda, M.1    Ping, L.H.2    Rijnbrand, R.C.3    Amphlett, E.4    Clarke, B.5    Rowlands, D.6    Lemon, S.M.7
  • 33
    • 33846064685 scopus 로고    scopus 로고
    • Functional architecture of HCV IRES domain II stabilized by divalent metal ions in the crystal and in solution
    • Dibrov, S.M.; Johnston-Cox, H.; Weng, Y.H.; Hermann, T. Functional architecture of HCV IRES domain II stabilized by divalent metal ions in the crystal and in solution. Angew. Chem. Int. Ed. Engl. 2007, 46, 226-229.
    • (2007) Angew. Chem. Int. Ed. Engl , vol.46 , pp. 226-229
    • Dibrov, S.M.1    Johnston-Cox, H.2    Weng, Y.H.3    Hermann, T.4
  • 34
    • 79959320660 scopus 로고    scopus 로고
    • HCV IRES domain IIb affects the configuration of coding RNA in the 40S subunit's decoding groove
    • Filbin, M.E.; Kieft, J.S. HCV IRES domain IIb affects the configuration of coding RNA in the 40S subunit's decoding groove. RNA 2011, 17, 1258-1273.
    • (2011) RNA , vol.17 , pp. 1258-1273
    • Filbin, M.E.1    Kieft, J.S.2
  • 36
    • 0033673387 scopus 로고    scopus 로고
    • Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function
    • Lukavsky, P.J.; Otto, G.A.; Lancaster, A.M.; Sarnow, P.; Puglisi, J.D. Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function. Nat. Struct. Biol. 2000, 7, 1105-1110.
    • (2000) Nat. Struct. Biol , vol.7 , pp. 1105-1110
    • Lukavsky, P.J.1    Otto, G.A.2    Lancaster, A.M.3    Sarnow, P.4    Puglisi, J.D.5
  • 37
    • 0035260658 scopus 로고    scopus 로고
    • Mechanism of ribosome recruitment by hepatitis C IRES RNA
    • Kieft, J.S.; Zhou, K.; Jubin, R.; Doudna, J.A. Mechanism of ribosome recruitment by hepatitis C IRES RNA. RNA 2001, 7, 194-206.
    • (2001) RNA , vol.7 , pp. 194-206
    • Kieft, J.S.1    Zhou, K.2    Jubin, R.3    Doudna, J.A.4
  • 38
    • 0029331431 scopus 로고
    • An RNA pseudoknot is an essential structural element of the internal ribosome entry site located within the hepatitis C virus 5' noncoding region
    • Wang, C.; Le, S.Y.; Ali, N.; Siddiqui, A. An RNA pseudoknot is an essential structural element of the internal ribosome entry site located within the hepatitis C virus 5' noncoding region. RNA 1995, 1, 526-537.
    • (1995) RNA , vol.1 , pp. 526-537
    • Wang, C.1    Le, S.Y.2    Ali, N.3    Siddiqui, A.4
  • 39
    • 80054080846 scopus 로고    scopus 로고
    • Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning
    • Berry, K.E.; Waghray, S.; Mortimer, S.A.; Bai, Y.; Doudna, J.A. Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning. Structure 2011, 19, 1456-1466.
    • (2011) Structure , vol.19 , pp. 1456-1466
    • Berry, K.E.1    Waghray, S.2    Mortimer, S.A.3    Bai, Y.4    Doudna, J.A.5
  • 40
    • 0031905698 scopus 로고    scopus 로고
    • A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs
    • Pestova, T.V.; Shatsky, I.N.; Fletcher, S.P.; Jackson, R.J.; Hellen, C.U. A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs. Genes Dev. 1998, 12, 67-83.
    • (1998) Genes Dev , vol.12 , pp. 67-83
    • Pestova, T.V.1    Shatsky, I.N.2    Fletcher, S.P.3    Jackson, R.J.4    Hellen, C.U.5
  • 41
    • 10344243545 scopus 로고    scopus 로고
    • Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA
    • Ji, H.; Fraser, C.S.; Yu, Y.; Leary, J.; Doudna, J.A. Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 16990-16995.
    • (2004) Proc. Natl. Acad. Sci. U. S. A , vol.101 , pp. 16990-16995
    • Ji, H.1    Fraser, C.S.2    Yu, Y.3    Leary, J.4    Doudna, J.A.5
  • 42
    • 33845623845 scopus 로고    scopus 로고
    • Structural and mechanistic insights into hepatitis C viral translation initiation
    • Fraser, C.S.; Doudna, J.A. Structural and mechanistic insights into hepatitis C viral translation initiation. Nat. Rev. Microbiol. 2007, 5, 29-38.
    • (2007) Nat. Rev. Microbiol , vol.5 , pp. 29-38
    • Fraser, C.S.1    Doudna, J.A.2
  • 43
    • 33846959081 scopus 로고    scopus 로고
    • HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly
    • Locker, N.; Easton, L.E.; Lukavsky, P.J. HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly. EMBO J. 2007, 26, 795-805.
    • (2007) EMBO J , vol.26 , pp. 795-805
    • Locker, N.1    Easton, L.E.2    Lukavsky, P.J.3
  • 44
    • 0035831269 scopus 로고    scopus 로고
    • Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit
    • Spahn, C.M.; Kieft, J.S.; Grassucci, R.A.; Penczek, P.A.; Zhou, K.; Doudna, J.A.; Frank, J. Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit. Science 2001, 291, 1959-1962.
    • (2001) Science , vol.291 , pp. 1959-1962
    • Spahn, C.M.1    Kieft, J.S.2    Grassucci, R.A.3    Penczek, P.A.4    Zhou, K.5    Doudna, J.A.6    Frank, J.7
  • 45
    • 0031901132 scopus 로고    scopus 로고
    • Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs
    • Sizova, D.V.; Kolupaeva, V.G.; Pestova, T.V.; Shatsky, I.N.; Hellen, C.U. Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs. J. Virol. 1998, 72, 4775-4782.
    • (1998) J. Virol , vol.72 , pp. 4775-4782
    • Sizova, D.V.1    Kolupaeva, V.G.2    Pestova, T.V.3    Shatsky, I.N.4    Hellen, C.U.5
  • 46
    • 0034852292 scopus 로고    scopus 로고
    • IRES interaction with translation initiation factors: Functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII
    • Lopez de Quinto, S.; Lafuente, E.; Martinez-Salas, E. IRES interaction with translation initiation factors: Functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII. RNA 2001, 7, 1213-1226.
    • (2001) RNA , vol.7 , pp. 1213-1226
    • Lopez de Quinto, S.1    Lafuente, E.2    Martinez-Salas, E.3
  • 47
    • 28544439977 scopus 로고    scopus 로고
    • Structural roles for human translation factor eIF3 in initiation of protein synthesis
    • Siridechadilok, B.; Fraser, C.S.; Hall, R.J.; Doudna, J.A.; Nogales, E. Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science 2005, 310, 1513-1515.
    • (2005) Science , vol.310 , pp. 1513-1515
    • Siridechadilok, B.1    Fraser, C.S.2    Hall, R.J.3    Doudna, J.A.4    Nogales, E.5
  • 48
    • 55849150550 scopus 로고    scopus 로고
    • Riboproteomic analysis of polypeptides interacting with the internal ribosome-entry site element of foot-and-mouth disease viral RNA
    • Pacheco, A.; Reigadas, S.; Martinez-Salas, E. Riboproteomic analysis of polypeptides interacting with the internal ribosome-entry site element of foot-and-mouth disease viral RNA. Proteomics 2008, 8, 4782-4790.
    • (2008) Proteomics , vol.8 , pp. 4782-4790
    • Pacheco, A.1    Reigadas, S.2    Martinez-Salas, E.3
  • 49
    • 22444444478 scopus 로고    scopus 로고
    • Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes
    • Yu, Y.; Ji, H.; Doudna, J.A.; Leary, J.A. Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes. Protein Sci. 2005, 14, 1438-1446.
    • (2005) Protein Sci , vol.14 , pp. 1438-1446
    • Yu, Y.1    Ji, H.2    Doudna, J.A.3    Leary, J.A.4
  • 50
    • 0035877795 scopus 로고    scopus 로고
    • Ribosomal protein S5 interacts with the internal ribosomal entry site of hepatitis C virus
    • Fukushi, S.; Okada, M.; Stahl, J.; Kageyama, T.; Hoshino, F.B.; Katayama, K. Ribosomal protein S5 interacts with the internal ribosomal entry site of hepatitis C virus. J. Biol. Chem. 2001, 276, 20824-20826.
    • (2001) J. Biol. Chem , vol.276 , pp. 20824-20826
    • Fukushi, S.1    Okada, M.2    Stahl, J.3    Kageyama, T.4    Hoshino, F.B.5    Katayama, K.6
  • 51
    • 10644253021 scopus 로고    scopus 로고
    • Functional and structural similarities between the internal ribosome entry sites of hepatitis C virus and porcine teschovirus, a picornavirus
    • Pisarev, A.V.; Chard, L.S.; Kaku, Y.; Johns, H.L.; Shatsky, I.N.; Belsham, G.J. Functional and structural similarities between the internal ribosome entry sites of hepatitis C virus and porcine teschovirus, a picornavirus. J. Virol. 2004, 78, 4487-4497.
    • (2004) J. Virol , vol.78 , pp. 4487-4497
    • Pisarev, A.V.1    Chard, L.S.2    Kaku, Y.3    Johns, H.L.4    Shatsky, I.N.5    Belsham, G.J.6
  • 52
    • 70449717470 scopus 로고    scopus 로고
    • Conserved functional domains and a novel tertiary interaction near the pseudoknot drive translational activity of hepatitis C virus and hepatitis C virus-like internal ribosome entry sites
    • Easton, L.E.; Locker, N.; Lukavsky, P.J. Conserved functional domains and a novel tertiary interaction near the pseudoknot drive translational activity of hepatitis C virus and hepatitis C virus-like internal ribosome entry sites. Nucleic Acids Res. 2009, 37, 5537-5549.
    • (2009) Nucleic Acids Res , vol.37 , pp. 5537-5549
    • Easton, L.E.1    Locker, N.2    Lukavsky, P.J.3
  • 53
    • 4644247805 scopus 로고    scopus 로고
    • Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: The IRES functions as an RNA-based translation factor
    • Spahn, C.M.; Jan, E.; Mulder, A.; Grassucci, R.A.; Sarnow, P.; Frank, J. Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: The IRES functions as an RNA-based translation factor. Cell 2004, 118, 465-475.
    • (2004) Cell , vol.118 , pp. 465-475
    • Spahn, C.M.1    Jan, E.2    Mulder, A.3    Grassucci, R.A.4    Sarnow, P.5    Frank, J.6
  • 54
    • 72549101167 scopus 로고    scopus 로고
    • RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs
    • Landry, D.M.; Hertz, M.I.; Thompson, S.R. RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs. Gene. Dev. 2009, 23, 2753-2764.
    • (2009) Gene. Dev , vol.23 , pp. 2753-2764
    • Landry, D.M.1    Hertz, M.I.2    Thompson, S.R.3
  • 55
    • 49649113339 scopus 로고    scopus 로고
    • Internal translation initiation on the foot-and-mouth disease virus IRES is affected by ribosomal stalk conformation
    • Martinez-Azorin, F.; Remacha, M.; Martinez-Salas, E.; Ballesta, J.P. Internal translation initiation on the foot-and-mouth disease virus IRES is affected by ribosomal stalk conformation. FEBS Lett. 2008, 582, 3029-3032.
    • (2008) FEBS Lett , vol.582 , pp. 3029-3032
    • Martinez-Azorin, F.1    Remacha, M.2    Martinez-Salas, E.3    Ballesta, J.P.4
  • 56
    • 0038373448 scopus 로고    scopus 로고
    • Detection of tRNA-like structure through RNase P cleavage of viral internal ribosome entry site RNAs near the AUG start triplet
    • Lyons, A.J.; Robertson, H.D. Detection of tRNA-like structure through RNase P cleavage of viral internal ribosome entry site RNAs near the AUG start triplet. J. Biol. Chem. 2003, 278, 26844-26850.
    • (2003) J. Biol. Chem , vol.278 , pp. 26844-26850
    • Lyons, A.J.1    Robertson, H.D.2
  • 57
    • 34249103881 scopus 로고    scopus 로고
    • Characterization of a cyanobacterial RNase P ribozyme recognition motif in the IRES of foot-and-mouth disease virus reveals a unique structural element
    • Serrano, P.; Gomez, J.; Martinez-Salas, E. Characterization of a cyanobacterial RNase P ribozyme recognition motif in the IRES of foot-and-mouth disease virus reveals a unique structural element. RNA 2007, 13, 849-859.
    • (2007) RNA , vol.13 , pp. 849-859
    • Serrano, P.1    Gomez, J.2    Martinez-Salas, E.3
  • 58
    • 77950234365 scopus 로고    scopus 로고
    • Tailoring the switch from IRES-dependent to 5'-end-dependent translation with the RNase P ribozyme
    • Fernandez, N.; Martinez-Salas, E. Tailoring the switch from IRES-dependent to 5'-end-dependent translation with the RNase P ribozyme. RNA 2010, 16, 852-862.
    • (2010) RNA , vol.16 , pp. 852-862
    • Fernandez, N.1    Martinez-Salas, E.2
  • 59
    • 14844339136 scopus 로고    scopus 로고
    • Characterizing the function and structural organization of the 5' tRNA-like motif within the hepatitis C virus quasispecies
    • Piron, M.; Beguiristain, N.; Nadal, A.; Martinez-Salas, E.; Gomez, J. Characterizing the function and structural organization of the 5' tRNA-like motif within the hepatitis C virus quasispecies. Nucleic Acids Res. 2005, 33, 1487-1502.
    • (2005) Nucleic Acids Res , vol.33 , pp. 1487-1502
    • Piron, M.1    Beguiristain, N.2    Nadal, A.3    Martinez-Salas, E.4    Gomez, J.5
  • 60
    • 77953021773 scopus 로고    scopus 로고
    • The terminal loop of a 3' proximal hairpin plays a critical role in replication and the structure of the 3' region of Turnip crinkle virus
    • Yuan, X.; Shi, K.; Young, M.Y.; Simon, A.E. The terminal loop of a 3' proximal hairpin plays a critical role in replication and the structure of the 3' region of Turnip crinkle virus. Virology 2010, 402, 271-280.
    • (2010) Virology , vol.402 , pp. 271-280
    • Yuan, X.1    Shi, K.2    Young, M.Y.3    Simon, A.E.4
  • 61
    • 79955452990 scopus 로고    scopus 로고
    • Ribosome binding to a 5' translational enhancer is altered in the presence of the 3' untranslated region in cap-independent translation of turnip crinkle virus
    • Stupina, V.A.; Yuan, X.; Meskauskas, A.; Dinman, J.D.; Simon, A.E. Ribosome binding to a 5' translational enhancer is altered in the presence of the 3' untranslated region in cap-independent translation of turnip crinkle virus. J. Virol. 2011, 85, 4638-4653.
    • (2011) J. Virol , vol.85 , pp. 4638-4653
    • Stupina, V.A.1    Yuan, X.2    Meskauskas, A.3    Dinman, J.D.4    Simon, A.E.5
  • 62
    • 77951901108 scopus 로고    scopus 로고
    • Insights into the biology of IRES elements through riboproteomic approaches
    • Pacheco, A.; Martinez-Salas, E. Insights into the biology of IRES elements through riboproteomic approaches. J. Biomed. Biotechnol. 2010, 2010, 458927.
    • (2010) J. Biomed. Biotechnol , vol.2010 , pp. 458927
    • Pacheco, A.1    Martinez-Salas, E.2
  • 64
    • 3543095590 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonucleoprotein L interacts with the 3' border of the internal ribosomal entry site of hepatitis C virus
    • Hahm, B.; Kim, Y.K.; Kim, J.H.; Kim, T.Y.; Jang, S.K. Heterogeneous nuclear ribonucleoprotein L interacts with the 3' border of the internal ribosomal entry site of hepatitis C virus. J. Virol. 1998, 72, 8782-8788.
    • (1998) J. Virol , vol.72 , pp. 8782-8788
    • Hahm, B.1    Kim, Y.K.2    Kim, J.H.3    Kim, T.Y.4    Jang, S.K.5
  • 65
    • 0342614202 scopus 로고    scopus 로고
    • Transient expression of cellular polypyrimidine-tract binding protein stimulates cap-independent translation directed by both picornaviral and flaviviral internal ribosome entry sites in vivo
    • Gosert, R.; Chang, K.H.; Rijnbrand, R.; Yi, M.; Sangar, D.V.; Lemon, S.M. Transient expression of cellular polypyrimidine-tract binding protein stimulates cap-independent translation directed by both picornaviral and flaviviral internal ribosome entry sites in vivo. Mol. Cell Biol. 2000, 20, 1583-1595.
    • (2000) Mol. Cell Biol , vol.20 , pp. 1583-1595
    • Gosert, R.1    Chang, K.H.2    Rijnbrand, R.3    Yi, M.4    Sangar, D.V.5    Lemon, S.M.6
  • 66
    • 56449100694 scopus 로고    scopus 로고
    • Structural determinant of human La protein critical for internal initiation of translation of hepatitis C virus RNA
    • Mondal, T.; Ray, U.; Manna, A.K.; Gupta, R.; Roy, S.; Das, S. Structural determinant of human La protein critical for internal initiation of translation of hepatitis C virus RNA. J. Virol. 2008, 82, 11927-11938.
    • (2008) J. Virol , vol.82 , pp. 11927-11938
    • Mondal, T.1    Ray, U.2    Manna, A.K.3    Gupta, R.4    Roy, S.5    Das, S.6
  • 69
    • 81255160914 scopus 로고    scopus 로고
    • Viral subversion of the host protein synthesis machinery
    • Walsh, D.; Mohr, I. Viral subversion of the host protein synthesis machinery. Nat. Rev. Microbiol. 2011, 9, 860-875.
    • (2011) Nat. Rev. Microbiol , vol.9 , pp. 860-875
    • Walsh, D.1    Mohr, I.2
  • 70
    • 24644483623 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    • Jopling, C.L.; Yi, M.; Lancaster, A.M.; Lemon, S.M.; Sarnow, P. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 2005, 309, 1577-1581.
    • (2005) Science , vol.309 , pp. 1577-1581
    • Jopling, C.L.1    Yi, M.2    Lancaster, A.M.3    Lemon, S.M.4    Sarnow, P.5
  • 71
    • 46749124698 scopus 로고    scopus 로고
    • Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome
    • Jopling, C.L.; Schutz, S.; Sarnow, P. Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome. Cell Host Microbe 2008, 4, 77-85.
    • (2008) Cell Host Microbe , vol.4 , pp. 77-85
    • Jopling, C.L.1    Schutz, S.2    Sarnow, P.3
  • 72
    • 79952768199 scopus 로고    scopus 로고
    • Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex
    • Machlin, E.S.; Sarnow, P.; Sagan, S.M. Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 3193-3198.
    • (2011) Proc. Natl. Acad. Sci. U. S. A , vol.108 , pp. 3193-3198
    • McHlin, E.S.1    Sarnow, P.2    Sagan, S.M.3
  • 74
    • 70449729916 scopus 로고    scopus 로고
    • In vitro characterization of a miR-122-sensitive double-helical switch element in the 5' region of hepatitis C virus RNA
    • Diaz-Toledano, R.; Ariza-Mateos, A.; Birk, A.; Martinez-Garcia, B.; Gomez, J. In vitro characterization of a miR-122-sensitive double-helical switch element in the 5' region of hepatitis C virus RNA. Nucleic Acids Res. 2009, 37, 5498-5510.
    • (2009) Nucleic Acids Res , vol.37 , pp. 5498-5510
    • Diaz-Toledano, R.1    Ariza-Mateos, A.2    Birk, A.3    Martinez-Garcia, B.4    Gomez, J.5
  • 75
    • 77953315225 scopus 로고    scopus 로고
    • Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122
    • Jangra, R.K.; Yi, M.; Lemon, S.M. Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122. J. Virol. 2010, 84, 6615-6625.
    • (2010) J. Virol , vol.84 , pp. 6615-6625
    • Jangra, R.K.1    Yi, M.2    Lemon, S.M.3
  • 76
    • 80053208713 scopus 로고    scopus 로고
    • miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components
    • Roberts, A.P.; Lewis, A.P.; Jopling, C.L. miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components. Nucleic Acids Res. 2011, 39, 7716-7729.
    • (2011) Nucleic Acids Res , vol.39 , pp. 7716-7729
    • Roberts, A.P.1    Lewis, A.P.2    Jopling, C.L.3
  • 77
    • 21844438516 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus translation and subgenomic replication by siRNAs directed against highly conserved HCV sequence and cellular HCV cofactors
    • Korf, M.; Jarczak, D.; Beger, C.; Manns, M.P.; Kruger, M. Inhibition of hepatitis C virus translation and subgenomic replication by siRNAs directed against highly conserved HCV sequence and cellular HCV cofactors. J. Hepatol. 2005, 43, 225-234.
    • (2005) J. Hepatol , vol.43 , pp. 225-234
    • Korf, M.1    Jarczak, D.2    Beger, C.3    Manns, M.P.4    Kruger, M.5
  • 78
    • 56649103774 scopus 로고    scopus 로고
    • Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro
    • Alotte, C.; Martin, A.; Caldarelli, S.A.; Di Giorgio, A.; Condom, R.; Zoulim, F.; Durantel, D.; Hantz, O. Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro. Antivir. Res. 2008, 80, 280-287.
    • (2008) Antivir. Res , vol.80 , pp. 280-287
    • Alotte, C.1    Martin, A.2    Caldarelli, S.A.3    Di Giorgio, A.4    Condom, R.5    Zoulim, F.6    Durantel, D.7    Hantz, O.8
  • 79
    • 13844306367 scopus 로고    scopus 로고
    • A hepatitis C virus (HCV) internal ribosome entry site (IRES) domain III-IV-targeted aptamer inhibits translation by binding to an apical loop of domain IIId
    • Kikuchi, K.; Umehara, T.; Fukuda, K.; Kuno, A.; Hasegawa, T.; Nishikawa, S. A hepatitis C virus (HCV) internal ribosome entry site (IRES) domain III-IV-targeted aptamer inhibits translation by binding to an apical loop of domain IIId. Nucleic Acids Res. 2005, 33, 683-692.
    • (2005) Nucleic Acids Res , vol.33 , pp. 683-692
    • Kikuchi, K.1    Umehara, T.2    Fukuda, K.3    Kuno, A.4    Hasegawa, T.5    Nishikawa, S.6
  • 80
    • 67849119062 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus replication and internal ribosome entry site-dependent translation by an RNA molecule
    • Romero-Lopez, C.; Diaz-Gonzalez, R.; Barroso-delJesus, A.; Berzal-Herranz, A. Inhibition of hepatitis C virus replication and internal ribosome entry site-dependent translation by an RNA molecule. J. Gen. Virol. 2009, 90, 1659-1669.
    • (2009) J. Gen. Virol , vol.90 , pp. 1659-1669
    • Romero-Lopez, C.1    Diaz-Gonzalez, R.2    Barroso-delJesus, A.3    Berzal-Herranz, A.4
  • 81
    • 79959223747 scopus 로고    scopus 로고
    • Selection, optimization, and pharmacokinetic properties of a novel, potent antiviral locked nucleic acid-based antisense oligomer targeting hepatitis C virus internal ribosome entry site
    • Laxton, C.; Brady, K.; Moschos, S.; Turnpenny, P.; Rawal, J.; Pryde, D.C.; Sidders, B.; Corbau, R.; Pickford, C.; Murray, E.J. Selection, optimization, and pharmacokinetic properties of a novel, potent antiviral locked nucleic acid-based antisense oligomer targeting hepatitis C virus internal ribosome entry site. Antimicrob. Agents Chemother. 2011, 55, 3105-3114.
    • (2011) Antimicrob. Agents Chemother , vol.55 , pp. 3105-3114
    • Laxton, C.1    Brady, K.2    Moschos, S.3    Turnpenny, P.4    Rawal, J.5    Pryde, D.C.6    Sidders, B.7    Corbau, R.8    Pickford, C.9    Murray, E.J.10
  • 84
    • 78650917501 scopus 로고    scopus 로고
    • Measuring antiviral activity of benzimidazole molecules that alter IRES RNA structure with an infectious hepatitis C virus chimera expressing Renilla luciferase
    • Liu, S.; Nelson, C.A.; Xiao, L.; Lu, L.; Seth, P.P.; Davis, D.R.; Hagedorn, C.H. Measuring antiviral activity of benzimidazole molecules that alter IRES RNA structure with an infectious hepatitis C virus chimera expressing Renilla luciferase. Antivir. Res. 2011, 89, 54-63.
    • (2011) Antivir. Res , vol.89 , pp. 54-63
    • Liu, S.1    Nelson, C.A.2    Xiao, L.3    Lu, L.4    Seth, P.P.5    Davis, D.R.6    Hagedorn, C.H.7
  • 86
  • 87
    • 84859454654 scopus 로고    scopus 로고
    • Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches
    • Dibrov, S.M.; Ding, K.; Brunn, N.D.; Parker, M.A.; Bergdahl, B.M.; Wyles, D.L.; Hermann, T. Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches. Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 5223-5228.
    • (2012) Proc. Natl. Acad. Sci. U. S. A , vol.109 , pp. 5223-5228
    • Dibrov, S.M.1    Ding, K.2    Brunn, N.D.3    Parker, M.A.4    Bergdahl, B.M.5    Wyles, D.L.6    Hermann, T.7
  • 89
    • 33751203577 scopus 로고    scopus 로고
    • The hepatitis C virus RNA 3'-untranslated region strongly enhances translation directed by the internal ribosome entry site
    • Song, Y.; Friebe, P.; Tzima, E.; Junemann, C.; Bartenschlager, R.; Niepmann, M. The hepatitis C virus RNA 3'-untranslated region strongly enhances translation directed by the internal ribosome entry site. J. Virol. 2006, 80, 11579-11588.
    • (2006) J. Virol , vol.80 , pp. 11579-11588
    • Song, Y.1    Friebe, P.2    Tzima, E.3    Junemann, C.4    Bartenschlager, R.5    Niepmann, M.6
  • 90
    • 69049116216 scopus 로고    scopus 로고
    • A long-range RNA-RNA interaction between the 5' and 3' ends of the HCV genome
    • Romero-Lopez, C.; Berzal-Herranz, A. A long-range RNA-RNA interaction between the 5' and 3' ends of the HCV genome. RNA 2009, 15, 1740-1752.
    • (2009) RNA , vol.15 , pp. 1740-1752
    • Romero-Lopez, C.1    Berzal-Herranz, A.2
  • 91
    • 10644226734 scopus 로고    scopus 로고
    • Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication
    • Friebe, P.; Boudet, J.; Simorre, J.P.; Bartenschlager, R. Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication. J. Virol. 2005, 79, 380-392.
    • (2005) J. Virol , vol.79 , pp. 380-392
    • Friebe, P.1    Boudet, J.2    Simorre, J.P.3    Bartenschlager, R.4
  • 92
    • 37349012884 scopus 로고    scopus 로고
    • 3' RNA elements in hepatitis C virus replication: Kissing partners and long poly(U)
    • You, S.; Rice, C.M. 3' RNA elements in hepatitis C virus replication: Kissing partners and long poly(U). J. Virol. 2008, 82, 184-195.
    • (2008) J. Virol , vol.82 , pp. 184-195
    • You, S.1    Rice, C.M.2
  • 93
    • 84856235423 scopus 로고    scopus 로고
    • The functional RNA domain 5BSL3.2 within the NS5B coding sequence influences hepatitis C virus IRES-mediated translation
    • Romero-Lopez, C.; Berzal-Herranz, A. The functional RNA domain 5BSL3.2 within the NS5B coding sequence influences hepatitis C virus IRES-mediated translation. Cell. Mol. Life Sci. 2012, 69, 103-113.
    • (2012) Cell. Mol. Life Sci , vol.69 , pp. 103-113
    • Romero-Lopez, C.1    Berzal-Herranz, A.2
  • 94
    • 84864951957 scopus 로고    scopus 로고
    • A twist in the tail: SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication
    • Tuplin, A.; Struthers, M.; Simmonds, P.; Evans, D.J. A twist in the tail: SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication. Nucleic Acids Res. 2012, 40, 6908-6921.
    • (2012) Nucleic Acids Res , vol.40 , pp. 6908-6921
    • Tuplin, A.1    Struthers, M.2    Simmonds, P.3    Evans, D.J.4
  • 96
    • 33749237734 scopus 로고    scopus 로고
    • Oscillating kissing stem-loop interactions mediate 5' scanning-dependent translation by a viral 3'-cap-independent translation element
    • Rakotondrafara, A.M.; Polacek, C.; Harris, E.; Miller, W.A. Oscillating kissing stem-loop interactions mediate 5' scanning-dependent translation by a viral 3'-cap-independent translation element. RNA 2006, 12, 1893-1906.
    • (2006) RNA , vol.12 , pp. 1893-1906
    • Rakotondrafara, A.M.1    Polacek, C.2    Harris, E.3    Miller, W.A.4
  • 98
    • 33749069918 scopus 로고    scopus 로고
    • The 3' end of the foot-and-mouth disease virus genome establishes two distinct long-range RNA-RNA interactions with the 5' end region
    • Serrano, P.; Pulido, M.R.; Saiz, M.; Martinez-Salas, E. The 3' end of the foot-and-mouth disease virus genome establishes two distinct long-range RNA-RNA interactions with the 5' end region. J. Gen. Virol. 2006, 87, 3013-3022.
    • (2006) J. Gen. Virol , vol.87 , pp. 3013-3022
    • Serrano, P.1    Pulido, M.R.2    Saiz, M.3    Martinez-Salas, E.4
  • 99
    • 34249899152 scopus 로고    scopus 로고
    • Foot-and-mouth disease virus infection induces proteolytic cleavage of PTB, eIF3a, b, and PABP RNA-binding proteins
    • Rodriguez Pulido, M.; Serrano, P.; Saiz, M.; Martinez-Salas, E. Foot-and-mouth disease virus infection induces proteolytic cleavage of PTB, eIF3a, b, and PABP RNA-binding proteins. Virology 2007, 364, 466-474.
    • (2007) Virology , vol.364 , pp. 466-474
    • Rodriguez Pulido, M.1    Serrano, P.2    Saiz, M.3    Martinez-Salas, E.4
  • 100
    • 0242473186 scopus 로고    scopus 로고
    • Members of the NF90/NFAR protein group are involved in the life cycle of a positive-strand RNA virus
    • Isken, O.; Grassmann, C.W.; Sarisky, R.T.; Kann, M.; Zhang, S.; Grosse, F.; Kao, P.N.; Behrens, S.E. Members of the NF90/NFAR protein group are involved in the life cycle of a positive-strand RNA virus. EMBO J. 2003, 22, 5655-5665.
    • (2003) EMBO J , vol.22 , pp. 5655-5665
    • Isken, O.1    Grassmann, C.W.2    Sarisky, R.T.3    Kann, M.4    Zhang, S.5    Grosse, F.6    Kao, P.N.7    Behrens, S.E.8
  • 102
    • 77953319069 scopus 로고    scopus 로고
    • DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation
    • Jangra, R.K.; Yi, M.; Lemon, S.M. DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation. J. Virol. 2010, 84, 6810-6824.
    • (2010) J. Virol , vol.84 , pp. 6810-6824
    • Jangra, R.K.1    Yi, M.2    Lemon, S.M.3
  • 104
    • 33846700754 scopus 로고    scopus 로고
    • Activation of PKR: An open and shut case?
    • Cole, J.L. Activation of PKR: An open and shut case? Trends Biochem. Sci. 2007, 32, 57-62.
    • (2007) Trends Biochem. Sci , vol.32 , pp. 57-62
    • Cole, J.L.1
  • 105
    • 79958804665 scopus 로고    scopus 로고
    • eIF2A mediates translation of hepatitis C viral mRNA under stress conditions
    • Kim, J.H.; Park, S.M.; Park, J.H.; Keum, S.J.; Jang, S.K. eIF2A mediates translation of hepatitis C viral mRNA under stress conditions. EMBO J. 2011, 30, 2454-2464.
    • (2011) EMBO J , vol.30 , pp. 2454-2464
    • Kim, J.H.1    Park, S.M.2    Park, J.H.3    Keum, S.J.4    Jang, S.K.5
  • 106
    • 33646186734 scopus 로고    scopus 로고
    • Initiation factor-independent translation mediated by the hepatitis C virus internal ribosome entry site
    • Lancaster, A.M.; Jan, E.; Sarnow, P. Initiation factor-independent translation mediated by the hepatitis C virus internal ribosome entry site. RNA 2006, 12, 894-902.
    • (2006) RNA , vol.12 , pp. 894-902
    • Lancaster, A.M.1    Jan, E.2    Sarnow, P.3
  • 109
    • 0033623486 scopus 로고    scopus 로고
    • Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo
    • Lopez de Quinto, S.; Martinez-Salas, E. Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo. RNA 2000, 6, 1380-1392.
    • (2000) RNA , vol.6 , pp. 1380-1392
    • Lopez de Quinto, S.1    Martinez-Salas, E.2
  • 110
    • 84862199735 scopus 로고    scopus 로고
    • Gemin5 proteolysis reveals a novel motif to identify L protease targets
    • Piñeiro, D.; Ramajo, J.; Bradrick, S.S.; Martinez-Salas, E. Gemin5 proteolysis reveals a novel motif to identify L protease targets. Nucleic Acids Res. 2012, 40, 4942-4953.
    • (2012) Nucleic Acids Res , vol.40 , pp. 4942-4953
    • Piñeiro, D.1    Ramajo, J.2    Bradrick, S.S.3    Martinez-Salas, E.4
  • 112
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan, E.; Curran, J.; Hofmann, K.; Moradpour, D.; Binder, M.; Bartenschlager, R.; Tschopp, J. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 2005, 437, 1167-1172.
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 116
    • 59249089462 scopus 로고    scopus 로고
    • Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes
    • Walters, K.A.; Syder, A.J.; Lederer, S.L.; Diamond, D.L.; Paeper, B.; Rice, C.M.; Katze, M.G. Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes. PLoS Pathog. 2009, 5, e1000269.
    • (2009) PLoS Pathog , vol.5
    • Walters, K.A.1    Syder, A.J.2    Lederer, S.L.3    Diamond, D.L.4    Paeper, B.5    Rice, C.M.6    Katze, M.G.7
  • 117
  • 118
    • 79955485187 scopus 로고    scopus 로고
    • Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer
    • McGivern, D.R.; Lemon, S.M. Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer. Oncogene 2011, 30, 1969-1983.
    • (2011) Oncogene , vol.30 , pp. 1969-1983
    • McGivern, D.R.1    Lemon, S.M.2


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