Interaction of the elF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo

RNA

Volumn 6, Issue 10, 2000, Pages 1380-1392

  Lopez De Quinto, S ^a   Martinez Salas, E ^a  

^a CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

Author keywords

elF4G; Internal ribosome entry site; Recruitment of translational machinery; RNA protein interaction; Translation initiation

Indexed keywords

INITIATION FACTOR; NUCLEOTIDE; PROTEIN; RNA; EIF-4B; INITIATION FACTOR 4B; INITIATION FACTOR 4G; RNA BINDING PROTEIN; VIRUS RNA;

ANIMAL CELL; APHTHOVIRUS; ARTICLE; CELL STRAIN BHK; FOOT AND MOUTH DISEASE VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; RIBOSOME; TRANSLATION INITIATION; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CELL LINE; CHEMISTRY; CONFORMATION; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HAMSTER; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN FOOTPRINTING; REGULATORY SEQUENCE; RNA TRANSLATION;

ANIMALIA; APHTHOVIRUS; FOOT-AND-MOUTH DISEASE VIRUS;

ANIMALS; APHTHOVIRUS; BASE SEQUENCE; BINDING SITES; CELL LINE; CONSERVED SEQUENCE; CRICETINAE; EUKARYOTIC INITIATION FACTOR-4G; EUKARYOTIC INITIATION FACTORS; GENE EXPRESSION REGULATION, VIRAL; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PEPTIDE INITIATION FACTORS; PROTEIN BINDING; PROTEIN FOOTPRINTING; REGULATORY SEQUENCES, NUCLEIC ACID; RIBOSOMES; RNA, VIRAL; RNA-BINDING PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 0033623486     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838200000753     Document Type: Article

References (53)

1. Intracellular determinants of picornavirus replication
2. Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus
3. A region of the 5' noncoding region of foot-and-mouth disease virus RNA directs efficient internal initiation of protein synthesis within cells: Involvement with the role of L protease in translational control
4. Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor elF3
5. elF4G and its proteolytic cleavage products: Effect on initiation of protein synthesis from capped, uncapped, and IRES-containing mRNAs
6. Functional analysis of the interaction between HCV 5'UTR and putative subunits of eukaryotic translation initiation factor elF3
7. Translation initiation: Adept at adapting
8. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase
9. Two functional complexes formed by KH domain containing proteins with the 5' noncoding region of poliovirus RNA
10. elF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
11. TIF4631 and TIF4632: Two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function
12. A novel functional human eukaryotic translation initiation factor 4G
13. Proteolysis of human eukaryotic translation initiation factor elF4GII, but not not elF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection
14. elF4G: A multipurpose adapter?
15. A newly identified N-terminal amino acid sequence of human elF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation
16. Human eukaryotic translation initiation factor 4G (elF4G) possesses two separate and independent binding sites for elF4A
17. Internal initiation of translation in eukaryotes: The picornavirus paradigm and beyond
18. Identification of eukaryotic mRNAs that are translated at reduced cap binding complex elF4F concentrations using a cDNA microarray
19. Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and elF4G conferred by internal ribosome entry sites
20. Identification of a nucleic acid binding domain in eukaryotic initiation factor elFiso4G from wheat
21. Foot-and-mouth disease virus leader proteinase: Purification of the Lb form and determination of its cleavage site on elF-4 gamma
22. Structural analysis of the interaction of the pyrimidine tract-binding protein with the internal ribosomal entry site of encephalomyocarditis virus and foot-and-mouth disease virus RNAs
23. Translation eukaryotic initiation factor 4G recognizes a specific structural element within the internal ribosome entry site of encephalomyocarditis virus RNA
24. Functional analysis of the internal translation initiation site of foot-and-mouth disease virus
25. A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs
26. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (elF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation
27. Mapping the cleavage site in protein synthesis initiation factor elF-4 gamma of the 2A proteases from human coxsackievirus and rhinovirus
28. Conserved structural motifs located in distal loops of the aphthovirus internal ribosome entry site domain 3 are required for internal initiation of translation
29. Parameters influencing translational efficiency in aphthovirus IRES-based bicistronic expression vectors
30. Involvement of the aphthovirus RNA sequence located between both functional AUGs in start codon selection
31. Interaction of a cellular 57-kilodalton protein with the internal translation initiation site of foot-and-mouth disease virus
32. Internal ribosome entry site (IRES) biology and use in gene expression vectors
33. Identification of an essential domain for internal initiation of translation in the aphthovirus IRES, and implications for viral evolution
34. A single nucleotide substitution in the internal ribosome entry site of foot-and-mouth disease virus leads to enhanced cap-independent translation in vivo
35. The two species of the foot-and-mouth disease virus leader protein, expressed individually, exhibit the same activities
36. The pathway and mechanism of eukaryotic protein synthesis
37. The translation initiation factor elF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence
38. In vitro RNA selection identifies RNA ligands that specifically bind to eukaryotic translation initiation factor elF4B: The role of the RNA recognition motif
39. A region rich in aspartic acid, arginine, tyrosine and glycine (DRYG) mediates eukaryotic initiation factor 4B (elF4B) self-association and interaction with elF3
40. Interaction of eukaryotic initiation factor elF-4B with a picornavirus internal translation initiation site
41. elF4G: Translation's mystery factor begins to yield its secrets
42. Two structural domains of initiation factor elF-4B are involved in binding to RNA
43. The C-terminal domain of eukaryotic protein synthesis initiation factor (elF) 4G is sufficient to support cap-independent translation in the absence of elF4E
44. Ribosome recruitment and scanning: What's new?
45. Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry
46. A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs
47. Functional dissection of eukaryotic initiation factor 4F. The 4A subunit and the central domain of 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes
48. Rotavirus RNA-binding protein NSP3 interacts with elF4GI and evicts the poly(A) binding protein from elF4F
49. From factors to mechanisms: Translation and translational control in eukaryotes
50. Long-range interactions in aphthovirus internal ribosome entry site elements
51. A new cationic liposome reagent mediating nearly quantitative transfection of animal cells
52. Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs
53. RNA determinants of picornavirus cap-independent translation initiation