Isotopic labeling of metabolites in drug discovery applications

Current Drug Metabolism

Volumn 13, Issue 9, 2012, Pages 1213-1225

  Iglesias, Jacobo ^a   Sleno, Lekha ^b   Volmer, Dietrich A ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

Author keywords

ADMET; Biomarker; Differential quantitation; Drug metabolites; Mass spectrometry; Metabolomics; Stable isotope labeling

Indexed keywords

2 AMINOPYRIDINE; 2 ANTHRANILIC ACID; 3 ACYLOXY 1 METHYLPYRIDINIUM; 3 HYDROXYMETHYL 1 ETHYLPYRIDIDINIUM IODIDE; 7 (N,N DIMETHYLAMINOSULFONYL) 4 (AMINOETHYL)PIPERAZINO 2,1,3 BENZOXADIAZOLE; ACETALDEHYDE; ACETIMIDIC ACID METHYL ESTER; ANILINE; BUTANOL; DANSYL CHLORIDE; DEHYDROCHOLIC ACID; DRUG METABOLITE; FORMALDEHYDE; ISOTOPE; MONO(DIMETHYLAMINOETHYL)SUCCINYL ESTER; PARA DIMETHYLAMINOPHENACYL BROMIDE; UNCLASSIFIED DRUG;

DRUG ABSORPTION; DRUG DEVELOPMENT; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; GLYCOBIOLOGY; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; ISOTOPE LABELING; MASS FRAGMENTOGRAPHY; METABOLOMICS; NONHUMAN; REVIEW;

ANIMALS; DRUG DISCOVERY; DRUG TOXICITY; HUMANS; ISOTOPE LABELING; METABOLOMICS; PHARMACEUTICAL PREPARATIONS; TOXICITY TESTS;

EID: 84868014069     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/138920012803341357     Document Type: Review

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