Metabolomics relative quantitation with mass spectrometry using chemical derivatization and isotope labeling

Spectroscopy

Volumn 22, Issue 5, 2008, Pages 327-343

  O'Maille, Grace ^a   Go, Eden P ^a   Hoang, Linh ^a   Want, Elizabeth J ^a   Smith, Colin ^a   O'Maille, Paul ^b   Nordström, Anders ^a   Morita, Hirotoshi ^a   Qin, Chuan ^a   Uritboonthai, Wilasinee ^a   Apon, Junefredo ^a   Moore, Richard ^c   Garrett, James ^c   Siuzdak, Gary ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c BD Technologies   (United States)

Author keywords

Human plasma; Isotope labeling; Mass spectrometry; Metabolomics; Quantitation

Indexed keywords

ACIDS; AMINATION; AMINES; AMINO ACIDS; BIOMOLECULES; BODY FLUIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; ISOTOPES; LABELING; MASS SPECTROMETRY; METABOLITES; ORGANIC ACIDS;

BIOLOGICAL SOURCES; BROAD SPECTRUM; BUTYLATION; CHEMICAL DERIVATIZATION; DERIVATIZATION; HUMAN PLASMA; HUMAN SERUM; ION CHROMATOGRAM; IONIZATION EFFICIENCIES; IONIZATION ENHANCEMENT; ISOTOPE LABELING; ISOTOPE LABELLING; LC-ESI-MS; METABOLOMICS; POOLED SAMPLES; QUANTITATION; SERUM SAMPLES;

CHEMICAL REACTIONS;

AMINO ACID; STEROID;

AMINATION; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DERIVATIZATION; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; METABOLOMICS; QUANTITATIVE ANALYSIS;

EID: 52449119444     PISSN: 07124813     EISSN: None     Source Type: Journal    
DOI: 10.3233/SPE-2008-0361     Document Type: Article

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