Differentiation between isomeric oxidative metabolites of a piperidine-containing drug by liquid chromatography-tandem mass spectrometry with stable-isotope tracer technique

Biomedical Chromatography

Volumn 16, Issue 1, 2002, Pages 25-30

  Kato, Koji ^a   Jingu, Shigeji ^a   Ogawa, Naoyoshi ^a   Higuchi, Shohei ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYANIDES; ELECTROSPRAY IONIZATION; IONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES;

ALIPHATIC HYDROXYLATION; ISOTOPE-TRACER TECHNIQUES; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; N-OXIDATION; ORAL ADMINISTRATION; PIPERIDINE RINGS; REVERSED PHASE; STABLE ISOTOPE TRACERS; URINE SAMPLE;

HYDROXYLATION;

CYANIDE; DEUTERIUM; ENAMINE; HISTAMINE H2 RECEPTOR ANTAGONIST; PIBUTIDINE; PIPERIDINE DERIVATIVE;

ADULT; AEROBIC METABOLISM; ARTICLE; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG OXIDATION; DRUG STRUCTURE; DRUG URINE LEVEL; ENZYME SUBSTRATE; HUMAN; HUMAN EXPERIMENT; INCUBATION TIME; ISOMER; ISOTOPE TRACING; MALE; MICROSOME; NONHUMAN; NORMAL HUMAN; PROTON TRANSPORT; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; VOLUNTEER;

EID: 0036163936     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.119     Document Type: Article

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