Structural elucidation of in vivo metabolites of penehyclidine in rats by the method of liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry and isotope ion cluster

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 873, Issue 1, 2008, Pages 41-50

  Liu, Ying ^a   Wang, Mingming ^a   Xue, Ming ^a   Li, Yuhang ^a   Li, Xiaorong ^a   Ruan, Jinxiu ^b   Liu, Keliang ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Gas chromatography mass spectrometry; Isopote cluster; Liquid chromatography mass spectrometry; Metabolite; Penehyclidine; Structural elucidation

Indexed keywords

BIOMOLECULES; BODY FLUIDS; CHEMOTHERAPY; CHLORINE COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DRUG DELIVERY; DRUG DOSAGE; ELECTROSPRAY IONIZATION; GAS CHROMATOGRAPHY; IMPACT IONIZATION; ION CHROMATOGRAPHY; ION SOURCES; IONIZATION OF GASES; IONIZATION OF LIQUIDS; IONS; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; RATS; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

ELECTRON IMPACT; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; IN-VIVO; ION CLUSTERS; ION PAIRS; ISOPOTE CLUSTER; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; METABOLITE; MOLECULAR MASSES; PENEHYCLIDINE; PHASE I; PHASE II; PROTONATED; STABLE ISOTOPES; STRUCTURAL ELUCIDATION; STRUCTURAL ELUCIDATIONS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CHOLINERGIC RECEPTOR BLOCKING AGENT; DEUTERIUM; DIHYDROXYPENEHYCLIDINE; DIHYDROXYPENEHYCLIDINE MONOXIDE; DIMETHOXYPENEHYCLIDINE; DRUG METABOLITE; HYDROXYPENEHYCLIDINE; HYDROXYPENEHYCLIDINE MONOXIDE; METHOXYPENEHYCLIDINE DIOXIDE; PENEHYCLIDINE; PENEHYCLIDINE DIOXIDE; PENEHYCLIDINE MONOXIDE; TRIHYDROXYMETHOXYPENEHYCLIDINE; TRIHYDROXYPENEHYCLIDINE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; IN VIVO STUDY; ISOTOPE ION CLUSTER; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MALE; MASS FRAGMENTOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ANALYSIS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; METABOLIC NETWORKS AND PATHWAYS; QUINUCLIDINES; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 50849093214     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.07.049     Document Type: Article

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