Use of a trapping agent for simultaneous capturing and high-throughput screening of both "soft" and "hard" reactive metabolites

Analytical Chemistry

Volumn 79, Issue 11, 2007, Pages 4206-4214

  Yan, Zhengyin ^a   Maher, Noureddine ^a   Torres, Rhoda ^a   Huebert, Norman ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; AMINES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SCREENING;

GLUTATHIONE (GSH); REACTIVE ALDEHYDES; REACTIVE METABOLITES; TRAPPING AGENT;

METABOLITES;

CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 3A4; GLUTATHIONE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DISSOCIATION CONSTANT; HIGH THROUGHPUT SCREENING; INCUBATION TIME; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; MICROSOME; TEMPERATURE SENSITIVITY;

CRESOLS; CYTOCHROME P-450 ENZYME SYSTEM; FURANS; GLUTATHIONE; HUMANS; MASS SPECTROMETRY; MICROSOMES; MOLECULAR STRUCTURE; OLIGOPEPTIDES; TANDEM MASS SPECTROMETRY;

EID: 34250190975     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac0701029     Document Type: Article

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