메뉴 건너뛰기




Volumn 19, Issue 6, 2012, Pages 351-362

Human correlates of provocative questions in pancreatic pathology

Author keywords

Epithelial mesenchymal transition; Metastasis; Pancreas; Pancreatic cancer; Stroma

Indexed keywords

CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; EPITHELIAL MESENCHYMAL TRANSITION; EVIDENCE BASED PRACTICE; HUMAN; NONHUMAN; PANCREAS CANCER; PANCREAS DISEASE; PRIORITY JOURNAL; QUESTIONNAIRE; REVIEW;

EID: 84867963218     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/PAP.0b013e318273f998     Document Type: Review
Times cited : (27)

References (128)
  • 1
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani SR, Petricoin EF, Maitra A, et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003;4:437-450.
    • (2003) Cancer Cell. , vol.4 , pp. 437-450
    • Hingorani, S.R.1    Petricoin, E.F.2    Maitra, A.3
  • 2
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani SR, Wang L, Multani AS, et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell. 2005;7:469-483.
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3
  • 3
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 2009;324: 1457-1461.
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 4
  • 5
    • 31544467540 scopus 로고    scopus 로고
    • Pathology of genetically engineered mouse models of pancreatic exocrine cancer: Consensus report and recommendations
    • Hruban RH, Adsay NV, Albores-Saavedra J, et al. Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res. 2006;66:95-106.
    • (2006) Cancer Res , vol.66 , pp. 95-106
    • Hruban, R.H.1    Adsay, N.V.2    Albores-Saavedra, J.3
  • 6
    • 70450198396 scopus 로고    scopus 로고
    • Epithelialmesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, et al. Epithelialmesenchymal transitions in development and disease. Cell. 2009;139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3
  • 7
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Investig. 2009;119:1420-1428.
    • (2009) J Clin Investig , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 8
    • 84857052013 scopus 로고    scopus 로고
    • Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression
    • Krantz SB, Shields MA, Dangi-Garimella S, et al. Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression. J Surg Res. 2012;173: 105-112.
    • (2012) J Surg Res , vol.173 , pp. 105-112
    • Krantz, S.B.1    Shields, M.A.2    Dangi-Garimella, S.3
  • 9
    • 78651108985 scopus 로고    scopus 로고
    • Pancreatic cancer: Understanding and overcoming chemoresistance
    • Wang Z, Li Y, Ahmad A, et al. Pancreatic cancer: understanding and overcoming chemoresistance. Nat Rev Gastroenterol Hepatol. 2011;8:27-33.
    • (2011) Nat Rev Gastroenterol Hepatol. , Issue.8 , pp. 27-33
    • Wang, Z.1    Li, Y.2    Ahmad, A.3
  • 10
    • 0020358296 scopus 로고
    • Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells
    • Greenburg G, Hay ED. Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol. 1982;95:333-339.
    • (1982) J Cell Biol , vol.95 , pp. 333-339
    • Greenburg, G.1    Hay, E.D.2
  • 11
    • 44449111555 scopus 로고    scopus 로고
    • Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    • Onder TT, Gupta PB, Mani SA, et al. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 2008;68:3645-3654.
    • (2008) Cancer Res , vol.68 , pp. 3645-3654
    • Onder, T.T.1    Gupta, P.B.2    Mani, S.A.3
  • 12
    • 38849093994 scopus 로고    scopus 로고
    • Direct evidence for epithelial-mesenchymal transitions in breast cancer
    • Trimboli AJ, Fukino K, de Bruin A, et al. Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res. 2008;68:937-945.
    • (2008) Cancer Res , vol.68 , pp. 937-945
    • Trimboli, A.J.1    Fukino, K.2    De Bruin, A.3
  • 13
    • 77749292153 scopus 로고    scopus 로고
    • Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma
    • Rasheed ZA, Yang J, Wang Q, et al. Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma. J Natl Cancer Inst. 2010;102:340-351.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 340-351
    • Rasheed, Z.A.1    Yang, J.2    Wang, Q.3
  • 14
    • 77955080125 scopus 로고    scopus 로고
    • Solitary cell infiltration is a novel indicator of poor prognosis and epithelial-mesenchymal transition in pancreatic cancer
    • Masugi Y, Yamazaki K, Hibi T, et al. Solitary cell infiltration is a novel indicator of poor prognosis and epithelial-mesenchymal transition in pancreatic cancer. Hum Pathol. 2010;41: 1061-1068.
    • (2010) Hum Pathol , vol.41 , pp. 1061-1068
    • Masugi, Y.1    Yamazaki, K.2    Hibi, T.3
  • 15
    • 38949178861 scopus 로고    scopus 로고
    • Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer
    • Winter JM, Ting AH, Vilardell F, et al. Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer. Clin Cancer Res. 2008;14:412-418.
    • (2008) Clin Cancer Res , vol.14 , pp. 412-418
    • Winter, J.M.1    Ting, A.H.2    Vilardell, F.3
  • 16
    • 84866324123 scopus 로고    scopus 로고
    • Cancer stem cells and epithelialmesenchymal transition: Concepts and molecular links
    • Scheel C, Weinberg RA. Cancer stem cells and epithelialmesenchymal transition: concepts and molecular links. Semin Cancer Biol. 2012;22:396-403.
    • (2012) Semin Cancer Biol. , Issue.22 , pp. 396-403
    • Scheel, C.1    Weinberg, R.A.2
  • 17
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133:704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 18
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta PB, Onder TT, Jiang G, et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009;138:645-659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3
  • 19
    • 36349006961 scopus 로고    scopus 로고
    • Development and characterization of gemcitabine-resistant pancreatic tumor cells
    • Shah AN, Summy JM, Zhang J, et al. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol. 2007;14:3629-3637.
    • (2007) Ann Surg Oncol. , vol.14 , pp. 3629-3637
    • Shah, A.N.1    Summy, J.M.2    Zhang, J.3
  • 20
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann PC, Huber SL, Herrler T, et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell. 2007;1:313-323.
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3
  • 21
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells. Cancer Res. 2007;67:1030-1037.
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 22
    • 67650999217 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer
    • Arumugam T, Ramachandran V, Fournier KF, et al. Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res. 2009;69: 5820-5828.
    • (2009) Cancer Res , vol.69 , pp. 5820-5828
    • Arumugam, T.1    Ramachandran, V.2    Fournier, K.F.3
  • 23
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelialmesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    • Wang Z, Li Y, Kong D, et al. Acquisition of epithelialmesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res. 2009;69:2400-2407.
    • (2009) Cancer Res , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3
  • 24
    • 70349873330 scopus 로고    scopus 로고
    • CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells
    • Hong SP, Wen J, Bang S, et al. CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells. Int J Cancer. 2009;125:2323-2331.
    • (2009) Int J Cancer , vol.125 , pp. 2323-2331
    • Hong, S.P.1    Wen, J.2    Bang, S.3
  • 26
    • 22144497081 scopus 로고    scopus 로고
    • Invasion and metastasis in colorectal cancer: Epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and betacatenin
    • Brabletz T, Hlubek F, Spaderna S, et al. Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and betacatenin. Cells Tissues Organs. 2005;179:56-65.
    • (2005) Cells Tissues Organs. , vol.179 , pp. 56-65
    • Brabletz, T.1    Hlubek, F.2    Spaderna, S.3
  • 27
    • 33645758275 scopus 로고    scopus 로고
    • Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplaninmediated remodeling of the actin cytoskeleton
    • Wicki A, Lehembre F, Wick N, et al. Tumor invasion in the absence of epithelial-mesenchymal transition: podoplaninmediated remodeling of the actin cytoskeleton. Cancer Cell. 2006;9:261-272.
    • (2006) Cancer Cell , vol.9 , pp. 261-272
    • Wicki, A.1    Lehembre, F.2    Wick, N.3
  • 28
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • Rhim AD, Mirek ET, Aiello NM, et al. EMT and dissemination precede pancreatic tumor formation. Cell. 2012; 148:349-361.
    • (2012) Cell. , Issue.148 , pp. 349-361
    • Rhim, A.D.1    Mirek, E.T.2    Aiello, N.M.3
  • 29
    • 0036828259 scopus 로고    scopus 로고
    • Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas
    • Chari ST, Yadav D, Smyrk TC, et al. Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas. Gastroenterology. 2002;123: 1500-1507.
    • (2002) Gastroenterology , vol.123 , pp. 1500-1507
    • Chari, S.T.1    Yadav, D.2    Smyrk, T.C.3
  • 30
    • 84861100536 scopus 로고    scopus 로고
    • Intraductal papillary mucinous neoplasms of the pancreas: Making a disposition using the natural history
    • Traverso LW, Moriya T, Hashimoto Y. Intraductal papillary mucinous neoplasms of the pancreas: making a disposition using the natural history. Curr Gastroenterol Rep. 2012;14:106-111.
    • (2012) Curr Gastroenterol Rep , vol.14 , pp. 106-111
    • Traverso, L.W.1    Moriya, T.2    Hashimoto, Y.3
  • 31
    • 84862168016 scopus 로고    scopus 로고
    • International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
    • Tanaka M, Fernandez-Del Castillo C, Adsay V, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012;12:183-197.
    • (2012) Pancreatology , vol.12 , pp. 183-197
    • Tanaka, M.1    Fernandez-Del Castillo, C.2    Adsay, V.3
  • 32
    • 33744775945 scopus 로고    scopus 로고
    • Screening for early pancreatic neoplasia in high-risk individuals: A prospective controlled study
    • quiz 665
    • Canto MI, Goggins M, Hruban RH, et al. Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study. Clin Gastroenterol Hepatol. 2006;4:766-781; quiz 665.
    • (2006) Clin Gastroenterol Hepatol. , vol.4 , pp. 766-781
    • Canto, M.I.1    Goggins, M.2    Hruban, R.H.3
  • 33
    • 84859393143 scopus 로고    scopus 로고
    • Frequent detection of pancreatic lesions in asymptomatic high-risk individuals
    • Canto MI, Hruban RH, Fishman EK, et al. Frequent detection of pancreatic lesions in asymptomatic high-risk individuals. Gastroenterology. 2012;142:796-804.
    • (2012) Gastroenterology , vol.142 , pp. 796-804
    • Canto, M.I.1    Hruban, R.H.2    Fishman, E.K.3
  • 34
    • 0018742498 scopus 로고
    • Relation of pancreatic duct hyperplasia to carcinoma
    • Kozuka S, Sassa R, Taki T. Relation of pancreatic duct hyperplasia to carcinoma. Cancer. 1979;43:1418-1428.
    • (1979) Cancer , vol.43 , pp. 1418-1428
    • Kozuka, S.1    Sassa, R.2    Taki, T.3
  • 35
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA III, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403-2413.
    • (1997) J Clin Oncol. , vol.15 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.J.2    Andersen, J.3
  • 36
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364:1817-1825.
    • (2011) N Engl J Med , vol.364 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 37
    • 38849141696 scopus 로고    scopus 로고
    • Cancer-associated stromal fibroblasts promote pancreatic tumor progression
    • Hwang RF, Moore T, Arumugam T, et al. Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res. 2008;68:918-926.
    • (2008) Cancer Res , vol.68 , pp. 918-926
    • Hwang, R.F.1    Moore, T.2    Arumugam, T.3
  • 38
    • 84866490065 scopus 로고    scopus 로고
    • Inhibition of the Hedgehog pathway targets the tumor-associated stroma in pancreatic cancer
    • Hwang RF, Moore TT, Mertens Hattersley M, et al. Inhibition of the Hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. Mol Cancer Res. 2012;10:1147-1157.
    • (2012) Mol Cancer Res , vol.10 , pp. 1147-1157
    • Hwang, R.F.1    Moore, T.T.2    Mertens Hattersley, M.3
  • 39
    • 84870909412 scopus 로고    scopus 로고
    • Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
    • Epub ahead of print]
    • Jacobetz MA, Chan DS, Neesse A, et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut. 2012; [Epub ahead of print].
    • (2012) Gut.
    • Jacobetz, M.A.1    Chan, D.S.2    Neesse, A.3
  • 40
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • Provenzano PP, Cuevas C, Chang AE, et al. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell. 2012;21: 418-429.
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1    Cuevas, C.2    Chang, A.E.3
  • 41
    • 33748056792 scopus 로고    scopus 로고
    • Multifocal neoplastic precusor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer
    • Brune KA, Abe T, Canto MI, et al. Multifocal neoplastic precusor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol. 2006;30:1067-1076.
    • (2006) Am J Surg Pathol , vol.30 , pp. 1067-1076
    • Brune, K.A.1    Abe, T.2    Canto, M.I.3
  • 42
    • 78149298209 scopus 로고    scopus 로고
    • Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha
    • Kraman M, Bambrough PJ, Arnold JN, et al. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science. 2010;330:827-830.
    • (2010) Science , vol.330 , pp. 827-830
    • Kraman, M.1    Bambrough, P.J.2    Arnold, J.N.3
  • 43
    • 84863082623 scopus 로고    scopus 로고
    • Dangerous liaisons: Pancreatic stellate cells and pancreatic cancer cells
    • Apte MV, Wilson JS. Dangerous liaisons: pancreatic stellate cells and pancreatic cancer cells. J Gastroenterol Hepatol. 2012;27(suppl 2):69-74.
    • (2012) J Gastroenterol Hepatol. , vol.27 , Issue.SUPPL. 2 , pp. 69-74
    • Apte, M.V.1    Wilson, J.S.2
  • 44
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 2003;425:846-851.
    • (2003) Nature. , vol.425 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3
  • 45
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    • Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003;425:851-856.
    • (2003) Nature. , vol.425 , pp. 851-856
    • Thayer, S.P.1    Di Magliano, M.P.2    Heiser, P.W.3
  • 46
    • 33947254016 scopus 로고    scopus 로고
    • Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
    • Feldmann G, Dhara S, Fendrich V, et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res. 2007;67:2187-2196.
    • (2007) Cancer Res. , vol.67 , pp. 2187-2196
    • Feldmann, G.1    Dhara, S.2    Fendrich, V.3
  • 47
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signalling in cancer
    • Yauch RL, Gould SE, Scales SJ, et al. A paracrine requirement for hedgehog signalling in cancer. Nature. 2008;455:406-410.
    • (2008) Nature. , vol.455 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3
  • 48
    • 63149124772 scopus 로고    scopus 로고
    • Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
    • Tian H, Callahan CA, DuPree KJ, et al. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A. 2009;106:4254-4259.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , pp. 4254-4259
    • Tian, H.1    Callahan, C.A.2    DuPree, K.J.3
  • 49
    • 78650175637 scopus 로고    scopus 로고
    • Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells
    • Kikuta K, Masamune A, Watanabe T, et al. Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells. Biochem Biophys Res Commun. 2010;403:380-384.
    • (2010) Biochem Biophys Res Commun. , vol.403 , pp. 380-384
    • Kikuta, K.1    Masamune, A.2    Watanabe, T.3
  • 50
    • 65949114866 scopus 로고    scopus 로고
    • Cancerstellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma
    • Erkan M, Reiser-Erkan C, Michalski CW, et al. Cancerstellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. Neoplasia. 2009;11: 497-508.
    • (2009) Neoplasia. , vol.11 , pp. 497-508
    • Erkan, M.1    Reiser-Erkan, C.2    Michalski, C.W.3
  • 51
    • 80052712201 scopus 로고    scopus 로고
    • The ins and outs of the epithelial to mesenchymal transition in health and disease
    • Nieto MA. The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu Rev Cell Dev Biol. 2011;27:347-376.
    • (2011) Annu Rev Cell Dev Biol. , vol.27 , pp. 347-376
    • Nieto, M.A.1
  • 52
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, Chiorean EG, Fishman MP, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science. 2011;331:1612-1616.
    • (2011) Science. , vol.331 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3
  • 55
    • 33847419143 scopus 로고    scopus 로고
    • Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by k-ras oncogenes in adult mice
    • Guerra C, Schuhmacher AJ, Canamero M, et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by k-ras oncogenes in adult mice. Cancer Cell. 2007;11:291-302.
    • (2007) Cancer Cell. , vol.11 , pp. 291-302
    • Guerra, C.1    Schuhmacher, A.J.2    Canamero, M.3
  • 56
    • 13644257727 scopus 로고    scopus 로고
    • The molecular basis of pancreatic fibrosis: Common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma
    • Binkley CE, Zhang L, Greenson JK, et al. The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma. Pancreas. 2004;29:254-263.
    • (2004) Pancreas. , vol.29 , pp. 254-263
    • Binkley, C.E.1    Zhang, L.2    Greenson, J.K.3
  • 57
    • 79958710624 scopus 로고    scopus 로고
    • Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence
    • Guerra C, Collado M, Navas C, et al. Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell. 2011;19:728-739.
    • (2011) Cancer Cell. , vol.19 , pp. 728-739
    • Guerra, C.1    Collado, M.2    Navas, C.3
  • 58
    • 80053405625 scopus 로고    scopus 로고
    • Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
    • Ijichi H, Chytil A, Gorska AE, et al. Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Investig. 2011;121:4106-4117.
    • (2011) J Clin Investig. , vol.121 , pp. 4106-4117
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3
  • 59
    • 84859710888 scopus 로고    scopus 로고
    • An NF-kappaB pathwaymediated positive feedback loop amplifies Ras activity to pathological levels in mice
    • Daniluk J, Liu Y, Deng D, et al. An NF-kappaB pathwaymediated positive feedback loop amplifies Ras activity to pathological levels in mice. J Clin Investig. 2012;122: 1519-1528.
    • (2012) J Clin Investig. , vol.122 , pp. 1519-1528
    • Daniluk, J.1    Liu, Y.2    Deng, D.3
  • 60
    • 0036334059 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials
    • Bloomston M, Zervos EE, Rosemurgy AS II. Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials. Ann Surg Oncol. 2002;9:668-674.
    • (2002) Ann Surg Oncol. , vol.9 , pp. 668-674
    • Bloomston, M.1    Zervos, E.E.2    Rosemurgy II, A.S.3
  • 61
    • 34248141223 scopus 로고    scopus 로고
    • Tumor-stroma interactions in pancreatic ductal adenocarcinoma
    • Mahadevan D, Von Hoff DD. Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 2007; 6:1186-1197.
    • (2007) Mol Cancer Ther. , vol.6 , pp. 1186-1197
    • Mahadevan, D.1    Von Hoff, D.D.2
  • 62
    • 0035022957 scopus 로고    scopus 로고
    • SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury
    • Bradshaw AD, Sage EH. SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury. J Clin Investig. 2001;107:1049-1054.
    • (2001) J Clin Investig. , vol.107 , pp. 1049-1054
    • Bradshaw, A.D.1    Sage, E.H.2
  • 63
    • 33846916208 scopus 로고    scopus 로고
    • Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
    • Infante JR, Matsubayashi H, Sato N, et al. Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol. 2007; 25:319-325.
    • (2007) J Clin Oncol. , vol.25 , pp. 319-325
    • Infante, J.R.1    Matsubayashi, H.2    Sato, N.3
  • 64
    • 77958171910 scopus 로고    scopus 로고
    • Stromal SPARC expression and patient survival after chemoradiation for nonresectable pancreatic adenocarcinoma
    • Mantoni TS, Schendel RR, Rodel F, et al. Stromal SPARC expression and patient survival after chemoradiation for nonresectable pancreatic adenocarcinoma. Cancer Biol Ther. 2008;7:1806-1815.
    • (2008) Cancer Biol Ther. , vol.7 , pp. 1806-1815
    • Mantoni, T.S.1    Schendel, R.R.2    Rodel, F.3
  • 65
    • 22744442244 scopus 로고    scopus 로고
    • Osteonectin influences growth and invasion of pancreatic cancer cells
    • Guweidhi A, Kleeff J, Adwan H, et al. Osteonectin influences growth and invasion of pancreatic cancer cells. Ann Surg. 2005;242:224-234.
    • (2005) Ann Surg. , vol.242 , pp. 224-234
    • Guweidhi, A.1    Kleeff, J.2    Adwan, H.3
  • 66
    • 3543090480 scopus 로고    scopus 로고
    • Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis
    • Puolakkainen PA, Brekken RA, Muneer S, et al. Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis. Mol Cancer Res. 2004; 2:215-224.
    • (2004) Mol Cancer Res. , vol.2 , pp. 215-224
    • Puolakkainen, P.A.1    Brekken, R.A.2    Muneer, S.3
  • 67
    • 79960047108 scopus 로고    scopus 로고
    • TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression
    • Seux M, Peuget S, Montero MP, et al. TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression. Oncogene. 2011;30:3049-3061.
    • (2011) Oncogene. , vol.30 , pp. 3049-3061
    • Seux, M.1    Peuget, S.2    Montero, M.P.3
  • 68
    • 78751661556 scopus 로고    scopus 로고
    • Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells
    • Notta F, Mullighan CG, Wang JC, et al. Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature. 2011;469:362-367.
    • (2011) Nature. , vol.469 , pp. 362-367
    • Notta, F.1    Mullighan, C.G.2    Wang, J.C.3
  • 69
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367:645-648.
    • (1994) Nature. , vol.367 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 70
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker N, Ridgway RA, van Es JH, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009;457: 608-611.
    • (2009) Nature. , vol.457 , pp. 608-611
    • Barker, N.1    Ridgway, R.A.2    Van Es, J.H.3
  • 71
    • 84864854371 scopus 로고    scopus 로고
    • Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
    • Schepers AG, Snippert HJ, Stange DE, et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science. 2012;337:730-735.
    • (2012) Science. , vol.337 , pp. 730-735
    • Schepers, A.G.1    Snippert, H.J.2    Stange, D.E.3
  • 72
    • 0038743167 scopus 로고    scopus 로고
    • The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice
    • Brembeck FH, Schreiber FS, Deramaudt TB, et al. The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice. Cancer Research. 2003;63:2005-2009.
    • (2003) Cancer Research. , vol.63 , pp. 2005-2009
    • Brembeck, F.H.1    Schreiber, F.S.2    Deramaudt, T.B.3
  • 73
    • 79551625078 scopus 로고    scopus 로고
    • Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model
    • Ray KC, Bell KM, Yan J, et al. Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model. PloS one. 2011;6:e16786.
    • (2011) PloS one. , Issue.6
    • Ray, K.C.1    Bell, K.M.2    Yan, J.3
  • 74
    • 57749113202 scopus 로고    scopus 로고
    • Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
    • Habbe N, Shi G, Meguid RA, et al. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A. 2008;105:18913-18918.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , pp. 18913-18918
    • Habbe, N.1    Shi, G.2    Meguid, R.A.3
  • 75
    • 70350513347 scopus 로고    scopus 로고
    • Contextdependent transformation of adult pancreatic cells by oncogenic K-Ras
    • Gidekel Friedlander SY, Chu GC, Snyder EL, et al. Contextdependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell. 2009;16:379-389.
    • (2009) Cancer Cell. , vol.16 , pp. 379-389
    • Gidekel Friedlander, S.Y.1    Chu, G.C.2    Snyder, E.L.3
  • 76
    • 57749116315 scopus 로고    scopus 로고
    • Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
    • De La OJ, Emerson LL, Goodman JL, et al. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A. 2008;105:18907-18912.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , pp. 18907-18912
    • De La, O.J.1    Emerson, L.L.2    Goodman, J.L.3
  • 77
    • 62949182142 scopus 로고    scopus 로고
    • Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia
    • Shi G, Zhu L, Sun Y, et al. Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia. Gastroenterology. 2009;136:1368-1378.
    • (2009) Gastroenterology. , vol.136 , pp. 1368-1378
    • Shi, G.1    Zhu, L.2    Sun, Y.3
  • 78
    • 0017156835 scopus 로고
    • Morphological lesions associated with human primary invasive nonendocrine pancreas cancer
    • Cubilla AL, Fitzgerald PJ. Morphological lesions associated with human primary invasive nonendocrine pancreas cancer. Cancer Res. 1976;36:2690-2698.
    • (1976) Cancer Res. , vol.36 , pp. 2690-2698
    • Cubilla, A.L.1    Fitzgerald, P.J.2
  • 79
    • 84865076498 scopus 로고    scopus 로고
    • Genetic basis of pancreas cancer development and progression: Insights from whole-exome and whole-genome sequencing
    • Iacobuzio-Donahue CA, Velculescu VE, Wolfgang CL, et al. Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing. Clin Cancer Res. 2012;18:4257-4265.
    • (2012) Clin Cancer Res. , vol.18 , pp. 4257-4265
    • Iacobuzio-Donahue, C.A.1    Velculescu, V.E.2    Wolfgang, C.L.3
  • 80
    • 0031891450 scopus 로고    scopus 로고
    • Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas
    • Brat DJ, Lillemoe KD, Yeo CJ, et al. Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas. Am J Surg Pathol. 1998;22:163-169.
    • (1998) Am J Surg Pathol. , vol.22 , pp. 163-169
    • Brat, D.J.1    Lillemoe, K.D.2    Yeo, C.J.3
  • 81
    • 61349100218 scopus 로고    scopus 로고
    • KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: Implications for the human pancreatic cancer cell of origin
    • Shi C, Hong SM, Lim P, et al. KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol Cancer Res. 2009;7:230-236.
    • (2009) Mol Cancer Res. , vol.7 , pp. 230-236
    • Shi, C.1    Hong, S.M.2    Lim, P.3
  • 82
    • 0038488950 scopus 로고    scopus 로고
    • A multigenic program mediating breast cancer metastasis to bone
    • Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell. 2003;3:537-549.
    • (2003) Cancer Cell. , vol.3 , pp. 537-549
    • Kang, Y.1    Siegel, P.M.2    Shu, W.3
  • 83
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature. 2005;436:518-524.
    • (2005) Nature. , vol.436 , pp. 518-524
    • Minn, A.J.1    Gupta, G.P.2    Siegel, P.M.3
  • 84
    • 13444268127 scopus 로고    scopus 로고
    • Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors
    • Minn AJ, Kang Y, Serganova I, et al. Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Investig. 2005;115:44-55.
    • (2005) J Clin Investig. , vol.115 , pp. 44-55
    • Minn, A.J.1    Kang, Y.2    Serganova, I.3
  • 85
    • 67649300721 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to the brain
    • Bos PD, Zhang XH, Nadal C, et al. Genes that mediate breast cancer metastasis to the brain. Nature. 2009;459:1005-1009.
    • (2009) Nature. , vol.459 , pp. 1005-1009
    • Bos, P.D.1    Zhang, X.H.2    Nadal, C.3
  • 86
    • 67649311599 scopus 로고    scopus 로고
    • Latent bone metastasis in breast cancer tied to Src-dependent survival signals
    • Zhang XH, Wang Q, Gerald W, et al. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell. 2009;16:67-78.
    • (2009) Cancer Cell. , vol.16 , pp. 67-78
    • Zhang, X.H.1    Wang, Q.2    Gerald, W.3
  • 88
  • 89
    • 62249176551 scopus 로고    scopus 로고
    • DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    • Iacobuzio-Donahue CA, Fu B, Yachida S, et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol. 2009;27:1806-1813.
    • (2009) J Clin Oncol. , vol.27 , pp. 1806-1813
    • Iacobuzio-Donahue, C.A.1    Fu, B.2    Yachida, S.3
  • 90
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida S, Jones S, Bozic I, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010;467:1114-1117.
    • (2010) Nature. , vol.467 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3
  • 91
    • 78049380554 scopus 로고    scopus 로고
    • The patterns and dynamics of genomic instability in metastatic pancreatic cancer
    • Campbell PJ, Yachida S, Mudie LJ, et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature. 2010;467:1109-1113.
    • (2010) Nature. , vol.467 , pp. 1109-1113
    • Campbell, P.J.1    Yachida, S.2    Mudie, L.J.3
  • 92
    • 84859947197 scopus 로고    scopus 로고
    • Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
    • Mann KM, Ward JM, Yew CC, et al. Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2012;109:5934-5941.
    • (2012) Proc Natl Acad Sci U S A. , vol.109 , pp. 5934-5941
    • Mann, K.M.1    Ward, J.M.2    Yew, C.C.3
  • 93
    • 84861990162 scopus 로고    scopus 로고
    • The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
    • Pérez-Mancera PA, Rust AG, van der Weyden L, et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature. 2012;486:266-270.
    • (2012) Nature. , vol.486 , pp. 266-270
    • Pérez-Mancera, P.A.1    Rust, A.G.2    Van Der Weyden, L.3
  • 94
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008;321:1801-1806.
    • (2008) Science. , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 95
    • 64849092309 scopus 로고    scopus 로고
    • Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
    • Jones S, Hruban RH, KamiyamaM, et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science. 2009;324:217.
    • (2009) Science , vol.324 , pp. 217
    • Jones, S.1    Hruban, R.H.2    Kamiyama, M.3
  • 96
    • 84862907854 scopus 로고    scopus 로고
    • Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
    • Wu J, Jiao Y, Dal Molin M, et al. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A. 2011;108:21188-21193.
    • (2011) Proc Natl Acad Sci U S A. , vol.108 , pp. 21188-21193
    • Wu, J.1    Jiao, Y.2    Dal Molin, M.3
  • 97
    • 79960660466 scopus 로고    scopus 로고
    • Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development
    • Wu J, Matthaei H, Maitra A, et al. Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Science Transl Med. 2011;3:92ra66.
    • (2011) Science Transl Med. , vol.3 , pp. 9266
    • Wu, J.1    Matthaei, H.2    Maitra, A.3
  • 98
    • 79952279828 scopus 로고    scopus 로고
    • DAXXATRX MEN1 And MTOR Pathway Genes Are Frequently Altered In Pancreatic Neuroendocrine Tumors
    • Jiao Y, Shi C, Edil BH, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011;331:1199-1203.
    • (2011) Science. , vol.331 , pp. 1199-1203
    • Jiao, Y.1    Shi, C.2    Edil, B.H.3
  • 99
    • 84863830403 scopus 로고    scopus 로고
    • ATM mutations in patients with hereditary pancreatic cancer
    • Roberts NJ, Jiao Y, Yu J, et al. ATM mutations in patients with hereditary pancreatic cancer. Cancer Discov. 2012;2:41-46.
    • (2012) Cancer Discov. , vol.2 , pp. 41-46
    • Roberts, N.J.1    Jiao, Y.2    Yu, J.3
  • 100
    • 2342645506 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
    • Van Cutsem E, van de Velde H, Karasek P, et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol. 2004;22:1430-1438.
    • (2004) J Clin Oncol. , vol.22 , pp. 1430-1438
    • Van Cutsem, E.1    Van De Velde, H.2    Karasek, P.3
  • 101
    • 0037025173 scopus 로고    scopus 로고
    • Cancer Addiction to oncogenes the Achilles heal of cancer
    • Weinstein IB. Cancer. Addiction to oncogenes - the Achilles heal of cancer. Science. 2002;297:63-64.
    • (2002) Science. , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 102
    • 0037025201 scopus 로고    scopus 로고
    • Sustained loss of a neoplastic phenotype by brief inactivation of MYC
    • Jain M, Arvanitis C, Chu K, et al. Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science. 2002;297:102-104.
    • (2002) Science. , vol.297 , pp. 102-104
    • Jain, M.1    Arvanitis, C.2    Chu, K.3
  • 103
    • 0033614962 scopus 로고    scopus 로고
    • Essential role for oncogenic Ras in tumour maintenance
    • Chin L, Tam A, Pomerantz J, et al. Essential role for oncogenic Ras in tumour maintenance. Nature. 1999;400: 468-472.
    • (1999) Nature. , vol.400 , pp. 468-472
    • Chin, L.1    Tam, A.2    Pomerantz, J.3
  • 104
    • 84863012865 scopus 로고    scopus 로고
    • Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
    • Collins MA, Bednar F, Zhang Y, et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Investig. 2012;122:639-653.
    • (2012) J Clin Investig. , vol.122 , pp. 639-653
    • Collins, M.A.1    Bednar, F.2    Zhang, Y.3
  • 105
    • 84860321700 scopus 로고    scopus 로고
    • Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
    • Ying H, Kimmelman AC, Lyssiotis CA, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 2012;149:656-670.
    • (2012) Cell. , vol.149 , pp. 656-670
    • Ying, H.1    Kimmelman, A.C.2    Lyssiotis, C.A.3
  • 106
    • 34547673400 scopus 로고    scopus 로고
    • Applying the discovery of the Philadelphia chromosome
    • Sherbenou DW, Druker BJ. Applying the discovery of the Philadelphia chromosome. J Clin Investig. 2007;117: 2067-2074.
    • (2007) J Clin Investig. , vol.117 , pp. 2067-2074
    • Sherbenou, D.W.1    Druker, B.J.2
  • 107
    • 33847191776 scopus 로고    scopus 로고
    • Mutations of the BCR-ABL-kinase domain occur in a minority of patients with stable complete cytogenetic response to imatinib
    • Sherbenou DW, Wong MJ, Humayun A, et al. Mutations of the BCR-ABL-kinase domain occur in a minority of patients with stable complete cytogenetic response to imatinib. Leukemia. 2007;21:489-493.
    • (2007) Leukemia. , vol.21 , pp. 489-493
    • Sherbenou, D.W.1    Wong, M.J.2    Humayun, A.3
  • 108
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
    • Diaz LA Jr, Williams RT, Wu J, et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature. 2012;486:537-540.
    • (2012) Nature. , vol.486 , pp. 537-540
    • Diaz Jr., L.A.1    Williams, R.T.2    Wu, J.3
  • 109
    • 33847419142 scopus 로고    scopus 로고
    • Molecular definition of breast tumor heterogeneity
    • Shipitsin M, Campbell LL, Argani P, et al. Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007; 11:259-273.
    • (2007) Cancer Cell. , vol.11 , pp. 259-273
    • Shipitsin, M.1    Campbell, L.L.2    Argani, P.3
  • 110
    • 76049114936 scopus 로고    scopus 로고
    • Heterogeneity for stem cellrelated markers according to tumor subtype and histologic stage in breast cancer
    • Park SY, Lee HE, Li H, et al. Heterogeneity for stem cellrelated markers according to tumor subtype and histologic stage in breast cancer. Clin Cancer Res. 2010;16:876-887.
    • (2010) Clin Cancer Res. , vol.16 , pp. 876-887
    • Park, S.Y.1    Lee, H.E.2    Li, H.3
  • 111
    • 75549083303 scopus 로고    scopus 로고
    • Tumor heterogeneity: Causes and consequences
    • Marusyk A, Polyak K. Tumor heterogeneity: causes and consequences. Biochim Biophys Acta. 2010;1805:105-117.
    • (2010) Biochim Biophys Acta. , vol.1805 , pp. 105117
    • Marusyk, A.1    Polyak, K.2
  • 112
    • 80053406583 scopus 로고    scopus 로고
    • Heterogeneity in breast cancer
    • Polyak K. Heterogeneity in breast cancer. J Clin Investig. 2011;121:3786-3788.
    • (2011) J Clin Investig. , vol.121 , pp. 3786-3788
    • Polyak, K.1
  • 113
  • 115
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350:2129-2139.
    • (2004) N Engl J Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 116
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304:1497-1500.
    • (2004) Science. , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 117
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-smallcell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-smallcell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2012;13:239-246.
    • (2012) Lancet Oncol. , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 118
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010;362:2380-2388.
    • (2010) N Engl J Med. , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 119
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364:2507-2516.
    • (2011) N Engl J Med. , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 120
    • 84863116743 scopus 로고    scopus 로고
    • Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
    • Sosman JA, Kim KB, Schuchter L, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med. 2012;366:707-714.
    • (2012) N Engl J Med. , vol.366 , pp. 707-714
    • Sosman, J.A.1    Kim, K.B.2    Schuchter, L.3
  • 121
    • 79960051265 scopus 로고    scopus 로고
    • Therapeutic strategies for targeting ras proteins
    • Gysin S, Salt M, Young A, et al. Therapeutic strategies for targeting ras proteins. Genes Cancer. 2011;2:359-372.
    • (2011) Genes Cancer. , vol.2 , pp. 359-372
    • Gysin, S.1    Salt, M.2    Young, A.3
  • 122
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316:1039-1043.
    • (2007) Science. , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 123
    • 84863230465 scopus 로고    scopus 로고
    • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    • Prahallad A, Sun C, Huang S, et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature. 2012;483:100-103.
    • (2012) Nature. , vol.483 , pp. 100-103
    • Prahallad, A.1    Sun, C.2    Huang, S.3
  • 126
    • 0022692565 scopus 로고
    • A brief historical note on staining by hematoxylin and eosin
    • King DF, King LA. A brief historical note on staining by hematoxylin and eosin. Am J Dermatopathol. 1986;8:168.
    • (1986) Am J Dermatopathol. , vol.8 , pp. 168
    • King, D.F.1    King, L.A.2
  • 127
    • 0033891752 scopus 로고    scopus 로고
    • Immunohistochemical labeling for Dpc4 mirrors genetic status in pancreatic adenocarcinomas: A new marker of DPC4 inactivation
    • Wilentz RE, Su GH, Dai JL, et al. Immunohistochemical labeling for Dpc4 mirrors genetic status in pancreatic adenocarcinomas: a new marker of DPC4 inactivation. Am J Pathol. 2000;156:37-43.
    • (2000) Am J Pathol. , vol.156 , pp. 37-43
    • Wilentz, R.E.1    Su, G.H.2    Dai, J.L.3
  • 128
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996;271:350-353.
    • (1996) Science. , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.