메뉴 건너뛰기




Volumn 5, Issue 28, 2003, Pages 1-16

Hepatocellular carcinoma: Molecular interactions between hepatitis C virus and p53 in hepatocarcinogenesis

Author keywords

core protein; HCC; HCV; hepatitis C virus; hepatocarcinogenesis; hepatocellular carcinoma; NS3 protein; NS5A protein; p53

Indexed keywords

CORE PROTEIN; PROTEIN P53;

EID: 84867536275     PISSN: 14623994     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1462399403006926     Document Type: Article
Times cited : (21)

References (154)
  • 2
    • 0033860678 scopus 로고    scopus 로고
    • Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)
    • DOI 10.1006/scbi.2000.0321
    • Brechot, C. et al. (2000) Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Semin Cancer Biol 10, 211-231, PubMed: 10936070 (Pubitemid 30614221)
    • (2000) Seminars in Cancer Biology , vol.10 , Issue.3 , pp. 211-231
    • Brechot, C.1    Gozuacik, D.2    Murakami, Y.3    Paterlini-Brechot, P.4
  • 3
    • 0035140369 scopus 로고    scopus 로고
    • Epidemiology of hepatocellular carcinoma
    • el-Serag, H.B. (2001) Epidemiology of hepatocellular carcinoma. Clin Liver Dis 5, 87-107, vi, PubMed: 11218921 (Pubitemid 32118640)
    • (2001) Clinics in Liver Disease , vol.5 , Issue.1 , pp. 87-107
    • El-Serag, H.B.1
  • 4
    • 0026634686 scopus 로고
    • Treatment of small hepatocellular carcinomas
    • PubMed: 1353202
    • Dusheiko, G.M. et al. (1992) Treatment of small hepatocellular carcinomas. Lancet 340, 285-288, PubMed: 1353202
    • (1992) Lancet , vol.340 , pp. 285-288
    • Dusheiko, G.M.1
  • 5
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • DOI 10.1056/NEJM199903113401001
    • El-Serag, H.B. and Mason, A.C. (1999) Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 340, 745-750, PubMed: 10072408 (Pubitemid 29114292)
    • (1999) New England Journal of Medicine , vol.340 , Issue.10 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 6
    • 0030626221 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma
    • PubMed: 9097291
    • Colombo, M. (1997) Treatment of hepatocellular carcinoma. J Viral Hepat 4 Suppl 1, 125-130, PubMed: 9097291
    • (1997) J Viral Hepat , vol.4 , Issue.SUPPL. 1 , pp. 125-130
    • Colombo, M.1
  • 9
    • 0024847083 scopus 로고
    • Dietary risk factors for primary hepatocellular carcinoma
    • PubMed: 2559796
    • Wogan, G.N. (1989) Dietary risk factors for primary hepatocellular carcinoma. Cancer Detect Prev 14, 209-213, PubMed: 2559796
    • (1989) Cancer Detect Prev , vol.14 , pp. 209-213
    • Wogan, G.N.1
  • 11
    • 0035143880 scopus 로고    scopus 로고
    • Pathogenesis of hepatocellular carcinoma
    • PubMed: 11218920
    • Macdonald, G.A. (2001) Pathogenesis of hepatocellular carcinoma. Clin Liver Dis 5, 69-85, PubMed: 11218920
    • (2001) Clin Liver Dis , vol.5 , pp. 69-85
    • MacDonald, G.A.1
  • 12
    • 0037184846 scopus 로고    scopus 로고
    • The natural history of hepatocellular carcinoma
    • DOI 10.1016/S0300-483X(02)00252-4, PII S0300483X02002524
    • Romeo, R. and Colombo, M. (2002) The natural history of hepatocellular carcinoma. Toxicology 181-182, 39-42, PubMed: 12505282 (Pubitemid 36015670)
    • (2002) Toxicology , vol.181-182 , pp. 39-42
    • Romeo, R.1    Colombo, M.2
  • 13
    • 0036859903 scopus 로고    scopus 로고
    • Understanding the hypercarcinogenic state in chronic hepatitis: A clue to the prevention of human hepatocellular carcinoma
    • DOI 10.1007/s005350200149
    • Hino, O. et al. (2002) Understanding the hypercarcinogenic state in chronic hepatitis: a clue to the prevention of human hepatocellular carcinoma. J Gastroenterol 37, 883-887, PubMed: 12483242 (Pubitemid 35423039)
    • (2002) Journal of Gastroenterology , vol.37 , Issue.11 , pp. 883-887
    • Hino, O.1    Kajino, K.2    Umeda, T.3    Arakawa, Y.4
  • 14
    • 0043013076 scopus 로고    scopus 로고
    • Advances in the diagnosis and management of human viral hepatitis
    • DOI 10.1016/S0011-8532(03)00021-1, PII S0011853203000211
    • Wisnom, C. and Siegel, M.A. (2003) Advances in the diagnosis and management of human viral hepatitis. Dent Clin North Am 47, 431-447, PubMed: 12848458 (Pubitemid 38952635)
    • (2003) Dental Clinics of North America , vol.47 , Issue.3 , pp. 431-447
    • Wisnom, C.1    Siegel, M.A.2
  • 15
    • 0037979127 scopus 로고    scopus 로고
    • Chronic hepatitis C virus infection
    • DOI 10.1001/jama.289.18.2413
    • Flamm, S.L. (2003) Chronic hepatitis C virus infection. Jama 289, 2413-2417, PubMed: 12746366 (Pubitemid 37430175)
    • (2003) Journal of the American Medical Association , vol.289 , Issue.18 , pp. 2413-2417
    • Flamm, S.L.1
  • 16
    • 0037397156 scopus 로고    scopus 로고
    • Regulatory mechanisms of viral hepatitis B and C
    • Waris, G. (2003) Regulatory mechanisms of viral hepatitis B and C. J Biosci 28, 311-321, PubMed: 12734409 (Pubitemid 36512806)
    • (2003) Journal of Biosciences , vol.28 , Issue.3 , pp. 311-321
    • Waris, G.1    Siddiqui, A.2
  • 18
    • 0035652140 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: An update
    • DOI 10.1080/019131201753343539
    • Dominguez-Malagon, H. and Gaytan-Graham, S. (2001) Hepatocellular carcinoma: an update. Ultrastruct Pathol 25, 497-516, PubMed: 11783914 (Pubitemid 34008404)
    • (2001) Ultrastructural Pathology , vol.25 , Issue.6 , pp. 497-516
    • Dominguez-Malagon, H.1    Gaytan-Graham, S.2
  • 19
    • 5044232164 scopus 로고
    • Biological features of hepadna viruses
    • Zuckerman, A.J., ed. Alan Liss, New York
    • Robinson, W.S. and Marion, P.L. (1988) Biological features of hepadna viruses. In Viral Hepatitis and Liver Disease (Zuckerman, A.J., ed.), pp. 449, Alan Liss, New York
    • (1988) Viral Hepatitis and Liver Disease , pp. 449
    • Robinson, W.S.1    Marion, P.L.2
  • 20
    • 0015978272 scopus 로고
    • Hepatitis-B antigen in saliva and semen
    • PubMed: 4129209
    • Heathcote, J., Cameron, C.H. and Dane, D.S. (1974) Hepatitis-B antigen in saliva and semen. Lancet 1, 71-73, PubMed: 4129209
    • (1974) Lancet , vol.1 , pp. 71-73
    • Heathcote, J.1    Cameron, C.H.2    Dane, D.S.3
  • 21
    • 0016752188 scopus 로고
    • The emerging pattern of post-transfusion hepatitis
    • PubMed: 1235474
    • Alter, H.J., Holland, P.V. and Purcell, R.H. (1975) The emerging pattern of post-transfusion hepatitis. Am J Med Sci 270, 329-334, PubMed: 1235474
    • (1975) Am J Med Sci , vol.270 , pp. 329-334
    • Alter, H.J.1    Holland, P.V.2    Purcell, R.H.3
  • 22
    • 0016804471 scopus 로고
    • On the role of sexual behavior in the spread of hepatitis B infection
    • PubMed: 1166979
    • Szmuness, W. et al. (1975) On the role of sexual behavior in the spread of hepatitis B infection. Ann Intern Med 83, 489-495, PubMed: 1166979
    • (1975) Ann Intern Med , vol.83 , pp. 489-495
    • Szmuness, W.1
  • 24
    • 0030965103 scopus 로고    scopus 로고
    • Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group
    • PubMed: 9197213
    • Chang, M.H. et al. (1997) Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. N Engl J Med 336, 1855-1859, PubMed: 9197213
    • (1997) N Engl J Med , vol.336 , pp. 1855-1859
    • Chang, M.H.1
  • 25
    • 0033027690 scopus 로고    scopus 로고
    • Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection
    • PubMed: 10051505
    • Lin, S.M. et al. (1999) Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection. Hepatology 29, 971-975, PubMed: 10051505
    • (1999) Hepatology , vol.29 , pp. 971-975
    • Lin, S.M.1
  • 27
    • 0642366709 scopus 로고    scopus 로고
    • Latent hepatitis B virus (HBV) infection and HBV DNA integration is associated with further transformation of hepatoma cells in vitro
    • PubMed: 12947486
    • Favre, D., Petit, M.A. and Trepot, C. (2003) Latent hepatitis B virus (HBV) infection and HBV DNA integration is associated with further transformation of hepatoma cells in vitro. Altex 20, 131-142, PubMed: 12947486
    • (2003) Altex , vol.20 , pp. 131-142
    • Favre, D.1    Petit, M.A.2    Trepot, C.3
  • 28
    • 0037663314 scopus 로고    scopus 로고
    • Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
    • DOI 10.1038/sj.onc.1206492
    • Paterlini-Brechot, P. et al. (2003) Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene 22, 3911-3916, PubMed: 12813464 (Pubitemid 36819664)
    • (2003) Oncogene , vol.22 , Issue.25 , pp. 3911-3916
    • Paterlini-Brechot, P.1    Saigo, K.2    Murakami, Y.3    Chami, M.4    Gozuacik, D.5    Mugnier, C.6    Lagorce, D.7    Brechot, C.8
  • 30
    • 0028053787 scopus 로고
    • Integrated hepatitis B virus X and 3' truncated preS/S sequences derived from human hepatomas encode functionally active transactivators
    • PubMed: 7936659
    • Schluter, V. et al. (1994) Integrated hepatitis B virus X and 3' truncated preS/S sequences derived from human hepatomas encode functionally active transactivators. Oncogene 9, 3335-3344, PubMed: 7936659
    • (1994) Oncogene , vol.9 , pp. 3335-3344
    • Schluter, V.1
  • 31
    • 0025231364 scopus 로고
    • A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA
    • PubMed: 2158099
    • Caselmann, W.H. et al. (1990) A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA. Proc Natl Acad Sci USA 87, 2970-2974, PubMed: 2158099
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 2970-2974
    • Caselmann, W.H.1
  • 32
    • 0038205418 scopus 로고    scopus 로고
    • Molecular aspects of hepatitis B viral infection and the viral carcinogenesis
    • PubMed: 12542984
    • Ryu, W.S. (2003) Molecular aspects of hepatitis B viral infection and the viral carcinogenesis. J Biochem Mol Biol 36, 138-143, PubMed: 12542984
    • (2003) J Biochem Mol Biol , vol.36 , pp. 138-143
    • Ryu, W.S.1
  • 33
    • 0036322490 scopus 로고    scopus 로고
    • Hepatocarcinogenesis in hepatitis viral infection: Lessons from transgenic mouse studies
    • DOI 10.1007/s535-002-8134-0
    • Koike, K. (2002) Hepatocarcinogenesis in hepatitis viral infection: lessons from transgenic mouse studies. J Gastroenterol 37 Suppl 13, 55-64, PubMed: 12109667 (Pubitemid 34846309)
    • (2002) Journal of Gastroenterology , vol.37 , Issue.SUPPL. 13 , pp. 55-64
    • Koike, K.1
  • 34
    • 0036292006 scopus 로고    scopus 로고
    • Molecular mechanism of viral hepatocarcinogenesis
    • DOI 10.1159/000048273
    • Koike, K. et al. (2002) Molecular mechanism of viral hepatocarcinogenesis. Oncology 62 Suppl 1, 29-37, PubMed: 11868782 (Pubitemid 34702017)
    • (2002) Oncology , vol.62 , Issue.SUPPL. 1 , pp. 29-37
    • Koike, K.1    Tsutsumi, T.2    Fujie, H.3    Shintani, Y.4    Moriya, K.5
  • 35
    • 0036635592 scopus 로고    scopus 로고
    • Overexpression of cyclin A in hepatocellular carcinoma and its relationship with HBx gene integration
    • PubMed: 12408762
    • Zhang, Y. et al. (2002) Overexpression of cyclin A in hepatocellular carcinoma and its relationship with HBx gene integration. Zhonghua Zhong Liu Za Zhi 24, 353-355, PubMed: 12408762
    • (2002) Zhonghua Zhong Liu Za Zhi , vol.24 , pp. 353-355
    • Zhang, Y.1
  • 36
    • 0028949528 scopus 로고
    • Transactivation of cellular gene expression by hepatitis B viral proteins: A possible molecular mechanism of hepatocarcinogenesis
    • PubMed: 7602073
    • Caselmann, W.H. (1995) Transactivation of cellular gene expression by hepatitis B viral proteins: a possible molecular mechanism of hepatocarcinogenesis. J Hepatol 22, 34-37, PubMed: 7602073
    • (1995) J Hepatol , vol.22 , pp. 34-37
    • Caselmann, W.H.1
  • 37
    • 0037869474 scopus 로고    scopus 로고
    • The dermatopathologic manifestations of hepatitis C infection: A clinical, histological, and molecular assessment of 35 cases
    • DOI 10.1016/S0046-8177(03)00193-X
    • Crowson, A.N. et al. (2003) The dermatopathologic manifestations of hepatitis C infection: a clinical, histological, and molecular assessment of 35 cases. Hum Pathol 34, 573-579, PubMed: 12827611 (Pubitemid 36750369)
    • (2003) Human Pathology , vol.34 , Issue.6 , pp. 573-579
    • Crowson, A.N.1    Nuovo, G.2    Ferri, C.3    Magro, C.M.4
  • 38
    • 0037221403 scopus 로고    scopus 로고
    • Differential distribution and internal translation efficiency of hepatitis C virus quasispecies present in dendritic and liver cells
    • DOI 10.1182/blood-2002-03-0818
    • Laporte, J. et al. (2003) Differential distribution and internal translation efficiency of hepatitis C virus quasispecies present in dendritic and liver cells. Blood 101, 52-57, PubMed: 12393733 (Pubitemid 36025886)
    • (2003) Blood , vol.101 , Issue.1 , pp. 52-57
    • Laporte, J.1    Bain, C.2    Maurel, P.3    Inchauspe, G.4    Agut, H.5    Cahour, A.6
  • 40
    • 0034906274 scopus 로고    scopus 로고
    • Study of the infection of human blood derived monocyte/macrophages with hepatitis C virus in vitro
    • PubMed: 11505438
    • Caussin-Schwemling, C., Schmitt, C. and Stoll-Keller, F. (2001) Study of the infection of human blood derived monocyte/macrophages with hepatitis C virus in vitro. J Med Virol 65, 14-22, PubMed: 11505438
    • (2001) J Med Virol , vol.65 , pp. 14-22
    • Caussin-Schwemling, C.1    Schmitt, C.2    Stoll-Keller, F.3
  • 41
    • 0036829856 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and hepatitis C in the United States
    • DOI 10.1053/jhep.2002.36807
    • El-Serag, H.B. (2002) Hepatocellular carcinoma and hepatitis C in the United States. Hepatology 36, S74-83, PubMed: 12407579 (Pubitemid 35253466)
    • (2002) Hepatology , vol.36 , Issue.5
    • El-Serag, H.B.1
  • 42
    • 0036829816 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis C
    • DOI 10.1053/jhep.2002.36806
    • Seeff, L.B. (2002) Natural history of chronic hepatitis C. Hepatology 36, S35-46, PubMed: 12407575 (Pubitemid 35253462)
    • (2002) Hepatology , vol.36 , Issue.5
    • Seeff, L.B.1
  • 43
    • 0037221473 scopus 로고    scopus 로고
    • Management of hepatitis C
    • PubMed: 12591189
    • Alberti, A. and Benvegnu, L. (2003) Management of hepatitis C. J Hepatol 38 Suppl 1, S104-118, PubMed: 12591189
    • (2003) J Hepatol , vol.38 , Issue.SUPPL. 1
    • Alberti, A.1    Benvegnu, L.2
  • 46
    • 0025862146 scopus 로고
    • Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral disease
    • PubMed: 1650328
    • Houghton, M. et al. (1991) Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology 14, 381-388, PubMed: 1650328
    • (1991) Hepatology , vol.14 , pp. 381-388
    • Houghton, M.1
  • 47
    • 0026084948 scopus 로고
    • Structure and organization of the hepatitis C virus genome isolated from human carriers
    • PubMed: 1847440
    • Takamizawa, A. et al. (1991) Structure and organization of the hepatitis C virus genome isolated from human carriers. J Virol 65, 1105-1113, PubMed: 1847440
    • (1991) J Virol , vol.65 , pp. 1105-1113
    • Takamizawa, A.1
  • 48
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • PubMed: 2523562
    • Choo, Q.L. et al. (1989) Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244, 359-362, PubMed: 2523562
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.L.1
  • 51
    • 85044703946 scopus 로고    scopus 로고
    • Analysis of hepatitis C virus proteins based on amino acid sequence data and literature data
    • PubMed: 11969155
    • Sobolev, B.N. et al. (2002) [Analysis of hepatitis C virus proteins based on amino acid sequence data and literature data]. Biofizika 47, 204-210, PubMed: 11969155
    • (2002) Biofizika , vol.47 , pp. 204-210
    • Sobolev, B.N.1
  • 53
    • 0031825974 scopus 로고    scopus 로고
    • Degree and distribution of variability in the 5' untranslated, E1, E2/NS1 and NS5 regions of the hepatitis C virus (HCV)
    • PubMed: 9751009
    • Vizmanos, J.L. et al. (1998) Degree and distribution of variability in the 5' untranslated, E1, E2/NS1 and NS5 regions of the hepatitis C virus (HCV). J Viral Hepat 5, 227-240, PubMed: 9751009
    • (1998) J Viral Hepat , vol.5 , pp. 227-240
    • Vizmanos, J.L.1
  • 54
    • 0034844003 scopus 로고    scopus 로고
    • Hepatitis C viral RNA: Challenges and promises
    • Shi, S.T. and Lai, M.M. (2001) Hepatitis C viral RNA: challenges and promises. Cell Mol Life Sci 58, 1276-1295, PubMed: 11577984 (Pubitemid 32844098)
    • (2001) Cellular and Molecular Life Sciences , vol.58 , Issue.9 , pp. 1276-1295
    • Shi, S.T.1    Lai, M.M.C.2
  • 55
    • 0034484070 scopus 로고    scopus 로고
    • Genome of human hepatitis C virus (HCV): Gene organization, sequence diversity, and variation
    • Kato, N. (2000) Genome of human hepatitis C virus (HCV): gene organization, sequence diversity, and variation. Microb Comp Genomics 5, 129-151, PubMed: 11252351 (Pubitemid 32183233)
    • (2000) Microbial and Comparative Genomics , vol.5 , Issue.3 , pp. 129-151
    • Kato, N.1
  • 56
    • 0033918172 scopus 로고    scopus 로고
    • Biochemical and immunologic properties of the nonstructural proteins of the hepatitis C virus: Implications for development of antiviral agents and vaccines
    • De Francesco, R. et al. (2000) Biochemical and immunologic properties of the nonstructural proteins of the hepatitis C virus: implications for development of antiviral agents and vaccines. Semin Liver Dis 20, 69-83, PubMed: 10895433 (Pubitemid 30421410)
    • (2000) Seminars in Liver Disease , vol.20 , Issue.1 , pp. 69-83
    • De Francesco, R.1    Neddermann, P.2    Tomei, L.3    Steinkuhler, C.4    Gallinari, P.5    Folgori, A.6
  • 57
    • 0028905430 scopus 로고
    • Variability of hepatitis C virus
    • PubMed: 7531173
    • Simmonds, P. (1995) Variability of hepatitis C virus. Hepatology 21, 570-583, PubMed: 7531173
    • (1995) Hepatology , vol.21 , pp. 570-583
    • Simmonds, P.1
  • 58
    • 0026726857 scopus 로고
    • Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: Variability and stability
    • PubMed: 1325713
    • Okamoto, H. et al. (1992) Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability. Virology 190, 894-899, PubMed: 1325713
    • (1992) Virology , vol.190 , pp. 894-899
    • Okamoto, H.1
  • 60
    • 0041382463 scopus 로고    scopus 로고
    • Direct comparison of hepatitis C virus genotypes tested by INNO-LiPA HCV II and TRUGENE HCV genotyping methods
    • DOI 10.1016/S1386-6532(03)00076-3
    • Zheng, X. et al. (2003) Direct comparison of hepatitis C virus genotypes tested by INNO-LiPA HCV II and TRUGENE HCV genotyping methods. J Clin Virol 28, 214-216, PubMed: 12957191 (Pubitemid 37040872)
    • (2003) Journal of Clinical Virology , vol.28 , Issue.2 , pp. 214-216
    • Zheng, X.1    Pang, M.2    Chan, A.3    Roberto, A.4    Warner, D.5    Yen-Lieberman, B.6
  • 61
    • 0041818282 scopus 로고    scopus 로고
    • Clinical trial results of peginterferons in combination with ribavirin
    • Craxi, A. and Licata, A. (2003) Clinical trial results of peginterferons in combination with ribavirin. Semin Liver Dis 23 Suppl 1, 35-46, PubMed: 12934167 (Pubitemid 37052443)
    • (2003) Seminars in Liver Disease , vol.23 , Issue.SUPPL. 1 , pp. 35-46
    • Craxi, A.1    Licata, A.2
  • 62
    • 0026563204 scopus 로고
    • Typing hepatitis C virus by polymerase chain reaction with type-specific primers: Application to clinical surveys and tracing infectious sources
    • PubMed: 1312125
    • Okamoto, H. et al. (1992) Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol 73 (Pt 3), 673-679, PubMed: 1312125
    • (1992) J Gen Virol , vol.73 , Issue.PART 3 , pp. 673-679
    • Okamoto, H.1
  • 63
    • 0025817071 scopus 로고
    • A second group of hepatitis C viruses
    • PubMed: 1663293
    • Tsukiyama-Kohara, K. et al. (1991) A second group of hepatitis C viruses. Virus Genes 5, 243-254, PubMed: 1663293
    • (1991) Virus Genes , vol.5 , pp. 243-254
    • Tsukiyama-Kohara, K.1
  • 64
    • 0033135353 scopus 로고    scopus 로고
    • Comparison of genetic heterogeneity of hepatitis C viral RNA in liver tissue and serum
    • DOI 10.1111/j.1572-0241.1999.01085.x, PII S0002927099001410
    • Fan, X. et al. (1999) Comparison of genetic heterogeneity of hepatitis C viral RNA in liver tissue and serum. Am J Gastroenterol 94, 1347-1354, PubMed: 10235217 (Pubitemid 29214652)
    • (1999) American Journal of Gastroenterology , vol.94 , Issue.5 , pp. 1347-1354
    • Fan, X.1
  • 66
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • PubMed: 2841597
    • Vogelstein, B. et al. (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319, 525-532, PubMed: 2841597
    • (1988) N Engl J Med , vol.319 , pp. 525-532
    • Vogelstein, B.1
  • 68
    • 0033867475 scopus 로고    scopus 로고
    • Genetics of hepatocellular carcinoma
    • PubMed: 10936068
    • Buendia, M.A. (2000) Genetics of hepatocellular carcinoma. Semin Cancer Biol 10, 185-200, PubMed: 10936068
    • (2000) Semin Cancer Biol , vol.10 , pp. 185-200
    • Buendia, M.A.1
  • 69
    • 0030733924 scopus 로고    scopus 로고
    • Molecular mechanism of hepatocarcinogenesis
    • PubMed: 9407351
    • Sheu, J.C. (1997) Molecular mechanism of hepatocarcinogenesis. J Gastroenterol Hepatol 12, S309-313, PubMed: 9407351
    • (1997) J Gastroenterol Hepatol , vol.12
    • Sheu, J.C.1
  • 71
    • 0026459290 scopus 로고
    • P53 gene mutation spectrum in hepatocellular carcinoma
    • PubMed: 1330291
    • Oda, T. et al. (1992) p53 gene mutation spectrum in hepatocellular carcinoma. Cancer Res 52, 6358-6364, PubMed: 1330291
    • (1992) Cancer Res , vol.52 , pp. 6358-6364
    • Oda, T.1
  • 72
    • 0026669469 scopus 로고
    • P53 function and dysfunction
    • PubMed: 1505019
    • Vogelstein, B. and Kinzler, K.W. (1992) p53 function and dysfunction. Cell 70, 523-526, PubMed: 1505019
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 73
    • 0025894713 scopus 로고
    • P53 mutations in human cancers
    • PubMed: 1905840
    • Hollstein, M. et al. (1991) p53 mutations in human cancers. Science 253, 49-53, PubMed: 1905840
    • (1991) Science , vol.253 , pp. 49-53
    • Hollstein, M.1
  • 74
    • 0025732215 scopus 로고
    • Mutational hotspot in the p53 gene in human hepatocellular carcinomas
    • Hsu, I.C. et al. (1991) Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 350, 427-428, PubMed: 1849234 (Pubitemid 21912245)
    • (1991) Nature , vol.350 , Issue.6317 , pp. 427-428
    • Hsu, I.C.1    Metcalf, R.A.2    Sun, T.3    Welsh, J.A.4    Wang, N.J.5    Harris, C.C.6
  • 75
    • 0026041836 scopus 로고
    • Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas
    • PubMed: 1655254
    • Murakami, Y. et al. (1991) Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas. Cancer Res 51, 5520-5525, PubMed: 1655254
    • (1991) Cancer Res , vol.51 , pp. 5520-5525
    • Murakami, Y.1
  • 76
    • 38049061212 scopus 로고    scopus 로고
    • Anti-p53-directed immunotherapy of malignant disease
    • 28 March, DOI: 10.1017/S1462399403006173
    • Theobald, M. and Offringa, R. (2003) Anti-p53-directed immunotherapy of malignant disease. Exp. Rev. Mol. Med. Vol. 5, 28 March, DOI: 10.1017/S1462399403006173
    • (2003) Exp. Rev. Mol. Med. , vol.5
    • Theobald, M.1    Offringa, R.2
  • 78
    • 0029972806 scopus 로고    scopus 로고
    • P53: Puzzle and paradigm
    • Ko, L.J. and Prives, C. (1996) p53: puzzle and paradigm. Genes Dev 10, 1054-1072, PubMed: 8654922 (Pubitemid 26152848)
    • (1996) Genes and Development , vol.10 , Issue.9 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 79
    • 0032411599 scopus 로고    scopus 로고
    • Roles for p53 in growth arrest and apoptosis: Putting on the brakes after genotoxic stress
    • Amundson, S.A., Myers, T.G. and Fornace, A.J., Jr. (1998) Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene 17, 3287-3299, PubMed: 9916991 (Pubitemid 29043981)
    • (1998) Oncogene , vol.17 , Issue.25 , pp. 3287-3299
    • Amundson, S.A.1    Myers, T.G.2    Fornace Jr., A.J.3
  • 80
    • 0031987277 scopus 로고    scopus 로고
    • Regulation of p53 downstream genes
    • DOI 10.1006/scbi.1998.0097
    • el-Deiry, W.S. (1998) Regulation of p53 downstream genes. Semin Cancer Biol 8, 345-357, PubMed: 10101800 (Pubitemid 29131356)
    • (1998) Seminars in Cancer Biology , vol.8 , Issue.5 , pp. 345-357
    • El-Deiry, W.S.1
  • 81
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
    • PubMed: 1423616
    • Kastan, M.B. et al. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597, PubMed: 1423616
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1
  • 83
    • 0032952004 scopus 로고    scopus 로고
    • MDM2: The ups and downs
    • Juven-Gershon, T. and Oren, M. (1999) Mdm2: the ups and downs. Mol Med 5, 71-83, PubMed: 10203572 (Pubitemid 29230686)
    • (1999) Molecular Medicine , vol.5 , Issue.2 , pp. 71-83
    • Juven-Gershon, T.1    Oren, M.2
  • 86
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • Levine, A.J., Momand, J. and Finlay, C.A. (1991) The p53 tumour suppressor gene. Nature 351, 453-456, PubMed: 2046748 (Pubitemid 21896613)
    • (1991) Nature , vol.351 , Issue.6326 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 87
    • 0026705327 scopus 로고
    • P53: The ultimate tumor suppressor gene?
    • PubMed: 1397838
    • Oren, M. (1992) p53: the ultimate tumor suppressor gene? Faseb J 6, 3169-3176, PubMed: 1397838
    • (1992) Faseb J , vol.6 , pp. 3169-3176
    • Oren, M.1
  • 88
    • 0026733635 scopus 로고
    • Biochemical properties of the growth suppressor/oncoprotein p53
    • PubMed: 1501881
    • Montenarh, M. (1992) Biochemical properties of the growth suppressor/oncoprotein p53. Oncogene 7, 1673-1680, PubMed: 1501881
    • (1992) Oncogene , vol.7 , pp. 1673-1680
    • Montenarh, M.1
  • 89
    • 0027358857 scopus 로고
    • Inhibition of DNA replication factor RPA by p53
    • DOI 10.1038/365079a0
    • Dutta, A. et al. (1993) Inhibition of DNA replication factor RPA by p53. Nature 365, 79-82, PubMed: 8361542 (Pubitemid 23305574)
    • (1993) Nature , vol.365 , Issue.6441 , pp. 79-82
    • Dutta, A.1    Ruppert, J.M.2    Aster, J.C.3    Winchester, E.4
  • 90
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • DOI 10.1016/S0092-8674(00)81871-1
    • Levine, A.J. (1997) p53, the cellular gatekeeper for growth and division. Cell 88, 323-331, PubMed: 9039259 (Pubitemid 27131374)
    • (1997) Cell , vol.88 , Issue.3 , pp. 323-331
    • Levine, A.J.1
  • 91
    • 0028913739 scopus 로고
    • A p53-dependent mouse spindle checkpoint
    • PubMed: 7871434
    • Cross, S.M. et al. (1995) A p53-dependent mouse spindle checkpoint. Science 267, 1353-1356, PubMed: 7871434
    • (1995) Science , vol.267 , pp. 1353-1356
    • Cross, S.M.1
  • 92
    • 0027489384 scopus 로고
    • Clinical implications of the p53 tumor-suppressor gene
    • DOI 10.1056/NEJM199310283291807
    • Harris, C.C. and Hollstein, M. (1993) Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 329, 1318-1327, PubMed: 8413413 (Pubitemid 23317333)
    • (1993) New England Journal of Medicine , vol.329 , Issue.18 , pp. 1318-1327
    • Harris, C.C.1    Hollstein, M.2
  • 93
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt, M.S. et al. (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54, 4855-4878, PubMed: 8069852 (Pubitemid 24289415)
    • (1994) Cancer Research , vol.54 , Issue.18 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 94
    • 0028456527 scopus 로고
    • Relationship of p53 to the control of apoptotic cell death
    • Oren, M. (1994) Relationship of p53 to the control of apoptotic cell death. Semin Cancer Biol 5, 221-227, PubMed: 7948950 (Pubitemid 124006732)
    • (1994) Seminars in Cancer Biology , vol.5 , Issue.3 , pp. 221-227
    • Oren, M.1
  • 95
    • 0026718812 scopus 로고
    • The p53 tumor suppressor protein, a modulator of cell proliferation
    • PubMed: 1639769
    • Ullrich, S.J. et al. (1992) The p53 tumor suppressor protein, a modulator of cell proliferation. J Biol Chem 267, 15259-15262, PubMed: 1639769
    • (1992) J Biol Chem , vol.267 , pp. 15259-15262
    • Ullrich, S.J.1
  • 96
    • 0034039040 scopus 로고    scopus 로고
    • Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress
    • Ljungman, M. (2000) Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress. Neoplasia 2, 208-225, PubMed: 10935507 (Pubitemid 30346077)
    • (2000) Neoplasia , vol.2 , Issue.3 , pp. 208-225
    • Ljungman, M.1
  • 97
    • 0034818446 scopus 로고    scopus 로고
    • Post-translational modifications and activation of p53 by genotoxic stresses
    • DOI 10.1046/j.1432-1327.2001.02225.x
    • Appella, E. and Anderson, C.W. (2001) Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 268, 2764-2772, PubMed: 11358490 (Pubitemid 32862957)
    • (2001) European Journal of Biochemistry , vol.268 , Issue.10 , pp. 2764-2772
    • Appella, E.1    Anderson, C.W.2
  • 99
    • 0025203803 scopus 로고
    • Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells
    • Shaulsky, G., Ben-Ze'ev, A. and Rotter, V. (1990) Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells. Oncogene 5, 1707-1711, PubMed: 2267137 (Pubitemid 120034693)
    • (1990) Oncogene , vol.5 , Issue.11 , pp. 1707-1711
    • Shaulsky, G.1    Ben-Ze'ev, A.2    Rotter, V.3
  • 101
    • 0036294965 scopus 로고    scopus 로고
    • Altered subcellular localization of p53 in estrogen-dependent and estrogen-independent breast cancer cells
    • DOI 10.1081/CNV-120002151
    • Lilling, G. et al. (2002) Altered subcellular localization of p53 in estrogen-dependent and estrogen-independent breast cancer cells. Cancer Invest 20, 509-517, PubMed: 12094546 (Pubitemid 34686347)
    • (2002) Cancer Investigation , vol.20 , Issue.4 , pp. 509-517
    • Lilling, G.1    Nordenberg, J.2    Rotter, V.3    Goldfinger, N.4    Peller, S.5    Sidi, Y.6
  • 102
    • 0028989844 scopus 로고
    • Bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas
    • PubMed: 7750937
    • Bosari, S. et al. (1995) bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas. Hum Pathol 26, 534-540, PubMed: 7750937
    • (1995) Hum Pathol , vol.26 , pp. 534-540
    • Bosari, S.1
  • 103
    • 0034642549 scopus 로고    scopus 로고
    • Nuclear exclusion of p53 in a subset of tumors requires MDM2 function
    • Lu, W. et al. (2000) Nuclear exclusion of p53 in a subset of tumors requires MDM2 function. Oncogene 19, 232-240, PubMed: 10645001 (Pubitemid 30077219)
    • (2000) Oncogene , vol.19 , Issue.2 , pp. 232-240
    • Lu, W.1    Pochampally, R.2    Chen, L.3    Traidej, M.4    Wang, Y.5    Chen, J.6
  • 104
    • 0030696170 scopus 로고    scopus 로고
    • Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells
    • Takada, S. et al. (1997) Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells. Oncogene 15, 1895-1901, PubMed: 9365235 (Pubitemid 27480677)
    • (1997) Oncogene , vol.15 , Issue.16 , pp. 1895-1901
    • Takada, S.1    Kaneniwa, N.2    Tsuchida, N.3    Koike, K.4
  • 105
    • 0028855276 scopus 로고
    • Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation
    • PubMed: 7853526
    • Truant, R. et al. (1995) Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation. J Virol 69, 1851-1859, PubMed: 7853526
    • (1995) J Virol , vol.69 , pp. 1851-1859
    • Truant, R.1
  • 106
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • DOI 10.1016/S0092-8674(00)81401-4
    • Zhang, Y., Xiong, Y. and Yarbrough, W.G. (1998) ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92, 725-734, PubMed: 9529249 (Pubitemid 28155312)
    • (1998) Cell , vol.92 , Issue.6 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 109
    • 0033552585 scopus 로고    scopus 로고
    • The role of the E6-p53 interaction in the molecular pathogenesis of HPV
    • Thomas, M., Pim, D. and Banks, L. (1999) The role of the E6-p53 interaction in the molecular pathogenesis of HPV. Oncogene 18, 7690-7700, PubMed: 10618709 (Pubitemid 30052696)
    • (1999) Oncogene , vol.18 , Issue.53 , pp. 7690-7700
    • Thomas, M.1    David, P.2    Banks, L.3
  • 110
    • 0035812298 scopus 로고    scopus 로고
    • waf1 promoter by hepatitis B virus X protein via a p53-independent pathway
    • DOI 10.1016/S0378-1119(01)00604-7, PII S0378111901006047
    • Ahn, J.Y. et al. (2001) Transcriptional repression of p21(waf1) promoter by hepatitis B virus X protein via a p53-independent pathway. Gene 275, 163-168, PubMed: 11574165 (Pubitemid 32907339)
    • (2001) Gene , vol.275 , Issue.1 , pp. 163-168
    • Ahn, J.Y.1    Chung, E.Y.2    Kwun, H.J.3    Jang, K.L.4
  • 111
    • 0036843524 scopus 로고    scopus 로고
    • Dual effects of hepatitis B virus X protein on the regulation of cell-cyle control depending on the status of cellular p53
    • Ahn, J.Y. et al. (2002) Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53. J Gen Virol 83, 2765-2772, PubMed: 12388812 (Pubitemid 35276976)
    • (2002) Journal of General Virology , vol.83 , Issue.11 , pp. 2765-2772
    • Ahn, J.Y.1    Jung, E.Y.2    Kwun, H.J.3    Lee, C.-W.4    Sung, Y.-C.5    Jang, K.L.6
  • 113
    • 0037440429 scopus 로고    scopus 로고
    • Regulation of tumor suppressors by nuclear-cytoplasmic shuttling
    • DOI 10.1016/S0014-4827(02)00019-8, PII S0014482702000198
    • Fabbro, M. and Henderson, B.R. (2003) Regulation of tumor suppressors by nuclear-cytoplasmic shuttling. Exp Cell Res 282, 59-69, PubMed: 12531692 (Pubitemid 36259901)
    • (2003) Experimental Cell Research , vol.282 , Issue.2 , pp. 59-69
    • Fabbro, M.1    Henderson, B.R.2
  • 114
    • 0037177836 scopus 로고    scopus 로고
    • Nuclear import and export signals in control of the p53-related protein p73
    • DOI 10.1074/jbc.M200248200
    • Inoue, T. et al. (2002) Nuclear import and export signals in control of the p53-related protein p73. J Biol Chem 277, 15053-15060, PubMed: 11847229 (Pubitemid 34952582)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.17 , pp. 15053-15060
    • Inoue, T.1    Stuart, J.2    Leno, R.3    Maki, C.G.4
  • 115
    • 0042692785 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination
    • DOI 10.1128/MCB.23.18.6396-6405.2003
    • O'Keefe, K., Li, H. and Zhang, Y. (2003) Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination. Mol Cell Biol 23, 6396-6405, PubMed: 12944468 (Pubitemid 37075753)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.18 , pp. 6396-6405
    • O'Keefe, K.1    Li, H.2    Zhang, Y.3
  • 116
    • 0035837241 scopus 로고    scopus 로고
    • The role of tetramerization in p53 function
    • DOI 10.1038/sj.onc.1204373
    • Chene, P. (2001) The role of tetramerization in p53 function. Oncogene 20, 2611-2617, PubMed: 11420672 (Pubitemid 32525291)
    • (2001) Oncogene , vol.20 , Issue.21 , pp. 2611-2617
    • Chene, P.1
  • 117
    • 0033973807 scopus 로고    scopus 로고
    • Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus
    • DOI 10.1002/(SICI)1097-4644 (20000315)76:4<572:: AID-JCB6>3.0.CO;2- 6
    • Atz, J., Wagner, P. and Roemer, K. (2000) Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus. J Cell Biochem 76, 572-584, PubMed: 10653977 (Pubitemid 30083140)
    • (2000) Journal of Cellular Biochemistry , vol.76 , Issue.4 , pp. 572-584
    • Atz, J.1    Wagner, P.2    Roemer, K.3
  • 118
    • 0036272911 scopus 로고    scopus 로고
    • P53 gene mutations: Case study of a clinical marker for solid tumors
    • DOI 10.1053/sonc.2002.32900
    • Liu, M.C. and Gelmann, E.P. (2002) P53 gene mutations: case study of a clinical marker for solid tumors. Semin Oncol 29, 246-257, PubMed: 12063677 (Pubitemid 34620441)
    • (2002) Seminars in Oncology , vol.29 , Issue.3 , pp. 246-257
    • Liu, M.C.1    Gelmann, E.P.2
  • 120
    • 0030272793 scopus 로고    scopus 로고
    • Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis
    • PubMed: 8921985
    • Shen, H.M. and Ong, C.N. (1996) Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis. Mutat Res 366, 23-44, PubMed: 8921985
    • (1996) Mutat Res , vol.366 , pp. 23-44
    • Shen, H.M.1    Ong, C.N.2
  • 121
    • 0023125537 scopus 로고
    • Primary structure polymorphism at amino acid residue 72 of human p53
    • Matlashewski, G.J. et al. (1987) Primary structure polymorphism at amino acid residue 72 of human p53. Mol Cell Biol 7, 961-963, PubMed: 3547088 (Pubitemid 17004567)
    • (1987) Molecular and Cellular Biology , vol.7 , Issue.2 , pp. 961-963
    • Matlashewski, G.J.1    Tuck, S.2    Pim, D.3
  • 122
    • 0037466368 scopus 로고    scopus 로고
    • Frequent loss of p53 codon 72 Pro variant in hepatitis C virus-positive carriers with hepatocellular carcinoma
    • DOI 10.1016/S0304-3835(03)00046-6
    • Anzola, M. et al. (2003) Frequent loss of p53 codon 72 Pro variant in hepatitis C virus-positive carriers with hepatocellular carcinoma. Cancer Lett 193, 199-205, PubMed: 12706878 (Pubitemid 36428903)
    • (2003) Cancer Letters , vol.193 , Issue.2 , pp. 199-205
    • Anzola, M.1    Cuevas, N.2    Lopez-Martinez, M.3    Saiz, A.4    Burgos, J.J.5    Martinez De Pancorbo, M.6
  • 123
    • 0035976046 scopus 로고    scopus 로고
    • A p53 polymorphism associated with increased risk of hepatitis C virus infection
    • DOI 10.1016/S0304-3835(01)00653-X, PII S030438350100653X
    • Okada, F. et al. (2001) A p53 polymorphism associated with increased risk of hepatitis C virus infection. Cancer Lett 172, 137-142, PubMed: 11566488 (Pubitemid 32889708)
    • (2001) Cancer Letters , vol.172 , Issue.2 , pp. 137-142
    • Okada, F.1    Shiraki, T.2    Maekawa, M.3    Sato, S.4
  • 124
    • 0036891628 scopus 로고    scopus 로고
    • Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus
    • DOI 10.1016/S0168-1702(02)00146-6, PII S0168170202001466
    • Florese, R.H. et al. (2002) Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus. Virus Res 90, 119-131, PubMed: 12457968 (Pubitemid 35375829)
    • (2002) Virus Research , vol.90 , Issue.1-2 , pp. 119-131
    • Florese, R.H.1    Nagano-Fujii, M.2    Iwanaga, Y.3    Hidajat, R.4    Hotta, H.5
  • 125
    • 0037152313 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3
    • PubMed: 12379483
    • Qadri, I., Iwahashi, M. and Simon, F. (2002) Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3. Biochim Biophys Acta 1592, 193-204, PubMed: 12379483
    • (2002) Biochim Biophys Acta , vol.1592 , pp. 193-204
    • Qadri, I.1    Iwahashi, M.2    Simon, F.3
  • 127
    • 0037130462 scopus 로고    scopus 로고
    • HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis
    • PubMed: 12101418
    • Lan, K.H. et al. (2002) HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis. Oncogene 21, 4801-4811, PubMed: 12101418
    • (2002) Oncogene , vol.21 , pp. 4801-4811
    • Lan, K.H.1
  • 128
    • 0037707408 scopus 로고    scopus 로고
    • Dual effects of hepatitis C virus Core protein on the transcription of cyclin-dependent kinase inhibitor p21 gene
    • DOI 10.1046/j.1365-2893.2003.00434.x
    • Kwun, H.J. and Jang, K.L. (2003) Dual effects of hepatitis C virus Core protein on the transcription of cyclin-dependent kinase inhibitor p21 gene. J Viral Hepat 10, 249-255, PubMed: 12823590 (Pubitemid 36801910)
    • (2003) Journal of Viral Hepatitis , vol.10 , Issue.4 , pp. 249-255
    • Kwun, H.J.1    Jang, K.L.2
  • 129
    • 0036290134 scopus 로고    scopus 로고
    • Subcellular localization of HCV core protein regulates its ability for p53 activation and p21 suppression
    • DOI 10.1016/S0006-291X(02)00508-9, PII S0006291X02005089
    • Yamanaka, T., Kodama, T. and Doi, T. (2002) Subcellular localization of HCV core protein regulates its ability for p53 activation and p21 suppression. Biochem Biophys Res Commun 294, 528-534, PubMed: 12056798 (Pubitemid 34694040)
    • (2002) Biochemical and Biophysical Research Communications , vol.294 , Issue.3 , pp. 528-534
    • Yamanaka, T.1    Kodama, T.2    Doi, T.3
  • 130
    • 0036289002 scopus 로고    scopus 로고
    • Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein
    • DOI 10.1016/S0006-291X(02)00507-7, PII S0006291X02005077
    • Yamanaka, T., Uchida, M. and Doi, T. (2002) Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein. Biochem Biophys Res Commun 294, 521-527, PubMed: 12056797 (Pubitemid 34694039)
    • (2002) Biochemical and Biophysical Research Communications , vol.294 , Issue.3 , pp. 521-527
    • Yamanaka, T.1    Uchida, M.2    Doi, T.3
  • 131
    • 0030589563 scopus 로고    scopus 로고
    • Suppression of apoptotic cell death by hepatitis C virus core protein
    • DOI 10.1006/viro.1996.0644
    • Ray, R.B., Meyer, K. and Ray, R. (1996) Suppression of apoptotic cell death by hepatitis C virus core protein. Virology 226, 176-182, PubMed: 8955036 (Pubitemid 27025796)
    • (1996) Virology , vol.226 , Issue.2 , pp. 176-182
    • Ray, R.B.1    Meyer, K.2    Ray, R.3
  • 132
    • 0030891710 scopus 로고    scopus 로고
    • Transcriptional repression of p53 promoter by hepatitis C virus core protein
    • DOI 10.1074/jbc.272.17.10983
    • Ray, R.B. et al. (1997) Transcriptional repression of p53 promoter by hepatitis C virus core protein. J Biol Chem 272, 10983-10986, PubMed: 9110985 (Pubitemid 27184081)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.17 , pp. 10983-10986
    • Ray, R.B.1    Steele, R.2    Meyer, K.3    Ray, R.4
  • 133
    • 0032570876 scopus 로고    scopus 로고
    • Hepatitis C virus core protein represses p21(WAF1/Cip1/Sid1) promoter activity
    • DOI 10.1016/S0378-1119(98)00030-4, PII S0378111998000304
    • Ray, R.B. et al. (1998) Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activity. Gene 208, 331-336, PubMed: 9524287 (Pubitemid 28120945)
    • (1998) Gene , vol.208 , Issue.2 , pp. 331-336
    • Ray, R.B.1    Steele, R.2    Meyer, K.3    Ray, R.4
  • 136
    • 0037124073 scopus 로고    scopus 로고
    • Alternate translation occurs within the core coding region of the hepatitis C viral genome
    • DOI 10.1074/jbc.M201722200
    • Varaklioti, A. et al. (2002) Alternate translation occurs within the core coding region of the hepatitis C viral genome. J Biol Chem 277, 17713-17721, PubMed: 11884417 (Pubitemid 34967576)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.20 , pp. 17713-17721
    • Varaklioti, A.1    Vassilaki, N.2    Georgopoulou, U.3    Mavromara, P.4
  • 137
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin- dependent kinases
    • DOI 10.1016/0092-8674(93)90499-G
    • Harper, J.W. et al. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816, PubMed: 8242751 (Pubitemid 23346377)
    • (1993) Cell , vol.75 , Issue.4 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 138
    • 0037304898 scopus 로고    scopus 로고
    • New roles for p21 and p27 cell-cycle inhibitors: A function for each cell compartment?
    • DOI 10.1016/S0962-8924(02)00043-0, PII S0962892402000430
    • Coqueret, O. (2003) New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol 13, 65-70, PubMed: 12559756 (Pubitemid 36135887)
    • (2003) Trends in Cell Biology , vol.13 , Issue.2 , pp. 65-70
    • Coqueret, O.1
  • 139
    • 0029125444 scopus 로고
    • The tumor suppression function of p21Waf is contained in its N-terminal half ('half-WAF')
    • PubMed: 7624153
    • Zakut, R. and Givol, D. (1995) The tumor suppression function of p21Waf is contained in its N-terminal half ('half-WAF'). Oncogene 11, 393-395, PubMed: 7624153
    • (1995) Oncogene , vol.11 , pp. 393-395
    • Zakut, R.1    Givol, D.2
  • 140
    • 0037222428 scopus 로고    scopus 로고
    • TP53 family members and human cancers
    • DOI 10.1002/humu.10172
    • Benard, J., Douc-Rasy, S. and Ahomadegbe, J.C. (2003) TP53 family members and human cancers. Hum Mutat 21, 182-191, PubMed: 12619104 (Pubitemid 36292961)
    • (2003) Human Mutation , vol.21 , Issue.3 , pp. 182-191
    • Benard, J.1    Douc-Rasy, S.2    Ahomadegbe, J.-C.3
  • 141
    • 0031738083 scopus 로고    scopus 로고
    • Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor
    • DOI 10.1016/S0014-5793(98)01312-X, PII S001457939801312X
    • Ishido, S. and Hotta, H. (1998) Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor. FEBS Lett 438, 258-262, PubMed: 9827557 (Pubitemid 28529285)
    • (1998) FEBS Letters , vol.438 , Issue.3 , pp. 258-262
    • Ishido, S.1    Hotta, H.2
  • 142
    • 0030997669 scopus 로고    scopus 로고
    • Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization
    • Muramatsu, S. et al. (1997) Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization. J Virol 71, 4954-4961, PubMed: 9188558 (Pubitemid 27258163)
    • (1997) Journal of Virology , vol.71 , Issue.7 , pp. 4954-4961
    • Muramatsu, S.1    Ishido, S.2    Fujita, T.3    Itoh, M.4    Hotta, H.5
  • 144
    • 0032034436 scopus 로고    scopus 로고
    • The effect of HCV NS3 protein on expression of p53 gene protein in hepatocarcinogenesis
    • PubMed: 10923485
    • Feng, D., Zheng, H. and Yan, Y. (1998) [The effect of HCV NS3 protein on expression of p53 gene protein in hepatocarcinogenesis]. Zhonghua Yi Xue Za Zhi 78, 278-280, PubMed: 10923485
    • (1998) Zhonghua Yi Xue Za Zhi , vol.78 , pp. 278-280
    • Feng, D.1    Zheng, H.2    Yan, Y.3
  • 146
    • 0036436838 scopus 로고    scopus 로고
    • Hepatitis C virus-host interactions: The NS5A protein and the interferon/chemokine systems
    • DOI 10.1089/107999002760624224
    • Khabar, K.S. and Polyak, S.J. (2002) Hepatitis C virus-host interactions: the NS5A protein and the interferon/chemokine systems. J Interferon Cytokine Res 22, 1005-1012, PubMed: 12433279 (Pubitemid 35379011)
    • (2002) Journal of Interferon and Cytokine Research , vol.22 , Issue.10 , pp. 1005-1012
    • Khabar, K.S.A.1    Polyak, S.J.2
  • 147
    • 0036017204 scopus 로고    scopus 로고
    • The nonstructural NS5a protein of hepatitis c virus: An expanding, multifunctional role in enhancing hepatitis C virus pathogenesis
    • DOI 10.1159/000059419
    • Reyes, G.R. (2002) The nonstructural NS5A protein of hepatitis C virus: an expanding, multifunctional role in enhancing hepatitis C virus pathogenesis. J Biomed Sci 9, 187-197, PubMed: 12065893 (Pubitemid 34639027)
    • (2002) Journal of Biomedical Science , vol.9 , Issue.3 , pp. 187-197
    • Reyes, G.R.1
  • 148
    • 17344381535 scopus 로고    scopus 로고
    • Hepatitis C virus biology
    • DOI 10.1038/sj.cdd.4401121
    • Giannini, C. and Brechot, C. (2003) Hepatitis C virus biology. Cell Death Differ 10 Suppl 1, S27-38, PubMed: 12655344 (Pubitemid 36519094)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.SUPPL. 1
    • Giannini, C.1    Brechot, C.2
  • 149
    • 0036435567 scopus 로고    scopus 로고
    • Expression of HCV structural proteins impairs IFN-mediated antiviral response
    • DOI 10.1006/viro.2002.1527
    • Keskinen, P., Melen, K. and Julkunen, I. (2002) Expression of HCV structural proteins impairs IFN-mediated antiviral response. Virology 299, 164-171, PubMed: 12202219 (Pubitemid 35356593)
    • (2002) Virology , vol.299 , Issue.2 , pp. 164-171
    • Keskinen, P.1    Melen, K.2    Julkunen, I.3
  • 150
    • 0032938224 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth
    • Ghosh, A.K. et al. (1999) Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. J Gen Virol 80 (Pt 5), 1179-1183, PubMed: 10355764 (Pubitemid 29213805)
    • (1999) Journal of General Virology , vol.80 , Issue.5 , pp. 1179-1183
    • Ghosh, A.K.1    Steele, R.2    Meyer, K.3    Ranjit, R.4    Ray, R.B.5
  • 151
    • 0035918320 scopus 로고    scopus 로고
    • Modulation of cell growth by the hepatitis C virus nonstructural protein NS5A
    • PubMed: 11278402
    • Arima, N. et al. (2001) Modulation of cell growth by the hepatitis C virus nonstructural protein NS5A. J Biol Chem 276, 12675-12684, PubMed: 11278402
    • (2001) J Biol Chem , vol.276 , pp. 12675-12684
    • Arima, N.1
  • 152
    • 0035148645 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner
    • PubMed: 11152513
    • Majumder, M. et al. (2001) Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner. J Virol 75, 1401-1407, PubMed: 11152513
    • (2001) J Virol , vol.75 , pp. 1401-1407
    • Majumder, M.1
  • 153
    • 0034602420 scopus 로고    scopus 로고
    • Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability
    • PubMed: 10924497
    • Otsuka, M. et al. (2000) Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability. J Biol Chem 275, 34122-34130, PubMed: 10924497
    • (2000) J Biol Chem , vol.275 , pp. 34122-34130
    • Otsuka, M.1
  • 154
    • 0032885602 scopus 로고    scopus 로고
    • The non-structural 5A protein of hepatitis C virus
    • DOI 10.1046/j.1365-2893.1999.00185.x
    • Pawlotsky, J.M. and Germanidis, G. (1999) The non-structural 5A protein of hepatitis C virus. J Viral Hepat 6, 343-356, PubMed: 10607250 (Pubitemid 29470164)
    • (1999) Journal of Viral Hepatitis , vol.6 , Issue.5 , pp. 343-356
    • Pawlotsky, J.M.1    Germanidis, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.