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Volumn 366, Issue 1, 1996, Pages 23-44

Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis

Author keywords

Aflatoxin B1; Hepatocellular carcinoma; Mutation; Oxidative DNA damage; p53 tumor suppressor gene; ras oncogene

Indexed keywords

AFLATOXIN B1; PROTEIN P53;

EID: 0030272793     PISSN: 01651110     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1110(96)90005-6     Document Type: Article
Times cited : (140)

References (167)
  • 1
    • 0027337609 scopus 로고
    • 1 induces the transversion of G → T in codon 249 of the p53 tumor suppressor gene in human hepatocytes
    • 1 induces the transversion of G → T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc. Natl. Acad. Sci. USA. 90:1993;8586-8590.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8586-8590
    • Aguilar, F.1    Hussain, S.P.2    Cerutti, P.3
  • 2
    • 0028343058 scopus 로고
    • Geographic variation of p53 mutational profile in nonmalignant human liver
    • Aguilar F., Harris C.C., Sun T., Hollstein M., Cerutti P. Geographic variation of p53 mutational profile in nonmalignant human liver. Science. 264:1994;1317-1319.
    • (1994) Science , vol.264 , pp. 1317-1319
    • Aguilar, F.1    Harris, C.C.2    Sun, T.3    Hollstein, M.4    Cerutti, P.5
  • 3
    • 0024462967 scopus 로고
    • Endogenous DNA damage as related to cancer and aging
    • Ames B.N. Endogenous DNA damage as related to cancer and aging. Mutation Res. 214:1989;41-46.
    • (1989) Mutation Res. , vol.214 , pp. 41-46
    • Ames, B.N.1
  • 6
    • 0025285159 scopus 로고
    • Ras oncogenes: Their role in neoplasia
    • Barbacid M. ras oncogenes: their role in neoplasia. Eur. J. Clin. Invest. 20:1990;225-235.
    • (1990) Eur. J. Clin. Invest. , vol.20 , pp. 225-235
    • Barbacid, M.1
  • 7
    • 0025066419 scopus 로고
    • Mutations in the Ha-ras proto-oncogene in spontaneous and chemically induced liver tumors of the CF1 mouse
    • Bauer-Hoffmann R., Buchmann A., Wright A.S., Schwarz M. Mutations in the Ha-ras proto-oncogene in spontaneous and chemically induced liver tumors of the CF1 mouse. Carcinogenesis. 11:1990;1875-1877.
    • (1990) Carcinogenesis , vol.11 , pp. 1875-1877
    • Bauer-Hoffmann, R.1    Buchmann, A.2    Wright, A.S.3    Schwarz, M.4
  • 9
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos J.L. ras oncogenes in human cancer: a review. Cancer Res. 49:1989;4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 10
    • 0028988112 scopus 로고
    • p53 protein accumulation in European hepatocellular carcinoma is not always dependent on p53 gene mutation
    • Bourdon J.C., D'Errico A., Paterlini P., Grigioni W., May E., Debuire B. p53 protein accumulation in European hepatocellular carcinoma is not always dependent on p53 gene mutation. Gastroenterology. 108:1995;1176-1182.
    • (1995) Gastroenterology , vol.108 , pp. 1176-1182
    • Bourdon, J.C.1    D'Errico, A.2    Paterlini, P.3    Grigioni, W.4    May, E.5    Debuire, B.6
  • 11
    • 0025828517 scopus 로고
    • Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
    • Bressac B., Kew M., Wands J., Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature. 350:1991;429-431.
    • (1991) Nature , vol.350 , pp. 429-431
    • Bressac, B.1    Kew, M.2    Wands, J.3    Ozturk, M.4
  • 12
    • 0025644741 scopus 로고
    • Risk assessment for aflatoxin: II. Implication of human epidemiology data
    • Bruce R.D. Risk assessment for aflatoxin: II. Implication of human epidemiology data. Risk Anal. 10:1990;561-569.
    • (1990) Risk Anal. , vol.10 , pp. 561-569
    • Bruce, R.D.1
  • 14
    • 0000613334 scopus 로고
    • Aflatoxins
    • Searle C.E. Washington DC: American Chemical Society
    • Busby W.F., Wogan G.N. Aflatoxins. Searle C.E. Chemical Carcinogens. Vol. 2:1984;945-1136 American Chemical Society, Washington DC.
    • (1984) Chemical Carcinogens , vol.2 , pp. 945-1136
    • Busby, W.F.1    Wogan, G.N.2
  • 15
    • 0028418872 scopus 로고
    • C-myc gene and p53 protein expression in human primary liver carcinoma (abstract)
    • Cai D.W., Gao C.Z., Wang N.J. c-myc gene and p53 protein expression in human primary liver carcinoma (abstract). Chung Hua Ping Li Hsueh Tsa Chih. 23:1994;100-103.
    • (1994) Chung Hua Ping Li Hsueh Tsa Chih , vol.23 , pp. 100-103
    • Cai, D.W.1    Gao, C.Z.2    Wang, N.J.3
  • 16
    • 0028093279 scopus 로고
    • 1 in the human hypoxanthine guanine phosphoribosyltransferase gene
    • 1 in the human hypoxanthine guanine phosphoribosyltransferase gene. Cancer Res. 54:1994;4436-4441.
    • (1994) Cancer Res. , vol.54 , pp. 4436-4441
    • Cariello, N.F.1    Cui, L.2    Skopek, T.R.3
  • 17
    • 0028289313 scopus 로고
    • Mutagenesis of the H-ras protooncogene and the p53 tumor suppressor gene
    • Cerutti P., Hussain P., Pourzand C., Aguilar F. Mutagenesis of the H-ras protooncogene and the p53 tumor suppressor gene. Cancer Res. 54:1994;1934s-1938s.
    • (1994) Cancer Res. , vol.54
    • Cerutti, P.1    Hussain, P.2    Pourzand, C.3    Aguilar, F.4
  • 18
    • 0027938689 scopus 로고
    • Oxy-radicals and cancer
    • Cerutti P.A. Oxy-radicals and cancer. Lancet. 344:1994;862-863.
    • (1994) Lancet , vol.344 , pp. 862-863
    • Cerutti, P.A.1
  • 19
    • 0026448806 scopus 로고
    • Analysis of the p53 tumor suppressor gene in hepatocellular carcinomas from Britain
    • Challen C., Lunec J., Warren W., Collier J., Bassendine M.F. Analysis of the p53 tumor suppressor gene in hepatocellular carcinomas from Britain. Hepatology. 16:1992a;1362-1366.
    • (1992) Hepatology , vol.16 , pp. 1362-1366
    • Challen, C.1    Lunec, J.2    Warren, W.3    Collier, J.4    Bassendine, M.F.5
  • 20
    • 0026553679 scopus 로고
    • Infrequent point mutations in codon 12 and 61 of ras oncogenes in human hepatocellular carcinoma
    • Challen C., Guo K., Collier J.D., Cavanagh D., Bassendine M.F. Infrequent point mutations in codon 12 and 61 of ras oncogenes in human hepatocellular carcinoma. J. Hepatol. 14:1992b;342-346.
    • (1992) J. Hepatol. , vol.14 , pp. 342-346
    • Challen, C.1    Guo, K.2    Collier, J.D.3    Cavanagh, D.4    Bassendine, M.F.5
  • 21
    • 0018778606 scopus 로고
    • Identification and partial characterization of new antigents from simian virus 40-transformed mouse cells
    • Chang C., Simmons D.T., Martin M.A., Mora P.T. Identification and partial characterization of new antigents from simian virus 40-transformed mouse cells. J. Virol. 31:1979;371-463.
    • (1979) J. Virol. , vol.31 , pp. 371-463
    • Chang, C.1    Simmons, D.T.2    Martin, M.A.3    Mora, P.T.4
  • 23
    • 0027368382 scopus 로고
    • 'Hot spots' mutation analysis of p53 gene in gastrointestinal cancers by amplification of naturally occurring and artificially created restriction sites
    • Chen P.H., Lin S.Y., Wang C.K., Chen Y.J., Chen T.C., Chang J.G. 'Hot spots' mutation analysis of p53 gene in gastrointestinal cancers by amplification of naturally occurring and artificially created restriction sites. Clin. Chem. 39:1993;2186-2191.
    • (1993) Clin. Chem. , vol.39 , pp. 2186-2191
    • Chen, P.H.1    Lin, S.Y.2    Wang, C.K.3    Chen, Y.J.4    Chen, T.C.5    Chang, J.G.6
  • 24
    • 0028024963 scopus 로고
    • Expression of mutant p53 in chronic HBV infection and hepatocellular carcinoma (abstract)
    • Chen Y., Tang Z.Y., Li J. Expression of mutant p53 in chronic HBV infection and hepatocellular carcinoma (abstract). Chung Hua Chung Liu Tsa Chih. 16:1994;184-187.
    • (1994) Chung Hua Chung Liu Tsa Chih , vol.16 , pp. 184-187
    • Chen, Y.1    Tang, Z.Y.2    Li, J.3
  • 25
    • 0026592966 scopus 로고
    • 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G to T and A to C substitutions
    • Cheng K.C., Cahill D.S., Kasai H., Nishimura S., Loeb L.A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G to T and A to C substitutions. J. Biol. Chem. 267:1992;166-172.
    • (1992) J. Biol. Chem. , vol.267 , pp. 166-172
    • Cheng, K.C.1    Cahill, D.S.2    Kasai, H.3    Nishimura, S.4    Loeb, L.A.5
  • 26
    • 0027250068 scopus 로고
    • The expression of p53 antigen in primary malignant epithelial tumors of the liver: An immunohistochemical study
    • Choi S.W., Hytiroglou P., Geller S.A., Kim S.M., Chung K.W., Park D.H., Theise N.D., Thung S.N. The expression of p53 antigen in primary malignant epithelial tumors of the liver: an immunohistochemical study. Liver. 13:1993;172-176.
    • (1993) Liver , vol.13 , pp. 172-176
    • Choi, S.W.1    Hytiroglou, P.2    Geller, S.A.3    Kim, S.M.4    Chung, K.W.5    Park, D.H.6    Theise, N.D.7    Thung, S.N.8
  • 27
    • 0028117354 scopus 로고
    • Expression of mutant p53 protein in hepatocellular carcinoma
    • Collier J.D., Carpenter M., Burt A.D., Bassendine M.F. Expression of mutant p53 protein in hepatocellular carcinoma. Gut. 35:1994;98-100.
    • (1994) Gut , vol.35 , pp. 98-100
    • Collier, J.D.1    Carpenter, M.2    Burt, A.D.3    Bassendine, M.F.4
  • 28
    • 0027325389 scopus 로고
    • High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal
    • Coursaget P., Depril N., Chabaud M., Nandi R., Mayelo V., LeCann P., Yvonnet B. High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal. Br. J. Cancer. 67:1993;1395-1397.
    • (1993) Br. J. Cancer , vol.67 , pp. 1395-1397
    • Coursaget, P.1    Depril, N.2    Chabaud, M.3    Nandi, R.4    Mayelo, V.5    LeCann, P.6    Yvonnet, B.7
  • 29
    • 0028202489 scopus 로고
    • 1 in human cells: Effects of sequence context on the supF mutational spectrum
    • 1 in human cells: effects of sequence context on the supF mutational spectrum. Mutation Res. 306:1994;143-151.
    • (1994) Mutation Res. , vol.306 , pp. 143-151
    • Courtemanche, C.1    Anderson, A.2
  • 32
    • 0028060647 scopus 로고
    • Overexpression of p53 protein and Ki67 proliferative index in hepatocellular carcinoma: An immunohistochemical study on 109 Italian patients
    • D'Errico A., Grigioni W.F., Fiorentino M., Baccarini P., Grazi G.L., Mancini A.M. Overexpression of p53 protein and Ki67 proliferative index in hepatocellular carcinoma: an immunohistochemical study on 109 Italian patients. Pathol. Int. 44:1994;682-687.
    • (1994) Pathol. Int. , vol.44 , pp. 682-687
    • D'Errico, A.1    Grigioni, W.F.2    Fiorentino, M.3    Baccarini, P.4    Grazi, G.L.5    Mancini, A.M.6
  • 34
    • 0027182097 scopus 로고
    • Analysis of the p53 gene in European hepatocellular carcinomas and hepatoblastomas
    • Debuire B., Paterlini P., Pontisso P., Basso G., May E. Analysis of the p53 gene in European hepatocellular carcinomas and hepatoblastomas. Oncogene. 8:1993;2303-2306.
    • (1993) Oncogene , vol.8 , pp. 2303-2306
    • Debuire, B.1    Paterlini, P.2    Pontisso, P.3    Basso, G.4    May, E.5
  • 35
    • 0018743916 scopus 로고
    • Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse
    • DeLeo A.B., Jay G., Appella E., Dubois G.C., Law L.W., Old L.J. Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc. Natl. Acad. Sci. USA. 76:1979;2420-2424.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 2420-2424
    • DeLeo, A.B.1    Jay, G.2    Appella, E.3    Dubois, G.C.4    Law, L.W.5    Old, L.J.6
  • 37
    • 0028341249 scopus 로고
    • Absence of p53 mutation at codon 249 in duck hepatocellular carcinomas from the high incidence area of Qidong (China)
    • Duflot A., Hollstein M., Mehrotra R., Trepo C., Montesano R., Cova L. Absence of p53 mutation at codon 249 in duck hepatocellular carcinomas from the high incidence area of Qidong (China). Carcinogenesis. 15:1994;1353-1357.
    • (1994) Carcinogenesis , vol.15 , pp. 1353-1357
    • Duflot, A.1    Hollstein, M.2    Mehrotra, R.3    Trepo, C.4    Montesano, R.5    Cova, L.6
  • 41
    • 0025045198 scopus 로고
    • The role of 8-hydroxyguanine in carcinogenesis
    • Floyd R.A. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 11:1990;1447-1450.
    • (1990) Carcinogenesis , vol.11 , pp. 1447-1450
    • Floyd, R.A.1
  • 43
    • 0026664507 scopus 로고
    • Carcinogen-mediated oxidant formation and oxidative DNA damage
    • Frenkel K. Carcinogen-mediated oxidant formation and oxidative DNA damage. Pharmacol. Ther. 53:1992;127-166.
    • (1992) Pharmacol. Ther. , vol.53 , pp. 127-166
    • Frenkel, K.1
  • 44
    • 0028511986 scopus 로고
    • Aberrations of tumor suppressor genes in hepatocellular carcinomas (abstract)
    • Fujimoto Y. Aberrations of tumor suppressor genes in hepatocellular carcinomas (abstract). Hokkaido. lgaku. Zasshi. 69:1994;252-260.
    • (1994) Hokkaido. Lgaku. Zasshi. , vol.69 , pp. 252-260
    • Fujimoto, Y.1
  • 46
    • 0028084735 scopus 로고
    • Alterations of tumor suppressor gene and allelic losses in human hepatocellular carcinomas in China
    • Fujimoto Y., Hampton L.L., Wirth P.J., Wang N.J., Xie J.P., Thorgeirsson S.S. Alterations of tumor suppressor gene and allelic losses in human hepatocellular carcinomas in China. Cancer Res. 54:1994;281-285.
    • (1994) Cancer Res. , vol.54 , pp. 281-285
    • Fujimoto, Y.1    Hampton, L.L.2    Wirth, P.J.3    Wang, N.J.4    Xie, J.P.5    Thorgeirsson, S.S.6
  • 47
    • 0024222256 scopus 로고
    • Structural alterations in c-myc and c-Ha-ras proto-oncogenes in human hepatocellular carcinoma (abstract)
    • Fukuda K., Ogasawara S., Maruiwa M., Yano H., Murakami T., Kojiro M. Structural alterations in c-myc and c-Ha-ras proto-oncogenes in human hepatocellular carcinoma (abstract). Kurume Med. J. 35:1988;77-87.
    • (1988) Kurume Med. J. , vol.35 , pp. 77-87
    • Fukuda, K.1    Ogasawara, S.2    Maruiwa, M.3    Yano, H.4    Murakami, T.5    Kojiro, M.6
  • 48
    • 0025248598 scopus 로고
    • Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form
    • Gannon J.V., Greaves R., Iggo R., Lane D.P. Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO J. 9:1990;1595-1602.
    • (1990) EMBO J. , vol.9 , pp. 1595-1602
    • Gannon, J.V.1    Greaves, R.2    Iggo, R.3    Lane, D.P.4
  • 49
    • 0029008198 scopus 로고
    • Characterization of a murine p53ser249 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure
    • Ghebranious N., Knoll B.J., Wu H., Lozano G., Sell S. Characterization of a murine p53ser249 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Mol. Carcinogen. 13:1995;104-111.
    • (1995) Mol. Carcinogen. , vol.13 , pp. 104-111
    • Ghebranious, N.1    Knoll, B.J.2    Wu, H.3    Lozano, G.4    Sell, S.5
  • 50
    • 0027423064 scopus 로고
    • Hepatitis B and alterations of the p53 tumor suppressor gene in hepatocellular carcinoma
    • Goldblum J.R., Bartos R.E., Carr K.A., Frank T.S. Hepatitis B and alterations of the p53 tumor suppressor gene in hepatocellular carcinoma. Am. J. Surg. Pathol. 17:1993;1244-1251.
    • (1993) Am. J. Surg. Pathol. , vol.17 , pp. 1244-1251
    • Goldblum, J.R.1    Bartos, R.E.2    Carr, K.A.3    Frank, T.S.4
  • 51
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt M.S., Bennett W.P., Hollstein M., Harris C.C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54:1994;4855-4878.
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 52
    • 0028293321 scopus 로고
    • Molecular biomarkers for aflatoxin and their application to human cancer prevention
    • Groopman J.D., Wogan G.N., Roebuck B.D., Kensler T.W. Molecular biomarkers for aflatoxin and their application to human cancer prevention. Cancer Res. 54:1994;1907s-1911s.
    • (1994) Cancer Res. , vol.54
    • Groopman, J.D.1    Wogan, G.N.2    Roebuck, B.D.3    Kensler, T.W.4
  • 53
    • 0024240828 scopus 로고
    • Aflatoxin exposure in human populations: Measurements and relationship to cancer
    • Groopman J.D., Cain L.G., Kensler T. Aflatoxin exposure in human populations: measurements and relationship to cancer. CRC Crit. Rev. Toxicol. 19:1988;113-143.
    • (1988) CRC Crit. Rev. Toxicol. , vol.19 , pp. 113-143
    • Groopman, J.D.1    Cain, L.G.2    Kensler, T.3
  • 56
    • 0026425585 scopus 로고
    • Chemical and physical carcinogenesis: Advances and perspectives for the 1990s
    • Harris C.C. Chemical and physical carcinogenesis: advances and perspectives for the 1990s. Cancer Res. 51:1991;5023s-5044s.
    • (1991) Cancer Res. , vol.51
    • Harris, C.C.1
  • 57
    • 0027756186 scopus 로고
    • p53 : At the crossroads of molecular carcinogenesis and risk assessment
    • Harris C.C. p53 : At the crossroads of molecular carcinogenesis and risk assessment. Science. 262:1993;1980-1981.
    • (1993) Science , vol.262 , pp. 1980-1981
    • Harris, C.C.1
  • 58
    • 0027489384 scopus 로고
    • Clinical implications of the p53 tumor suppressor gene
    • Harris C.C., Hollstein M. Clinical implications of the p53 tumor suppressor gene. N. Engl. J. Med. 329:1993;1318-1327.
    • (1993) N. Engl. J. Med. , vol.329 , pp. 1318-1327
    • Harris, C.C.1    Hollstein, M.2
  • 59
    • 0028867236 scopus 로고
    • The clinical significance of p53 gene mutation in hepatocellular carcinomas from Japan
    • Hayashi H., Sugio K., Matsumata T., Adachi E., Tanaka K., Sugimachi K. The clinical significance of p53 gene mutation in hepatocellular carcinomas from Japan. Hepatology. 22:1995;1702-1707.
    • (1995) Hepatology , vol.22 , pp. 1702-1707
    • Hayashi, H.1    Sugio, K.2    Matsumata, T.3    Adachi, E.4    Tanaka, K.5    Sugimachi, K.6
  • 60
    • 0027436854 scopus 로고
    • The mutation of codon 249 in the p53 gene is not specific in Japanese hepatocellular carcinoma
    • Hayashi H., Sugio K., Matsumata T., Adachi E., Urata K., Tanaka S., Sugimachi K. The mutation of codon 249 in the p53 gene is not specific in Japanese hepatocellular carcinoma. Liver. 13:1993;279-281.
    • (1993) Liver , vol.13 , pp. 279-281
    • Hayashi, H.1    Sugio, K.2    Matsumata, T.3    Adachi, E.4    Urata, K.5    Tanaka, S.6    Sugimachi, K.7
  • 64
    • 0026022059 scopus 로고
    • Molecular analysis of the p53 alleles in primary hepatocellular carcinoma and cell lines
    • Hosono S., Lee C.S., Chou M.J., Yang C.S., Shih C. Molecular analysis of the p53 alleles in primary hepatocellular carcinoma and cell lines. Oncogene. 6:1991;237-248.
    • (1991) Oncogene , vol.6 , pp. 237-248
    • Hosono, S.1    Lee, C.S.2    Chou, M.J.3    Yang, C.S.4    Shih, C.5
  • 65
    • 0027510125 scopus 로고
    • Infrequent mutation of p53 gene in hepatitis B virus positive primary hepatocellular carcinomas
    • Hosono S., Chou M.J., Lee C.S., Shih C. Infrequent mutation of p53 gene in hepatitis B virus positive primary hepatocellular carcinomas. Oncogene. 8:1993;491-496.
    • (1993) Oncogene , vol.8 , pp. 491-496
    • Hosono, S.1    Chou, M.J.2    Lee, C.S.3    Shih, C.4
  • 67
    • 0028997943 scopus 로고
    • Recent aflatoxin exposure and mutation at codon 249 of the human p53 gene: Lack of association
    • Hsieh D.P., Atkinson D.N. Recent aflatoxin exposure and mutation at codon 249 of the human p53 gene: lack of association. Food Addit. Contam. 12:1995;421-424.
    • (1995) Food Addit. Contam. , vol.12 , pp. 421-424
    • Hsieh, D.P.1    Atkinson, D.N.2
  • 68
    • 0027483964 scopus 로고
    • Expression of p53 gene in 184 unifocal hepatocellular carcinomas: Association with tumor growth and invasiveness
    • Hsu H.C., Tseng H.J., Lai P.L., Lee P.H., Peng S.Y. Expression of p53 gene in 184 unifocal hepatocellular carcinomas: association with tumor growth and invasiveness. Cancer Res. 53:1993a;4691-4694.
    • (1993) Cancer Res. , vol.53 , pp. 4691-4694
    • Hsu, H.C.1    Tseng, H.J.2    Lai, P.L.3    Lee, P.H.4    Peng, S.Y.5
  • 69
    • 0025732215 scopus 로고
    • Mutational hotspot in the p53 gene in human hepatocellular carcinomas
    • Hsu I.C., Metcalf R.A., Sun T., Welsh J.A., Wang N.J., Harris C.C. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature. 350:1991;427-428.
    • (1991) Nature , vol.350 , pp. 427-428
    • Hsu, I.C.1    Metcalf, R.A.2    Sun, T.3    Welsh, J.A.4    Wang, N.J.5    Harris, C.C.6
  • 70
    • 0027207612 scopus 로고
    • p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines
    • Hsu I.C., Tokiwa T., Bennett W., Metcalf R.A., Welsh J.A., Sun T., Harris C.C. p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines. Carcinogenesis. 14:1993b;987-992.
    • (1993) Carcinogenesis , vol.14 , pp. 987-992
    • Hsu, I.C.1    Tokiwa, T.2    Bennett, W.3    Metcalf, R.A.4    Welsh, J.A.5    Sun, T.6    Harris, C.C.7
  • 71
    • 0027344549 scopus 로고
    • 1-induced rat hepatic hyperplastic nodules do not exhibit a site-specific mutation within the p53 gene
    • 1-induced rat hepatic hyperplastic nodules do not exhibit a site-specific mutation within the p53 gene. Cancer Res. 53:1993;9-11.
    • (1993) Cancer Res. , vol.53 , pp. 9-11
    • Hulla, J.E.1    Chen, Z.Y.2    Eaton, D.L.3
  • 72
    • 0028365709 scopus 로고
    • Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene
    • Hussain S.P., Aguilar F., Amstad P., Cerutti P. Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene. Oncogene. 9:1994;2277-2281.
    • (1994) Oncogene , vol.9 , pp. 2277-2281
    • Hussain, S.P.1    Aguilar, F.2    Amstad, P.3    Cerutti, P.4
  • 75
    • 67649338899 scopus 로고
    • IARC monographs on the evaluation of carcinogenic risks to humans
    • Lyon, France: IARC
    • International Agency for Research on Cancer (IARC). IARC monographs on the evaluation of carcinogenic risks to humans. Hepatitis viruses. Vol. 59:1994;45-255 IARC, Lyon, France.
    • (1994) Hepatitis Viruses , vol.59 , pp. 45-255
  • 77
    • 0026650584 scopus 로고
    • C-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions
    • Kamiya H., Miura K., Ishikawa H., Inoue H., Nishimura S., Ohtsuka E. C-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions. Cancer Res. 52:1992;3483-3485.
    • (1992) Cancer Res. , vol.52 , pp. 3483-3485
    • Kamiya, H.1    Miura, K.2    Ishikawa, H.3    Inoue, H.4    Nishimura, S.5    Ohtsuka, E.6
  • 78
    • 0028944525 scopus 로고
    • 8-Hydroxyguanine(7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene: Effects of sequence contexts on mutation spectra
    • Murata
    • Kamiya H., Murata, Kamiya N., Koizume S., Inoue H., Nishimura S., Ohtsuka E. 8-Hydroxyguanine(7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene: effects of sequence contexts on mutation spectra. Carcinogenesis. 16:1995;883-889.
    • (1995) Carcinogenesis , vol.16 , pp. 883-889
    • Kamiya, H.1    Kamiya, N.2    Koizume, S.3    Inoue, H.4    Nishimura, S.5    Ohtsuka, E.6
  • 79
    • 0027185250 scopus 로고
    • Mutation at codon 249 of p53 gene in a human hepatoblastoma
    • Kar S., Jaffe R., Carr B.I. Mutation at codon 249 of p53 gene in a human hepatoblastoma. Hepatology. 18:1993;566-569.
    • (1993) Hepatology , vol.18 , pp. 566-569
    • Kar, S.1    Jaffe, R.2    Carr, B.I.3
  • 80
    • 0028205042 scopus 로고
    • Salmonella typhimurium strain TA100 differentiates several classes of carcinogens and mutagens by base substitution specificity
    • Koch W.H., Henrikson E.N., Kupchella E., Cebula T.A. Salmonella typhimurium strain TA100 differentiates several classes of carcinogens and mutagens by base substitution specificity. Carcinogenesis. 15:1994;79-88.
    • (1994) Carcinogenesis , vol.15 , pp. 79-88
    • Koch, W.H.1    Henrikson, E.N.2    Kupchella, E.3    Cebula, T.A.4
  • 83
    • 0018769971 scopus 로고
    • Simian vireus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum
    • Kress M., May E., Cassingena R., May P. Simian vireus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum. J. Virol. 31:1979;472-483.
    • (1979) J. Virol. , vol.31 , pp. 472-483
    • Kress, M.1    May, E.2    Cassingena, R.3    May, P.4
  • 84
  • 85
    • 0023647116 scopus 로고
    • Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues
    • Kuchino Y., Mori F., Kasai H., Inoue H., Iwai S., Miura K., Ohtsuka E., Nishimura S. Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature. 327:1987;77-79.
    • (1987) Nature , vol.327 , pp. 77-79
    • Kuchino, Y.1    Mori, F.2    Kasai, H.3    Inoue, H.4    Iwai, S.5    Miura, K.6    Ohtsuka, E.7    Nishimura, S.8
  • 86
    • 0018348655 scopus 로고
    • T antigen is bound to a host protein in SV40-transformed cells
    • Lane D.P., Crawford L.V. T antigen is bound to a host protein in SV40-transformed cells. Nature. 278:1979;261-263.
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 87
    • 0026497325 scopus 로고
    • Overexpression of p53 : A rare event in a large series of white patients with hepatocellular carcinoma
    • Laurent-Puig P., Flejou J.F., Fabre M., Bedossa P., Belghiti J., Gayral F., Franco D. Overexpression of p53 : a rare event in a large series of white patients with hepatocellular carcinoma. Hepatology. 16:1992;1171-1175.
    • (1992) Hepatology , vol.16 , pp. 1171-1175
    • Laurent-Puig, P.1    Flejou, J.F.2    Fabre, M.3    Bedossa, P.4    Belghiti, J.5    Gayral, F.6    Franco, D.7
  • 88
    • 84969103377 scopus 로고
    • Mutational spectra of protooncogenes and tumor suppressor genes: Clues in predicting cancer etiology
    • K. et al. Hemminki. Lyon: International Agency for Research on Cancer IARC Scientific Publications No. 125.
    • Lehman T.A., Harris C.C. Mutational spectra of protooncogenes and tumor suppressor genes: clues in predicting cancer etiology. Hemminki K., et al. DNA Adducts: identification and biological significance. IARC Scientific Publications No. 125. 1994;139-412 International Agency for Research on Cancer, Lyon.
    • (1994) DNA Adducts: Identification and Biological Significance , pp. 139-412
    • Lehman, T.A.1    Harris, C.C.2
  • 89
    • 0028983193 scopus 로고
    • Analysis of ras gene mutations in hepatocellular carcinoma in southern African blacks
    • Leon M., Kew M.C. Analysis of ras gene mutations in hepatocellular carcinoma in southern African blacks. Anticancer Res. 15:1995;859-861.
    • (1995) Anticancer Res. , vol.15 , pp. 859-861
    • Leon, M.1    Kew, M.C.2
  • 90
    • 0025876591 scopus 로고
    • The p53 tumor suppressor gene
    • Levin A.J., Momand J., Finlay C.A. The p53 tumor suppressor gene. Nature. 351:1991;453-456.
    • (1991) Nature , vol.351 , pp. 453-456
    • Levin, A.J.1    Momand, J.2    Finlay, C.A.3
  • 91
    • 0026698102 scopus 로고
    • 1-induced mutations in a plasmid replicated in xeroderma pigmentosum and DNA repair proficient human cells
    • 1-induced mutations in a plasmid replicated in xeroderma pigmentosum and DNA repair proficient human cells. Cancer Res. 52:1992;5668-5673.
    • (1992) Cancer Res. , vol.52 , pp. 5668-5673
    • Levy, D.D.1    Groopman, J.D.2    Lim, S.E.3    Seidman, M.M.4    Kraemer, K.H.5
  • 92
    • 0027210367 scopus 로고
    • Aberrations of p53 gene in human hepatocellular carcinoma from China
    • Li D., Cao Y., He L., Wang N.J., Gu J.R. Aberrations of p53 gene in human hepatocellular carcinoma from China. Carcinogenesis. 14:1993;169-173.
    • (1993) Carcinogenesis , vol.14 , pp. 169-173
    • Li, D.1    Cao, Y.2    He, L.3    Wang, N.J.4    Gu, J.R.5
  • 95
    • 0017716393 scopus 로고
    • 1-DNA or -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo
    • 1-DNA or -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo. Cancer Res. 37:1977;4430-4438.
    • (1977) Cancer Res. , vol.37 , pp. 4430-4438
    • Lin, J.K.1    Miller, J.A.2    Miller, E.C.3
  • 96
    • 0018760324 scopus 로고
    • Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
    • Linzer I.H., Levine A.J. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell. 17:1979;43-52.
    • (1979) Cell , vol.17 , pp. 43-52
    • Linzer, I.H.1    Levine, A.J.2
  • 101
    • 0023371229 scopus 로고
    • Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors
    • McMahon G., Davis E., Wogan G.N. Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors. Proc. Natl. Acad. Sci. USA. 84:1987;4974-4978.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 4974-4978
    • McMahon, G.1    Davis, E.2    Wogan, G.N.3
  • 104
    • 0021095495 scopus 로고
    • Covalent and noncovalent interaction of aflatoxin with defined deoxyribonucleic acid sequences
    • Misra R.P., Muench K.F., Humayun M.Z. Covalent and noncovalent interaction of aflatoxin with defined deoxyribonucleic acid sequences. Biochemistry. 22:1983;3351-3359.
    • (1983) Biochemistry , vol.22 , pp. 3351-3359
    • Misra, R.P.1    Muench, K.F.2    Humayun, M.Z.3
  • 105
    • 0027399969 scopus 로고
    • Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted GC → TA transversions in simian kidney cells
    • Moriya M. Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted GC → TA transversions in simian kidney cells. Proc. Natl. Acad. Sci. USA. 90:1993;1122-1126.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1122-1126
    • Moriya, M.1
  • 106
    • 0025802822 scopus 로고
    • Site-specific mutagenesis using a gapped duplex vector: A study of translation synthesis past 8-oxodeoxyguanosine in E. coli
    • Moriya M., Ou C., Bodepudi V., Johnson F., Takeshita M., Grollma A.P. Site-specific mutagenesis using a gapped duplex vector: a study of translation synthesis past 8-oxodeoxyguanosine in E. coli. Mutation Res. 254:1991;281-288.
    • (1991) Mutation Res. , vol.254 , pp. 281-288
    • Moriya, M.1    Ou, C.2    Bodepudi, V.3    Johnson, F.4    Takeshita, M.5    Grollma, A.P.6
  • 108
    • 0026041836 scopus 로고
    • Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas
    • Murakami Y., Hayashi K., Hirohashi S., Sekiya T. Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas. Cancer Res. 51:1991;5520-5525.
    • (1991) Cancer Res. , vol.51 , pp. 5520-5525
    • Murakami, Y.1    Hayashi, K.2    Hirohashi, S.3    Sekiya, T.4
  • 109
    • 0028906781 scopus 로고
    • Immunohistochemical detection of aberrant p53 expression in hepatocellular carcinoma: Correlation with cell proliferative activity indices, including mitotic index and MIB 1 immunostaining
    • Nagao T., Kondo F., Sato T., Nagato Y., Kondo Y. Immunohistochemical detection of aberrant p53 expression in hepatocellular carcinoma: correlation with cell proliferative activity indices, including mitotic index and MIB 1 immunostaining. Hum. Pathol. 26:1995;326-333.
    • (1995) Hum. Pathol. , vol.26 , pp. 326-333
    • Nagao, T.1    Kondo, F.2    Sato, T.3    Nagato, Y.4    Kondo, Y.5
  • 110
    • 0028226101 scopus 로고
    • Overexpression and point mutations of p53 tumor suppressor gene in hepatocellular carcinomas in Hong Kong Chinese people
    • Ng I.O., Srivastava G., Chung L.P., Tsang S.W., Ng M.M. Overexpression and point mutations of p53 tumor suppressor gene in hepatocellular carcinomas in Hong Kong Chinese people. Cancer. 74:1994a;30-37.
    • (1994) Cancer , vol.74 , pp. 30-37
    • Ng, I.O.1    Srivastava, G.2    Chung, L.P.3    Tsang, S.W.4    Ng, M.M.5
  • 111
    • 0028123801 scopus 로고
    • p53 gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese
    • Ng I.O., Chung L.P., Tsang S.W., Lam C.L., Lai E.C., Fan S.T., Ng M. p53 gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese. Oncogene. 9:1994b;985-990.
    • (1994) Oncogene , vol.9 , pp. 985-990
    • Ng, I.O.1    Chung, L.P.2    Tsang, S.W.3    Lam, C.L.4    Lai, E.C.5    Fan, S.T.6    Ng, M.7
  • 113
    • 0027243142 scopus 로고
    • p53 gene mutations and 17p allelic deletions in hepatocellular carcinoma from Japan
    • Nose H., Imazeki F., Ohto M., Omata M. p53 gene mutations and 17p allelic deletions in hepatocellular carcinoma from Japan. Cancer. 72:1993;355-360.
    • (1993) Cancer , vol.72 , pp. 355-360
    • Nose, H.1    Imazeki, F.2    Ohto, M.3    Omata, M.4
  • 115
    • 0026080914 scopus 로고
    • Point mutation, allelic loss and increased methylation of c-Ha-ras gene in human hepatocellular carcinoma
    • Ogata N., Kamimura T., Asakura H. Point mutation, allelic loss and increased methylation of c-Ha-ras gene in human hepatocellular carcinoma. Hepatology. 13:1991;31-37.
    • (1991) Hepatology , vol.13 , pp. 31-37
    • Ogata, N.1    Kamimura, T.2    Asakura, H.3
  • 116
    • 0028909746 scopus 로고
    • p53 immunoreactivity in hepatocellular adenoma, focal nodular hyperplasia, cirrhosis and hepatocellular carcinoma
    • Ojanguren I., Ariza A., Castella E.M., Vasalo A. Fernandez, Mate J.L., Palacios J.J. Navas. p53 immunoreactivity in hepatocellular adenoma, focal nodular hyperplasia, cirrhosis and hepatocellular carcinoma. Histopathology. 26:1995;63-68.
    • (1995) Histopathology , vol.26 , pp. 63-68
    • Ojanguren, I.1    Ariza, A.2    Castella, E.M.3    Vasalo, A.F.4    Mate, J.L.5    Palacios, J.J.N.6
  • 117
    • 0028928354 scopus 로고
    • p53 mutations in nonmalignant human liver: Fingerprints of aflatoxins?
    • Ozturk M. p53 mutations in nonmalignant human liver: fingerprints of aflatoxins? Hepatology. 21:1995;600-601.
    • (1995) Hepatology , vol.21 , pp. 600-601
    • Ozturk, M.1
  • 118
    • 0025748539 scopus 로고
    • p53 mutation in hepatocellular carcinoma after aflatoxin exposure
    • Ozturk M., et al. p53 mutation in hepatocellular carcinoma after aflatoxin exposure. Lancet. 338:1991;1356-1359.
    • (1991) Lancet , vol.338 , pp. 1356-1359
    • Ozturk, M.1
  • 119
    • 0027111365 scopus 로고
    • p53 Codon -249 (ser) mutations in hepatocellular carcinoma patients with low aflatoxin exposure
    • Patel P., Stephenson J., Scheuer P.J., Francis G.E. p53 Codon -249 (ser) mutations in hepatocellular carcinoma patients with low aflatoxin exposure. Lancet. 339:1992;881.
    • (1992) Lancet , vol.339 , pp. 881
    • Patel, P.1    Stephenson, J.2    Scheuer, P.J.3    Francis, G.E.4
  • 120
    • 0026356298 scopus 로고
    • Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens
    • Puisieux A., Lim S., Groopman J., Ozturk M. Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res. 51:1991;6185-6189.
    • (1991) Cancer Res. , vol.51 , pp. 6185-6189
    • Puisieux, A.1    Lim, S.2    Groopman, J.3    Ozturk, M.4
  • 121
    • 0027986684 scopus 로고
    • State of the p53 gene in hepatocellular carcinomas of ground squirrels and woodchucks with past and ongoing infection with hepadnaviruses
    • Rivkina M.B., Cullen J.M., Robinson W.S., Marion P.L. State of the p53 gene in hepatocellular carcinomas of ground squirrels and woodchucks with past and ongoing infection with hepadnaviruses. Cancer Res. 54:1994;5430-5437.
    • (1994) Cancer Res. , vol.54 , pp. 5430-5437
    • Rivkina, M.B.1    Cullen, J.M.2    Robinson, W.S.3    Marion, P.L.4
  • 122
    • 0028306247 scopus 로고
    • Molecular events in the pathogenesis of hepadnavirus-associated hepatocellular carcinoma
    • Robinson W.S. Molecular events in the pathogenesis of hepadnavirus-associated hepatocellular carcinoma. Annu. Rev. Med. 45:1994;297-323.
    • (1994) Annu. Rev. Med. , vol.45 , pp. 297-323
    • Robinson, W.S.1
  • 124
    • 0027427539 scopus 로고
    • Comparative analysis of p53 and c-myc expression and cell proliferation in human hepatocellular carcinomas an enhanced immunohistochemical approach
    • Saegusa M., Takano Y., Kishimoto H., Wakabayashi G., Nohga K., Okudaira M. Comparative analysis of p53 and c-myc expression and cell proliferation in human hepatocellular carcinomas an enhanced immunohistochemical approach. J. Cancer Res. Clin. Oncol. 119:1993;737-744.
    • (1993) J. Cancer Res. Clin. Oncol. , vol.119 , pp. 737-744
    • Saegusa, M.1    Takano, Y.2    Kishimoto, H.3    Wakabayashi, G.4    Nohga, K.5    Okudaira, M.6
  • 128
    • 0026518760 scopus 로고
    • p53 Mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinoma from China
    • Scorsone K.A., Zhou Y.Z., Butel J.S., Slagle B.L. p53 Mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinoma from China. Cancer Res. 52:1992;1635-1638.
    • (1992) Cancer Res. , vol.52 , pp. 1635-1638
    • Scorsone, K.A.1    Zhou, Y.Z.2    Butel, J.S.3    Slagle, B.L.4
  • 129
    • 5344273523 scopus 로고
    • Dietary aflatoxins and human liver cancer. III. Field survey of rural Thai families for ingested aflatoxins
    • Shank R.C., Gordon J.E., Wogan G.N., Nondasuta A., Subhamani B. Dietary aflatoxins and human liver cancer. III. Field survey of rural Thai families for ingested aflatoxins. Food Cosmet. Toxicol. 10:1972;71-84.
    • (1972) Food Cosmet. Toxicol. , vol.10 , pp. 71-84
    • Shank, R.C.1    Gordon, J.E.2    Wogan, G.N.3    Nondasuta, A.4    Subhamani, B.5
  • 134
    • 0029005157 scopus 로고
    • Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore
    • Shi C.Y., Phang T.W., Lin Y., Wee A., Li B., Lee H.P., Ong C.N. Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore. Br. J. Cancer. 72:1995;146-149.
    • (1995) Br. J. Cancer , vol.72 , pp. 146-149
    • Shi, C.Y.1    Phang, T.W.2    Lin, Y.3    Wee, A.4    Li, B.5    Lee, H.P.6    Ong, C.N.7
  • 135
    • 0025981359 scopus 로고
    • Insertion of specific bases during DNA synthesis past the oxidation damaged base 8-oxodG
    • Shibutani S., Takeshita M., Grollman A.P. Insertion of specific bases during DNA synthesis past the oxidation damaged base 8-oxodG. Nature. 349:1991;431-434.
    • (1991) Nature , vol.349 , pp. 431-434
    • Shibutani, S.1    Takeshita, M.2    Grollman, A.P.3
  • 136
    • 0027196416 scopus 로고
    • Tumor suppressor p53 gene in hepatitis C and B virus associated human hepatocellular carcinoma
    • Shieh Y.S., Nguyen C., Vocal M.V., Chu H.W. Tumor suppressor p53 gene in hepatitis C and B virus associated human hepatocellular carcinoma. Int. J. Cancer. 54:1993;558-562.
    • (1993) Int. J. Cancer , vol.54 , pp. 558-562
    • Shieh, Y.S.1    Nguyen, C.2    Vocal, M.V.3    Chu, H.W.4
  • 138
    • 0026089373 scopus 로고
    • Hepatitis B virus integration event in human chromosome 17q near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas
    • Slagle B.L., Zhou Y.Z., Butel J.S. Hepatitis B virus integration event in human chromosome 17q near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas. Cancer Res. 51:1991;49-54.
    • (1991) Cancer Res. , vol.51 , pp. 49-54
    • Slagle, B.L.1    Zhou, Y.Z.2    Butel, J.S.3
  • 139
    • 0027409774 scopus 로고
    • 1-induced hepatocellular carcinoma and adenoma in the rat: Detection by denaturing gradient get electrophoresis
    • 1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient get electrophoresis. Proc. Natl. Acad. Sci. USA. 90:1993;2045-2049.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2045-2049
    • Soman, N.R.1    Wogan, G.N.2
  • 140
    • 0025375355 scopus 로고
    • Structural aspects of the p53 protein in relation to gene evolution
    • Soussi T., de Fromentel C. Carton, May P. Structural aspects of the p53 protein in relation to gene evolution. Oncogene. 5:1990;945-952.
    • (1990) Oncogene , vol.5 , pp. 945-952
    • Soussi, T.1    De Fromentel, C.C.2    May, P.3
  • 141
    • 0025804315 scopus 로고
    • Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction
    • Stork P., Loda M., Bosari S., Wiley B., Poppenhusen K., Wolfe H. Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction. Oncogene. 6:1991;857-862.
    • (1991) Oncogene , vol.6 , pp. 857-862
    • Stork, P.1    Loda, M.2    Bosari, S.3    Wiley, B.4    Poppenhusen, K.5    Wolfe, H.6
  • 142
    • 0021227417 scopus 로고
    • Carcinogenesis and prevention strategy of liver cancer in areas in prevalence
    • Sun T.T., Chu Y.Y. Carcinogenesis and prevention strategy of liver cancer in areas in prevalence. J. Cell. Physiol. 3:(Suppl.):1984;38-44.
    • (1984) J. Cell. Physiol. , vol.3 , Issue.SUPPL. , pp. 38-44
    • Sun, T.T.1    Chu, Y.Y.2
  • 143
    • 0025169651 scopus 로고
    • Analysis of ras gene mutations in human hepatocellular malignant tumors by polymerase chain reaction and direct sequencing
    • Tada M., Omata M., Ohto M. Analysis of ras gene mutations in human hepatocellular malignant tumors by polymerase chain reaction and direct sequencing. Cancer Res. 50:1990;1121-1124.
    • (1990) Cancer Res. , vol.50 , pp. 1121-1124
    • Tada, M.1    Omata, M.2    Ohto, M.3
  • 144
    • 0027241524 scopus 로고
    • Tumor progression in hepatocellular carcinoma may be mediated by p53 mutation
    • Tanaka S., Toh Y., Adachi E., Matsumata T., Mori R., Sugimachi K. Tumor progression in hepatocellular carcinoma may be mediated by p53 mutation. Cancer Res. 53:1993;2884-2887.
    • (1993) Cancer Res. , vol.53 , pp. 2884-2887
    • Tanaka, S.1    Toh, Y.2    Adachi, E.3    Matsumata, T.4    Mori, R.5    Sugimachi, K.6
  • 146
    • 0028180458 scopus 로고
    • p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis
    • Teramoto T., Satonaka K., Kitazawa S., Fujimori T., Hayashi K., Maeda S. p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis. Cancer Res. 54:1994;231-235.
    • (1994) Cancer Res. , vol.54 , pp. 231-235
    • Teramoto, T.1    Satonaka, K.2    Kitazawa, S.3    Fujimori, T.4    Hayashi, K.5    Maeda, S.6
  • 147
    • 0024363702 scopus 로고
    • Expression of ras and myc oncogenes in human hepatocellular carcinoma and non-neoplastic liver tissues
    • Tiniakos D., Spandidos D.A., Kakkanas A., Pintzas A., Pollice L., Tiniakos G. Expression of ras and myc oncogenes in human hepatocellular carcinoma and non-neoplastic liver tissues. Anticancer Res. 9:1989;715-722.
    • (1989) Anticancer Res. , vol.9 , pp. 715-722
    • Tiniakos, D.1    Spandidos, D.A.2    Kakkanas, A.3    Pintzas, A.4    Pollice, L.5    Tiniakos, G.6
  • 148
    • 0028287495 scopus 로고
    • Absence of p53 mutations and various frequencies of Ki-ras exon 1 mutations in rat hepatic tumors induced by different carcinogens
    • Tokusashi Y., Fukuda I., Ogawa K. Absence of p53 mutations and various frequencies of Ki-ras exon 1 mutations in rat hepatic tumors induced by different carcinogens. Mol. Carcinogen. 10:1994;45-51.
    • (1994) Mol. Carcinogen. , vol.10 , pp. 45-51
    • Tokusashi, Y.1    Fukuda, I.2    Ogawa, K.3
  • 149
    • 0026657434 scopus 로고
    • 1 in a shuttle vector replicating in human cells transiently expressing cytochrome-P450 1A2 cDNA
    • 1 in a shuttle vector replicating in human cells transiently expressing cytochrome-P450 1A2 cDNA. Mol. Carcinogen. 6:1992;147-148.
    • (1992) Mol. Carcinogen. , vol.6 , pp. 147-148
    • Trottier, Y.1    Waithe, W.I.2    Anderson, A.3
  • 151
    • 0024801490 scopus 로고
    • Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma
    • Tsuda H., Hirohashi S., Shimosato Y., Ino Y., Yoshida T., Terada M. Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma. Jpn. J. Cancer Res. 80:1989;196-199.
    • (1989) Jpn. J. Cancer Res. , vol.80 , pp. 196-199
    • Tsuda, H.1    Hirohashi, S.2    Shimosato, Y.3    Ino, Y.4    Yoshida, T.5    Terada, M.6
  • 155
    • 0028029126 scopus 로고
    • p53 Overexpression is frequent in European hepatocellular carcinoma and largely independent of the codon 249 hot spot mutation
    • Volkmann M., Hofmann W.J., Muller M., Rath U., Otto G., Zentgraf H., Galle P.R. p53 Overexpression is frequent in European hepatocellular carcinoma and largely independent of the codon 249 hot spot mutation. Oncogene. 9:1994;195-204.
    • (1994) Oncogene , vol.9 , pp. 195-204
    • Volkmann, M.1    Hofmann, W.J.2    Muller, M.3    Rath, U.4    Otto, G.5    Zentgraf, H.6    Galle, P.R.7
  • 156
    • 0028946119 scopus 로고
    • p53 expression in hepatocellular carcinoma in a population in Singapore with endemic hepatitis B virus infection
    • Wee A., Teh M., Raju G.C. p53 expression in hepatocellular carcinoma in a population in Singapore with endemic hepatitis B virus infection. J. Clin. Pathol. 48:1995;236-238.
    • (1995) J. Clin. Pathol. , vol.48 , pp. 236-238
    • Wee, A.1    Teh, M.2    Raju, G.C.3
  • 157
    • 0025139784 scopus 로고
    • Evaluation of methods for quantitation of aflatoxin-albumin adducts and their application to human exposure assessment
    • Wild C.P., Jiang Y.Z., Sabbioni G., Chpot B., Montesano R. Evaluation of methods for quantitation of aflatoxin-albumin adducts and their application to human exposure assessment. Cancer Res. 50:1990;245-251.
    • (1990) Cancer Res. , vol.50 , pp. 245-251
    • Wild, C.P.1    Jiang, Y.Z.2    Sabbioni, G.3    Chpot, B.4    Montesano, R.5
  • 158
    • 0026525527 scopus 로고
    • Aflatoxins as risk factors for hepatocellular carcinoma in humans
    • Wogan G.N. Aflatoxins as risk factors for hepatocellular carcinoma in humans. Cancer Res. 52:1992;2114s-2118s.
    • (1992) Cancer Res. , vol.52
    • Wogan, G.N.1
  • 159
    • 0025334691 scopus 로고
    • Mechanistic studies of ionizing radiation and oxidative mutagenesis: Genetic effects of a single 8-hydroguanine(7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome
    • Wood M.L., Dizdaroglu M., Gajewski E., Essigmann J.M. Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroguanine(7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry. 29:1990;7024-7032.
    • (1990) Biochemistry , vol.29 , pp. 7024-7032
    • Wood, M.L.1    Dizdaroglu, M.2    Gajewski, E.3    Essigmann, J.M.4
  • 160
    • 0027479511 scopus 로고
    • p53 codon 249ser hot-spot mutation in HBV-negative hepatocellular carcinoma
    • Yap E.P., Cooper K., Maharaj B., McGee J.O. p53 codon 249ser hot-spot mutation in HBV-negative hepatocellular carcinoma. Lancet. 341:1993;251.
    • (1993) Lancet , vol.341 , pp. 251
    • Yap, E.P.1    Cooper, K.2    Maharaj, B.3    McGee, J.O.4
  • 161
    • 0024550770 scopus 로고
    • Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi
    • Yeh F.S., Yu M., Mo C.C., Luo S., Tong M.J., Henderson B.E. Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi. China. Cancer Res. 49:1989;2506-2509.
    • (1989) China. Cancer Res. , vol.49 , pp. 2506-2509
    • Yeh, F.S.1    Yu, M.2    Mo, C.C.3    Luo, S.4    Tong, M.J.5    Henderson, B.E.6
  • 164
    • 0023720932 scopus 로고
    • Structural analysis of a hepatitis B virus genome integrated into chromosome 17q of a human hepatocellular carcinoma
    • Zhou Y.Z., Slagle B.L., Donehower L.A., van Tuinen P., Ledbetter D.H., Butel J.S. Structural analysis of a hepatitis B virus genome integrated into chromosome 17q of a human hepatocellular carcinoma. J. Virol. 62:1988;4224-4231.
    • (1988) J. Virol. , vol.62 , pp. 4224-4231
    • Zhou, Y.Z.1    Slagle, B.L.2    Donehower, L.A.3    Van Tuinen, P.4    Ledbetter, D.H.5    Butel, J.S.6
  • 165
    • 0027605820 scopus 로고
    • Hepatitis B X antigen binding to p53 protein in the pathogenesis of primary hepatocellular carcinoma (abstract)
    • Zhu M.H. Hepatitis B X antigen binding to p53 protein in the pathogenesis of primary hepatocellular carcinoma (abstract). Chung Hua I Hsueh Tsa Chih. 73:1993a;325-328.
    • (1993) Chung Hua I Hsueh Tsa Chih , vol.73 , pp. 325-328
    • Zhu, M.H.1
  • 166
    • 0027815639 scopus 로고
    • Relationship between mutation of tumor suppressor gene p53 and development of hepatocellular carcinoma (abstract)
    • Zhu M.H. Relationship between mutation of tumor suppressor gene p53 and development of hepatocellular carcinoma (abstract). Chung Hua Chung Liu Tsa Chih. 15:1993b;245-247.
    • (1993) Chung Hua Chung Liu Tsa Chih , vol.15 , pp. 245-247
    • Zhu, M.H.1
  • 167
    • 0028491273 scopus 로고
    • Mutation of p53 gene and expression of alpha-fetoprotein during hepatocarcinogenesis (abstract)
    • Zou H.Q., Tang Z.Y., Ye S.L. Mutation of p53 gene and expression of alpha-fetoprotein during hepatocarcinogenesis (abstract). Chung Hua I Hsueh Tsa Chih. 74:1994;474-475.
    • (1994) Chung Hua I Hsueh Tsa Chih , vol.74 , pp. 474-475
    • Zou, H.Q.1    Tang, Z.Y.2    Ye, S.L.3


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