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Volumn 76, Issue 4, 2000, Pages 572-584

Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus

Author keywords

Apoptosis; Li Fraumeni syndrome; Tetramerization; Transactivation

Indexed keywords

PROTEIN P53;

EID: 0033973807     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(20000315)76:4<572::AID-JCB6>3.0.CO;2-6     Document Type: Article
Times cited : (21)

References (42)
  • 1
    • 0030013337 scopus 로고    scopus 로고
    • Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis
    • Attardi LD, Lowe SW, Brugarolas J, Jacks T. 1996. Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J 15:3693-3701.
    • (1996) EMBO J , vol.15 , pp. 3693-3701
    • Attardi, L.D.1    Lowe, S.W.2    Brugarolas, J.3    Jacks, T.4
  • 2
    • 0344267643 scopus 로고    scopus 로고
    • p53 mutants without a functional tetramerization domain are not oncogenic
    • Chene P. 1999. p53 mutants without a functional tetramerization domain are not oncogenic. J Mol Biol 286:1269-1274.
    • (1999) J Mol Biol , vol.286 , pp. 1269-1274
    • Chene, P.1
  • 5
    • 0028131554 scopus 로고
    • Transcriptional activation by p53 correlates with suppression of growth but not transformation
    • Crook T, Marston NJ, Sara EA, Vousden KH. 1994. Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell 79:817-827.
    • (1994) Cell , vol.79 , pp. 817-827
    • Crook, T.1    Marston, N.J.2    Sara, E.A.3    Vousden, K.H.4
  • 6
    • 0032490855 scopus 로고    scopus 로고
    • Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome
    • Davison TS, Yin P, Nie E, Kay C, Arrowsmith CH. 1998. Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome. Oncogene 17:651-656.
    • (1998) Oncogene , vol.17 , pp. 651-656
    • Davison, T.S.1    Yin, P.2    Nie, E.3    Kay, C.4    Arrowsmith, C.H.5
  • 7
    • 0029980043 scopus 로고    scopus 로고
    • p53 in growth control and neoplasia
    • Gottlieb TM, Oren M. 1996. p53 in growth control and neoplasia. Biochim Biophys Acta 1287:77-102.
    • (1996) Biochim Biophys Acta , vol.1287 , pp. 77-102
    • Gottlieb, T.M.1    Oren, M.2
  • 8
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • Gu W, Roeder RG. 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595-606.
    • (1997) Cell , vol.90 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 9
    • 0028830748 scopus 로고
    • Modulation by copper of p53 conformation and sequence-specific DNA binding: Role for Cu(II)/Cu(I) redox mechanism
    • Hainaut P, Rolley N, Davies M, Milner J. 1995. Modulation by copper of p53 conformation and sequence-specific DNA binding: role for Cu(II)/Cu(I) redox mechanism. Oncogene 10:27-32.
    • (1995) Oncogene , vol.10 , pp. 27-32
    • Hainaut, P.1    Rolley, N.2    Davies, M.3    Milner, J.4
  • 10
    • 0028804617 scopus 로고
    • Structural and kinetic analysis of p53-DNA complexes and comparison of human and murine p53
    • Hall AR, Milner J. 1995. Structural and kinetic analysis of p53-DNA complexes and comparison of human and murine p53. Oncogene 10:561-567.
    • (1995) Oncogene , vol.10 , pp. 561-567
    • Hall, A.R.1    Milner, J.2
  • 11
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 13
    • 0026448672 scopus 로고
    • Regulation of the specific DNA binding function of p53
    • Hupp TR, Meek DW, Midgley CA, Lane DP. 1992. Regulation of the specific DNA binding function of p53. Cell 71:875-886.
    • (1992) Cell , vol.71 , pp. 875-886
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 14
    • 0027250493 scopus 로고
    • Activation of the cryptic DNA binding function of mutant forms of p53
    • Hupp TR, Meek DW, Midgley CA, Lane DP. 1993. Activation of the cryptic DNA binding function of mutant forms of p53. Nucleic Acids Res 21:3167-3174.
    • (1993) Nucleic Acids Res , vol.21 , pp. 3167-3174
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 16
    • 0030877395 scopus 로고    scopus 로고
    • Functional dissection of p53 tumor suppressor protein
    • Jayaraman L, Freulich E, Prives C. 1997. Functional dissection of p53 tumor suppressor protein. Methods Enzymol 283:245-256.
    • (1997) Methods Enzymol , vol.283 , pp. 245-256
    • Jayaraman, L.1    Freulich, E.2    Prives, C.3
  • 17
    • 0028952841 scopus 로고
    • Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7
    • Jeffrey PD, Gorina S, Pavletich NP. 1995. Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 Angstroms. Science 267:1498-1502.
    • (1995) Angstroms. Science , vol.267 , pp. 1498-1502
    • Jeffrey, P.D.1    Gorina, S.2    Pavletich, N.P.3
  • 20
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 21
    • 0030298294 scopus 로고    scopus 로고
    • Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death
    • Liu Z, Hsu H, Goeddel DV, Karin M. 1996. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87:565-576.
    • (1996) Cell , vol.87 , pp. 565-576
    • Liu, Z.1    Hsu, H.2    Goeddel, D.V.3    Karin, M.4
  • 22
    • 0030926817 scopus 로고    scopus 로고
    • Two functional assays employed to detect an unusual mutation in the oligomerization domain of p53 in a Li-Fraumeni-like family
    • Lomax ME, Barnes DM, Gilchrist R, Picksley S, Varley JG, Camplejohn RS. 1997. Two functional assays employed to detect an unusual mutation in the oligomerization domain of p53 in a Li-Fraumeni-like family. Oncogene 14: 1869-1874.
    • (1997) Oncogene , vol.14 , pp. 1869-1874
    • Lomax, M.E.1    Barnes, D.M.2    Gilchrist, R.3    Picksley, S.4    Varley, J.G.5    Camplejohn, R.S.6
  • 23
    • 0032490875 scopus 로고    scopus 로고
    • Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni-like family members
    • Lomax ME, Barnes DM, Hupp TR, Picksley SM, Camplejohn RS. 1998. Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni-like family members. Oncogene 17:643-649.
    • (1998) Oncogene , vol.17 , pp. 643-649
    • Lomax, M.E.1    Barnes, D.M.2    Hupp, T.R.3    Picksley, S.M.4    Camplejohn, R.S.5
  • 24
    • 0032525133 scopus 로고    scopus 로고
    • Nine hydrophobic side chains are key determinants of the thermodynamic stability and oligomerization status of tumor suppressor p53 tetramerization domain
    • Mateu MG, Fersht AR. 1998. Nine hydrophobic side chains are key determinants of the thermodynamic stability and oligomerization status of tumor suppressor p53 tetramerization domain. EMBO J 17:2748-2758.
    • (1998) EMBO J , vol.17 , pp. 2748-2758
    • Mateu, M.G.1    Fersht, A.R.2
  • 25
    • 0029803281 scopus 로고    scopus 로고
    • Wild-type p53 negatively regulates the expression of a microtubule-associated protein
    • Murphy M, Hinman A, Levine AJ. 1996. Wild-type p53 negatively regulates the expression of a microtubule-associated protein. Genes Dev 10:2971-2980.
    • (1996) Genes Dev , vol.10 , pp. 2971-2980
    • Murphy, M.1    Hinman, A.2    Levine, A.J.3
  • 27
    • 0029126566 scopus 로고
    • The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth
    • Pellegata NS, Cajot JF, Stanbridge EJ. 1995. The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth. Oncogene 11:337-349.
    • (1995) Oncogene , vol.11 , pp. 337-349
    • Pellegata, N.S.1    Cajot, J.F.2    Stanbridge, E.J.3
  • 30
    • 0032475878 scopus 로고    scopus 로고
    • Signaling to p53: Breaking the MDM2-p53 circuit
    • Prives C. 1998. Signaling to p53: Breaking the MDM2-p53 circuit. Cell 95:5-8.
    • (1998) Cell , vol.95 , pp. 5-8
    • Prives, C.1
  • 31
    • 0029891536 scopus 로고    scopus 로고
    • p53 transactivation domain mutant Q22,S23 is impaired for repression of promoters and mediation of apoptosis
    • Roemer K, Mueller-Lantzsch N. 1996. p53 transactivation domain mutant Q22,S23 is impaired for repression of promoters and mediation of apoptosis. Oncogene 12:2069-2079.
    • (1996) Oncogene , vol.12 , pp. 2069-2079
    • Roemer, K.1    Mueller-Lantzsch, N.2
  • 32
    • 0032578694 scopus 로고    scopus 로고
    • Characterization of p53 mutants identified in human tumors with a missense mutation in the tetramerization domain
    • Rollenhagen C, Chene P. 1998. Characterization of p53 mutants identified in human tumors with a missense mutation in the tetramerization domain. Int J Cancer 78:372-376.
    • (1998) Int J Cancer , vol.78 , pp. 372-376
    • Rollenhagen, C.1    Chene, P.2
  • 33
    • 0031806708 scopus 로고    scopus 로고
    • Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest
    • Ryan KM, Vousden KH. 1998. Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest. Mol Cell Biol 18:3692-3698.
    • (1998) Mol Cell Biol , vol.18 , pp. 3692-3698
    • Ryan, K.M.1    Vousden, K.H.2
  • 34
    • 0030798557 scopus 로고    scopus 로고
    • The polyproline region of p53 is required to activate apoptosis but not growth arrest
    • Sakamuro D, Sabbatini P, White E, Prendergast GC. 1997. The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene 15:887-898.
    • (1997) Oncogene , vol.15 , pp. 887-898
    • Sakamuro, D.1    Sabbatini, P.2    White, E.3    Prendergast, G.C.4
  • 35
    • 0032569782 scopus 로고    scopus 로고
    • Regulation of CAK kinase activity by p53
    • Schneider E, Montenarh M, Wagner P. 1998. Regulation of CAK kinase activity by p53. Oncogene 17:2733-2741.
    • (1998) Oncogene , vol.17 , pp. 2733-2741
    • Schneider, E.1    Montenarh, M.2    Wagner, P.3
  • 36
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh S-Y, Ikeda M, Taya Y, Prives C. 1997. DNA damage induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91:325-334.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.-Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 39
    • 0032495575 scopus 로고    scopus 로고
    • Fine mapping and regulation of the association of p53 with p34cdc2
    • Wagner P, Fuchs A, Götz C, Nastainczyk W, Montenarh M. 1998. Fine mapping and regulation of the association of p53 with p34cdc2. Oncogene 16:105-111.
    • (1998) Oncogene , vol.16 , pp. 105-111
    • Wagner, P.1    Fuchs, A.2    Götz, C.3    Nastainczyk, W.4    Montenarh, M.5
  • 41
    • 0028888020 scopus 로고
    • The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding
    • Waterman JLF, Shenk JL, Halazonetis TD. 1995. The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding. EMBO J 14:512-519.
    • (1995) EMBO J , vol.14 , pp. 512-519
    • Waterman, J.L.F.1    Shenk, J.L.2    Halazonetis, T.D.3
  • 42
    • 0031840253 scopus 로고    scopus 로고
    • ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
    • Waterman MJF, Stavridi ES, Waterman JLF, Halazonetis TD. 1998. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nature Genet 19:175-178.
    • (1998) Nature Genet , vol.19 , pp. 175-178
    • Waterman, M.J.F.1    Stavridi, E.S.2    Waterman, J.L.F.3    Halazonetis, T.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.