Pituitary adenomas: Screening for Gαq mutations

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 12, 1997, Pages 4184-4188

  Oyesiku, Nelson M ^a,b   Evans, Chheng Orn ^a   Brown, Milton R ^a   Blevins, Lewis S ^a   Tindall, George T ^a   Parks, John S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; FOLLITROPIN; GUANINE NUCLEOTIDE BINDING PROTEIN; LUTEINIZING HORMONE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DNA SEQUENCE; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; HYPOPHYSIS TUMOR; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0030780227     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.12.4436     Document Type: Article

References (18)

1. Strathmann M, Simon MI. 1990 G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. Proc Natl Acad Sci USA. 87:9113-9117.
2. Aragay AM, Katz A, Simon MI. 1992 The G alpha q and G alpha 11 proteins couple the thyrotropin-releasing hormone receptor to phospholipase C in GH3 rat pituitary cells. J Biol Chem. 267:24983-24988.
3. Hsieh KP, Martin TF. 1992 Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11. Mol Endocrinol. 6:1673-1681.
4. Spada A, Vallar L. 1992 G-protein oncogenes in acromegaly. Horm Res. 38:90-93.
5. Harris PE. 1996 Gs protein mutations and the pathogenesis and Function of pituitary tumors. Metab Clin Exp. 45:120-122.
6. Vallar L. 1996 Oncogenic role of heterotrimeric G proteins. Cancer Surv. 27:325-338.
7. Boothroyd CV, Grimmond SM, Cameron DP, Hayward NK. 1995 G protein mutations in tumours of the pituitary, parathyroid and endocrine pancreas. Biochem Biophys Res Commun. 211:1063-1070.
8. Chabre O. 1994 G-proteins and endocrine tumors. The example of acromegaly. Rev Prat. 44:1177-1183.
9. Clementi E, Malgaretti N, Meldolesi J, Taramelli R. 1990 A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours. Oncogene. 5:1059-1061.
10. Williamson EA, Ince PG, Harrison D, Kendall-Taylor P, Harris PE. 1995 G-protein mutations in human pituitary adrenocorticotrophic hormone-secreting adenomas. Eur J Clin Invest. 25:128-131.
11. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. 1989 GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature. 340:692-696.
12. Williamson EA, Daniels M, Foster S, Kelly WF, Kendall-Taylor P, Harris PE. 1994 Gs alpha and Gi2 alpha mutations in clinically non-functioning pituitary tumours. Clin Endocrinol (Oxf). 41:815-820.
13. Wu DQ, Lee CH, Rhee SG, Simon MI. 1992 Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells, J Biol Chem. 267:1811-1817.
14. Kalinec G, Nazarali AJ, Hermouet S, Xu N, Gutkind JS. 1992 Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells. Mol Cell Biol. 12:4687-4693.
15. Dong Q, Shenker A, Way J, et al. 1995 Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene. Genomics. 30:470-475.
16. Conklin BR, Chabre O, Wong YH, Federman AD, Bourne HR. 1992 Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C. J Biol Chem. 267:31-34.
17. Dong Q, Brucker-Davis F, Weintraub BD, et al. 1996 Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes. J Clin Endocrinol Metab. 81:1134-1140.
18. Katznelson L, Klibanski A. Endocrine-inactive, FH, LH and α-subunit adenomas: clinical findings and endocrinology. In: Landolt A, Vance M, Reilly P, eds. Pituitary adenomas. New York: Churchill Livingstone; 127-138.