PI3K-AKT-mTOR inhibitors for the systemic treatment of endometrial cancer

Expert Review of Obstetrics and Gynecology

Volumn 7, Issue 5, 2012, Pages 421-430

  Church, David N ^a   Koppensteiner, Romana ^b   Yap, Timothy A ^c   Fink, Daniel ^b,d   Dedes, Konstantin J ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c ROYAL MARSDEN HOSPITAL   (United Kingdom)

^d UNIVERSITÄTSSPITAL ZÜRICH   (Switzerland)

Author keywords

AKT mouse models; mTOR inhibitors; PI3KCA; PTEN; targeted treatments; uterine cancers

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 4 [2 (4 AMINO 1,2,5 OXADIAZOL 3 YL) 1 ETHYL 7 (3 PIPERIDINYLMETHOXY) 1H IMIDAZO[4,5 C]PYRIDIN 4 YL] 2 METHYL 3 BUTYN 2 OL; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ANTINEOPLASTIC AGENT; AT 12148; AT 13148; AT 7867; BEVACIZUMAB; BUPARLISIB; CCT 128930; CYTOTOXIC AGENT; EVEROLIMUS; GDC 0980; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PF 04691502; PF 05212384; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; RAPAMYCIN; RAPAMYCIN DERIVATIVE; RIDAFOROLIMUS; TEMSIROLIMUS; TEMSIROLIMUSIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; XL 147;

ADVANCED CANCER; AREA UNDER THE CURVE; CANCER CHEMOTHERAPY; CANCER HORMONE THERAPY; CANCER MODEL; CANCER PROGNOSIS; CHEMOSENSITIVITY; DRUG TARGETING; ENDOMETRIUM CANCER; ENDOMETRIUM TUMOR; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFECT; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FATIGUE; GLIOBLASTOMA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; LYMPHOMA; MAXIMUM PLASMA CONCENTRATION; METASTASIS POTENTIAL; MUCOSA INFLAMMATION; NONHUMAN; PNEUMONIA; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SOLID TUMOR; TREATMENT RESPONSE;

EID: 84867525469     PISSN: 17474108     EISSN: 17474116     Source Type: Journal    
DOI: 10.1586/eog.12.51     Document Type: Review

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