Cyclic compression-induced p38 activation and subsequent MMP13 expression requires Rho/ROCK activity in bovine cartilage explants

Inflammation Research

Volumn 61, Issue 10, 2012, Pages 1093-1100

  Nakagawa, Koichi ^a   Teramura, Takeshi ^a   Takehara, Toshiyuki ^a   Onodera, Yuta ^a   Hamanishi, Chiaki ^a   Akagi, Masao ^a   Fukuda, Kanji ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

Cartilage; Matrix metalloproteinase; Mechanical stress; Osteoarthritis; Rho ROCK

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COLLAGENASE 3; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; COMPRESSION; CONTROLLED STUDY; COW; DEGRADATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; EXPLANT; EXTRACELLULAR MATRIX; MECHANICAL STRESS; METACARPAL BONE; NONHUMAN; OSTEOARTHRITIS; PHALANX; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AMIDES; ANIMALS; CARTILAGE; CATTLE; CELLS, CULTURED; CHONDROCYTES; ENZYME INHIBITORS; IMIDAZOLES; MATRIX METALLOPROTEINASE 13; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; STRESS, MECHANICAL;

EID: 84867400022     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-012-0500-4     Document Type: Article

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