Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression

BMC Cell Biology

Volumn 11, Issue , 2010, Pages

  Ziegler, Nelli ^a,b   Alonso, Angel ^c   Steinberg, Thorsten ^a   Woodnutt, Dale ^b   Kohl, Annette ^b   Müssig, Eva ^a   Schulz, Simon ^a   Tomakidi, Pascal ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA3 INTEGRIN; BETA1 INTEGRIN; COLLAGENASE 3; FOCAL ADHESION KINASE; MACROPHAGE ELASTASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C FOS; BETA3 INTEGRIN; FOCAL ADHESION KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PTK2 PROTEIN, HUMAN;

ARTICLE; CELL CYCLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOFLUORESCENCE; MECHANOTRANSDUCTION; PERIODONTAL LIGAMENT; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; ADOLESCENT; CHILD; CYTOLOGY; DOWN REGULATION; ENZYMOLOGY; GENETICS; METABOLISM; PHOSPHORYLATION;

ADOLESCENT; ANTIGENS, CD29; CHILD; DOWN-REGULATION; FOCAL ADHESION KINASE 1; HUMANS; INTEGRIN BETA3; MATRIX METALLOPROTEINASE 13; MECHANOTRANSDUCTION, CELLULAR; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PERIODONTAL LIGAMENT; PHOSPHORYLATION; RNA, MESSENGER;

EID: 77349115759     PISSN: None     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-11-10     Document Type: Article

References (40)

1. von Bohl M, Kuijpers-Jagtman AM. Hyalinization during orthodontic tooth movement: a systematic review on tissue reactions. Eur J Orthod 2009, 31:30-36. 10.1093/ejo/cjn080, 19073957.
2. Bartold PM, McCulloch CA, Narayanan AS, Pitaru S. Tissue engineering: a new paradigm for periodontal regeneration based on molecular and cell biology. Periodontol 2000, 24:253-269.
3. Cho MI, Garant PR. Development and general structure of the periodontium. Periodontol 2000, 24:9-27.
4. Tsuruga E, Sato A, Ueki T, Nakashima K, Nakatomi Y, Ishikawa H, Yajima T, Sawa Y. Integrin alphavbeta3 regulates microfibril assembly in human periodontal ligament cells. Tissue Cell 2009, 41:85-89. 10.1016/j.tice.2008.07.005, 18789468.
5. Himmel M, Ritter A, Rothemund S, Pauling BV, Rottner K, Gingras AR, Ziegler WH. Control of high affinity interactions in the talin C-terminus - how talin domains coordinate protein dynamics in cell adhesions. J Biol Chem 2009, 284:13832-13842. 10.1074/jbc.M900266200, 19278997.
6. Muller EJ, Williamson L, Kolly C, Suter MM. Outside-in signaling through integrins and cadherins: a central mechanism to control epidermal growth and differentiation?. J Invest Dermatol 2008, 128:501-516. 10.1038/sj.jid.5701248, 18268536.
7. Papusheva E, de Queiroz FM, Dalous J, Han Y, Esposito A, Jares-Erijmanxa EA, Jovin TM, Bunt G. Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility. J Cell Sci 2009, 122:656-666. 10.1242/jcs.028738, 19208768.
8. Roy S, Ruest PJ, Hanks SK. FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation. J Cell Biochem 2002, 84:377-388. 10.1002/jcb.10025, 11787067.
9. Molina T, Kabsch K, Alonso A, Kohl A, Komposch G, Tomakidi P. Topographic changes of focal adhesion components and modulation of p125FAK activation in stretched human periodontal ligament fibroblasts. J Dent Res 2001, 80:1984-1989. 10.1177/00220345010800110701, 11759007.
10. Sturgill TW. MAP kinase: it's been longer than fifteen minutes. Biochem Biophys Res Commun 2008, 371:1-4. 10.1016/j.bbrc.2008.04.002, 18406346.
11. Gaestel M. Specificity of signaling from MAPKs to MAPKAPKs: kinases' tango nuevo. Front Biosci 2008, 13:6050-6059. 10.2741/3136, 18508642.
12. Rauch C, Loughna PT. Stretch-induced activation of ERK in myocytes is p38 and calcineurin-dependent. Cell Biochem Funct 2008, 26:866-869. 10.1002/cbf.1518, 18956431.
13. Fulton DL, Sundararajan S, Badis G, Hughes TR, Wasserman WW, Roach JC, Sladek R. TFCat: the curated catalog of mouse and human transcription factors. Genome Biol 2009, 10:R29. 10.1186/gb-2009-10-3-r29, 2691000, 19284633.
14. Haasper C, Jagodzinski M, Drescher M, Meller R, Wehmeier M, Krettek C, Hesse E. Cyclic strain induces FosB and initiates osteogenic differentiation of mesenchymal cells. Exp Toxicol Pathol 2008, 59:355-363.
15. Sakai H, Urasawa K, Oyama N, Kaneta S, Saito T, Kitabatake A, Tsutsui H. Induction of c-fos mRNA expression by pure pressure overload in cultured cardiac myocytes. Int Heart J 2007, 48:359-367. 10.1536/ihj.48.359, 17592200.
16. Song G, Ju Y, Shen X, Luo Q, Shi Y, Qin J. Mechanical stretch promotes proliferation of rat bone marrow mesenchymal stem cells. Colloids Surf B Biointerfaces 2007, 58:271-277. 10.1016/j.colsurfb.2007.04.001, 17499488.
17. Tan TW, Yang WH, Lin YT, Hsu SF, Li TM, Kao ST, Chen WC, Fong YC, Tang CH. Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells. Carcinogenesis 2009, 30:258-268. 10.1093/carcin/bgn284, 19126648.
18. Embery G, Waddington RJ, Hall RC, Last KS. Connective tissue elements as diagnostic aids in periodontology. Periodontol 2000, 24:193-214.
19. Melendez-Zajgla J, Del Pozo L, Ceballos G, Maldonado V. Tissue inhibitor of metalloproteinases-4. The road less traveled. Mol Cancer 2008, 7:85. 10.1186/1476-4598-7-85, 2599898, 19025595.
20. Geiger B, Spatz JP, Bershadsky AD. Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol 2009, 10:21-33. 10.1038/nrm2593, 19197329.
21. Flier A, Sonnenberg A. Function and interactions of integrins. Cell Tissue Res 2001, 305:285-298. 10.1007/s004410100417, 11572082.
22. Krepinsky J. Mechanical stretch-induced signal transduction in cultured mesangial cells. Methods Mol Biol 2009, 466:205-221.
23. Rauch C, Loughna PT. Stretch-induced activation of ERK in myocytes is p38 and calcineurin-dependent. Cell Biochem Funct 2008, 26:866-869. 10.1002/cbf.1518, 18956431.
24. Leonardi R, Talic NF, Loreto C. MMP-13 (collagenase 3) immunolocalisation during initial orthodontic tooth movement in rats. Acta Histochem 2007, 109:215-220. 10.1016/j.acthis.2007.01.002, 17350083.
25. Bolcato-Bellemin AL, Elkaim R, Abehsera A, Fausser JL, Haikel Y, Tenenbaum H. Expression of mRNAs encoding for alpha and beta integrin subunits, MMPs, and TIMPs in stretched human periodontal ligament and gingival fibroblasts. J Dent Res 2000, 79:1712-1716. 10.1177/00220345000790091201, 11023268.
26. Boutahar N, Guignandon A, Vico L, Lafage-Proust MH. Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation. J Biol Chem 2004, 279:30588-30599. 10.1074/jbc.M313244200, 15096502.
27. Jansen JH, Jahr H, Verhaar JA, Pols HA, Chiba H, Weinans H, van Leeuwen JP. Stretch-induced modulation of matrix metalloproteinases in mineralizing osteoblasts via extracellular signal-regulated kinase-1/2. J Orthop Res 2006, 24:1480-1488. 10.1002/jor.20186, 16705736.
28. Tan TW, Yang WH, Lin YT, Hsu SF, Li TM, Kao ST, Chen WC, Fong YC, Tang CH. Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells. Carcinogenesis 2009, 30:258-268. 10.1093/carcin/bgn284, 19126648.
29. Carter WG, Kaur P, Gil SG, Gahr PJ, Wayner EA. Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J Cell Biol 1990, 111:3141-3154. 10.1083/jcb.111.6.3141, 2116384, 2269668.
30. Redlich M, Roos H, Reichenberg E, Zaks B, Grosskop A, Bar Kana I, Pitaru S, Palmon A. The effect of centrifugal force on mRNA levels of collagenase, collagen type-I, tissue inhibitors of metalloproteinases and beta-actin in cultured human periodontal ligament fibroblasts. J Periodontal Res 2004, 39:27-32. 10.1111/j.1600-0765.2004.00700.x, 14687224.
31. Zhou J, Windsor LJ. Porphyromonas gingivalis affects host collagen degradation by affecting expression, activation, and inhibition of matrix metalloproteinases. J Periodontal Res 2006, 41:47-54. 10.1111/j.1600-0765.2005.00835.x, 16409255.
32. Wongkhantee S, Yongchaitrakul T, Pavasant P. Mechanical stress induces osteopontin expression in human periodontal ligament cells through rho kinase. J Periodontol 2007, 78:1113-1119. 10.1902/jop.2007.060433, 17539726.
33. Issa MJPTR, Pitol DL, Mello SAS. TGF-[beta] and new bone formation. Int J Morphol 2006, 24:399-405.
34. Basaran G, Ozer T, Kaya FA, Hamamci O. Interleukins 2, 6, and 8 levels in human gingival sulcus during orthodontic treatment. Am J Orthod Dentofacial Orthop 2006, 130:7 e1-6.
35. Zeng F, Singh AB, Harris RC. The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology. Exp Cell Res 2009, 315:602-610. 10.1016/j.yexcr.2008.08.005, 18761338.
36. Hernandez M, Martinez B, Tejerina JM, Valenzuela MA, Gamonal J. MMP-13 and TIMP-1 determinations in progressive chronic periodontitis. J Clin Periodontol 2007, 34:729-735. 10.1111/j.1600-051X.2007.01107.x, 17716308.
37. Hasegawa S, Sato S, Saito S, Suzuki Y, Brunette DM. Mechanical stretching increases the number of cultured bone cells synthesizing DNA and alters their pattern of protein synthesis. Calcif Tissue int 1985, 37:431-436. 10.1007/BF02553714, 3930042.
38. Waddington RJ, Embery G. Proteoglycans and orthodontic tooth movement. J Orthod 2001, 28:281-290. 10.1093/ortho/28.4.281, 11709593.
39. Diedrich P. Praxis der Zanhheilkunde: Kieferorthopädie II. 2000, Urban & Fischer, München, Jena.
40. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262, 11846609.