메뉴 건너뛰기




Volumn 58, Issue 11, 2008, Pages 3520-3529

Reduced limb length and worsened osteoarthritis in adult mice after genetic inhibition of p38 MAP kinase activity in cartilage

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38;

EID: 55849133703     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.23999     Document Type: Article
Times cited : (35)

References (50)
  • 1
    • 0035207024 scopus 로고    scopus 로고
    • CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK)
    • Yosimichi G, Nakanishi T, Nishida T, Hattori T, Takano-Yamamoto T, Takigawa M. CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK). Eur J Biochem 2001;268: 6058-65.
    • (2001) Eur J Biochem , vol.268 , pp. 6058-6065
    • Yosimichi, G.1    Nakanishi, T.2    Nishida, T.3    Hattori, T.4    Takano-Yamamoto, T.5    Takigawa, M.6
  • 2
    • 0035861541 scopus 로고    scopus 로고
    • Integrin β1 signaling is necessary for transforming growth factor-β activation of p38MAPK and epithelial plasticity
    • Bhowmick NA, Zent R, Ghiassi M, McDonnell M, Moses HL. Integrin β1 signaling is necessary for transforming growth factor-β activation of p38MAPK and epithelial plasticity. J Biol Chem 2001;276:46707-13.
    • (2001) J Biol Chem , vol.276 , pp. 46707-46713
    • Bhowmick, N.A.1    Zent, R.2    Ghiassi, M.3    McDonnell, M.4    Moses, H.L.5
  • 3
    • 0028022750 scopus 로고
    • A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
    • Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, et al. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 1994;78:1027-37.
    • (1994) Cell , vol.78 , pp. 1027-1037
    • Rouse, J.1    Cohen, P.2    Trigon, S.3    Morange, M.4    Alonso-Llamazares, A.5    Zamanillo, D.6
  • 4
    • 0028935270 scopus 로고
    • Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    • Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, et al. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 1995;270:7420-6.
    • (1995) J Biol Chem , vol.270 , pp. 7420-7426
    • Raingeaud, J.1    Gupta, S.2    Rogers, J.S.3    Dickens, M.4    Han, J.5    Ulevitch, R.J.6
  • 5
    • 55849143421 scopus 로고    scopus 로고
    • Regulation of chondrocyte death during endochondral ossification by p38 mitogen-activated protein kinase: Mechanism of coupling hypertrophy and apoptosis
    • Rosemont IL, Orthopaedic Research Society;
    • Wei L, Chen Q. Regulation of chondrocyte death during endochondral ossification by p38 mitogen-activated protein kinase: mechanism of coupling hypertrophy and apoptosis. Transactions of the 47th Annual Meeting of the Orthopaedic Research Society. Rosemont (IL): Orthopaedic Research Society; 2001, vol. 26, no. 0329.
    • (2001) Transactions of the 47th Annual Meeting of the Orthopaedic Research Society , vol.26 , Issue.329
    • Wei, L.1    Chen, Q.2
  • 6
    • 0031114081 scopus 로고    scopus 로고
    • Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: Regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels
    • Ridley SH, Sarsfield SJ, Lee JC, Bigg HF, Cawston TF, Taylor DJ, et al. Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels. J Immunol 1997; 158:3165-73.
    • (1997) J Immunol , vol.158 , pp. 3165-3173
    • Ridley, S.H.1    Sarsfield, S.J.2    Lee, J.C.3    Bigg, H.F.4    Cawston, T.F.5    Taylor, D.J.6
  • 7
    • 0033593335 scopus 로고    scopus 로고
    • Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase
    • Ravanti L, Heino J, Lopez-Otin C, Kahari VM. Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase. J Biol Chem 1999;274;2446-55.
    • (1999) J Biol Chem , vol.274 , pp. 2446-2455
    • Ravanti, L.1    Heino, J.2    Lopez-Otin, C.3    Kahari, V.M.4
  • 8
    • 0039552125 scopus 로고    scopus 로고
    • Transforming growth factor-β induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase
    • Ravanti L, Hakkinen L, Larjava H, Saarialho-Kere U, Foschi M, Han J, et al. Transforming growth factor-β induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase. J Biol Chem 1999;274:37292-300.
    • (1999) J Biol Chem , vol.274 , pp. 37292-37300
    • Ravanti, L.1    Hakkinen, L.2    Larjava, H.3    Saarialho-Kere, U.4    Foschi, M.5    Han, J.6
  • 9
    • 0032520916 scopus 로고    scopus 로고
    • Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion
    • Simon C, Goepfert H, Boyd D. Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion. Cancer Res 1998;58:1135-9.
    • (1998) Cancer Res , vol.58 , pp. 1135-1139
    • Simon, C.1    Goepfert, H.2    Boyd, D.3
  • 10
    • 0035226687 scopus 로고    scopus 로고
    • P38 MAP kinase: Molecular target for the inhibition of pro-inflammatory cytokines
    • Adams JL, Badger AM, Kumar S, Lee JC. P38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines. Prog Med Chem 2001;38:1-60.
    • (2001) Prog Med Chem , vol.38 , pp. 1-60
    • Adams, J.L.1    Badger, A.M.2    Kumar, S.3    Lee, J.C.4
  • 11
    • 33644899652 scopus 로고    scopus 로고
    • Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: Possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis
    • Dai SM, Shan ZZ, Nakamura H, Masuko-Hongo K, Kato T, Nishioka K, et al. Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis. Arthritis Rheum 2006; 54:818-31.
    • (2006) Arthritis Rheum , vol.54 , pp. 818-831
    • Dai, S.M.1    Shan, Z.Z.2    Nakamura, H.3    Masuko-Hongo, K.4    Kato, T.5    Nishioka, K.6
  • 12
    • 34548229166 scopus 로고    scopus 로고
    • CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: Dependency on p38 mitogen-activated protein kinase
    • Wei L, Sun X, Wang Z, Chen Q. CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase. Arthritis Res Ther 2006;8:R37.
    • (2006) Arthritis Res Ther , vol.8
    • Wei, L.1    Sun, X.2    Wang, Z.3    Chen, Q.4
  • 15
    • 30844463770 scopus 로고    scopus 로고
    • Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes
    • Ea HK, Uzan B, Rey C, Liote F. Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes. Arthritis Res Ther 2005;7:R915-26.
    • (2005) Arthritis Res Ther , vol.7
    • Ea, H.K.1    Uzan, B.2    Rey, C.3    Liote, F.4
  • 16
    • 19544368809 scopus 로고    scopus 로고
    • The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway
    • Boileau C, Pelletier JP, Tardif G, Fahmi H, Laufer S, Lavigne M, et al. The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway. Ann Rheum Dis 2005;64:891-8.
    • (2005) Ann Rheum Dis , vol.64 , pp. 891-898
    • Boileau, C.1    Pelletier, J.P.2    Tardif, G.3    Fahmi, H.4    Laufer, S.5    Lavigne, M.6
  • 17
    • 5444228751 scopus 로고    scopus 로고
    • Protein kinases in chondrocyte signaling and osteoarthritis
    • Malemud CJ. Protein kinases in chondrocyte signaling and osteoarthritis. Clin Orthop Relat Res 2004;427 Suppl:S145-51.
    • (2004) Clin Orthop Relat Res , vol.427 , Issue.SUPPL.
    • Malemud, C.J.1
  • 18
    • 4344586823 scopus 로고    scopus 로고
    • Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: Critical roles of the ERK-1/2 and p38 signaling pathways
    • Masuko-Hongo K, Berenbaum F, Humbert L, Salvat C, Goldring MB, Thirion S. Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways. Arthritis Rheum 2004;50: 2829-38.
    • (2004) Arthritis Rheum , vol.50 , pp. 2829-2838
    • Masuko-Hongo, K.1    Berenbaum, F.2    Humbert, L.3    Salvat, C.4    Goldring, M.B.5    Thirion, S.6
  • 19
    • 0033506581 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase and nuclear factor -B together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: Possible role of transactivating factor mitogen-activated protein kinase-activated protein kinase (MAPKAPK)
    • Martel-Pelletier J, Mineau F, Jovanovic D, Di Battista JA, Pelletier JP. Mitogen-activated protein kinase and nuclear factor -B together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-activated protein kinase (MAPKAPK). Arthritis Rheum 1999;42:2399-409.
    • (1999) Arthritis Rheum , vol.42 , pp. 2399-2409
    • Martel-Pelletier, J.1    Mineau, F.2    Jovanovic, D.3    Di Battista, J.A.4    Pelletier, J.P.5
  • 20
    • 0345932931 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
    • Iwasa H, Han J, Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 2003;8:131-44.
    • (2003) Genes Cells , vol.8 , pp. 131-144
    • Iwasa, H.1    Han, J.2    Ishikawa, F.3
  • 21
    • 29144510038 scopus 로고    scopus 로고
    • Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products
    • Cecil DL, Johnson K, Rediske J, Lotz M, Schmidt AM, Terkeltaub R. Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products. J Immunol 2005; 175:8296-302.
    • (2005) J Immunol , vol.175 , pp. 8296-8302
    • Cecil, D.L.1    Johnson, K.2    Rediske, J.3    Lotz, M.4    Schmidt, A.M.5    Terkeltaub, R.6
  • 22
    • 25144514862 scopus 로고    scopus 로고
    • Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: Involvement of HIF-1α in the pathogenesis of osteoarthritis
    • Yudoh K, Nakamura H, Masuko-Hongo K, Kato T, Nishioka K. Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis. Arthritis Res Ther 2005;7:R904-14.
    • (2005) Arthritis Res Ther , vol.7
    • Yudoh, K.1    Nakamura, H.2    Masuko-Hongo, K.3    Kato, T.4    Nishioka, K.5
  • 23
    • 33644805943 scopus 로고    scopus 로고
    • The mechanism of low-concentration sodium nitroprusside-mediated protection of chondrocyte death
    • Kim HA, Lee KB, Bae SC. The mechanism of low-concentration sodium nitroprusside-mediated protection of chondrocyte death. Arthritis Res Ther 2005;7:R526-35.
    • (2005) Arthritis Res Ther , vol.7
    • Kim, H.A.1    Lee, K.B.2    Bae, S.C.3
  • 24
    • 0035895905 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone
    • Zhen X, Wei L, Wu Q, Zhang Y, Chen Q. Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone. J Biol Chem 2001;276:4879-85.
    • (2001) J Biol Chem , vol.276 , pp. 4879-4885
    • Zhen, X.1    Wei, L.2    Wu, Q.3    Zhang, Y.4    Chen, Q.5
  • 25
    • 4344688814 scopus 로고    scopus 로고
    • Signaling transduction: Target in osteoarthritis
    • Berenbaum F. Signaling transduction: target in osteoarthritis. Curr Opin Rheumatol 2004;16:616-22.
    • (2004) Curr Opin Rheumatol , vol.16 , pp. 616-622
    • Berenbaum, F.1
  • 26
    • 33746225582 scopus 로고    scopus 로고
    • Protein tyrosine kinase and p38 MAPK pathways involved in stimulation of matrix metalloproteinase-9 by TNF-α in human monocytes
    • Nguyen J, Gogusev J, Knapnougel P, Bauvois B. Protein tyrosine kinase and p38 MAPK pathways involved in stimulation of matrix metalloproteinase-9 by TNF-α in human monocytes. Immunol Lett 2006;106:34-41.
    • (2006) Immunol Lett , vol.106 , pp. 34-41
    • Nguyen, J.1    Gogusev, J.2    Knapnougel, P.3    Bauvois, B.4
  • 27
    • 11144357130 scopus 로고    scopus 로고
    • Distinct roles of SMAD pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts
    • Seto H, Kamekura S, Miura T, Yamamoto A, Chikuda H, Ogata T, et al. Distinct roles of SMAD pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts. J Clin Invest 2004;113:718-26.
    • (2004) J Clin Invest , vol.113 , pp. 718-726
    • Seto, H.1    Kamekura, S.2    Miura, T.3    Yamamoto, A.4    Chikuda, H.5    Ogata, T.6
  • 29
    • 0042170212 scopus 로고    scopus 로고
    • Inhibition of p38 MAPK signaling promotes late stages of myogenesis
    • Weston AD, Sampaio AV, Ridgeway AG, Underhill TM. Inhibition of p38 MAPK signaling promotes late stages of myogenesis. J Cell Sci 2003;116:2885-93.
    • (2003) J Cell Sci , vol.116 , pp. 2885-2893
    • Weston, A.D.1    Sampaio, A.V.2    Ridgeway, A.G.3    Underhill, T.M.4
  • 30
    • 16344382525 scopus 로고    scopus 로고
    • Mitogen activated protein kinase signal transduction pathways in the prostate [review]
    • Maroni PD, Koul S, Meacham RB, Koul HK. Mitogen activated protein kinase signal transduction pathways in the prostate [review]. Cell Commun Signal 2004;2:5.
    • (2004) Cell Commun Signal , vol.2 , pp. 5
    • Maroni, P.D.1    Koul, S.2    Meacham, R.B.3    Koul, H.K.4
  • 31
    • 0033791689 scopus 로고    scopus 로고
    • Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1β
    • Robbins JR, Thomas B, Tan L, Choy B, Arbiser JL, Berenbaum F, et al. Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1β. Arthritis Rheum 2000;43:2189-201.
    • (2000) Arthritis Rheum , vol.43 , pp. 2189-2201
    • Robbins, J.R.1    Thomas, B.2    Tan, L.3    Choy, B.4    Arbiser, J.L.5    Berenbaum, F.6
  • 32
    • 85176674571 scopus 로고    scopus 로고
    • Alessi DR, Ceunda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995;270: 27489-94.
    • Alessi DR, Ceunda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995;270: 27489-94.
  • 33
    • 0033974686 scopus 로고    scopus 로고
    • Upregulation of the chondrogenic sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway
    • Murakami S, Kan M, McKeehan WL, de Crombrugghe B. Upregulation of the chondrogenic sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A 2000;91:1113-8.
    • (2000) Proc Natl Acad Sci U S A , vol.91 , pp. 1113-1118
    • Murakami, S.1    Kan, M.2    McKeehan, W.L.3    de Crombrugghe, B.4
  • 34
    • 0032859366 scopus 로고    scopus 로고
    • Transforming growth factor-β stimulates articular chondrocyte cell growth through p44/42 MAP kinase (ERK) activation
    • Yonekura A, Osaki M, Hirota Y, Tsukazaki T, Miyazaki Y, Matsumoto T, et al. Transforming growth factor-β stimulates articular chondrocyte cell growth through p44/42 MAP kinase (ERK) activation. Endocr J 1999;46:545-53.
    • (1999) Endocr J , vol.46 , pp. 545-553
    • Yonekura, A.1    Osaki, M.2    Hirota, Y.3    Tsukazaki, T.4    Miyazaki, Y.5    Matsumoto, T.6
  • 35
    • 0033178337 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells
    • Nakamura K, Shirai T, Morishita S, Uchida S, Saeki-Miura K, Makishima F. p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells. Exp Cell Res 1999;250:351-63.
    • (1999) Exp Cell Res , vol.250 , pp. 351-363
    • Nakamura, K.1    Shirai, T.2    Morishita, S.3    Uchida, S.4    Saeki-Miura, K.5    Makishima, F.6
  • 36
    • 0036499910 scopus 로고    scopus 로고
    • Differentiation regulates interleukin-1β-induced cyclooxygenase-2 in human articular chondrocytes: Role of p38 mitogen-activated protein kinase
    • Thomas B, Thirion S, Humbert L, Tan L, Goldring MB, Bereziat G, et al. Differentiation regulates interleukin-1β-induced cyclooxygenase-2 in human articular chondrocytes: role of p38 mitogen-activated protein kinase. Biochem J 2002;362(Pt 2):367-73.
    • (2002) Biochem J , vol.362 , Issue.PART 2 , pp. 367-373
    • Thomas, B.1    Thirion, S.2    Humbert, L.3    Tan, L.4    Goldring, M.B.5    Bereziat, G.6
  • 37
    • 16244421738 scopus 로고    scopus 로고
    • Inactivation of p38 kinase delays the onset of senescence in rabbit articular chondrocytes
    • Kang S, Jung M, Kim CW, Shin DY. Inactivation of p38 kinase delays the onset of senescence in rabbit articular chondrocytes. Mech Ageing Dev 2005;126:591-7.
    • (2005) Mech Ageing Dev , vol.126 , pp. 591-597
    • Kang, S.1    Jung, M.2    Kim, C.W.3    Shin, D.Y.4
  • 38
    • 33846069310 scopus 로고    scopus 로고
    • BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated downregulation of Wnt-7a pathway
    • Jin EJ, Lee SY, Choi YA, Jung JC, Bang OS, Kang SS. BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated downregulation of Wnt-7a pathway. Mol Cells 2006;22:353-9.
    • (2006) Mol Cells , vol.22 , pp. 353-359
    • Jin, E.J.1    Lee, S.Y.2    Choi, Y.A.3    Jung, J.C.4    Bang, O.S.5    Kang, S.S.6
  • 39
    • 0034653850 scopus 로고    scopus 로고
    • Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
    • Enslen H, Brancho DM, Davis RJ. Molecular determinants that mediate selective activation of p38 MAP kinase isoforms. EMBO J 2000;19:1301-11.
    • (2000) EMBO J , vol.19 , pp. 1301-1311
    • Enslen, H.1    Brancho, D.M.2    Davis, R.J.3
  • 40
    • 55849111664 scopus 로고    scopus 로고
    • Abolition of endochondral bone formation by a dominant negative p38 MAP kinase transgene in a transgenic mouse model
    • Rosemont IL, Orthopaedic Research Society;
    • Sun X, Wei L, Cheah K, Bronson S, Chen Q. Abolition of endochondral bone formation by a dominant negative p38 MAP kinase transgene in a transgenic mouse model. Transactions of the 49th Annual Meeting of the Orthopaedic Research Society. Rosemont (IL): Orthopaedic Research Society; 2003, vol. 28, no. 0341.
    • (2003) Transactions of the 49th Annual Meeting of the Orthopaedic Research Society , vol.28 , Issue.341
    • Sun, X.1    Wei, L.2    Cheah, K.3    Bronson, S.4    Chen, Q.5
  • 41
    • 0028877808 scopus 로고
    • Human COL2A1-directed SV40 T antigen expression in transgenic and chimeric mice results in abnormal skeletal development
    • Cheah KS, Levy A, Trainor PA, Wai AW, Kuffner T, So CL, et al. Human COL2A1-directed SV40 T antigen expression in transgenic and chimeric mice results in abnormal skeletal development. J Cell Biol 1995;128:223-37.
    • (1995) J Cell Biol , vol.128 , pp. 223-237
    • Cheah, K.S.1    Levy, A.2    Trainor, P.A.3    Wai, A.W.4    Kuffner, T.5    So, C.L.6
  • 42
    • 0027558772 scopus 로고
    • A standardized experimental fracture in the mouse tibia
    • Hiltunen A, Vuorio E, Aro HT. A standardized experimental fracture in the mouse tibia. J Orthop Res 1993;11:305-12.
    • (1993) J Orthop Res , vol.11 , pp. 305-312
    • Hiltunen, A.1    Vuorio, E.2    Aro, H.T.3
  • 43
    • 0032145985 scopus 로고    scopus 로고
    • Comparison of three-point bending test and peripheral quantitative computed tomography analysis in the evaluation of the strength of mouse femur and tibia
    • Jamsa T, Jalovaara P, Peng Z, Vaananen HK, Tuukkanen J. Comparison of three-point bending test and peripheral quantitative computed tomography analysis in the evaluation of the strength of mouse femur and tibia. Bone 1998;23:155-61.
    • (1998) Bone , vol.23 , pp. 155-161
    • Jamsa, T.1    Jalovaara, P.2    Peng, Z.3    Vaananen, H.K.4    Tuukkanen, J.5
  • 44
    • 0027175806 scopus 로고
    • Basic biomechanical measurements of bone: A tutorial
    • Turner CH, Burr DB. Basic biomechanical measurements of bone: a tutorial. Bone 1993;14:595-608.
    • (1993) Bone , vol.14 , pp. 595-608
    • Turner, C.H.1    Burr, D.B.2
  • 45
    • 0006349054 scopus 로고
    • Osteoarthrosis-like disease in mice: Effects of anti-arthrotic and anti-rheumatic agents
    • Lott DJ, Jasani MK, Birdwood GF, editors, Chichester UK, John Wiley & Sons;
    • Maier I, Wilhelmi G. Osteoarthrosis-like disease in mice: effects of anti-arthrotic and anti-rheumatic agents. In: Lott DJ, Jasani MK, Birdwood GF, editors. Studies in osteoarthrosis: pathogenesis, intervention and assessment. Chichester (UK): John Wiley & Sons; 1987. p. 75-83.
    • (1987) Studies in osteoarthrosis: Pathogenesis, intervention and assessment , pp. 75-83
    • Maier, I.1    Wilhelmi, G.2
  • 46
    • 0034610981 scopus 로고    scopus 로고
    • Deficiency of the stress kinase p38α results in embryonic lethality: Characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells
    • Allen M, Svensson L, Roach M, Hambor J, McNeish J, Gabel CA. Deficiency of the stress kinase p38α results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med 2000;191: 859-70.
    • (2000) J Exp Med , vol.191 , pp. 859-870
    • Allen, M.1    Svensson, L.2    Roach, M.3    Hambor, J.4    McNeish, J.5    Gabel, C.A.6
  • 47
    • 33746145655 scopus 로고    scopus 로고
    • Distinct signaling pathways are involved in hypoxia- and IL-1-induced VEGF expression in human articular chondrocytes
    • Murata M, Yudoh K, Nakamura H, Kato T, Inoue K, Chiba J, et al. Distinct signaling pathways are involved in hypoxia- and IL-1-induced VEGF expression in human articular chondrocytes. J Orthop Res 2006;24:1544-54.
    • (2006) J Orthop Res , vol.24 , pp. 1544-1554
    • Murata, M.1    Yudoh, K.2    Nakamura, H.3    Kato, T.4    Inoue, K.5    Chiba, J.6
  • 48
    • 0037371287 scopus 로고    scopus 로고
    • Chondrogenesis induced by actin cytoskeleton disruption is regulated via protein kinase C-dependent p38 mitogen-activated protein kinase signaling
    • Lim YB, Kang SS, An WG, Lee YS, Chun JS, Sonn JK. Chondrogenesis induced by actin cytoskeleton disruption is regulated via protein kinase C-dependent p38 mitogen-activated protein kinase signaling. J Cell Biochem 2003;88:713-8.
    • (2003) J Cell Biochem , vol.88 , pp. 713-718
    • Lim, Y.B.1    Kang, S.S.2    An, W.G.3    Lee, Y.S.4    Chun, J.S.5    Sonn, J.K.6
  • 49
    • 33746674531 scopus 로고    scopus 로고
    • p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes
    • Radons J, Bosserhoff AK, Grassel S, Falk W, Schubert TE. p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes. Int J Mol Med 2006;17: 661-8.
    • (2006) Int J Mol Med , vol.17 , pp. 661-668
    • Radons, J.1    Bosserhoff, A.K.2    Grassel, S.3    Falk, W.4    Schubert, T.E.5
  • 50
    • 31944431897 scopus 로고    scopus 로고
    • A common pathway in differentiation and inflammation: P38 mediates expression of the acute phase SIP24 iron binding lipocalin in chondrocytes
    • Ulivi V, Tutolo G, Mallein-Gerin F, Daga A, Cancedda R, Cancedda FD. A common pathway in differentiation and inflammation: p38 mediates expression of the acute phase SIP24 iron binding lipocalin in chondrocytes. J Cell Physiol 2006;206:728-37.
    • (2006) J Cell Physiol , vol.206 , pp. 728-737
    • Ulivi, V.1    Tutolo, G.2    Mallein-Gerin, F.3    Daga, A.4    Cancedda, R.5    Cancedda, F.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.