Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression

Arthritis and Rheumatism

Volumn 52, Issue 8, 2005, Pages 2386-2395

  Lee, Jennifer H ^a   Fitzgerald, Jonathan B ^a   DiMicco, Michael A ^a   Grodzinsky, Alan J ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECANASE; BETA ACTIN; CYTOKINE; INTERLEUKIN 1BETA; MATRIX METALLOPROTEINASE; MESSENGER RNA; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE DEGENERATION; CATTLE; EXPLANT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; JOINT INJURY; MECHANICAL STRESS; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION;

ANIMALS; ANIMALS, NEWBORN; CARTILAGE, ARTICULAR; CATTLE; CHONDROCYTES; CLUSTER ANALYSIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; KNEE JOINT; PRESSURE; STRESS, MECHANICAL; TIME FACTORS; WOUNDS AND INJURIES;

EID: 23644459677     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.21215     Document Type: Article

References (44)

1. Gelber AC, Hochberg MC, Mead LA, Wang NY, Wigley FM, Klag MJ. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med 2000;133:321-8.
2. Davis MA, Ettinger WH, Neuhaus JM, Cho SA, Hauck WW. The association of knee injury and obesity with unilateral and bilateral osteoarthritis of the knee. Am J Epidemiol 1989;130:278-88.
3. Von Porat A, Roos EM, Roos H. High prevalence of osteoarthritis 14 years after an anterior cruciate ligament tear in male soccer players: a study of radiographic and patient relevant outcomes. Ann Rheum Dis 2004;63:269-73.
4. Roos H, Adalberth T, Dahlberg L, Lohmander LS. Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. Osteoarthritis Cartilage 1995;3:261-7.
5. Lohmander LS, Roos H, Dahlberg L, Hoerrner LA, Lark MW. Temporal patterns of stromelysin-1, tissue inhibitor, and proteoglycan fragments in human knee joint fluid after injury to the cruciate ligament or meniscus. J Orthop Res 1994;12:21-8.
6. Lohmander LS, Alley LM, Pietka TA, Eyre DR. The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum 2003;48:3130-9.
7. Irie K, Uchiyama E, Iwaso H. Intraarticular inflammatory cytokines in acute anterior cruciate ligament injured knee. Knee 2003;10:93-6.
8. Bau B, Gebhard PM, Haag J, Knorr T, Bartnik E, Aigner T. Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. Arthritis Rheum 2002;46:2648-57.
9. Fukui N, Zhu Y, Maloney WJ, Clohisy J, Sandell LJ. Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-α in normal and osteoarthritic chondrocytes. J Bone Joint Surg Am 2003;85 Suppl 3:59-66.
10. Takahashi K, Goomer RS, Harwood F, Kubo T, Hirasawa Y, Amiel D. The effects of hyaluronan on matrix metalloproteinase-3 (MMP-3), interleukin-1β(IL-1β), and tissue inhibitor of metalloproteinase-1 (TIMP-1) gene expression during the development of osteoarthritis. Osteoarthritis Cartilage 1999;7:182-90.
11. Le Graverand MP, Eggerer J, Vignon E, Otterness IG, Barclay L, Hart DA. Assessment of specific mRNA levels in cartilage regions in a lapine model of osteoarthritis. J Orthop Res 2002;20:535-44.
12. Kurz B, Jin M, Patwari P, Cheng DM, Lark MW, Grodzinsky AJ. Biosynthetic response and mechanical properties of articular cartilage after injurious compression. J Orthop Res 2001;19: 1140-6.
13. Patwari P, Cook MN, DiMicco MA, Blake SM, James IE, Kumar S, et al. Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines. Arthritis Rheum 2003;48:1292-301.
14. D'Lima DD, Hashimoto S, Chen PC, Colwell CW Jr, Lotz MK. Human chondrocyte apoptosis in response to mechanical injury. Osteoarthritis Cartilage 2001;9:712-9.
15. DiMicco MA, Patwari P, Siparsky PN, Kumar S, Pratta MA, Lark MW, et al. Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. Arthritis Rheum 2004;50:840-8.
16. Torzilli PA, Grigiene R, Borrelli J Jr, Helfet DL. Effect of impact load on articular cartilage: cell metabolism and viability, and matrix water content. J Biomech Eng 1999;121:433-41.
17. Ewers BJ, Dvoracek-Driksna D, Orth MW, Haut RC. The extent of matrix damage and chondrocyte death in mechanically traumatized articular cartilage explants depends on rate of loading. J Orthop Res 2001;19:779-84.
18. Chen CT, Burton-Wurster N, Lust G, Bank RA, Tekoppele JM. Compositional and metabolic changes in damaged cartilage are peak-stress, stress-rate, and loading-duration dependent. J Orthop Res 1999;17:870-9.
19. Chen CT, Burton-Wurster N, Borden C, Hueffer K, Bloom SE, Lust G. Chondrocyte necrosis and apoptosis in impact damaged articular cartilage. J Orthop Res 2001;19:703-11.
20. Thibault M, Poole AR, Buschmann MD. Cyclic compression of cartilage/bone explants in vitro leads to physical weakening, mechanical breakdown of collagen and release of matrix fragments. J Orthop Res 2002;20:1265-73.
21. Chen CT, Bhargava M, Lin PM, Torzilli PA. Time, stress, and location dependent chondrocyte death and collagen damage in cyclically loaded articular cartilage. J Orthop Res 2003;21:888-98.
22. Loening AM, James IE, Levenston ME, Badger AM, Frank EH, Kurz B, et al. Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis. Arch Biochem Biophys 2000;381:205-12.
23. Quinn TM, Grodzinsky AJ, Hunziker EB, Sandy JD. Effects of injurious compression on matrix turnover around individual cells in calf articular cartilage explants. J Orthop Res 1998;16:490-9.
24. Sah RL, Kim YJ, Doong JY, Grodzinsky AJ, Plaas AH, Sandy JD. Biosynthetic response of cartilage explants to dynamic compression. J Orthop Res 1989;7:619-36.
25. Frank EH, Jin M, Loening AM, Levenston ME, Grodzinsky AJ. A versatile shear and compression apparatus for mechanical stimulation of tissue culture explants. J Biomech 2000;33:1523-7.
26. Troyanskaya OG, Garber ME, Brown PO, Botstein D, Altman RB. Nonparametric methods for identifying differentially expressed genes in microarray data. Bioinformatics 2002;18:1454-61.
27. Good P. Permutation tests: a practical guide to resampling methods for testing hypotheses. New York: Springer; 2000.
28. Jain A, Murty MN, Flynn PJ. Data clustering: a review. ACM Computing Surveys 1999;31:264-323.
29. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 1998;95:14863-8.
30. Dougherty ER, Barrera J, Brun M, Kim S, Cesar RM, Chen Y, et al. Inference from clustering with application to gene-expression microarrays [review][published erratum appears in J Comput Biol 2002;9:594-5]. J Comput Biol 2002;9:105-26.
31. Fitzgerald JB, Jin M, Dean D, Wood DJ, Zheng MH, Grodzinsky AJ. Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP. J Biol Chem 2004;279:19502-11.
32. Vincenti MP, Brinckerhoff CE. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res 2002;4:157-64.
33. Pufe T, Lemke A, Kurz B, Petersen W, Tillmann B, Grodzinsky AJ, et al. Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am J Pathol 2004;164:185-92.
34. Blain EJ, Gilbert SJ, Wardale RJ, Capper SJ, Mason DJ, Duance VC. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Arch Biochem Biophys 2001;396:49-55.
35. Vincent T, Hermansson M, Bolton M, Wait R, Saklatvala J. Basic FGF mediates an immediate response of articular cartilage to mechanical injury. Proc Natl Acad Sci U S A 2002;99:8259-64.
36. Murata M, Trahan C, Hirahashi J, Mankin HJ, Towle CA. Intracellular interleukin-1 receptor antagonist in osteoarthritis chondrocytes. Clin Orthop Relat Res 2003;409:285-95.
37. Gebhard PM, Gehrsitz A, Bau B, Soder S, Eger W, Aigner T. Quantification of expression levels of cellular differentiation markers does not support a general shift in the cellular phenotype of osteoarthritic chondrocytes. J Orthop Res 2003;21:96-101.
38. Buckwalter JA, Mankin HJ. Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect 1998;47:487-504.
39. Patwari P, Fay J, Cook MN, Badger AM, Kerin AJ, Lark MW, et al. In vitro models for investigation of the effects of acute mechanical injury on cartilage [review]. Clin Orthop Relat Res 2001;391 Suppl:S61-71.
40. Kim YJ, Grodzinsky AJ, Plaas AH. Compression of cartilage results in differential effects on biosynthetic pathways for aggrecan, link protein, and hyaluronan. Arch Biochem Biophys 1996; 328:331-40.
41. Ragan PM, Badger AM, Cook M, Chin VI, Gowen M, Grodzinsky AJ, et al. Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration. J Orthop Res 1999;17:836-42.
42. Hunter CJ, Imler SM, Malaviya P, Nerem RM, Levenston ME. Mechanical compression alters gene expression and extracellular matrix synthesis by chondrocytes cultured in collagen I gels. Biomaterials 2002;23:1249-59.
43. Fehrenbacher A, Steck E, Rickert M, Roth W, Richter W. Rapid regulation of collagen but not metalloproteinase 1, 3, 13, 14 and tissue inhibitor of metalloproteinase 1, 2, 3 expression in response to mechanical loading of cartilage explants in vitro. Arch Biochem Biophys 2003;410:39-47.
44. Kurz B, Lemke A, Kehn M, Domm C, Patwari P, Frank EH, et al. Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression. Arthritis Rheum 2004;50:123-30.