Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects

Osteoarthritis and Cartilage

Volumn 14, Issue 8, 2006, Pages 749-758

  Pei, Yong ^a   Harvey, Anita ^a   Yu, Xiao Peng ^a   Chandrasekhar, Srinivasan ^a   Thirunavukkarasu, Kannan ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Cytokines; Human chondrosarcoma cells; MAP kinase; MMP 1; MMP 13; p38 Kinase inhibitor; SW1353

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COLLAGENASE 3; CYTOKINE; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; SB 242235; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; SYNAPTOPHYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSCRIPTION FACTOR RUNX2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CARTILAGE CELL; CHONDROSARCOMA; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INHIBITION KINETICS; OSTEOARTHRITIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPORTER GENE; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE, TUMOR; CHONDROSARCOMA; CORE BINDING FACTOR ALPHA 1 SUBUNIT; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOPRECIPITATION; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 33745623947     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2006.01.017     Document Type: Article

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