Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation

Laboratory Investigation

Volumn 90, Issue 1, 2010, Pages 20-30

  Appleton, C Thomas G ^a,b   Usmani, Shirine E ^a,b   Mort, John S ^c   Beier, Frank ^a,b  

^a CIHR Group in Skeletal Development and Remodeling   (Canada)

^b WESTERN UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Articular cartilage; Chondrocyte; Epidermal growth factor receptor; Osteoarthritis; Transforming growth factor alpha

Indexed keywords

ACTIN; AGGRECAN; COLLAGEN TYPE 2; COLLAGENASE 3; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; RHO KINASE; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME INHIBITION; EXPLANT; GENE EXPRESSION; MALE; MORPHOLOGY; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN MODIFICATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

AGGRECANS; ANIMALS; BONE AND BONES; CARTILAGE, ARTICULAR; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR MEMBRANES; MALE; METABOLISM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 73349091526     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.111     Document Type: Article

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