Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor α in immature bovine and adult human articular cartilage

Arthritis and Rheumatism

Volumn 60, Issue 10, 2009, Pages 2985-2996

  Sui, Yihong ^a,c   Lee, Jennifer H ^a,c   DiMicco, Michael A ^b,c   Vanderploeg, Eric J ^c   Blake, Simon M ^d,e   Hung, Han Hwa ^c   Plaas, Anna H K ^f   James, Ian E ^d,e   Song, Xiao Yu ^d,e   Lark, Michael W ^d,e   Grodzinsky, Alan J ^c  

^a PFIZER INC   (United States)

^b Genzyme   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d TREVENA INC   (United States)

^e CENTOCOR INC   (United States)

^f RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSAMINOGLYCAN; IMMUNOGLOBULIN F(AB) FRAGMENT; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; PROTEOGLYCAN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANIMAL TISSUE; ANKLE INJURY; ARTICLE; ARTICULAR CARTILAGE; BIOSYNTHESIS; CARTILAGE CELL; CARTILAGE INJURY; CATABOLISM; CONTROLLED STUDY; COW; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; ISOTOPE LABELING; KNEE INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; WESTERN BLOTTING; ZYMOGRAPHY;

ADULT; ANIMALS; ANKLE INJURIES; BIOMECHANICS; CARTILAGE, ARTICULAR; CATTLE; CELLS, CULTURED; CHONDROCYTES; DISEASE MODELS, ANIMAL; FEMALE; GLYCOSAMINOGLYCANS; HUMANS; INTERLEUKIN-6; JOINTS; KNEE INJURIES; MALE; MIDDLE AGED; PROTEOGLYCANS; RECEPTORS, INTERLEUKIN-6; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70349777471     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24857     Document Type: Article

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