Synthesis of some imidazolyl-substituted 2-benzylidene indanone derivatives as potent aromatase inhibitors for breast cancer therapy

Medicinal Chemistry Research

Volumn 20, Issue 6, 2011, Pages 661-669

  Bansal, Ranju ^a   Narang, Gaurav ^a   Zimmer, Christina ^b   Hartmann, Rolf W ^b  

^a PANJAB UNIVERSITY   (India)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Aldol condensation; Aromatase; Breast cancer; Indanone derivatives; Nonsteroidal aromatase inhibitors

Indexed keywords

2 (3 INDOLYLMETHYLENE)INDAN 1 ONE; 2 [2 (3 CHLOROPROPOXY)BENZYLIDENE]INDAN 1 ONE; 2 [2 (3 IMIDAZOL 1 YL PROPOXY)BENZYLIDENE]INDAN 1 ONE; 2 [3 (3 CHLOROPROPOXY) 4 METHOXYBENZYLIDENE]INDAN 1 ONE; 2 [3 (3 CHLOROPROPOXY)BENZYLIDENE]INDAN 1 ONE; 2 [3 (3 IMIDAZOL 1 YL PROPOXY) 4 METHOXYBENZYLIDENE]INDAN 1 ONE; 2 [3 (3 IMIDAZOL 1 YL PROPOXY)BENZYLIDENE]INDAN 1 ONE; 2 [4 (3 CHLOROPROPOXY) 3 METHOXYBENZYLIDENE]INDAN 1 ONE; 2 [4 (3 IMIDAZOL 1 YL PROPOXY) 3 METHOXYBENZYLIDENE]INDAN 1 ONE; AMINOGLUTETHIMIDE; ANTINEOPLASTIC AGENT; AROMATASE; AROMATASE INHIBITOR; BENZYLIDENE DERIVATIVE; DPJ 1007; DPJ 1026; DPJ 1045; DPJ 1054; DPJ 1055; DPJ RG 1039; DPJ RG 1088; DPJ RG 1090; DPJ RG 1091; IMIDAZOLE DERIVATIVE; INDANONE DERIVATIVE; RG DPJ 195; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

EID: 80052037432     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-010-9368-4     Document Type: Article

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