-
1
-
-
44349104723
-
New global map of Crohn's disease: Genetic, environmental, and socioeconomic correlations
-
Economou M, Pappas G (2008) New global map of Crohn's disease: Genetic, environmental, and socioeconomic correlations. Inflamm Bowel Dis 14:709-720
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 709-720
-
-
Economou, M.1
Pappas, G.2
-
2
-
-
68049113587
-
The evolving epidemiology of inflammatory bowel disease
-
Shanahan F, Bernstein CN (2009) The evolving epidemiology of inflammatory bowel disease. Curr Opin Gastroenterol 25:301-305
-
(2009)
Curr Opin Gastroenterol
, vol.25
, pp. 301-305
-
-
Shanahan, F.1
Bernstein, C.N.2
-
3
-
-
72549110486
-
Clustering in time of familial IBD separates ulcerative colitis from Crohn's disease
-
Bengtson MB, Solberg C, Aamodt G, Jahnsen J, Moum B, Sauar J, Vatn MH (2009) Clustering in time of familial IBD separates ulcerative colitis from Crohn's disease. Inflamm Bowel Dis 15:1867-1874
-
(2009)
Inflamm Bowel Dis
, vol.15
, pp. 1867-1874
-
-
Bengtson, M.B.1
Solberg, C.2
Aamodt, G.3
Jahnsen, J.4
Moum, B.5
Sauar, J.6
Vatn, M.H.7
-
4
-
-
47949106374
-
Epidemiology of inflammatory bowel disease in a German twin cohort: Results of a nationwide study
-
Spehlmann ME, Begun AZ, Burghardt J, Lepage P, Raedler A, Schreiber S (2008) Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study. Inflamm Bowel Dis 14:968-976
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 968-976
-
-
Spehlmann, M.E.1
Begun, A.Z.2
Burghardt, J.3
Lepage, P.4
Raedler, A.5
Schreiber, S.6
-
5
-
-
11144354272
-
Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs
-
van Heel DA, Fisher SA, Kirby A, Daly MJ, Rioux JD, Lewis CM (2004) Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. Hum Mol Genet 13:763-770
-
(2004)
Hum Mol Genet
, vol.13
, pp. 763-770
-
-
Van Heel, D.A.1
Fisher, S.A.2
Kirby, A.3
Daly, M.J.4
Rioux, J.D.5
Lewis, C.M.6
-
6
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M et al (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599-603
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
Chamaillard, M.2
Zouali, H.3
Lesage, S.4
Cezard, J.P.5
Belaiche, J.6
Almer, S.7
Tysk, C.8
O'Morain, C.A.9
Gassull, M.10
-
7
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH et al (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411:603-606
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
Bonen, D.K.2
Inohara, N.3
Nicolae, D.L.4
Chen, F.F.5
Ramos, R.6
Britton, H.7
Moran, T.8
Karaliuskas, R.9
Duerr, R.H.10
-
8
-
-
79959216005
-
Genetics and pathogenesis of inflammatory bowel disease
-
Khor B, Gardet A, Xavier RJ (2011) Genetics and pathogenesis of inflammatory bowel disease. Nature 474:307-317
-
(2011)
Nature
, vol.474
, pp. 307-317
-
-
Khor, B.1
Gardet, A.2
Xavier, R.J.3
-
9
-
-
78649489009
-
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
-
Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R et al (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 42:1118-1125
-
(2010)
Nat Genet
, vol.42
, pp. 1118-1125
-
-
Franke, A.1
McGovern, D.P.2
Barrett, J.C.3
Wang, K.4
Radford-Smith, G.L.5
Ahmad, T.6
Lees, C.W.7
Balschun, T.8
Lee, J.9
Roberts, R.10
-
10
-
-
50249086073
-
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH et al (2008) XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134:743-756
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
Lee, A.H.2
Franke, A.3
Glickman, J.N.4
Zeissig, S.5
Tilg, H.6
Nieuwenhuis, E.E.7
Higgins, D.E.8
Schreiber, S.9
Glimcher, L.H.10
-
11
-
-
80054975975
-
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
-
Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, Zhang CK, Boucher G, Ripke S, Ellinghaus D, Burtt N et al (2011) Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat Genet 43:1066-1073
-
(2011)
Nat Genet
, vol.43
, pp. 1066-1073
-
-
Rivas, M.A.1
Beaudoin, M.2
Gardet, A.3
Stevens, C.4
Sharma, Y.5
Zhang, C.K.6
Boucher, G.7
Ripke, S.8
Ellinghaus, D.9
Burtt, N.10
-
12
-
-
0025887076
-
Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum
-
Rutgeerts P, Goboes K, Peeters M, Hiele M, Penninckx F, Aerts R, Kerremans R, Vantrappen G (1991) Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Lancet 338:771-774
-
(1991)
Lancet
, vol.338
, pp. 771-774
-
-
Rutgeerts, P.1
Goboes, K.2
Peeters, M.3
Hiele, M.4
Penninckx, F.5
Aerts, R.6
Kerremans, R.7
Vantrappen, G.8
-
14
-
-
33645019411
-
Specificities of the fecal microbiota in inflammatory bowel disease
-
Sokol H, Seksik P, Rigottier-Gois L, Lay C, Lepage P, Podglajen I, Marteau P, Dore J (2006) Specificities of the fecal microbiota in inflammatory bowel disease. Inflamm Bowel Dis 12:106-111
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 106-111
-
-
Sokol, H.1
Seksik, P.2
Rigottier-Gois, L.3
Lay, C.4
Lepage, P.5
Podglajen, I.6
Marteau, P.7
Dore, J.8
-
15
-
-
54349126970
-
Highthroughput diversity and functionality analysis of the gastrointestinal tract microbiota
-
Zoetendal EG, Rajilic-Stojanovic M, de Vos WM (2008) Highthroughput diversity and functionality analysis of the gastrointestinal tract microbiota. Gut 57:1605-1615
-
(2008)
Gut
, vol.57
, pp. 1605-1615
-
-
Zoetendal, E.G.1
Rajilic-Stojanovic, M.2
De Vos, W.M.3
-
17
-
-
34548483459
-
Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum
-
Baumgart M, Dogan B, Rishniw M, Weitzman G, Bosworth B, Yantiss R, Orsi RH, Wiedmann M, McDonough P, Kim SG et al (2007) Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum. Isme J 1:403-418
-
(2007)
Isme J
, vol.1
, pp. 403-418
-
-
Baumgart, M.1
Dogan, B.2
Rishniw, M.3
Weitzman, G.4
Bosworth, B.5
Yantiss, R.6
Orsi, R.H.7
Wiedmann, M.8
McDonough, P.9
Kim, S.G.10
-
18
-
-
4143069158
-
High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
-
Darfeuille-Michaud A, Boudeau J, Bulois P, Neut C, Glasser AL, Barnich N, Bringer MA, Swidsinski A, Beaugerie L, Colombel JF (2004) High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 127:412-421
-
(2004)
Gastroenterology
, vol.127
, pp. 412-421
-
-
Darfeuille-Michaud, A.1
Boudeau, J.2
Bulois, P.3
Neut, C.4
Glasser, A.L.5
Barnich, N.6
Bringer, M.A.7
Swidsinski, A.8
Beaugerie, L.9
Colombel, J.F.10
-
19
-
-
0031758230
-
Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease
-
Darfeuille-Michaud A, Neut C, Barnich N, Lederman E, Di Martino P, Desreumaux P, Gambiez L, Joly B, Cortot A, Colombel JF (1998) Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease. Gastroenterology 115:1405-1413
-
(1998)
Gastroenterology
, vol.115
, pp. 1405-1413
-
-
Darfeuille-Michaud, A.1
Neut, C.2
Barnich, N.3
Lederman, E.4
Di Martino, P.5
Desreumaux, P.6
Gambiez, L.7
Joly, B.8
Cortot, A.9
Colombel, J.F.10
-
20
-
-
44349143335
-
Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells
-
Eaves-Pyles T, Allen CA, Taormina J, Swidsinski A, Tutt CB, Eric Jezek G, Islas-Islas M, Torres AG (2008) Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells. Int J Med Microbiol 298:397-409
-
(2008)
Int J Med Microbiol
, vol.298
, pp. 397-409
-
-
Eaves-Pyles, T.1
Allen, C.A.2
Taormina, J.3
Swidsinski, A.4
Tutt, C.B.5
Eric Jezek, G.6
Islas-Islas, M.7
Torres, A.G.8
-
21
-
-
67649509224
-
Molecular diversity of Escherichia coli in the human gut: New ecological evidence supporting the role of adherent-invasive E. coli (AIEC) in Crohn's disease
-
Martinez-Medina M, Aldeguer X, Lopez-Siles M, Gonzalez-Huix F, Lopez-Oliu C, Dahbi G, Blanco JE, Blanco J, Garcia-Gil LJ, Darfeuille-Michaud A (2009) Molecular diversity of Escherichia coli in the human gut: new ecological evidence supporting the role of adherent-invasive E. coli (AIEC) in Crohn's disease. Inflamm Bowel Dis 15:872-882
-
(2009)
Inflamm Bowel Dis
, vol.15
, pp. 872-882
-
-
Martinez-Medina, M.1
Aldeguer, X.2
Lopez-Siles, M.3
Gonzalez-Huix, F.4
Lopez-Oliu, C.5
Dahbi, G.6
Blanco, J.E.7
Blanco, J.8
Garcia-Gil, L.J.9
Darfeuille-Michaud, A.10
-
22
-
-
34548770119
-
Invasive Escherichia coli are a feature of Crohn's disease
-
Sasaki M, Sitaraman SV, Babbin BA, Gerner-Smidt P, Ribot EM, Garrett N, Alpern JA, Akyildiz A, Theiss AL, Nusrat A et al (2007) Invasive Escherichia coli are a feature of Crohn's disease. Lab Invest 87:1042-1054
-
(2007)
Lab Invest
, vol.87
, pp. 1042-1054
-
-
Sasaki, M.1
Sitaraman, S.V.2
Babbin, B.A.3
Gerner-Smidt, P.4
Ribot, E.M.5
Garrett, N.6
Alpern, J.A.7
Akyildiz, A.8
Theiss, A.L.9
Nusrat, A.10
-
23
-
-
34249886868
-
CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease
-
Barnich N, Carvalho FA, Glasser AL, Darcha C, Jantscheff P, Allez M, Peeters H, Bommelaer G, Desreumaux P, Colombel JF et al (2007) CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest 117:1566-1574
-
(2007)
J Clin Invest
, vol.117
, pp. 1566-1574
-
-
Barnich, N.1
Carvalho, F.A.2
Glasser, A.L.3
Darcha, C.4
Jantscheff, P.5
Allez, M.6
Peeters, H.7
Bommelaer, G.8
Desreumaux, P.9
Colombel, J.F.10
-
24
-
-
70350468598
-
Crohn's disease adherentinvasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM
-
Carvalho FA, Barnich N, Sivignon A, Darcha C, Chan CH, Stanners CP, Darfeuille-Michaud A (2009) Crohn's disease adherentinvasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM. J Exp Med 206:2179-2189
-
(2009)
J Exp Med
, vol.206
, pp. 2179-2189
-
-
Carvalho, F.A.1
Barnich, N.2
Sivignon, A.3
Darcha, C.4
Chan, C.H.5
Stanners, C.P.6
Darfeuille-Michaud, A.7
-
25
-
-
67650973314
-
Increased short-and long-term risk of inflammatory bowel disease after salmonella or campylobacter gastroenteritis
-
Gradel KO, Nielsen HL, Schonheyder HC, Ejlertsen T, Kristensen B, Nielsen H (2009) Increased short-and long-term risk of inflammatory bowel disease after salmonella or campylobacter gastroenteritis. Gastroenterology 137:495-501
-
(2009)
Gastroenterology
, vol.137
, pp. 495-501
-
-
Gradel, K.O.1
Nielsen, H.L.2
Schonheyder, H.C.3
Ejlertsen, T.4
Kristensen, B.5
Nielsen, H.6
-
27
-
-
77955708390
-
Overview of macroautophagy regulation in mammalian cells
-
Mehrpour M, Esclatine A, Beau I, Codogno P (2010) Overview of macroautophagy regulation in mammalian cells. Cell Res 20:748-762
-
(2010)
Cell Res
, vol.20
, pp. 748-762
-
-
Mehrpour, M.1
Esclatine, A.2
Beau, I.3
Codogno, P.4
-
28
-
-
33750363298
-
The roles of intracellular proteindegradation pathways in neurodegeneration
-
Rubinsztein DC (2006) The roles of intracellular proteindegradation pathways in neurodegeneration. Nature 443:780-786
-
(2006)
Nature
, vol.443
, pp. 780-786
-
-
Rubinsztein, D.C.1
-
29
-
-
33645221489
-
Excess peroxisomes are degraded by autophagic machinery in mammals
-
Iwata J, Ezaki J, Komatsu M, Yokota S, Ueno T, Tanida I, Chiba T, Tanaka K, Kominami E (2006) Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem 281:4035-4041
-
(2006)
J Biol Chem
, vol.281
, pp. 4035-4041
-
-
Iwata, J.1
Ezaki, J.2
Komatsu, M.3
Yokota, S.4
Ueno, T.5
Tanida, I.6
Chiba, T.7
Tanaka, K.8
Kominami, E.9
-
30
-
-
67650246357
-
Mitochondriaanchored receptor Atg32 mediates degradation of mitochondria via selective autophagy
-
Okamoto K, Kondo-Okamoto N, Ohsumi Y (2009) Mitochondriaanchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell 17:87-97
-
(2009)
Dev Cell
, vol.17
, pp. 87-97
-
-
Okamoto, K.1
Kondo-Okamoto, N.2
Ohsumi, Y.3
-
31
-
-
33845480131
-
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response
-
Bernales S, McDonald KL, Walter P (2006) Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol 4:e423
-
(2006)
PLoS Biol
, vol.4
-
-
Bernales, S.1
McDonald, K.L.2
Walter, P.3
-
32
-
-
77951256153
-
Autophagy in infection
-
Deretic V (2010) Autophagy in infection. Curr Opin Cell Biol 22:252-262
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 252-262
-
-
Deretic, V.1
-
33
-
-
78649338141
-
Autophagy and the integrated stress response
-
Kroemer G, Marino G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40:280-293
-
(2010)
Mol Cell
, vol.40
, pp. 280-293
-
-
Kroemer, G.1
Marino, G.2
Levine, B.3
-
34
-
-
77954754620
-
Autophagy and Crohn's disease: At the crossroads of infection, inflammation, immunity, and cancer
-
Brest P, Corcelle EA, Cesaro A, Chargui A, Belaid A, Klionsky DJ, Vouret-Craviari V, Hebuterne X, Hofman P, Mograbi B (2010) Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer. Curr Mol Med 10:486-502
-
(2010)
Curr Mol Med
, vol.10
, pp. 486-502
-
-
Brest, P.1
Corcelle, E.A.2
Cesaro, A.3
Chargui, A.4
Belaid, A.5
Klionsky, D.J.6
Vouret-Craviari, V.7
Hebuterne, X.8
Hofman, P.9
Mograbi, B.10
-
35
-
-
84855959618
-
Genetic variants in autophagy-related genes and granuloma formation in a cohort of surgically treated Crohn's disease patients
-
Brinar M, Vermeire S, Cleynen I, Lemmens B, Sagaert X, Henckaerts L, Van Assche G, Geboes K, Rutgeerts P, De Hertogh G (2012) Genetic variants in autophagy-related genes and granuloma formation in a cohort of surgically treated Crohn's disease patients. J Crohns Colitis 6:43-50
-
(2012)
J Crohns Colitis
, vol.6
, pp. 43-50
-
-
Brinar, M.1
Vermeire, S.2
Cleynen, I.3
Lemmens, B.4
Sagaert, X.5
Henckaerts, L.6
Van Assche, G.7
Geboes, K.8
Rutgeerts, P.9
De Hertogh, G.10
-
36
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
-
Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J et al (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39:207-211
-
(2007)
Nat Genet
, vol.39
, pp. 207-211
-
-
Hampe, J.1
Franke, A.2
Rosenstiel, P.3
Till, A.4
Teuber, M.5
Huse, K.6
Albrecht, M.7
Mayr, G.8
De La Vega, F.M.9
Briggs, J.10
-
37
-
-
79955790354
-
Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease
-
Henckaerts L, Cleynen I, Brinar M, John JM, Van Steen K, Rutgeerts P, Vermeire S (2011) Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease. Inflamm Bowel Dis 17:1392-1397
-
(2011)
Inflamm Bowel Dis
, vol.17
, pp. 1392-1397
-
-
Henckaerts, L.1
Cleynen, I.2
Brinar, M.3
John, J.M.4
Van Steen, K.5
Rutgeerts, P.6
Vermeire, S.7
-
38
-
-
34347338690
-
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
-
Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D et al (2007) Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 39:830-832
-
(2007)
Nat Genet
, vol.39
, pp. 830-832
-
-
Parkes, M.1
Barrett, J.C.2
Prescott, N.J.3
Tremelling, M.4
Anderson, C.A.5
Fisher, S.A.6
Roberts, R.G.7
Nimmo, E.R.8
Cummings, F.R.9
Soars, D.10
-
39
-
-
34247554965
-
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
-
Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW et al (2007) Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 39:596-604
-
(2007)
Nat Genet
, vol.39
, pp. 596-604
-
-
Rioux, J.D.1
Xavier, R.J.2
Taylor, K.D.3
Silverberg, M.S.4
Goyette, P.5
Huett, A.6
Green, T.7
Kuballa, P.8
Barmada, M.M.9
Datta, L.W.10
-
40
-
-
84871462682
-
Toll-like receptor gene polymorphisms and susceptibility to inflammatory bowel disease in Chinese Han and Caucasian populations
-
Shen XY, Shi RH, Wang Y, Zhang HJ, Zhou XQ, Shen FC, Li KB (2010) Toll-like receptor gene polymorphisms and susceptibility to inflammatory bowel disease in Chinese Han and Caucasian populations. Zhonghua Yi Xue Za Zhi 90:1416-1420
-
(2010)
Zhonghua Yi Xue Za Zhi
, vol.90
, pp. 1416-1420
-
-
Shen, X.Y.1
Shi, R.H.2
Wang, Y.3
Zhang, H.J.4
Zhou, X.Q.5
Shen, F.C.6
Li, K.B.7
-
41
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM et al (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40:955-962
-
(2008)
Nat Genet
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
Hansoul, S.2
Nicolae, D.L.3
Cho, J.H.4
Duerr, R.H.5
Rioux, J.D.6
Brant, S.R.7
Silverberg, M.S.8
Taylor, K.D.9
Barmada, M.M.10
-
42
-
-
73849151394
-
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
-
Cooney R, Baker J, Brain O, Danis B, Pichulik T, Allan P, Ferguson DJ, Campbell BJ, Jewell D, Simmons A (2010) NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 16:90-97
-
(2010)
Nat Med
, vol.16
, pp. 90-97
-
-
Cooney, R.1
Baker, J.2
Brain, O.3
Danis, B.4
Pichulik, T.5
Allan, P.6
Ferguson, D.J.7
Campbell, B.J.8
Jewell, D.9
Simmons, A.10
-
43
-
-
54849421128
-
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
-
Kuballa P, Huett A, Rioux JD, Daly MJ, Xavier RJ (2008) Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE 3:e3391
-
(2008)
PLoS ONE
, vol.3
-
-
Kuballa, P.1
Huett, A.2
Rioux, J.D.3
Daly, M.J.4
Xavier, R.J.5
-
44
-
-
77649194674
-
Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly
-
Lapaquette P, Glasser AL, Huett A, Xavier RJ, Darfeuille-Michaud A (2010) Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol 12:99-113
-
(2010)
Cell Microbiol
, vol.12
, pp. 99-113
-
-
Lapaquette, P.1
Glasser, A.L.2
Huett, A.3
Xavier, R.J.4
Darfeuille-Michaud, A.5
-
45
-
-
73849121209
-
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
-
Travassos LH, Carneiro LA, Ramjeet M, Hussey S, Kim YG, Magalhaes JG, Yuan L, Soares F, Chea E, Le Bourhis L et al (2010) Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 11:55-62
-
(2010)
Nat Immunol
, vol.11
, pp. 55-62
-
-
Travassos, L.H.1
Carneiro, L.A.2
Ramjeet, M.3
Hussey, S.4
Kim, Y.G.5
Magalhaes, J.G.6
Yuan, L.7
Soares, F.8
Chea, E.9
Le Bourhis, L.10
-
46
-
-
77957682295
-
ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis
-
1641 e1631-1632
-
Homer CR, Richmond AL, Rebert NA, Achkar JP, McDonald C (2010) ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis. Gastroenterology 139:1630-1641, 1641 e1631-1632
-
(2010)
Gastroenterology
, vol.139
, pp. 1630-1641
-
-
Homer, C.R.1
Richmond, A.L.2
Rebert, N.A.3
Achkar, J.P.4
McDonald, C.5
-
47
-
-
84861186087
-
Defects in autophagy favour adherent-invasive E. coli persistence within macrophages leading to increased pro-inflammatory response
-
Lapaquette P, Bringer MA, Darfeuille-Michaud A (2012) Defects in autophagy favour adherent-invasive E. coli persistence within macrophages leading to increased pro-inflammatory response. Cell Microbiol 14:791-807
-
(2012)
Cell Microbiol
, vol.14
, pp. 791-807
-
-
Lapaquette, P.1
Bringer, M.A.2
Darfeuille-Michaud, A.3
-
48
-
-
80051550866
-
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
-
Plantinga TS, Crisan TO, Oosting M, van de Veerdonk FL, de Jong DJ, Philpott DJ, van der Meer JW, Girardin SE, Joosten LA, Netea MG (2011) Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut 60:1229-1235
-
(2011)
Gut
, vol.60
, pp. 1229-1235
-
-
Plantinga, T.S.1
Crisan, T.O.2
Oosting, M.3
Van De Veerdonk, F.L.4
De Jong, D.J.5
Philpott, D.J.6
Van Der Meer, J.W.7
Girardin, S.E.8
Joosten, L.A.9
Netea, M.G.10
-
49
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
-
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M et al (2008) Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456:264-268
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
Uematsu, S.4
Yang, B.G.5
Satoh, T.6
Omori, H.7
Noda, T.8
Yamamoto, N.9
Komatsu, M.10
-
50
-
-
77953904042
-
Virusplus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
-
Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW (2010) Virusplus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 141:1135-1145
-
(2010)
Cell
, vol.141
, pp. 1135-1145
-
-
Cadwell, K.1
Patel, K.K.2
Maloney, N.S.3
Liu, T.C.4
Ng, A.C.5
Storer, C.E.6
Head, R.D.7
Xavier, R.8
Stappenbeck, T.S.9
Virgin, H.W.10
-
51
-
-
56249135538
-
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
-
Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S et al (2008) A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456:259-263
-
(2008)
Nature
, vol.456
, pp. 259-263
-
-
Cadwell, K.1
Liu, J.Y.2
Brown, S.L.3
Miyoshi, H.4
Loh, J.5
Lennerz, J.K.6
Kishi, C.7
Kc, W.8
Carrero, J.A.9
Hunt, S.10
-
52
-
-
79952134938
-
A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease
-
Brest P, Lapaquette P, Souidi M, Lebrigand K, Cesaro A, Vouret-Craviari V, Mari B, Barbry P, Mosnier JF, Hebuterne X et al (2011) A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat Genet 43:242-245
-
(2011)
Nat Genet
, vol.43
, pp. 242-245
-
-
Brest, P.1
Lapaquette, P.2
Souidi, M.3
Lebrigand, K.4
Cesaro, A.5
Vouret-Craviari, V.6
Mari, B.7
Barbry, P.8
Mosnier, J.F.9
Hebuterne, X.10
-
53
-
-
34047256441
-
IRG proteins: Key mediators of interferonregulated host resistance to intracellular pathogens
-
Taylor GA (2007) IRG proteins: key mediators of interferonregulated host resistance to intracellular pathogens. Cell Microbiol 9:1099-1107
-
(2007)
Cell Microbiol
, vol.9
, pp. 1099-1107
-
-
Taylor, G.A.1
-
54
-
-
33744509713
-
The interferoninducible p47 (IRG) GTPases in vertebrates: Loss of the cell autonomous resistance mechanism in the human lineage
-
Bekpen C, Hunn JP, Rohde C, Parvanova I, Guethlein L, Dunn DM, Glowalla E, Leptin M, Howard JC (2005) The interferoninducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol 6:R92
-
(2005)
Genome Biol
, vol.6
-
-
Bekpen, C.1
Hunn, J.P.2
Rohde, C.3
Parvanova, I.4
Guethlein, L.5
Dunn, D.M.6
Glowalla, E.7
Leptin, M.8
Howard, J.C.9
-
55
-
-
62149128961
-
Death and resurrection of the human IRGM gene
-
Bekpen C, Marques-Bonet T, Alkan C, Antonacci F, Leogrande MB, Ventura M, Kidd JM, Siswara P, Howard JC, Eichler EE (2009) Death and resurrection of the human IRGM gene. PLoS Genet 5:e1000403
-
(2009)
PLoS Genet
, vol.5
-
-
Bekpen, C.1
Marques-Bonet, T.2
Alkan, C.3
Antonacci, F.4
Leogrande, M.B.5
Ventura, M.6
Kidd, J.M.7
Siswara, P.8
Howard, J.C.9
Eichler, E.E.10
-
56
-
-
0035898464
-
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection
-
Collazo CM, Yap GS, Sempowski GD, Lusby KC, Tessarollo L, Woude GF, Sher A, Taylor GA (2001) Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med 194:181-188
-
(2001)
J Exp Med
, vol.194
, pp. 181-188
-
-
Collazo, C.M.1
Yap, G.S.2
Sempowski, G.D.3
Lusby, K.C.4
Tessarollo, L.5
Woude, G.F.6
Sher, A.7
Taylor, G.A.8
-
57
-
-
10944253145
-
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
-
Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V (2004) Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119:753-766
-
(2004)
Cell
, vol.119
, pp. 753-766
-
-
Gutierrez, M.G.1
Master, S.S.2
Singh, S.B.3
Taylor, G.A.4
Colombo, M.I.5
Deretic, V.6
-
58
-
-
0142240338
-
Immune control of tuberculosis by IFN-gamma-inducible LRG-47
-
MacMicking JD, Taylor GA, McKinney JD (2003) Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 302:654-659
-
(2003)
Science
, vol.302
, pp. 654-659
-
-
MacMicking, J.D.1
Taylor, G.A.2
McKinney, J.D.3
-
59
-
-
33748506089
-
Human IRGM induces autophagy to eliminate intracellular mycobacteria
-
Singh SB, Davis AS, Taylor GA, Deretic V (2006) Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313:1438-1441
-
(2006)
Science
, vol.313
, pp. 1438-1441
-
-
Singh, S.B.1
Davis, A.S.2
Taylor, G.A.3
Deretic, V.4
-
60
-
-
50449091647
-
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
-
McCarroll SA, Huett A, Kuballa P, Chilewski SD, Landry A, Goyette P, Zody MC, Hall JL, Brant SR, Cho JH et al (2008) Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 40:1107-1112
-
(2008)
Nat Genet
, vol.40
, pp. 1107-1112
-
-
McCarroll, S.A.1
Huett, A.2
Kuballa, P.3
Chilewski, S.D.4
Landry, A.5
Goyette, P.6
Zody, M.C.7
Hall, J.L.8
Brant, S.R.9
Cho, J.H.10
-
61
-
-
11844278458
-
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
-
Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15-20
-
(2005)
Cell
, vol.120
, pp. 15-20
-
-
Lewis, B.P.1
Burge, C.B.2
Bartel, D.P.3
-
62
-
-
79959931707
-
Risk predisposition for Crohn disease: A "menage a trois" combining IRGM allele, miRNA and xenophagy
-
Brest P, Lapaquette P, Mograbi B, Darfeuille-Michaud A, Hofman P (2011) Risk predisposition for Crohn disease: a "menage a trois" combining IRGM allele, miRNA and xenophagy. Autophagy 7:786-787
-
(2011)
Autophagy
, vol.7
, pp. 786-787
-
-
Brest, P.1
Lapaquette, P.2
Mograbi, B.3
Darfeuille-Michaud, A.4
Hofman, P.5
-
63
-
-
78049340862
-
Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease
-
Fasseu M, Treton X, Guichard C, Pedruzzi E, Cazals-Hatem D, Richard C, Aparicio T, Daniel F, Soule JC, Moreau R et al (2010) Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS One 5:e13160
-
(2010)
PLoS One
, vol.5
-
-
Fasseu, M.1
Treton, X.2
Guichard, C.3
Pedruzzi, E.4
Cazals-Hatem, D.5
Richard, C.6
Aparicio, T.7
Daniel, F.8
Soule, J.C.9
Moreau, R.10
-
64
-
-
78649833818
-
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
-
Singh SB, Ornatowski W, Vergne I, Naylor J, Delgado M, Roberts E, Ponpuak M, Master S, Pilli M, White E et al (2010) Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol 12:1154-1165
-
(2010)
Nat Cell Biol
, vol.12
, pp. 1154-1165
-
-
Singh, S.B.1
Ornatowski, W.2
Vergne, I.3
Naylor, J.4
Delgado, M.5
Roberts, E.6
Ponpuak, M.7
Master, S.8
Pilli, M.9
White, E.10
-
65
-
-
84855293818
-
IRGM is a common target of RNAviruses that subvert the autophagy network
-
Gregoire IP, Richetta C, Meyniel-Schicklin L, Borel S, Pradezynski F, Diaz O, Deloire A, Azocar O, Baguet J, Le Breton M et al (2011) IRGM is a common target of RNAviruses that subvert the autophagy network. PLoS Pathog 7:e1002422
-
(2011)
PLoS Pathog
, vol.7
-
-
Gregoire, I.P.1
Richetta, C.2
Meyniel-Schicklin, L.3
Borel, S.4
Pradezynski, F.5
Diaz, O.6
Deloire, A.7
Azocar, O.8
Baguet, J.9
Le Breton, M.10
-
66
-
-
46049115921
-
Everolimus for refractory Crohn's disease: A case report
-
Dumortier J, Lapalus MG, Guillaud O, Poncet G, Gagnieu MC, Partensky C, Scoazec JY (2008) Everolimus for refractory Crohn's disease: a case report. Inflamm Bowel Dis 14:874-877
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 874-877
-
-
Dumortier, J.1
Lapalus, M.G.2
Guillaud, O.3
Poncet, G.4
Gagnieu, M.C.5
Partensky, C.6
Scoazec, J.Y.7
-
67
-
-
50249111131
-
Use of sirolimus (rapamycin) to treat refractory Crohn's disease
-
Massey DC, Bredin F, Parkes M (2008) Use of sirolimus (rapamycin) to treat refractory Crohn's disease. Gut 57:1294-1296
-
(2008)
Gut
, vol.57
, pp. 1294-1296
-
-
Massey, D.C.1
Bredin, F.2
Parkes, M.3
-
68
-
-
70349616273
-
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling
-
Balgi AD, Fonseca BD, Donohue E, Tsang TC, Lajoie P, Proud CG, Nabi IR, Roberge M (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4:e7124
-
(2009)
PLoS One
, vol.4
-
-
Balgi, A.D.1
Fonseca, B.D.2
Donohue, E.3
Tsang, T.C.4
Lajoie, P.5
Proud, C.G.6
Nabi, I.R.7
Roberge, M.8
-
69
-
-
37649024076
-
Small molecule regulators of autophagy identified by an image-based high-throughput screen
-
Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD, Xie X, Ma D et al (2007) Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A 104:19023-19028
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19023-19028
-
-
Zhang, L.1
Yu, J.2
Pan, H.3
Hu, P.4
Hao, Y.5
Cai, W.6
Zhu, H.7
Yu, A.D.8
Xie, X.9
Ma, D.10
-
70
-
-
34248994604
-
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
-
Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL et al (2007) Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol 3:331-338
-
(2007)
Nat Chem Biol
, vol.3
, pp. 331-338
-
-
Sarkar, S.1
Perlstein, E.O.2
Imarisio, S.3
Pineau, S.4
Cordenier, A.5
Maglathlin, R.L.6
Webster, J.A.7
Lewis, T.A.8
O'Kane, C.J.9
Schreiber, S.L.10
|