New global map of Crohn's disease: Genetic, environmental, and socioeconomic correlations

Inflammatory Bowel Diseases

Volumn 14, Issue 5, 2008, Pages 709-720

  Economou, Michael ^a   Pappas, Georgios ^a  

^a Institute of Continuing Medical Education of Ioannina   (Greece)

Author keywords

Affluence; Crohn's disease; Epidemiology; Etiology; Genetics; Incidence; NOD2; Paratuberculosis

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15;

CORRELATION ANALYSIS; CROHN DISEASE; ENVIRONMENTAL FACTOR; GENE MUTATION; HEREDITY; HUMAN; INCIDENCE; MYCOBACTERIUM AVIUM; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; REVIEW; SOCIOECONOMICS;

CROHN DISEASE; ENVIRONMENTAL EXPOSURE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MORBIDITY; SOCIOECONOMIC FACTORS; WORLD HEALTH;

EID: 44349104723     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.20352     Document Type: Review

References (156)

1. Gaya DR, Russell RK, Nimmo ER, et al. New genes in inflammatory bowel disease: lessons for complex diseases? Lancet. 2006;367:1271-1284.
2. Greenstein RJ. Is Crohn's disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johne's disease. Lancet Infect Dis. 2003;3:507-514.
3. Binder V. Epidemiology of IBD during the twentieth century: an integrated view. Best Pract Res Clin Gastroenterol. 2004;18:463-479.
4. Latour P, Louis E, Belaiche J. Incidence of inflammatory bowel disease in the area of Liege: a 3 years prospective study (1993-1996). Acta Gastroenterol Belg. 1998;61:410-413.
5. Van Gossum A, Adler M, De Reuck M, et al. Epidemiology of inflammatory bowel disease in Brussels' area (1992-1993). Acta Gastroenterol Belg. 1996;59:7-9.
6. Souza MH, Troncon LE, Rodrigues CM, et al. Trends in the occurrence (1980-1999) and clinical features of Crohn's disease and ulcerative colitis in a university hospital in southeastern Brazil. Arq Gastroenterol. 2002. Apr;39:98-105.
7. Bernstein CN, Wajda A, Svenson LW, et al. The epidemiology of inflammatory bowel disease in Canada: a population-based study. Am J Gastroenterol. 2006;101:1559-1568.
8. Bernstein CN, Blanchard JF, Rawsthorne P, et al. Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian province: a population-based study. Am J Epidemiol. 1999;149:916-924.
9. Figueroa CC, Quera PR, Valenzuela EJ, et al. Inflammatory bowel disease: experience of two Chilean centers. Rev Med Chil. 2005;133:1295-1304.
10. Zheng J, Zhu X, Hungfu Z, et al. Crohn's disease in mainland China: a systematic analysis of 50 years of research. Chin J Dig Dis. 2005;6:175-181.
11. Sincic BM, Vucelic B, Persic M, et al. Incidence of inflammatory bowel disease in Primorsko-goranska County, Croatia, 2000-2004: A prospective population-based study. Scand J Gastroenterol. 2006;41:437-444.
12. Vind I, Riis L, Jess T, et al. Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003-2005: a population-based study from the Danish Crohn colitis database. Am J Gastroenterol. 2006;101:1274-1282.
13. Fonager K, Sorensen HT, Olsen J. Change in incidence of Crohn's disease and ulcerative colitis in Denmark. A study based on the National Registry of Patients, 1981-1992. Int J Epidemiol. 1997;26:1003-1008.
14. Salupere R. Inflammatory bowel disease in Estonia: a prospective epidemiologic study 1993-1998. World J Gastroenterol. 2001;7:387-388.
15. Molinie F, Gower-Rousseau C, Yzet T, et al. Opposite evolution in incidence of Crohn's disease and ulcerative colitis in Northern France (1988-1999). Gut. 2004;53:843-848.
16. Shivananda S, Lennard-Jones J, Logan R, et al. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut. 1996;39:690-697.
17. Pagenault M, Tron I, Alexandre JL. Incidence of inflammatory bowel diseases in Bretagne (1994-1995). ABERMAD. Association Bertonne d'Etude et de Recherche des Maladies de l'Appareil Digesif. Gastroenterol Clin Biol. 1997;21:483-490.
18. Flamenbaum M, Zenut M, Aublet-Cuvelier B, et al. Incidence of inflammatory bowel diseases in the department of Puy-de-Dome in 1993 and 1994. Gastroenterol Clin Biol. 1997;21:491-496.
19. Timmer A, Breuer-Katschinski B, Goebell H. Time trends in the incidence and disease location of Crohn's disease 1980-1995: a prospective analysis in an urban population in Germany. Inflamm Bowel Dis. 1999;5:79-84.
20. Loffler A, Glados M. Data on the epidemiology of Crohn disease in the city of Cologne. Med Klin (Munich). 1993;88:516-519.
21. Tsianos EV, Masalas CN, Merkouropoulos M, Dalekos GN, Logan RF. Incidence of inflammatory bowel disease in north west Greece: rarity of Crohn's disease in an area where ulcerative colitis is common. Gut. 1994;35:369-372.
22. Manousos ON, Koutroubakis I, Potamianos S, et al. A prospective epidemiologic study of Crohn's disease in Heraklion, Crete. Incidence over a 5-year period. Scand J Gastroenterol. 1996;31:599-603.
23. Lakatos L, Mester G, Erdelyi Z, et al. Epidemiology of inflammatory bowel diseases in Veszprem county of Western Hungary between 1977 and 2001. Orv Hetil. 2003;144:1819-1827.
24. Bjornsson S, Johannsson JH. Inflammatory bowel disease in Iceland, 1990-1994: a prospective, nationwide, epidemiological study. Eur J Gastroenterol Hepatol. 2000;12:31-38.
25. Fidder HH, Avidan B, Lahav M, et al. Clinical and demographic characterization of Jewish Crohn's disease patients in Israel. J Clin Gastroenterol. 2003;36:8-12.
26. Niv Y, Abuksis G, Fraser GM. Epidemiology of Crohn's disease in Israel: a survey of Israeli kibbutz settlements. Am J Gastroenterol. 1999;94:2961-2965.
27. Tragnone A, Corrao G, Miglio F, et al. Incidence of inflammatory bowel disease in Italy: a nationwide population-based study. Gruppo Italiano per lo Studio del Colon e del Retto (GISC). Int J Epidemiol. 1996;25:1044-1052.
28. Yao T, Matsui T, Hiwatashi N. Crohn's disease in Japan: diagnostic criteria and epidemiology. Dis Colon Rectum. 2000;43:S85-93.
29. Morita N, Toki S, Hirohashi T, et al. Incidence and prevalence of inflammatory bowel disease in Japan: nationwide epidemiological survey during the year 1991. J Gastroenterol. 1995;30(suppl 8):1-4.
30. Abdul-Baki H, ElHajj I, El-Zahabi LM, et al. Clinical epidemiology of inflammatory bowel disease in Lebanon. Inflamm Bowel Dis. 2007;13:475-480.
31. Russel MG, Dorant E, Volovics A, et al. High incidence of inflammatory bowel disease in the Netherlands: results of a prospective study. The South Limburg IBD Study Group. Dis Colon Rectum. 1998;41:33-40.
32. Gearry RB, Richardson A, Frampton CM, et al. High incidence of Crohn's disease in Canterbury, New Zealand: results of an epidemiologic study. Inflamm Bowel Dis. 2006;12:936-943.
33. Moum B, Vatn MH, Ekbom A, et al. Incidence of Crohn's disease in four counties in southeastern Norway, 1990-93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists. Scand J Gastroenterol. 1996;31:355-361.
34. Wiercinska-Drapalo A, Jaroszewicz J, Flisiak R, et al. Epidemiological characteristics of inflammatory bowel disease in North-Eastern Poland. World J Gastroenterol. 2005;11:2630-2633.
35. Appleyard CB, Hernandez G, Rios-Bedoya CF. Basic epidemiology of inflammatory bowel disease in Puerto Rico. Inflamm Bowel Dis. 2004;10:106-111.
36. Al-Ghamdi AS, Al-Mofleh IA, Al-Rashed RS, et al. Epidemiology and outcome of Crohn's disease in a teaching hospital in Riyadh. World J Gastroenterol. 2004;10:1341-1344.
37. Prikazka M, Letkovicova M, Matejickova V. Crohn's disease in Slovakia: prevalence, socioeconomic and psychological analysis. Eur J Epidemiol. 1998;14:49-53.
38. Lopez Miguel C, Sicilia B, Sierra E, et al. Incidence of inflammatory bowel disease in Aragon: outcome of a prospective population-based study. Gastroenterol Hepatol. 1999;22:323-328.
39. Saro Gismera C, Lacort Fernandez M, Arguelles Fernandez G, et al. Incidence and prevalence of inflammatory bowel disease in Gijon, Asturias, Spain. Gastroenterol Hepatol. 2000;23:322-327.
40. Mate-Jimenez J, Munoz S, Vicent D, et al. Incidence and prevalence of ulcerative colitis and Crohn's disease in urban and rural areas of Spain from 1981 to 1988. J Clin Gastroenterol. 1994;18:27-31.
41. 4L Martinez-Salmeron JF, Rodrigo M, de Teresa J, et al. Epidemiology of inflammatory bowel disease in the Province of Granada. Spain: a retrospective study from 1979 to 1988. Gut. 1993;34:1207-1209.
42. Garrido A, Martinez MJ, Ortega JA, et al. Epidemiology of chronic inflammatory bowel disease in the Northern area of Huelva. Rev Esp Enferm Dig. 2004;96:687-694.
43. Brullet E, Bonfill X, Urrutia G, et al. Epidemiological study on the incidence of inflammatory bowel disease in 4 Spanish areas. Spanish Group on the Epidemiological Study of Inflammatory Bowel Disease. Med Clin (Barc). 1998;110:651-656.
44. Arin Letamendia A, Burusco Paternain MJ, Borda Celaya F, et al. Epidemiological aspects of inflammatory bowel disease in the Pamplona area. Rev Esp Enferm Dig. 1999;91:769-776.
45. Lapidus A. Crohn's disease in Stockholm County during 1990-2001: an epidemiological update. World J Gastroenterol. 2006;12:75-81.
46. Seagroatt V, Goldacre MJ. Crohn's disease, ulcerative colitis, and measles vaccine in an English population, 1979-1998. J Epidemiol Community Health. 2003;57:883-887.
47. Rubin GP, Hungin AP, Kelly PJ, et al. Inflammatory bowel disease: epidemiology and management in an English general practice population. Aliment Pharmacol Ther. 2000;14:1553-1559.
48. Thompson NP, Fleming DM, Charlton J, et al. Patients consulting with Crohn's disease in primary care in England and Wales. Eur J Gastroenterol Hepatol. 1998;10:1007-1012.
49. Kyle J. Crohn's disease in the northeastern and northern Isles of Scotland: an epidemiological review. Gastroenterology. 1992;103:392-399.
50. Bland R, Evans TJ, Raine P, et al. Inflammatory bowel disease in Scottish children. Health Bull (Edinb). 1999;57:365-373.
51. Watson AJ, Johnston AT, Barker PM, et al. The presentation and management of juvenile-onset chronic inflammatory bowel disease in Northeastern Scotland. J Pediatr Surg. 2002;37:83-86.
52. Jess T, Loftus EV Jr, Harmsen WS, et al. Survival and cause specific mortality in patients with inflammatory bowel disease: a long term outcome study in Olmsted County, Minnesota, 1940-2004. Gut. 2006;55:1248-1254.
53. Loftus EV Jr. Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology. 2004;126:1504-1517.
54. Kugathasan S, Judd RH, Hoffmann RG, et al. Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study. J Pediatr. 2003;143:525-531.
55. Ogunbi SO, Ransom JA, Sullivan K, et al. Inflammatory bowel disease in African-American children living in Georgia. J Pediatr. 1998;133:103-107.
56. Mendelhoff AI, Calkin BM. The epidemiology of inflammatory bowel disease. In: Kirsner JB, Shorter RG, eds. Inflammatory Bowel Disease. 3rd ed. Philadelphia: Lea and Febriger; 1988:3-34.
57. Depew WT. Clinical presentation and course of Crohn's disease in southeastern Ontario. Can J Gastroenterol. 1988;2:107-116.
58. Linares de la Cal JA, Canton C, Pajares JM, et al. Inflammatory bowel disease in Argentina and Panama (1987-1993). Eur J Gastroenterol Hepatol. 1997;9:1129.
59. Lapidus A, Bernell O, Hellers G, et al. Incidence of Crohn's disease in Stockholm County 1955-1989. Gut. 1997;41:480-486.
60. Ekbom A, Helmick C, Zack M, et al. The epidemiology of inflammatory bowel disease: a large, population-based study in Sweden. Gastroenterology. 1991;100:350-358.
61. Sepp E, Julge K, Vasar M, et al. Intestinal microflora of Estonian and Swedish infants. Acta Paediatr. 1997;86:956-961.
62. Fellows IW, Freeman JG, Holmes GK. Crohn's disease in the city of Derby, 1951-85. Gut. 1990;31:1262-1265.
63. Pickup RW, Rhodes G, Arnott S, et al. Mycobacterium avium subsp. paratuberculosis in the catchment area and water of the River Taff in South Wales, United Kingdom, and its potential relationship to clustering of Crohn's disease cases in the city of Cardiff. Appl Environ Microbiol. 2005;71:2130-2139.
64. Pozler O, Maly J, Bonova O. et al. Incidence of Crohn disease in the Czech Republic in the years 1990 to 2001 and assessment of pediatric population with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2006;42:186-189.
65. Yang SK, Loftus EV Jr, Sandborn WJ. Epidemiology of inflammatory bowel disease in Asia. Inflamm Bowel Dis. 2001;7:260-270.
66. Butt MT, Bener A, Al-Kaabi S, et al. Clinical characteristics of Crohns disease in Qatar. Saudi Med J. 2005;26:1796-1799.
67. Al-Nakib B, Radhakrishan S, Jacob GS, et al. Inflammatory bowel disease in Kuwait. Am J Gastroenterol. 1984;79:191-194.
68. Aghazadeh R, Zali MR, Bahari A, et al. Inflammatory bowel disease in Iran: a review of 457 cases. J Gastroenterol Hepatol. 2005;20:1691-1695.
69. Desai HG, Gupte PA. Increasing incidence of Crohn's disease in India: is it related to improved sanitation? Indian J Gastroenterol. 2005;24:23-24.
70. Tsironi E, Feakins RM, Probert CS, et al. Incidence of inflammatory bowel disease is rising and abdominal tuberculosis is falling in Bangladeshis in East London, United Kingdom. Am J Gastroenterol. 2004;99:1749-1755.
71. Rerknimitr R, Chalapipat O, Kongkam P, et al. Clinical characteristics of inflammatory bowel disease in Thailand: a 16 years review. J Med Assoc Thai. 2005;88(suppl 4):S129-133.
72. Hilmi I, Tan YM, Goh KL. Crohn's disease in adults: observations in a multiracial Asian population. World J Gastroenterol. 2006;12:1435-1438.
73. Lee YM, Fock K, See SJ, et al. Racial differences in the prevalence of ulcerative colitis and Crohn's disease in Singapore. J Gastroenterol Hepatol. 2000;15:622-625.
74. Jiang L, Xia B, Li J, et al. Retrospective survey of 452 patients with inflammatory bowel disease in Wuhan city, central China. Inflamm Bowel Dis. 2006;12:212-217.
75. McDermott FT, Whelan G, St John DJ, et al. Relative incidence of Crohn's disease and ulcerative colitis in six Melbourne hospitals. Med J Aust. 1987;146:525-529.
76. Phavichitr N, Cameron DJ, Catto-Smith AG. Increasing incidence of Crohn's disease in Victorian children. J Gastroenterol Hepatol. 2003;18:329-332.
77. Wright JP, Froggatt J, O'Keefe EA, et al. The epidemiology of inflammatory bowel disease in Cape Town 1980-1984. S Afr Med J. 1986;70:10-15.
78. Khalifa SE, Mudawi HM, Fedail SS. Presentation and management outcome of inflammatory bowel disease in Sudan. Trop Gastroenterol. 2005;26:194-196.
79. Mahiou H, Nakmouche M, Kaddache N, et al. Outcome of the first corticosteroid treatment course in uncomplicated Crohn's disease: a multicenter study. Proceedings of the 14th United European Gastroenterology Week, Abstract MON-G-107.
80. Joossens M, Simoens M, Vermeire S, et al. Contribution of genetic and environmental factors in the pathogenesis of Crohn's disease in a large family with multiple cases. Inflamm Bowel Dis. 2007;13:580-584.
81. Cuthbert AP, Fisher SA, Mirza MM, et al. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology. 2002;122:867-874.
82. Vermeire S, Louis E, Rutgeerts P, et al. NOD2/CARD15 does not influence response to infliximab in Crohn's disease. Gastroenterology. 2002;123:106-111.
83. Zhou Z, Lin XY, Akolkar PN, et al. Variation at NOD2/CARD15 in familial and sporadic cases of Crohn's disease in the Ashkenazi Jewish population. Am J Gastroenterol. 2002;97:3095-3101.
84. Croucher PJ, Mascheretti S, Hampe J, et al. Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations. Eur J Hum Genet. 2003;11:6-16.
85. Cavanaugh JA, Adams KE, Quak EJ, et al. CARD15/NOD2 risk alleles in the development of Crohn's disease in the Australian population. Ann Hum Genet. 2003;67:35-41.
86. Leong RW, Armuzzi A, Ahmad T, et al. NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population. Aliment Pharmacol Ther. 2003;17:1465-1470.
87. Newman B, Silverberg MS, Gu X, et al. CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease. Am J Gastroenterol. 2004;99:306-315.
88. Karban A, Waterman M, Panhuysen CI, et al. NOD2/CARD15 genotype and phenotype differences between Ashkenazi and Sephardic Jews with Crohn's disease. Am J Gastroenterol. 2004;99:1134-1140.
89. Vavassori P, Borgiani P, Biancone L, et al. CARD15 mutation analysis in an Italian population: Leu1007fsinsC but neither Arg702Trp nor Gly908Arg mutations are associated with Crohn's disease. Inflamm Bowel Dis. 2004;10:116-121.
90. Arnott ID, Nimmo ER, Drummond HE, et al. NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe? Genes Immun. 2004;5:417-425.
91. Lakatos L, Lakatos PL, Willheim-Polli C, et al. NOD2/CARD15 mutations and genotype-phenotype correlations in patients with Crohn's disease. Hungarian multicenter study. Orv Hetil. 2004;145:1403-1411.
92. Gazouli M, Zacharatos P, Mantzaris GJ, et al. Association of NOD2/CARD15 variants with Crohn's disease in a Greek population. Eur J Gastroenterol Hepatol. 2004;16:1177-1182.
93. Gazouli M, Mantzaris G, Kotsinas A, et al. Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population. World J Gastroenterol. 2005;11:681-685.
94. Gao M, Cao Q, Luo LH, et al. NOD2/CARD15 gene polymorphisms and susceptibility to Crohn's disease in Chinese Han population. Zhonghua Nei Ke Za Zhi. 2005;44:210-212.
95. Kugathasan S, Loizides A, Babusukumar U, et al. Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease. Inflamm Bowel Dis. 2005;11:631-638.
96. Braat H, Stokkers P, Hommes T, et al. Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn's disease patients. J Mol Med. 2005;83:601-609.
97. Karban A, Atia O, Leitersdorf E, et al. The relation between NOD2/CARD15 mutations and the prevalence and phenotypic heterogeneity of Crohn's disease: lessons from the Israeli Arab Crohn's disease cohort. Dig Dis Sci. 2005;50:1692-1697.
98. Vind I, Vieira A, Hougs L, et al. NOD2/CARD15 gene polymorphisms in Crohn's disease: a genotype-phenotype analysis in Danish and Portuguese patients and controls. Digestion. 2005;72:156-163.
99. Russell RK, Drummond HE, Nimmo EE, et al. Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease. Inflamm Bowel Dis. 2005;11:955-964.
100. Fries W, Renda MC, Lo Presti MA, et al. Intestinal permeability and genetic determinants in patients, first-degree relatives, and controls in a high-incidence area of Crohn's disease in Southern Italy. Am J Gastroenterol. 2005;100:2730-2736.
101. Mardini HE, Gregory KJ, Nasser M, et al. Gastroduodenal Crohn's disease is associated with NOD2/CARD15 gene polymorphisms, particularly L1007P homozygosity. Dig Dis Sci. 2005;50:2316-2322.
102. Uyar FA, Over-Hamzaoglu H, Ture F, et al. Distribution of common CARD15 variants in patients with sporadic Crohn's disease: cases from Turkey. Dig Dis Sci. 2006;51:706-710.
103. Torkvist L, Noble CL, Lordal M, et al. Contribution of CARD15 variants in determining susceptibility to Crohn's disease in Sweden. Scand J Gastroenterol. 2006;41:700-705.
104. Ozen SC, Dagli U, Kilic MY, et al. NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene polymorphisms in Turkish patients with inflammatory bowel disease. J Gastroenterol. 2006;41:304-310.
105. Cukovic-Cavka S, Vermeire S, Hrstic I, et al. NOD2/CARD15 mutations in Croatian patients with Crohn's disease: prevalence and genotype-phenotype relationship. Eur J Gastroenterol Hepatol. 2006;18:895-899.
106. De Diego C, Alcantara M, Valle J, et al. Frequency of CARD15 polymorphisms in patients with Crohn's disease from Toledo, Spain: genotype-phenotype correlation. Genet Test. 2006;10:178-185.
107. Cottone M, Renda MC, Mattaliano A, et al. Incidence of Crohn's disease and CARD15 mutation in a small township in Sicily. Eur J Epidemiol. 2006;21:887-892.
108. Brant SR, Wang MH, Rawsthorne P, et al. A population-based case-control study of CARD15 and other risk factors in Crohn's disease and ulcerative colitis. Am J Gastroenterol. 2007;102:313-323.
109. Riis L, Vind I, Vermeire S, et al. The prevalence of genetic and serologic markers in an unselected European population-based cohort of IBD patients. Inflamm Bowel Dis. 2007;13:24-32.
110. van der Linde K, Boor PP, Houwing-Duistermaat JJ, et al. CARD15 mutations in Dutch familial and sporadic inflammatory bowel disease and an overview of European studies. Eur J Gastroenterol Hepatol. 2007;19:449-459.
111. Aithal GP, Day CP, Leathart J, et al. Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population. Genes Immun. 2001;2:44-47.
112. Xia B, Crusius JB, Wu J, et al. CTLA4 gene polymorphisms in Dutch and Chinese patients with inflammatory bowel disease. Scand J Gastroenterol. 2002;37:1296-1300.
113. Tamura K, Fukuda Y, Sashio H, et al. IL18 polymorphism is associated with an increased risk of Crohn's disease. J Gastroenterol. 2002;37S14:111-116.
114. Stoll M, Corneliussen B, Costello CM, et al. Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet. 2004;36:476-480.
115. Urcelay E, Mendoza JL, Martinez A, et al. IBD5 polymorphisms in inflammatory bowel disease: association with response to infliximab. World J Gastroenterol. 2005;11:1187-1192.
116. Noble CL, Nimmo ER, Drummond H, et al. DLG5 variants do not influence susceptibility to inflammatory bowel disease in the Scottish population. Gut. 2005;54:1416-1420.
117. Gazouli M, Mantzaris G, Archimandritis AJ, et al. Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease. World J Gastroenterol. 2005;11:7525-7530.
118. Fernandez L, Martinez A, Mendoza JL, et al. Interleukin-10 polymorphisms in Spanish patients with IBD. Inflamm Bowel Dis. 2005;11:739-743.
119. Mittal RD, Bid HK, Ghoshal UC. IL-1 receptor antagonist (IL-1Ra) gene polymorphism in patients with inflammatory bowel disease in India. Scand J Gastroenterol. 2005;40:827-831.
120. Brand S, Staudinger T, Schnitzler F, et al. The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease. Inflamm Bowel Dis. 2005;11:645-652.
121. Yamazaki K, McGovern D, Ragoussis J, et al. Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum Mol Genet. 2005;14:3499-3506.
122. Song Y, Wu KC, Zhang L, et al. Correlation between a gene polymorphism of tumor necrosis factor and inflammatory bowel disease. Chin J Dig Dis. 2005;6:170-174.
123. Newman WG, Gu X, Wintle RF, et al. DLG5 variants contribute to Crohn disease risk in a Canadian population. Hum Mutat. 2006;27:353-358.
124. Tremelling M, Waller S, Bredin F, et al. Genetic variants in TNF-alpha but not DLG5 are associated with inflammatory bowel disease in a large United Kingdom cohort. Inflamm Bowel Dis. 2006;12:178-184.
125. Fidder HH, Heijmans R, Chowers Y, et al. TNF-857 polymorphism in Israeli Jewish patients with inflammatory bowel disease. Int J Immunogenet. 2006;33:81-85.
126. Tremelling M, Hancock L, Bredin F, et al. Complex insertion/deletion polymorphism in NOD1 (CARD4) is not associated with inflammatory bowel disease susceptibility in East Anglia panel. Inflamm Bowel Dis. 2006;12:967-971.
127. McGovern DP, Butler H, Ahmad T, et al. TUCAN (CARD8) genetic variants and inflammatory bowel disease. Gastroenterology. 2006;131:1190-1196.
128. Hume GE, Fowler EV, Lincoln D, et al. Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease. J Med Genet. 2006;43:e51.
129. Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006;314:1461-1463.
130. Biank V, Friedrichs F, Babusukumar U, et al. DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease. Am J Gastroenterol. 2007;102:391-398.
131. Silverberg MS, Duerr RH, Brant SR, et al. Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease. Eur J Hum Genet. 2007;15:328-335.
132. Glas J, Torek HP, Tonenchi L, et al. The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease. Int Immunol. 2007;19:621-626.
133. Magyari L, Farago B, Bene J, et al. No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples. World J Gastroenterol. 2007;13:2205-2208.
134. Torkvist L, Noble CL, Lordal M, et al. Contribution of the IBD5 locus to Crohn's disease in the Swedish population. Scand J Gastroenterol. 2007;42:200-206.
135. Glas J, Seiderer J, Wetzke M, et al. rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants. PLoS ONE. 2007;2:e819.
136. Tremelling M, Cummings F, Fisher SA, et al. IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology. 2007;132:1657-1664.
137. Cummings JR, Ahmad T, Geremia A, et al. Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype. Inflamm Bowel Dis. 2007;13:1063-1068.
138. Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 2007;39:207-211.
139. Rioux JD, Xavier RJ, Taylor KD, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet. 2007;39:596-604.
140. Prescott NJ, Fisher SA, Franke A, et al. A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology. 2007;132:1665-1671.
141. Cummings JR, Cooney R, Pathan S, et al. Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene. Inflamm Bowel Dis. 2007;13:941-946.
142. Yamazaki K, Onouchi Y, Takazoe M, et al. Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J Hum Genet. 2007;52:575-583.
143. Baldassano RN, Bradfield JP, Monos DS, et al. Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease. Gut. 2007;56:1171-1173.
144. Roberts RL, Gearry RB, Hollis-Moffatt JE, et al. IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease. Am J Gastroenterol. 2007 (in press).
145. Economou M, Trikalinos TA, Loizou KT, et al. Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am J Gastroenterol. 2004;99:2393-2404.
146. Gearry RB, Lea RA, Roberts RL, et al. CARD15 allele frequency differences in New Zealand Maori: ancestry specific susceptibility to Crohn's disease in New Zealand? Gut. 2006;55:580.
147. Hugot JP, Zaccaria I, Cavanaugh J, et al. Prevalence of CARD15/NOD2 mutations in Caucasian healthy people. Am J Gastroenterol. 2007;102:1259-1267.
148. Sechi LA, Gazouli M, Sieswerda LE, et al. Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients. World J Gastroenterol. 2006;12:7161-7164.
149. Van Kruiningen HJ, Freda BJ. A clustering of Crohn's disease in Mankato, Minnesota. Inflamm Bowel Dis. 2001;7:27-33.
150. Feller M, Huwiler K, Stephan R, et al. Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis. Lancet Infect Dis. 2007;7:607-613.
151. Jones PH, Farver TB, Beaman B, et al. Crohn's disease in people exposed to clinical cases of bovine paratuberculosis. Epidemiol Infect. 2006;134:49-56.
152. Tiwari A, VanLeeuwen JA, McKenna SL, et al. Johne's disease in Canada Part I: clinical symptoms, pathophysiology, diagnosis, and prevalence in dairy herds. Can Vet J. 2006;47:874-882.
153. World Organization for Animal Health. Handistatus II: zoonoses: global cases of paratuberculosis 2004 (http://www.oie.int/hs2/sit_mald-_cont.asp? amp;c_mald=27&c_cont=6&annee=2004#). Accessed October 15, 2007.
154. Park KT, Ahn J, Davis WC, et al. Analysis of the seroprevalence of bovine paratuberculosis and the application of modified absorbed ELISA to field sample testing in Korea. J Vet Sci. 2006;7:349-354.
155. de Lisle GW, Cannon MC, Yates GF, et al. Use of a polymerase chain reaction to subtype Mycobacterium avium subspecies paratuberculosis, an increasingly important pathogen from farmed deer in New Zealand. N Z Vet J. 2006;54:195-197.
156. Hugot JP, Alberti C, Berrebi D, et al. Crohn's disease: the cold chain hypothesis. Lancet. 2003;362:2012-2015.